Abstract：
:This investigation describes the synthesis and in vitro evaluation of cationic hydrogel sub-microparticles based on polydimethylaminoethylmethacrylate for oral insulin delivery. Polymerization of dimethylaminoethylmethacrylate was carried out in aqueous medium with potassium persulfate as the initiator. Quaternization of the resulting hydrogel was carried out to introduce cationic surface groups and the derivatization was confirmed by zeta potential measurements, nuclear magnetic resonance and infrared spectroscopies. Swelling behavior of these particles was evaluated for dependence of pH. Insulin-loaded particles were subjected to in vitro release experiments at gastric and intestinal pH. Moreover, cytotoxicity evaluation showed that both polydimethylaminoethylmethacrylate and its quaternized derivative were non-toxic to Caco-2 and L929 cell lines. The presence of quaternary ammonium groups improved the cationic charge and enhanced the mucoadhesive properties of the hydrogel. Confocal microscopic observations showed that these sub-microparticles were capable of opening tight junctions between the Caco-2 cells and thus increased the paracellular permeability. The above studies suggest that cationic hydrogel sub-microparticles can act as a good candidate for oral insulin delivery.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Sonia TA,Sharma CPdoi
10.1177/0885328212437392subject
Has Abstractpub_date
2013-07-01 00:00:00pages
62-73issue
1eissn
0885-3282issn
1530-8022pii
0885328212437392journal_volume
28pub_type
杂志文章abstract：:Gold nanomaterials possess unique physical and chemical properties, which attracted much attention in recent years. As a new type of gold nanomaterials, gold nanostars (GNSTs) have been prepared and characterized in this study. GNSTs under near-infrared (NIR) light irradiation can exert not only cancer photothermal th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215594481
更新日期：2015-11-01 00:00:00
abstract：:The effect of an ampholytic surfactant on the swelling properties of polymeric materials was studied, using various swelling liquids. Tablets were prepared consisting of hydroxypropyl methylcellulose, poly(oxyethylene) and sodium alginate. Tego betain was the non-ionic surfactant used as an additive in a series of sam...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/GX1T-2JC6-QWC6-69GC
更新日期：2000-07-01 00:00:00
abstract：:Biomaterials and devices have been used in a variety of applications ranging from disposable extracorporeal devices and soft and hard tissue augmentation, to total artificial internal organs. However, there are risks and failures in each application which are a result of undesirable biological interactions. This artic...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829300800104
更新日期：1993-07-01 00:00:00
abstract：:Understanding the structure-function relationship in biomaterial constructs is critical in optimizing biological outcomes. For ensheathed structures such as peripheral nerve, engineering implantable tissue substitutes has been challenging. This is due to a unique geometry of thin-walled microtube arrays composed mostl...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218804338
更新日期：2018-10-01 00:00:00
abstract：:The purpose of this investigation is to study the effect of long-term subcutaneous aluminum polymeric implants on aluminum release and accumulation in various tissues in rats. The implants were formulated using silicone rubber and polyurethane polymers and three different aluminum salts. The polymeric matrices were ev...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829601100103
更新日期：1996-07-01 00:00:00
abstract：:Compounds of a silicone elastomer suitable for preparing maxillofacial prostheses, reinforced with various amounts of silica powder, have been studied for their mechanical response and wetting properties in terms of contact angle. Tensile strength and elongation at break showed an increase with increasing silica volum...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829801300104
更新日期：1998-07-01 00:00:00
abstract：:Reconstruction of critical sized bone injuries is a major problem that continues to inspire the design of new materials and grafts. Natural ceramics (hydroxyapatite (HA) coralline HA, or synthetic HA) and β-tricalcium phosphate (β-TCP) are being explored for use as scaffolds in bone tissue engineering, among several o...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211415132
更新日期：2013-01-01 00:00:00
abstract：:Chitosan-glutaraldehyde microparticles were produced by emulsion crosslinking method to be used as drug delivery system for polyphenols from Thymus serpyllum L. aqueous extract. The effect of preparation conditions, chitosan concentration (1.5-3% w/v), and glutaraldehyde/chitosan (GA/Ch) mass ratio (0.15-1.20) on wate...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215598940
更新日期：2015-11-01 00:00:00
abstract：:Devices such as contact lenses and collagen shields have been used to improve the antibiotic bioavailability of eye drops formulations in the treatment of ulcerative keratitis. Nevertheless, these devices are not sustained drug delivery systems, and a combination with eye drops is necessary. In animal patients, it req...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220931733
更新日期：2020-09-01 00:00:00
abstract：:Among biomaterials used as implants in human body, sutures constitute the largest groups of materials having a huge market exceeding $1.3 billion annually. Sutures are the most widely used materials in wound closure and have been in use for many centuries. With the development of the synthetic absorbable polymer, poly...
journal_title：Journal of biomaterials applications
pub_type： 历史文章,杂志文章,评审
doi：10.1177/0885328210384890
更新日期：2010-11-01 00:00:00
abstract：:The manufacture of a polyester vascular prosthesis in the southern hemisphere is a new development in the global dissemination of this maturing technology. Hence the recent introduction of the Barone Microvelour arterial graft from Argentina has highlighted the need for a comparative in vitro and in vivo study to comp...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532828800300302
更新日期：1989-01-01 00:00:00
abstract：:Biodegradable sponges, as a promising hemostatic biomaterial, has been clinically required over the past decades. Current hemostatic sponges are generally prepared by crosslinking and freeze-drying, but the quality control or biocompatibility is often unsatisfactory due to the freezing-caused morphological non-uniform...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328216687663
更新日期：2017-03-01 00:00:00
abstract：:Appropriate design of dialysis membranes requires correct values of structural parameters such as pore radius, surface porosity, water content and tortuosity. It is impossible, however, to find the pore radius of dialysis membranes using a mercury porosimeter or an electron microscope because the pores are only severa...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532828900400201
更新日期：1989-10-01 00:00:00
abstract：:Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328209344003
更新日期：2010-08-01 00:00:00
abstract：:An experimental and computational investigation of the self-tapping ability of carbon fibre reinforced polyetheretherketone (CFR-PEEK) has been conducted. Six CFR-PEEK suture anchor designs were investigated using PEEK-OPTIMA® Reinforced, a medical grade of CFR-PEEK. Experimental tests were conducted to investigate th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214535274
更新日期：2014-10-01 00:00:00
abstract：:The in vitro effect of platelet-rich plasma (PRP) on cell loading, proliferation, and osteogenic differentiation of human mesenchymal stem cells (MSC) is assessed on distinct resorbable and synthetic calcium phosphate scaffolds. A high specific surface area scaffold composed of calcium-deficient hydroxyapatite (CDHA; ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328207088269
更新日期：2008-09-01 00:00:00
abstract：:In this study, a novel bilayer scaffold composed of electrospun polycaprolactone and poly(lacto-co-glycolic acid) (PCL/PLGA) membrane and glutaraldehyde (3.5% v/v) cross-linked chitosan/gelatin hydrogel was fabricated using two methods: electrospinning of the membrane onto the lyophilized hydrogel (BS-1) and membrane ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211416527
更新日期：2013-01-01 00:00:00
abstract：:Transarterial embolization is an established minimally invasive treatment for solid tumors. Unintended inflammation, foreign body reactions and ischemia-triggered neoangiogenesis are clinical drawbacks of permanent embolic materials. The aim of the current study was to characterize a new type of biodegradable starch m...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217746674
更新日期：2018-02-01 00:00:00
abstract：:The effect of hybrid material-graphene flakes with Fe3O4 nanospheres (GO-Fe3O4), graphene oxide (GO) and magnetite nanospheres (Fe3O4) in rotating magnetic field on mammalian cells metabolism has been studied. Several reports shown that exposure to magnetic field may have influence on cellular membrane permeability. T...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328216628762
更新日期：2016-04-01 00:00:00
abstract：:The purpose of this study is the development of a nerve electrode that reorganizes nerve geometry slowly and controllably. The Flat Interface Nerve Electrode (FINE) can reshape the nerve into an elongated oval and provide selective stimulation. However, the rate of closure of this electrode is difficult to control. Th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208097426
更新日期：2009-09-01 00:00:00
abstract：:The production of large quantities of functional vascularized bone tissue ex vivo still represent an unmet clinical challenge. Microcarriers offer a potential solution to scalable manufacture of bone tissue due to their high surface area-to-volume ratio and the capacity to be assembled using a modular approach. Microc...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217720812
更新日期：2017-09-01 00:00:00
abstract：:Nonviral gene delivery systems are finding widespread use due to their safety, rapid and economical production, and ease of modification. In this work, series of N-alkyl-substituted linear polyethylenimine (CP) polymers have been synthesized, characterized, and investigated about how degree of substitution (hydrophobi...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217710125
更新日期：2017-07-01 00:00:00
abstract：:The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Quest...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212473510
更新日期：2014-01-01 00:00:00
abstract：:Sodium alginate is an effective biomaterial for tissue engineering applications. Non-purified alginate is contaminated with protein, lipopolysaccharide, DNA, and RNA, which could elicit adverse immunological reactions. We developed a purification protocol to generate biocompatible alginate based on (a) activated charc...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328216645952
更新日期：2016-10-01 00:00:00
abstract：:This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)-pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS-pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microen...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328206056771
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:To produce biodurable small diameter microporous vascular grafts with self-sealing properties for vascular access, for peripheral vascular and potentially for coronary artery bypass. The prosthesis should retain compliance and pulsatile flow in situ using a unique modus operandi permitting wall compression whic...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829501000207
更新日期：1995-10-01 00:00:00
abstract：:Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215597818
更新日期：2015-11-01 00:00:00
abstract：:A biodegradable polylactic acid composite containing tricalcium phosphate microsphere was fabricated. The composite exhibited enhanced biocompatibility and a well-interconnected porous structure that enabled tissue ingrowth after degradation. The tricalcium phosphate microspheres had an average size of 106 ± 43 μm and...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218763660
更新日期：2018-05-01 00:00:00
abstract：:Bioimaging at a subcellular resolution to label cytoplasm and nucleus in living cell by just one photoluminescent nanoparticle has great application potential in bioresearch, preclinical diagnosis, screening, and image-guided therapy of life-threatening diseases. Herein, we report a novel arginine (Arg) functionalized...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217725203
更新日期：2017-10-01 00:00:00
abstract：:In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220952594
更新日期：2020-08-27 00:00:00
