Abstract:
:The effect of hybrid material-graphene flakes with Fe3O4 nanospheres (GO-Fe3O4), graphene oxide (GO) and magnetite nanospheres (Fe3O4) in rotating magnetic field on mammalian cells metabolism has been studied. Several reports shown that exposure to magnetic field may have influence on cellular membrane permeability. Thus, the aim of presented study was to determine the cellular response of L929 fibroblast cells to nanomaterials and rotating magnetic field for 8-h exposure experiment. The GO had tendency to adsorb proteins, thus cell metabolism was decreased and the effect of that mechanism was enhanced by impact of nanospheres and rotating magnetic field. The highest reduction of cellular metabolism was recorded for WST-1 and NR assays at concentration 100 µg/mL of all tested nanomaterials and magnetic induction value 10.06 mT. The lactate dehydrogenase leakage assay has shown significant changes in membrane permeability. Further studies need to be carried out to precisely determine the mechanism of that process.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Urbas K,Jedrzejczak-Silicka M,Rakoczy R,Zaborski D,Mijowska Edoi
10.1177/0885328216628762subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1392-406issue
9eissn
0885-3282issn
1530-8022pii
0885328216628762journal_volume
30pub_type
杂志文章abstract::Polymer biocomposites based on segmented poly(ester urethane) and extracellular matrix components have been prepared for the development of tissue engineering applications with improved biological characteristics of the materials in contact with blood and tissues for long periods. Thermal, dynamical, and dielectrical ...
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journal_title:Journal of biomaterials applications
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