当前位置： SCI文献检索 > JOURNAL OF BIOMATERIALS APPLICATIONS期刊下所有文献 > Chitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release properties.

Chitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release properties.

Abstract：

:Chitosan-glutaraldehyde microparticles were produced by emulsion crosslinking method to be used as drug delivery system for polyphenols from Thymus serpyllum L. aqueous extract. The effect of preparation conditions, chitosan concentration (1.5-3% w/v), and glutaraldehyde/chitosan (GA/Ch) mass ratio (0.15-1.20) on water and polyphenols transport properties was investigated. Swelling ratio of dry particles (68-230 µm) in water ranged from 280% to 530%, depending on the formulation. The decrease in swelling was observed with increased GA/Ch mass ratio (i.e. crosslinking degree) at the same chitosan concentration, or with increased chitosan concentration at the same GA/Ch mass ratio. The increase in GA/Ch mass ratio was also manifested by increased particle compactness i.e. decreased size and reduced surface roughness. The sorption capacity for polyphenols seems to be a complex interplay of swelling behaviour and interactions chitosan-glutaraldehyde-polyphenols identified by Fourier transmission infrared analysis. An increase in crystallinity of chitosan was observed upon crosslinking with glutaraldehyde and encapsulation of polyphenols, as observed by X-ray diffraction analysis. The results obtained from release kinetics of selected polyphenolic compounds (caffeic acid, rosmarinic acid, total flavonoids, and total phenol content) showed that polyphenols were released at a lower amount (2-4 times) in water, but more rapidly (45-120 min) in comparison with the release in gastric followed by intestinal simulated fluid (SGF-SIF) (120-240 min). The experimental results of the time-dependent swelling in water and polyphenols release in both, water and SGF-SIF, were analyzed with several mathematical models. The results depicted Fickian diffusion as the water transport mechanism. In the case of polyphenols, only empirical Weibull model could be suggested for describing release kinetics.

journal_name

J Biomater Appl

journal_title

Journal of biomaterials applications

authors

Trifković K,Milašinović N,Djordjević V,Zdunić G,Kalagasidis Krušić M,Knežević-Jugović Z,Šavikin K,Nedović V,Bugarski B

doi

10.1177/0885328215598940

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

618-31

issue

eissn

0885-3282

issn

1530-8022

pii

0885328215598940

journal_volume

pub_type

杂志文章

在线工具

Chitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release properties.