Abstract:
:Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lactic-co-glycolic acid) (PLGA) produced by using chloroform, dichloromethane, and acetone. The results demonstrate that solvent choice and PLGA molecular weight are critical factors in terms of solvent removal rate and maintaining sample integrity, respectively. The protocols widely employed result in high levels of residual solvent and a new protocol is presented together with solutions to commonly encountered problems.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Manson J,Dixon Ddoi
10.1177/0885328210376997subject
Has Abstractpub_date
2012-01-01 00:00:00pages
623-34issue
5eissn
0885-3282issn
1530-8022pii
0885328210376997journal_volume
26pub_type
杂志文章abstract::An electronic sensor system for urinary bladder pressure monitoring requires an imbedding into a biocompatible, flexible, and liquid-impermeable material. Poly(dimethylsiloxane) (PDMS) was selected in the present set-up as packaging material because it fulfills the abovementioned requirements. However, the surface of ...
journal_title:Journal of biomaterials applications
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doi:10.1177/0885328211422119
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abstract::Plastics are fulfilling a number of critical roles in a variety of medical applications. While some of these are low-technology, throw-away products, many of the applications impose critical requirements as to mechanical performance, chemical resistance, biocompatibility, ability to be sterilized and to remain sterile...
journal_title:Journal of biomaterials applications
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doi:10.1177/088532828700200305
更新日期:1988-01-01 00:00:00
abstract:PURPOSE:A functionalized graphene oxide-based thermosensitive hydrogel loaded with docetaxel for intratumoral delivery was designed to enhance therapeutic efficacy and alleviate system toxicity. METHODS:First, graphene oxide was functionalized with chitosan to acquire high stability in physiological solutions. And the...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215619583
更新日期:2016-03-01 00:00:00
abstract::Polylactic acid (PLA)-derived polymers are widely used in many biotechnological fields, thanks to their biocompatibility and resorbability through natural pathways. Moreover, PLA is one of the few polymers in which both the properties and the stereochemical structure can be easily modified, making possible a specific ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211398298
更新日期:2012-08-01 00:00:00
abstract::The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/su...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829200700105
更新日期:1992-07-01 00:00:00
abstract::Nanohydroxyapatite (nanoHA), due to its chemical properties, has appeared as an exceptionally promising bioceramic to be used as bone regeneration material. Staphylococcus epidermidis have emerged as major nosocomial pathogens associated with infections of implanted medical devices. In this work, the purpose was to st...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
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更新日期:2014-05-01 00:00:00
abstract::Cellulose acetate phthalate and Pluronic F-127 combined together (70:30 wt:wt) create a rigid, surface-eroding association polymer. To impart flexibility into the polymer system and allow for a drug delivery film that can contour to varying wound shapes, plasticizers were added. Triethyl citrate or tributyl citrate wa...
journal_title:Journal of biomaterials applications
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更新日期:2014-01-01 00:00:00
abstract::Even though Ti-based implants are the most used materials for hard tissue replacement, they may present lack of osseointegration on the long term, due to their inertness. Hydrothermal treatment (HT) is a useful technique for the synthesis of firmly attached, highly crystalline coatings made of anatase titanium dioxide...
journal_title:Journal of biomaterials applications
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abstract::A rapid and continuous hydrothermal route for the synthesis of nano-sized hydroxyapatite rods co-precipitated with calcium-doped zirconia nanoparticles using a superheated water flow at 450°C and 24.1 MPa as a crystallizing medium is described. Hydroxyapatite and calcium-doped zirconia phases in the powder mixtures co...
journal_title:Journal of biomaterials applications
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更新日期:2012-07-01 00:00:00
abstract::Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years. However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexi...
journal_title:Journal of biomaterials applications
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doi:10.1177/0885328220972219
更新日期:2020-11-11 00:00:00
abstract::This study's aim consists of evaluating the adhesion and proliferation of mesenchymal stem cells (MSCs) derived from rat bone marrow on nanoparticle Titanium (Ti) surface. Hence, passage 3 MSCs were, respectively, seeded on nanoparticle Ti and pure Ti surfaces and then cultured for 32 h. Cell morphology and viability ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
abstract::Sodium alginate is an effective biomaterial for tissue engineering applications. Non-purified alginate is contaminated with protein, lipopolysaccharide, DNA, and RNA, which could elicit adverse immunological reactions. We developed a purification protocol to generate biocompatible alginate based on (a) activated charc...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216645952
更新日期:2016-10-01 00:00:00
abstract::Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood-brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the ben...
journal_title:Journal of biomaterials applications
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doi:10.1177/0885328218799551
更新日期:2018-10-01 00:00:00
abstract::In this study, a phosphorylation treatment of porous anodic alumina (PAA) was performed by wet impregnation in phosphoric acid and a subsequent heat treatment. The PAA and phosphorylated PAA specimens were analyzed using a field emission scanning electron microscope, an energy-dispersive X-ray spectrometer, and Fourie...
journal_title:Journal of biomaterials applications
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doi:10.1177/0885328214526765
更新日期:2014-09-01 00:00:00
abstract::Poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) copolymers have been widely used for various biomedical applications. However, their hemocompatibility has not been clarified, which would lag their developments and clinical applications. In this work, we studied the effect of PEG-PLA copolymers on key human blood com...
journal_title:Journal of biomaterials applications
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doi:10.1177/0885328215627404
更新日期:2016-05-01 00:00:00
abstract::The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Quest...
journal_title:Journal of biomaterials applications
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doi:10.1177/0885328212473510
更新日期:2014-01-01 00:00:00
abstract::Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...
journal_title:Journal of biomaterials applications
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doi:10.1177/0885328218759043
更新日期:2018-05-01 00:00:00
abstract::Polyelectrolyte capsules are seen as promising nanotechnology based drug delivery systems. In previous works, we have demonstrated the possibility to fabricate bio-activated surface layer containing capsules with improved features in terms of biocompatibility. In this study, we have characterized the permeability prop...
journal_title:Journal of biomaterials applications
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doi:10.1177/0885328212446358
更新日期:2013-08-01 00:00:00
abstract::Compounds of a silicone elastomer suitable for preparing maxillofacial prostheses, reinforced with various amounts of silica powder, have been studied for their mechanical response and wetting properties in terms of contact angle. Tensile strength and elongation at break showed an increase with increasing silica volum...
journal_title:Journal of biomaterials applications
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doi:10.1177/088532829801300104
更新日期:1998-07-01 00:00:00
abstract::A series of cellulose/soy protein isolate (SPI) sponges was prepared using a freeze-drying process. The effect of the SPI content on the structure of the sponges was characterized by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). It showed that...
journal_title:Journal of biomaterials applications
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更新日期:2010-02-01 00:00:00
abstract::Polysulfone (PSU) composite films filled with Beta-dicalcium silicate (Beta-Ca(2)SiO(4)) particles are prepared by the solvent casting-evaporation method. The surface morphologies and mechanical properties of the films are determined. The bioactivity of the composite films is evaluated by soaking them in simulated bod...
journal_title:Journal of biomaterials applications
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更新日期:2006-04-01 00:00:00
abstract::A series biodegradable poly (γ-glutamic acid)/beta-tricalcium phosphate (γ-PGA/TCP) nanocomposites were prepared which were composed of poly-γ-glutamic acid polymerized in situ with β-tricalcium phosphate and physiochemically characterized as bone graft substitutes. The particle size via dynamic light scattering, the ...
journal_title:Journal of biomaterials applications
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更新日期:2016-07-01 00:00:00
abstract::Novel in situ polymerizable liquid three-arm biodegradable oligomeric polyesters based upon glycolic acid (GA), L-lactic acid (LLA), and their copolymers are synthesized and characterized. Injectable and in situ curable polymer neat resins and their composites formulated with bioabsorbable beta-tricalcium phosphate ar...
journal_title:Journal of biomaterials applications
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更新日期:2007-07-01 00:00:00
abstract::The controlled release of insulin from a series of biodegradable hybrid hydrogel network containing dextran derivative of allyl isocyanate (dex-AI) and poly (D,L) lactide diacrylate macromer (PDLLAM) over a wide range of composition ratio was investigated. Laser confocal scanning microscope was used to understand the ...
journal_title:Journal of biomaterials applications
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doi:10.1106/088532802024248
更新日期:2002-04-01 00:00:00
abstract::Hydroxyapatite (Ca10(PO4)6(OH)2) is widely investigated as an implantable material for hard tissue restoration due to its osteoconductive properties. However, hydroxyapatite in bulk form is limited as its mechanical properties are insufficient for load-bearing orthopedic applications. Attempts have been made to improv...
journal_title:Journal of biomaterials applications
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doi:10.1177/0885328215592866
更新日期:2015-11-01 00:00:00
abstract::Sternotomy and sternal closure occur prior to and post cardiac surgery, respectively. Although post-operative complications associated with poor sternal fixation can result in morbidity, mortality, and considerable resource utilization, sternotomy is preferred over other methods such as lateral thoracotomy. Rigid ster...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/0885328213495426
更新日期:2013-11-01 00:00:00
abstract::The manufacture of a polyester vascular prosthesis in the southern hemisphere is a new development in the global dissemination of this maturing technology. Hence the recent introduction of the Barone Microvelour arterial graft from Argentina has highlighted the need for a comparative in vitro and in vivo study to comp...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532828800300302
更新日期:1989-01-01 00:00:00
abstract::In this study, a novel bilayer scaffold composed of electrospun polycaprolactone and poly(lacto-co-glycolic acid) (PCL/PLGA) membrane and glutaraldehyde (3.5% v/v) cross-linked chitosan/gelatin hydrogel was fabricated using two methods: electrospinning of the membrane onto the lyophilized hydrogel (BS-1) and membrane ...
journal_title:Journal of biomaterials applications
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更新日期:2013-01-01 00:00:00
abstract::The animal immune response against Galα1,3-Galβ1-4GlcNAc-R(α-Gal) epitopes gives an important cause for the failure of glutaraldehyde(GA)-fixed cardiac xenografts. This study aimed to assess the in vivo effect of our novel combined anticalcification treatment, which includes immunologic modification, using α1,3-galact...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214552710
更新日期:2015-02-01 00:00:00
abstract::Three types of commercially available ultra-high molecular weight polyethylene (UHMWPE) acetabular cups currently used in total hip arthroplasty have been studied by means of Raman micro-spectroscopy to unfold the microstructural modification induced by the oxidative degradation after accelerated aging with and withou...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214548693
更新日期:2015-01-01 00:00:00