Abstract:
:Adhesions commonly occur after internal disease or surgery. The natural healing response leads to the formation of vascular and avascular adhesions after inflammatory diseases and surgical interventions. A barrier film could be incorporated during surgery between layers of tissues that must not adhere to one another. The film would be biodegradable so that it disappears over a period of time, and would ideally be two sided, allowing relative movement at that interface, while being firmly anchored on the opposite side to prevent displacement. Polyesterurethane-polydimethylsiloxane graft polymers are synthesised. Chemical characterisation of the polymer is performed by using Fourier transform infrared spectroscopy and gel permeation chromatography. In vitro hydrolytic degradation is carried out in which films are immersed at 37 degrees C in alkaline solution. Degradation is assessed by tensile testing as a function of time to determine the degradation of mechanical strength, infrared spectroscopy, and mass loss. A titration method is also used to determine quantitatively the hydrolytic degradation. In order to study the adhesions of films, an in-vitro model based on a gelatine test, which is simple and rapid, is described. Suitable candidate films investigated from the in-vitro work are subjected to in vivo tests for both biodegradation and their ability to prevent adhesion.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Rehman IUdoi
10.1177/088532829601100203subject
Has Abstractpub_date
1996-10-01 00:00:00pages
182-257issue
2eissn
0885-3282issn
1530-8022journal_volume
11pub_type
杂志文章abstract::The aim of this study was to evaluate the possibility of metal complex formation between sodium-phosphorylated chitosan (PCTS) and ZnO. The polymer-metal complex formation was investigated in terms of thermal degradation. The structure deduction of the PCTS/ZnO complex was investigated by means of Fourier transform in...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211408371
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abstract::Thrombosis is the most serious acute problem for small diameter arterial bypass grafts. In this research, small diameter expanded polytetrafluoroethylene (e-PTFE) vascular grafts were coated with acetylsalicylic acid (ASA) loaded poly (d,l-lactide) (PLA) by a solvent casting method. The feasibility and efficacy of thi...
journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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abstract::Among biomaterials used as implants in human body, sutures constitute the largest groups of materials having a huge market exceeding $1.3 billion annually. Sutures are the most widely used materials in wound closure and have been in use for many centuries. With the development of the synthetic absorbable polymer, poly...
journal_title:Journal of biomaterials applications
pub_type: 历史文章,杂志文章,评审
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abstract::In this work, we report brushite-based calcium phosphate cement (CPC) system to enhance the in vivo biodegradation and tissue in-growth by incorporation of micro-channeled hydroxyapatite (HAp) granule and silicon and sodium addition in calcium phosphate precursor powder. Sodium- and silicon-rich calcium phosphate powd...
journal_title:Journal of biomaterials applications
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abstract::The animal immune response against Galα1,3-Galβ1-4GlcNAc-R(α-Gal) epitopes gives an important cause for the failure of glutaraldehyde(GA)-fixed cardiac xenografts. This study aimed to assess the in vivo effect of our novel combined anticalcification treatment, which includes immunologic modification, using α1,3-galact...
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journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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abstract::Chitosan-glutaraldehyde microparticles were produced by emulsion crosslinking method to be used as drug delivery system for polyphenols from Thymus serpyllum L. aqueous extract. The effect of preparation conditions, chitosan concentration (1.5-3% w/v), and glutaraldehyde/chitosan (GA/Ch) mass ratio (0.15-1.20) on wate...
journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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abstract::Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis...
journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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abstract::Fracture resistance of provisional restorations is an important clinical concern. This property is directly related to transverse strength. Strengthening of provisional fixed partial dentures may result from reinforcement with various fiber types. This study evaluated the effect of fiber type and water storage on the ...
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journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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journal_title:Journal of biomaterials applications
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