Abstract:
:Polylactic acid (PLA)-derived polymers are widely used in many biotechnological fields, thanks to their biocompatibility and resorbability through natural pathways. Moreover, PLA is one of the few polymers in which both the properties and the stereochemical structure can be easily modified, making possible a specific 'tailoring' of the final polymer according to the desired use. In this study, we obtained, by salt leaching technique, P(D,L)LA sponges in which various concentrations of α-tocopherol (Vit. E 10-40%, w/w) were incorporated. Vit.E is a natural biological antioxidant, also known to have anti-inflammatory activity, which has been extensively used to improve biostability and biocompatibility of different biomaterials. To assess whether Vit.E could modify the main physical-chemical properties of P(D,L)LA sponges, their morphology, water uptake and hydrolytic degradation kinetics, along with protein loading and releasing attitudes, were investigated. Our results highlighted that incorporation of Vit.E into P(D,L)LA sponges modified the sponge morphology, decreased P(D,L)LA water uptake and degradation, and modified protein releasing kinetics. These Vit.E-related effects could make P(D,L)LA more suitable as drug delivery system and tissue engineering scaffold.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Renò F,Rizzi M,Cannas Mdoi
10.1177/0885328211398298subject
Has Abstractpub_date
2012-08-01 00:00:00pages
165-70issue
2eissn
0885-3282issn
1530-8022pii
0885328211398298journal_volume
27pub_type
杂志文章abstract::Aluminum-free glass ionomer cements (GICs) are under development for orthopedic applications, but are limited by their insufficient handling properties. Here, the addition of calcium polyphosphate (CPP) was investigated as an additive to an experimental zinc-silicate glass ionomer cement. A 50% maximum increase in wor...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215568985
更新日期:2015-07-01 00:00:00
abstract::Single nanofibers with chemical and functional properties consistent with artery extracellular matrix nanofibers were produced by electrospinning. Using weight ratios to mimic artery extracellular matrix, five materials were tested: (1) Collagen type I, (2) Collagen type I + Collagen type III, (3) Collagen type I + po...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213477893
更新日期:2014-01-01 00:00:00
abstract::Composite hydrogel systems consisting of oxidized alginate, gelatin, and biphasic calcium phosphate were fabricated by the Schiff-base reaction and the effect of oxidation of alginate on the microstructure, material properties, and biocompatibility were evaluated. Alginate was modified by oxidizing the attached -OH gr...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211404265
更新日期:2012-09-01 00:00:00
abstract::The aim of this work was to study the cytotoxicity of different fractions of gold nanoparticles prepared by ultrasonic spray pyrolysis from gold scrap. The target cells were rat thymocytes, as a type of nonproliferating cells, and L929 mouse fibroblasts, as a type of continuous proliferating cells. Fractions 1 and 2, ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328210377536
更新日期:2012-01-01 00:00:00
abstract::In this study, a phosphorylation treatment of porous anodic alumina (PAA) was performed by wet impregnation in phosphoric acid and a subsequent heat treatment. The PAA and phosphorylated PAA specimens were analyzed using a field emission scanning electron microscope, an energy-dispersive X-ray spectrometer, and Fourie...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214526765
更新日期:2014-09-01 00:00:00
abstract::The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocol...
journal_title:Journal of biomaterials applications
pub_type: 临床试验,杂志文章
doi:10.1177/0885328207078260
更新日期:2008-01-01 00:00:00
abstract::An electronic sensor system for urinary bladder pressure monitoring requires an imbedding into a biocompatible, flexible, and liquid-impermeable material. Poly(dimethylsiloxane) (PDMS) was selected in the present set-up as packaging material because it fulfills the abovementioned requirements. However, the surface of ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211422119
更新日期:2013-02-01 00:00:00
abstract::A rapid and continuous hydrothermal route for the synthesis of nano-sized hydroxyapatite rods co-precipitated with calcium-doped zirconia nanoparticles using a superheated water flow at 450°C and 24.1 MPa as a crystallizing medium is described. Hydroxyapatite and calcium-doped zirconia phases in the powder mixtures co...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212444483
更新日期:2012-07-01 00:00:00
abstract::Poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) copolymers have been widely used for various biomedical applications. However, their hemocompatibility has not been clarified, which would lag their developments and clinical applications. In this work, we studied the effect of PEG-PLA copolymers on key human blood com...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215627404
更新日期:2016-05-01 00:00:00
abstract::Thrombosis is the most serious acute problem for small diameter arterial bypass grafts. In this research, small diameter expanded polytetrafluoroethylene (e-PTFE) vascular grafts were coated with acetylsalicylic acid (ASA) loaded poly (d,l-lactide) (PLA) by a solvent casting method. The feasibility and efficacy of thi...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829400800404
更新日期:1994-04-01 00:00:00
abstract::The different barriers that slow the penetration of active ingredients administered by the ocular route are described, and some novel dosage forms designed for this route are discussed. Both precorneal and corneal factors considerably restrict ocular penetration. The low bioavailability of classical ophthalmic dosage ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829701100305
更新日期:1997-01-01 00:00:00
abstract::The synthesis, tensile strength, thermostability and hydrophilicity of the poly(urethaneamideimide) and the poly(urethaneureas) with N-aliphatic side chains are presented. These elastomers were compared in blood compatibility with determination of the common indices and with immunologic tests of the beta-thromboglobul...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1106/TBUW-TWW9-EC7X-YA3H
更新日期:2000-10-01 00:00:00
abstract::In this paper, the authors describe a novel type of hydrogel coating prepared from the copolymer of human serum albumin and oxidized dextran. The material was designed as a hydrogel sealant for polyester (Dacron®)-based vascular grafts. Dextran was chosen as a coating material due to its anti-thrombogenic properties. ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213509676
更新日期:2014-05-01 00:00:00
abstract::Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood-brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the ben...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218799551
更新日期:2018-10-01 00:00:00
abstract::Hydroxyapatite (Ca10(PO4)6(OH)2) is widely investigated as an implantable material for hard tissue restoration due to its osteoconductive properties. However, hydroxyapatite in bulk form is limited as its mechanical properties are insufficient for load-bearing orthopedic applications. Attempts have been made to improv...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215592866
更新日期:2015-11-01 00:00:00
abstract::The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defec...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218765847
更新日期:2018-07-01 00:00:00
abstract::Fabrication of osteoconductive scaffold with osteoinductive capability and appropriate resorption rate is of great significance for treating bone defects. To achieve this aim, strontium-substituted calcium sulfate hemihydrate (Sr-CSH) and hydroxyapatite (HA) were mixed to develop a novel composite. Sr-CSH containing 5...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220915816
更新日期:2020-07-01 00:00:00
abstract::Titanium and hydroxyapatite (HA) are widely used as biomaterials for dental and medical applications. HA-coated titanium implants have excellent biocompatibility and mechanical properties. However, the adherence of HA film formed on titanium substrate is weak because of the lack of chemical interaction between HA and ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328209340334
更新日期:2010-03-01 00:00:00
abstract::The process of molecular self-assembly plays a crucial role in formulation of polymeric nanoparticulated drug delivery carriers as it creates the possibility for enhanced drug encapsulation and carrier surface engineering. This study aimed to develop a novel self-assembled polymeric micelles for targeted delivery in t...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214549612
更新日期:2015-01-01 00:00:00
abstract::In this study, the effects of sodium carbonate (Na(2)CO(3) ) solution with different concentrations (10, 15, 20, and 25 wt%) as liquid phase on the setting time and compressive strength of tricalcium silicate bone cements are investigated. The in vitro bioactivity and degradability of the resultant Ca(3)SiO(5)-Na(2)CO...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328208088714
更新日期:2008-11-01 00:00:00
abstract::Transarterial embolization is an established minimally invasive treatment for solid tumors. Unintended inflammation, foreign body reactions and ischemia-triggered neoangiogenesis are clinical drawbacks of permanent embolic materials. The aim of the current study was to characterize a new type of biodegradable starch m...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217746674
更新日期:2018-02-01 00:00:00
abstract::The effect of an ampholytic surfactant on the swelling properties of polymeric materials was studied, using various swelling liquids. Tablets were prepared consisting of hydroxypropyl methylcellulose, poly(oxyethylene) and sodium alginate. Tego betain was the non-ionic surfactant used as an additive in a series of sam...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1106/GX1T-2JC6-QWC6-69GC
更新日期:2000-07-01 00:00:00
abstract::Medical sheets are useful in surgically repair vascular disease. To avoid long-term side effects, they are to be replaced with regenerated tissue after implantation. Silk fibroin is a fibrous protein secreted by silkworm. The advantage of silk fibroin is its biocompatibility and has been used as regenerative artificia...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220928660
更新日期:2020-06-02 00:00:00
abstract::The effect of hybrid material-graphene flakes with Fe3O4 nanospheres (GO-Fe3O4), graphene oxide (GO) and magnetite nanospheres (Fe3O4) in rotating magnetic field on mammalian cells metabolism has been studied. Several reports shown that exposure to magnetic field may have influence on cellular membrane permeability. T...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216628762
更新日期:2016-04-01 00:00:00
abstract::The aim of this study was to evaluate the possibility of metal complex formation between sodium-phosphorylated chitosan (PCTS) and ZnO. The polymer-metal complex formation was investigated in terms of thermal degradation. The structure deduction of the PCTS/ZnO complex was investigated by means of Fourier transform in...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211408371
更新日期:2012-11-01 00:00:00
abstract::The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Quest...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212473510
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to investigate if newly developed polyurethane (PU) scaffolds are suitable as scaffold for cell-seeded meniscus tissue engineered constructs. Scaffolds were seeded with goat meniscal fibrochondrocytes and cultured to assess changes in biological and mechanical properties. Furthermore, the eff...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211417317
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to develop a specific targeting magnetic nanoparticle probe for magnetic resonance imaging and therapy in the form of local hyperthermia. Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-asparti...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213493486
更新日期:2014-03-01 00:00:00
abstract::The relative surface charge and free energy of forty-one coagulase-negative staphylococci were found to be normally distributed; therefore, they can be considered a homogeneous group under strict statistical criteria. The adherence of these bacteria to eight different biomaterials (seven synthetic and one biologic) wa...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829200700203
更新日期:1992-10-01 00:00:00
abstract::Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing proce...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/0885328219834656
更新日期:2019-05-01 00:00:00