A nerve cuff electrode for controlled reshaping of nerve geometry.


:The purpose of this study is the development of a nerve electrode that reorganizes nerve geometry slowly and controllably. The Flat Interface Nerve Electrode (FINE) can reshape the nerve into an elongated oval and provide selective stimulation. However, the rate of closure of this electrode is difficult to control. The Slowly Closing - FINE (SC-FINE) is designed with an opening height larger than the size of the nerve to accommodate initial swelling. The electrode closes slowly to reshape the nerve into the desired flat geometry. The SC-FINE is created by combining the reshaping properties of the FINE and the controllable degradation of Poly (DL lactic-co-glycolic) acid (PLGA). Bonding 50/50 or 65/35 PLGA to a stretched FINE increased the opening heights (OH) on average from 0.1 mm to 1.66 +/- 0.45 and 2.05 +/- 0.55 mm respectively. The addition of the PLGA films controls the time course of closure over a period of 16 +/- 1 days and 14 to 16 hours for the 50/50 and 65/35 SC-FINEs respectively in vitro. An in vivo chronic experiment using 50/50 SC-FINEs implanted in 28 rats with an average OH of 1.87 +/- 0.34 mm show that the reshaping periods in vivo and in vitro are similar.


J Biomater Appl


Caparso AV,Durand DM,Mansour JM




Has Abstract


2009-09-01 00:00:00














  • Fabrication of oxidized alginate-gelatin-BCP hydrogels and evaluation of the microstructure, material properties and biocompatibility for bone tissue regeneration.

    abstract::Composite hydrogel systems consisting of oxidized alginate, gelatin, and biphasic calcium phosphate were fabricated by the Schiff-base reaction and the effect of oxidation of alginate on the microstructure, material properties, and biocompatibility were evaluated. Alginate was modified by oxidizing the attached -OH gr...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Nguyen TP,Lee BT

    更新日期:2012-09-01 00:00:00

  • Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue.

    abstract::Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: O'Rourke C,Drake RA,Cameron GW,Loughlin AJ,Phillips JB

    更新日期:2015-11-01 00:00:00

  • Biological interactions: causes for risks and failures of biomaterials and devices.

    abstract::Biomaterials and devices have been used in a variety of applications ranging from disposable extracorporeal devices and soft and hard tissue augmentation, to total artificial internal organs. However, there are risks and failures in each application which are a result of undesirable biological interactions. This artic...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Jayabalan M

    更新日期:1993-07-01 00:00:00

  • Release of silica, calcium, phosphorus, and fluoride from glass ionomer cement containing bioactive glass.

    abstract::The aim of this study was to examine the release of silica (Si), calcium (Ca), phosphorous (P), and fluoride (F) from conventional glass ionomer cement (GI) and resin-modified glass ionomer cement (LCGI), containing different quantities of bioactive glass (BAG). Further aim was to evaluate in vitro biomineralization o...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Yli-Urpo H,Vallittu PK,Närhi TO,Forsback AP,Väkiparta M

    更新日期:2004-07-01 00:00:00

  • Healing properties of surface-coated polycaprolactone-co-lactide scaffolds: a pilot study in sheep.

    abstract::The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds we...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Rentsch C,Schneiders W,Hess R,Rentsch B,Bernhardt R,Spekl K,Schneider K,Scharnweber D,Biewener A,Rammelt S

    更新日期:2014-01-01 00:00:00

  • In vitro construction and in vivo regeneration of esophageal bilamellar muscle tissue.

    abstract::In order to induce esophageal muscle cells' orientation, the silicon wafer with prototype 1 and prototype 2 was designed. Prototype 1 has micro-channels of 200 µm width and 30 µm depth with 30 µm wide wall as the interval. Prototype 2 has channels of 100 µm width and 30 µm depth with a discontinuous wall which has 30 ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Hou L,Gong C,Zhu Y

    更新日期:2016-04-01 00:00:00

  • In vivo characterization of a new type of biodegradable starch microsphere for transarterial embolization.

    abstract::Transarterial embolization is an established minimally invasive treatment for solid tumors. Unintended inflammation, foreign body reactions and ischemia-triggered neoangiogenesis are clinical drawbacks of permanent embolic materials. The aim of the current study was to characterize a new type of biodegradable starch m...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Sommer CM,Do TD,Schlett CL,Flechsig P,Gockner TL,Kuthning A,Vollherbst DF,Pereira PL,Kauczor HU,Macher-Göppinger S

    更新日期:2018-02-01 00:00:00

  • Isoniazid-loaded chitosan/carbon nanotubes microspheres promote secondary wound healing of bone tuberculosis.

    abstract::Poor blood circulation makes it difficult for antitubercular drugs to achieve effective bactericidal concentration at tuberculose focus. The residual Mycobacterium tuberculosis around surgical wound would multiply, resulting in nonunion or sinus formation. Carbon nanotubes have strong tissue penetration and can cross ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Chen G,Wu Y,Yu D,Li R,Luo W,Ma G,Zhang C

    更新日期:2019-02-01 00:00:00

  • Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (L-lactide-co-ε-caprolactone) scaffold.

    abstract::The aim of this study was to design a new natural/synthetic bioactive bone scaffold for potential use in bone replacement applications. We developed a tri-component osteogenic composite scaffold made of collagen (Coll), hydroxyapatite (HA) and poly(l-lactide-co-ε-caprolactone) (PLCL). This Coll/HA/PLCL composite scaff...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Akkouch A,Zhang Z,Rouabhia M

    更新日期:2014-02-01 00:00:00

  • Comparative evaluation of in vivo biocompatibility and biodegradability of regenerated silk scaffolds reinforced with/without natural silk fibers.

    abstract::Nowadays, exceptional advantages of silk fibroin over synthetic and natural polymers have impelled the scientists to application of this biomaterial for tissue engineering purposes. Recently, we showed that embedding natural degummed silk fibers in regenerated Bombyx mori silk-based scaffold significantly increases th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Mobini S,Taghizadeh-Jahed M,Khanmohammadi M,Moshiri A,Naderi MM,Heidari-Vala H,Ashrafi Helan J,Khanjani S,Springer A,Akhondi MM,Kazemnejad S

    更新日期:2016-01-01 00:00:00

  • Development of poly(N-isopropylacrylamide)/alginate copolymer hydrogel-grafted fabrics embedding of berberine nanosuspension for the infected wound treatment.

    abstract::In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was pr...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Xu H,Yuan XD,Shen BD,Han J,Lv QY,Dai L,Lin MG,Yu C,Bai JX,Yuan HL

    更新日期:2014-05-01 00:00:00

  • Factor analysis in the evaluation of the relationship between bacterial adherence to biomaterials and changes in free energy.

    abstract::The relative surface charge and free energy of forty-one coagulase-negative staphylococci were found to be normally distributed; therefore, they can be considered a homogeneous group under strict statistical criteria. The adherence of these bacteria to eight different biomaterials (seven synthetic and one biologic) wa...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Carballo J,Ferreirós CM,Criado MT

    更新日期:1992-10-01 00:00:00

  • Hemodynamic predictors for weaning patients from ventricular assist devices (VADs).

    abstract::In order to find hemodynamic parameters that can accurately predict whether patients can be successfully weaned from ventricular assist devices (VADs), we studied data from 17 patients supported with Pierce-Donachy VADs [11 left VAD (LVAD); 6 right VAD (RVAD)] following cardiogenic shock for periods from 1.3 to 22 day...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Termuhlen DF,Swartz MT,Ruzevich SA,Reedy JE,Pennington DG

    更新日期:1990-04-01 00:00:00

  • Preparation, characterization, and in vitro and in vivo evaluation of cellulose/soy protein isolate composite sponges.

    abstract::A series of cellulose/soy protein isolate (SPI) sponges was prepared using a freeze-drying process. The effect of the SPI content on the structure of the sponges was characterized by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). It showed that...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Luo LH,Zhang YF,Wang XM,Wan Y,Chang PR,Anderson DP,Chen Y

    更新日期:2010-02-01 00:00:00

  • In vitro proliferation and osteogenic differentiation of human dental pulp stem cells in injectable thermo-sensitive chitosan/β-glycerophosphate/hydroxyapatite hydrogel.

    abstract::Injectable thermo-sensitive hydrogels have a potential application in bone tissue engineering for their sensitivities and minimal invasive properties. Human dental pulp stem cells have been considered a promising tool for tissue reconstruction. The objective of this study was to investigate the proliferation and osteo...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Chen Y,Zhang F,Fu Q,Liu Y,Wang Z,Qi N

    更新日期:2016-09-01 00:00:00

  • Bioactive polymers 55. Synthesis and characterization of a macromolecular drug based on 5-acetylamino-2-sulfamoyl-1,3,4-thiodiazole.

    abstract::The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/su...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Dumitriu S,Popa M,Dărângă M,Dumitriu C

    更新日期:1992-07-01 00:00:00

  • Influence of MMP inhibitor GM6001 loading of fibre coated polypropylene meshes on wound healing: Implications for hernia repair.

    abstract::Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Böhm G,Groll J,Heffels KH,Heussen N,Ink P,Alizai HP,Neumann UP,Schnabel R,Mirastschijski U

    更新日期:2018-05-01 00:00:00

  • Stimulus-responsive tea polyphenols as nanocarrier for selective intracellular drug delivery.

    abstract::Nanodrug delivery systems have been widely researched to achieve efficient antitumor drug delivery. However, the controlled drug delivery at tumor cells remains the main challenge for antitumor therapy. Herein, a pH and reduction-responsive nanocarrier based on green tea polyphenols was employed as a smart excipient f...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Guo Z,Yang Y,Shu Y,Qiao L,Peng M,Wang Z

    更新日期:2020-08-01 00:00:00

  • Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6.

    abstract::Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Kevadiya BD,Joshi GV,Patel HA,Ingole PG,Mody HM,Bajaj HC

    更新日期:2010-08-01 00:00:00

  • Impact of polyelectrolytes and their corresponding multilayers to human primary endothelial cells.

    abstract::The layer-by-layer technique, which allows simple preparation of polyelectrolyte multilayers, came into the focus of research for development of functionalized medical devices. Numerous literature exist that concentrate on the film build-up and the behaviour of cells on polyelectrolyte multilayers. However, in case of...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Nolte A,Hossfeld S,Schroeppel B,Mueller A,Stoll D,Walker T,Wendel HP,Krastev R

    更新日期:2013-07-01 00:00:00

  • Physical properties and blood compatibility of poly(urethaneamideimide) and poly(urethaneureas) with aliphatic side chains.

    abstract::The synthesis, tensile strength, thermostability and hydrophilicity of the poly(urethaneamideimide) and the poly(urethaneureas) with N-aliphatic side chains are presented. These elastomers were compared in blood compatibility with determination of the common indices and with immunologic tests of the beta-thromboglobul...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Calusinski G,Masiulanis B,Jurkowski P

    更新日期:2000-10-01 00:00:00

  • A clinical report of bone regeneration in maxillofacial surgery using bonelike synthetic bone graft.

    abstract::The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocol...

    journal_title:Journal of biomaterials applications

    pub_type: 临床试验,杂志文章


    authors: Sousa RC,Lobato JV,Maurício AC,Hussain NS,Botelho CM,Lopes MA,Santos JD

    更新日期:2008-01-01 00:00:00

  • Strontium-substituted calcium sulfate hemihydrate/hydroxyapatite scaffold enhances bone regeneration by recruiting bone mesenchymal stromal cells.

    abstract::Fabrication of osteoconductive scaffold with osteoinductive capability and appropriate resorption rate is of great significance for treating bone defects. To achieve this aim, strontium-substituted calcium sulfate hemihydrate (Sr-CSH) and hydroxyapatite (HA) were mixed to develop a novel composite. Sr-CSH containing 5...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Chang H,Xiang H,Yao Z,Yang S,Tu M,Zhang X,Yu B

    更新日期:2020-07-01 00:00:00

  • Thermal, dynamic mechanical, and dielectric analyses of some polyurethane biocomposites.

    abstract::Polymer biocomposites based on segmented poly(ester urethane) and extracellular matrix components have been prepared for the development of tissue engineering applications with improved biological characteristics of the materials in contact with blood and tissues for long periods. Thermal, dynamical, and dielectrical ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Macocinschi D,Filip D,Vlad S,Cristea M,Musteata V,Ibanescu S

    更新日期:2012-08-01 00:00:00

  • Fabrication and characterization of polysulfone-dicalcium silicate composite films.

    abstract::Polysulfone (PSU) composite films filled with Beta-dicalcium silicate (Beta-Ca(2)SiO(4)) particles are prepared by the solvent casting-evaporation method. The surface morphologies and mechanical properties of the films are determined. The bioactivity of the composite films is evaluated by soaking them in simulated bod...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Cheng W,Chang J

    更新日期:2006-04-01 00:00:00

  • Polymer-based material containing calcium phosphate particles functionalized with a dimethacrylate monomer for use in restorative dentistry.

    abstract::Dicalcium phosphate dihydrate particles functionalized with triethyleneglycol dimethacrylate were synthesized and added to a photocurable mixture of bisphenol-A glycidyl dimethacrylate and triethyleneglycol dimethacrylate with the purpose of developing a resin composite capable of releasing calcium and phosphate ions ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Rodrigues MC,Xavier TA,Arana-Chavez VE,Braga RR

    更新日期:2017-01-01 00:00:00

  • Characterization of a new composite PMMA-HA/Brushite bone cement for spinal augmentation.

    abstract::Calcium phosphate fillers have been shown to increase cement osteoconductivity, but have caused drawbacks in cement properties. Hydroxyapatite and Brushite were introduced in an acrylic two-solution cement at varying concentrations. Novel composite bone cements were developed and characterized using rheology, injectab...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Aghyarian S,Rodriguez LC,Chari J,Bentley E,Kosmopoulos V,Lieberman IH,Rodrigues DC

    更新日期:2014-11-01 00:00:00

  • Cellular interactions with biodegradable polyurethanes formulated from L-tyrosine.

    abstract::L-Tyrosine polyurethanes (LTUs) have been synthesized by structural modification of the poly (amino acid) backbone to circumvent the problems associated with the processing of poly (amino acids) arising from their high crystallinity, insolubility in common organic solvents, and high glass-transition and melting temper...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Shah PN,Yun YH

    更新日期:2013-05-01 00:00:00

  • The effect of plasticizers on the erosion and mechanical properties of polymeric films.

    abstract::Cellulose acetate phthalate and Pluronic F-127 combined together (70:30 wt:wt) create a rigid, surface-eroding association polymer. To impart flexibility into the polymer system and allow for a drug delivery film that can contour to varying wound shapes, plasticizers were added. Triethyl citrate or tributyl citrate wa...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Rabek CL,Van Stelle R,Dziubla TD,Puleo DA

    更新日期:2014-01-01 00:00:00

  • Drug release from PLGA microspheres attached to solids using supercritical CO₂.

    abstract::Functionalization of a porous orthopedic implant with dexamethasone, a widely used anti-inflammatory drug, encapsulated within a biodegradable polymer for controlled release could help reduce or eliminate the inflammation response by the local tissue. In this research, we investigated the possibility of using supercri...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Mulia K,Witkamp GJ,Dawes GJ,Fratila-Apachitei LE,Apachitei I,Duszczyk J,Pellikaan H

    更新日期:2011-01-01 00:00:00