The influence of solvent processing on polyester bioabsorbable polymers.

Abstract:

:Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lactic-co-glycolic acid) (PLGA) produced by using chloroform, dichloromethane, and acetone. The results demonstrate that solvent choice and PLGA molecular weight are critical factors in terms of solvent removal rate and maintaining sample integrity, respectively. The protocols widely employed result in high levels of residual solvent and a new protocol is presented together with solutions to commonly encountered problems.

journal_name

J Biomater Appl

authors

Manson J,Dixon D

doi

10.1177/0885328210376997

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

623-34

issue

5

eissn

0885-3282

issn

1530-8022

pii

0885328210376997

journal_volume

26

pub_type

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