解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Melt electrowriting (MEW) can print high-resolution scaffolds with the ultrafine fibers from 800 nm to 20 µm. However, the cell seeding efficiency relatively low due to the large pore size of the MEW scaffold. Here, we reported a method to solve this dilemma by electrospinning a gelatin methacrylate (GelMA) hydrogel f...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220962606
更新日期:2021-01-01 00:00:00
abstract::Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years. However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexi...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220972219
更新日期:2020-11-11 00:00:00
abstract::The quality and quantity of bone are crucial to the success of dental implant treatment. Recently, bone grafting materials have reached some limitations. This study aimed to evaluate the biocompatibility of novel drug delivery material, injectable methacrylated hyaluronic acid hydrogel incorporated with different rati...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220971746
更新日期:2020-11-04 00:00:00
abstract::The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix. In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl ch...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220930714
更新日期:2020-10-01 00:00:00
abstract::Devices such as contact lenses and collagen shields have been used to improve the antibiotic bioavailability of eye drops formulations in the treatment of ulcerative keratitis. Nevertheless, these devices are not sustained drug delivery systems, and a combination with eye drops is necessary. In animal patients, it req...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220931733
更新日期:2020-09-01 00:00:00
abstract::A multifunctional targeted nanoplatform combining photothermal therapy and chemotherapy has emerged as a promising strategy for comprehensive therapies of breast cancer. In this study, we constructed human epidermal growth factor receptor 2 (Her2)-targeted gold nanoshelled poly(lactic-co-glycolic acid) hybrid nanocaps...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220929616
更新日期:2020-09-01 00:00:00
abstract::In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220952594
更新日期:2020-08-27 00:00:00
abstract::Nanodrug delivery systems have been widely researched to achieve efficient antitumor drug delivery. However, the controlled drug delivery at tumor cells remains the main challenge for antitumor therapy. Herein, a pH and reduction-responsive nanocarrier based on green tea polyphenols was employed as a smart excipient f...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220924539
更新日期:2020-08-01 00:00:00
abstract::Fabrication of osteoconductive scaffold with osteoinductive capability and appropriate resorption rate is of great significance for treating bone defects. To achieve this aim, strontium-substituted calcium sulfate hemihydrate (Sr-CSH) and hydroxyapatite (HA) were mixed to develop a novel composite. Sr-CSH containing 5...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220915816
更新日期:2020-07-01 00:00:00
abstract::The aim of the in vitro study was a comparison of an allogenic (ABSM) and a xenogenic bone substitute material (XBSM) with and without injectable platelet-rich fibrin (ABSM-i-PRF & XBSM-i-PRF) on cell characteristics of human osteoblasts (HOB). Here, ABSM and XBSM (+ i-PRF = test; - i-PRF = control) were incubated wit...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220914407
更新日期:2020-07-01 00:00:00
abstract::Medical sheets are useful in surgically repair vascular disease. To avoid long-term side effects, they are to be replaced with regenerated tissue after implantation. Silk fibroin is a fibrous protein secreted by silkworm. The advantage of silk fibroin is its biocompatibility and has been used as regenerative artificia...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220928660
更新日期:2020-06-02 00:00:00
abstract::Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing proce...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/0885328219834656
更新日期:2019-05-01 00:00:00
abstract::Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any promise of a cure in the near future. Although islet transplantation has proven to be an effective means of treating type 1 diabetes mell...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/0885328219831391
更新日期:2019-04-01 00:00:00
abstract::Poor blood circulation makes it difficult for antitubercular drugs to achieve effective bactericidal concentration at tuberculose focus. The residual Mycobacterium tuberculosis around surgical wound would multiply, resulting in nonunion or sinus formation. Carbon nanotubes have strong tissue penetration and can cross ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218814988
更新日期:2019-02-01 00:00:00
abstract::Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood-brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the ben...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218799551
更新日期:2018-10-01 00:00:00
abstract::Understanding the structure-function relationship in biomaterial constructs is critical in optimizing biological outcomes. For ensheathed structures such as peripheral nerve, engineering implantable tissue substitutes has been challenging. This is due to a unique geometry of thin-walled microtube arrays composed mostl...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218804338
更新日期:2018-10-01 00:00:00
abstract::This study aims the in vivo biological characterization of an innovative minocycline delivery system, based on polymethylmethacrylate bone cement. Bone cements containing 1% or 2.5% (w/w) minocycline were formulated and evaluated through solid-state characterization. Biological evaluation was conducted in vivo, within...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218795290
更新日期:2018-09-01 00:00:00
abstract::The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defec...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218765847
更新日期:2018-07-01 00:00:00
abstract::Tendon tears are a relevant concern for today's national health systems because of their social impact and high recurrence rate. The current gold standard for fixing tendon tears is surgical repair; however, this strategy is not able to fully re-establish tendon integrity and functionality. Tissue engineering approach...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218779846
更新日期:2018-07-01 00:00:00
abstract::A biodegradable polylactic acid composite containing tricalcium phosphate microsphere was fabricated. The composite exhibited enhanced biocompatibility and a well-interconnected porous structure that enabled tissue ingrowth after degradation. The tricalcium phosphate microspheres had an average size of 106 ± 43 μm and...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218763660
更新日期:2018-05-01 00:00:00
abstract::Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218759043
更新日期:2018-05-01 00:00:00
abstract::Transarterial embolization is an established minimally invasive treatment for solid tumors. Unintended inflammation, foreign body reactions and ischemia-triggered neoangiogenesis are clinical drawbacks of permanent embolic materials. The aim of the current study was to characterize a new type of biodegradable starch m...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217746674
更新日期:2018-02-01 00:00:00
abstract::Central venous access devices play an important role in patients with prolonged intravenous administration requirements. In the last years, the coating of these devices with bactericidal compounds has emerged as a potential tool to prevent bacterial colonization. Our study describes the modification of 3D-printed rese...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217739199
更新日期:2018-01-01 00:00:00
abstract::The development of an effective wound dressing with the ability to induce skin wound healing is a great challenge in medicine. Nanofibers are highly attractive for wound dressing preparation due to their properties such as hemostasis induction, good absorption of wound exudates, and facilitation of cell growth. Chitos...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217739562
更新日期:2018-01-01 00:00:00
abstract::Bioimaging at a subcellular resolution to label cytoplasm and nucleus in living cell by just one photoluminescent nanoparticle has great application potential in bioresearch, preclinical diagnosis, screening, and image-guided therapy of life-threatening diseases. Herein, we report a novel arginine (Arg) functionalized...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217725203
更新日期:2017-10-01 00:00:00
abstract::The production of large quantities of functional vascularized bone tissue ex vivo still represent an unmet clinical challenge. Microcarriers offer a potential solution to scalable manufacture of bone tissue due to their high surface area-to-volume ratio and the capacity to be assembled using a modular approach. Microc...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217720812
更新日期:2017-09-01 00:00:00
abstract::Silicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217715428
更新日期:2017-08-01 00:00:00
abstract::Nonviral gene delivery systems are finding widespread use due to their safety, rapid and economical production, and ease of modification. In this work, series of N-alkyl-substituted linear polyethylenimine (CP) polymers have been synthesized, characterized, and investigated about how degree of substitution (hydrophobi...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217710125
更新日期:2017-07-01 00:00:00
abstract::Biodegradable sponges, as a promising hemostatic biomaterial, has been clinically required over the past decades. Current hemostatic sponges are generally prepared by crosslinking and freeze-drying, but the quality control or biocompatibility is often unsatisfactory due to the freezing-caused morphological non-uniform...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216687663
更新日期:2017-03-01 00:00:00
abstract::Dicalcium phosphate dihydrate particles functionalized with triethyleneglycol dimethacrylate were synthesized and added to a photocurable mixture of bisphenol-A glycidyl dimethacrylate and triethyleneglycol dimethacrylate with the purpose of developing a resin composite capable of releasing calcium and phosphate ions ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216680116
更新日期:2017-01-01 00:00:00
abstract::Excessive demineralization in osteoporotic bones impairs its self-regeneration potential following a defect/fracture and is of great concern among the aged population. In this context, implants with inherent osteogenic ability loaded with therapeutic ions like Strontium (Sr2+) may bring forth promising outcomes. Micro...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216647197
更新日期:2016-10-01 00:00:00
abstract::Sodium alginate is an effective biomaterial for tissue engineering applications. Non-purified alginate is contaminated with protein, lipopolysaccharide, DNA, and RNA, which could elicit adverse immunological reactions. We developed a purification protocol to generate biocompatible alginate based on (a) activated charc...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216645952
更新日期:2016-10-01 00:00:00
abstract::Injectable thermo-sensitive hydrogels have a potential application in bone tissue engineering for their sensitivities and minimal invasive properties. Human dental pulp stem cells have been considered a promising tool for tissue reconstruction. The objective of this study was to investigate the proliferation and osteo...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216661566
更新日期:2016-09-01 00:00:00
abstract::Phenylalanine ethyl ester (PAE)-alginate (Alg) conjugate (PAE-Alg, PEA) was synthesized and formation of an amide bond between PAE and Alg was confirmed by Fourier transformed-infrared and (1)H nuclear magnetic resonance spectroscopy. The degree of PAE substitution was 3.5-4.7 (PAE group per hundred sugar residues of ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216630497
更新日期:2016-07-01 00:00:00
abstract::A series biodegradable poly (γ-glutamic acid)/beta-tricalcium phosphate (γ-PGA/TCP) nanocomposites were prepared which were composed of poly-γ-glutamic acid polymerized in situ with β-tricalcium phosphate and physiochemically characterized as bone graft substitutes. The particle size via dynamic light scattering, the ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216632444
更新日期:2016-07-01 00:00:00
abstract::Poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) copolymers have been widely used for various biomedical applications. However, their hemocompatibility has not been clarified, which would lag their developments and clinical applications. In this work, we studied the effect of PEG-PLA copolymers on key human blood com...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215627404
更新日期:2016-05-01 00:00:00
abstract::In order to induce esophageal muscle cells' orientation, the silicon wafer with prototype 1 and prototype 2 was designed. Prototype 1 has micro-channels of 200 µm width and 30 µm depth with 30 µm wide wall as the interval. Prototype 2 has channels of 100 µm width and 30 µm depth with a discontinuous wall which has 30 ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215627585
更新日期:2016-04-01 00:00:00
abstract::The effect of hybrid material-graphene flakes with Fe3O4 nanospheres (GO-Fe3O4), graphene oxide (GO) and magnetite nanospheres (Fe3O4) in rotating magnetic field on mammalian cells metabolism has been studied. Several reports shown that exposure to magnetic field may have influence on cellular membrane permeability. T...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216628762
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:A functionalized graphene oxide-based thermosensitive hydrogel loaded with docetaxel for intratumoral delivery was designed to enhance therapeutic efficacy and alleviate system toxicity. METHODS:First, graphene oxide was functionalized with chitosan to acquire high stability in physiological solutions. And the...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215619583
更新日期:2016-03-01 00:00:00
abstract::To develop biocompatible composite microspheres for novel hemostatic use, we designed and prepared a novel biomaterial, composite microspheres consisting of carboxymethyl chitosan, sodium alginate, and collagen (CSCM). The ultra-structure of CSCM was investigated by scanning electron microscopy assay. In hemostatic fu...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215618354
更新日期:2016-02-01 00:00:00