Abstract:
:Poly(2-hydroxyethyl methacrylate) hydrogel intraocular lenses, containing adrenochrome-melanin, were manufactured and implanted in animal eyes in order to assess the effect of melanin upon (a) biocompatibility of implants with the eye tissues, and (b) fibrous proliferation of lens epithelium responsible for the opacification of the posterior capsular membrane. An equal number of control lenses were also implanted. The animals were followed up for durations up to two years, and a detailed histopathological examination of the eyes was performed subsequent to their enucleation. The postoperative complications were minor and probably caused by surgical trauma. The study failed to give any indication of the postulated antiproliferative activity of adrenochrome-melanin since minimal capsular opacification occurred in the operated eyes, regardless of the presence of melanin.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Chirila TV,Constable IJ,Vijayasekaran S,Ben-Hun Jdoi
10.1177/088532829500900305subject
Has Abstractpub_date
1995-01-01 00:00:00pages
262-74issue
3eissn
0885-3282issn
1530-8022journal_volume
9pub_type
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