Abstract：
:This study's aim consists of evaluating the adhesion and proliferation of mesenchymal stem cells (MSCs) derived from rat bone marrow on nanoparticle Titanium (Ti) surface. Hence, passage 3 MSCs were, respectively, seeded on nanoparticle Ti and pure Ti surfaces and then cultured for 32 h. Cell morphology and viability were separately examined by scanning electron microscopy and 3-(4,5-dimethylthiazsol-2-yl)-2,5-diphenyltetrazolium bromide assay. Moreover, the mitotic rate of the attached MSCs was observed through immunocytochemistry. The real-time polymerase chain reaction was applied to determine the adhesion-associated messenger ribonucleic acid (mRNA), CD44 gene encoding variant isoform 6 (CD44 V6), and the integrinβ1 level. The results showed that MSCs performed better in faster extension on the nanoparticle Ti surface than on the pure Ti surface after culturing for 4 h, and were quicker in fusion patterns after 16 h. Furthermore, cell viability was significantly increased on the nanoparticle Ti surface compared to that of the pure Ti surface 16 h after initial seeding (p < 0.05), and the mitotic rate of attached MSCs on the nanoparticle Ti surface was higher than that on the pure Ti surface after 32 h (p < 0.05). More interestingly, the CD44 V6 and integrinβ1 mRNA in the nanoparticle Ti surface group expressed higher than that in the pure Ti surface group after 4 h (p < 0.05), and positive correlation between CD44 V6 and integrinβ1 was found through statistical analysis (correlation coefficient r (s) = 0.98, p < 0.05). Our study's result indicates that a nanoparticle Ti surface can significantly promote the adhesion and proliferation of MSCs, and also improve the bioactivity of Ti surface.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Chen L,Sun J,Zhu Z,Wu K,Li W,Liu H,Xu Sdoi
10.1177/0885328211414750subject
Has Abstractpub_date
2013-01-01 00:00:00pages
525-36issue
5eissn
0885-3282issn
1530-8022pii
0885328211414750journal_volume
27pub_type
杂志文章abstract：:This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)-pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS-pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microen...
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abstract：:Poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) copolymers have been widely used for various biomedical applications. However, their hemocompatibility has not been clarified, which would lag their developments and clinical applications. In this work, we studied the effect of PEG-PLA copolymers on key human blood com...
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abstract：:Medical sheets are useful in surgically repair vascular disease. To avoid long-term side effects, they are to be replaced with regenerated tissue after implantation. Silk fibroin is a fibrous protein secreted by silkworm. The advantage of silk fibroin is its biocompatibility and has been used as regenerative artificia...
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更新日期：2020-06-02 00:00:00
