Dextran/Albumin hydrogel sealant for Dacron(R) vascular prosthesis.

Abstract:

:In this paper, the authors describe a novel type of hydrogel coating prepared from the copolymer of human serum albumin and oxidized dextran. The material was designed as a hydrogel sealant for polyester (Dacron®)-based vascular grafts. Dextran was chosen as a coating material due to its anti-thrombogenic properties. Prepared hydrogels were compared with similar, already known biomaterial made from gelatine with the same cross-linking agent. Obtained hydrogels, prepared from various ratios of oxidized dextran/albumin or oxidized dextran/gelatine, showed different cross-linking densities, which caused differences in swelling, degradation rate and mechanical properties. Permeability tests confirmed the complete tightness of the hydrogel-modified prosthesis. Results showed that application of the hydrogel coating provided leakage-free prosthesis and eliminated the need of pre-clotting.

journal_name

J Biomater Appl

authors

Lisman A,Butruk B,Wasiak I,Ciach T

doi

10.1177/0885328213509676

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

1386-96

issue

9

eissn

0885-3282

issn

1530-8022

pii

0885328213509676

journal_volume

28

pub_type

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