Abstract:
:Thrombosis is the most serious acute problem for small diameter arterial bypass grafts. In this research, small diameter expanded polytetrafluoroethylene (e-PTFE) vascular grafts were coated with acetylsalicylic acid (ASA) loaded poly (d,l-lactide) (PLA) by a solvent casting method. The feasibility and efficacy of this approach were evaluated by ASA release studies and platelet adhesion tests. First, the ASA release kinetics were evaluated from the ASA/PLA coated vascular grafts in an in vitro steady flow loop model. ASA release was measured by a spectrophotometric technique. Finally, the efficacy of local ASA release to reduce in vitro canine platelet adhesion to grafts was determined with epifluorescent video microscopy and quantitative image analysis. The steady state release rates from the 5%, 10%, and 15% ASA/PLA coated grafts were 13.2 x 10(-5), 32.0 x 10(-5), and 41.5 x 10(-5) micrograms/cm2.sec, respectively. Platelet adhesion to 10% and 15% ASA/PLA coated grafts was reduced with respect to the control and 5% grafts for 10 days. Platelet adhesion to 5% ASA/PLA coated grafts was reduced with respect to controls at 2 and 10 days, but not initially.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Hall JD,Rittgers SE,Schmidt SPdoi
10.1177/088532829400800404subject
Has Abstractpub_date
1994-04-01 00:00:00pages
361-84issue
4eissn
0885-3282issn
1530-8022journal_volume
8pub_type
杂志文章abstract::Biomaterials and devices have been used in a variety of applications ranging from disposable extracorporeal devices and soft and hard tissue augmentation, to total artificial internal organs. However, there are risks and failures in each application which are a result of undesirable biological interactions. This artic...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829300800104
更新日期:1993-07-01 00:00:00
abstract::Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any promise of a cure in the near future. Although islet transplantation has proven to be an effective means of treating type 1 diabetes mell...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/0885328219831391
更新日期:2019-04-01 00:00:00
abstract::Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211427774
更新日期:2013-03-01 00:00:00
abstract::Biodegradable magnesium-based implants are currently being developed for use in orthopedic applications. The aim of this study was to investigate the acute, subacute, and chronic local effects on bone tissue as well as the systemic reactions to a magnesium-based (MgYREZr-alloy) screw containing rare earth elements. Th...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212472215
更新日期:2014-01-01 00:00:00
abstract::Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328209344003
更新日期:2010-08-01 00:00:00
abstract::The in vitro effect of platelet-rich plasma (PRP) on cell loading, proliferation, and osteogenic differentiation of human mesenchymal stem cells (MSC) is assessed on distinct resorbable and synthetic calcium phosphate scaffolds. A high specific surface area scaffold composed of calcium-deficient hydroxyapatite (CDHA; ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328207088269
更新日期:2008-09-01 00:00:00
abstract:PURPOSE:To produce biodurable small diameter microporous vascular grafts with self-sealing properties for vascular access, for peripheral vascular and potentially for coronary artery bypass. The prosthesis should retain compliance and pulsatile flow in situ using a unique modus operandi permitting wall compression whic...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829501000207
更新日期:1995-10-01 00:00:00
abstract::Chitosan-glutaraldehyde microparticles were produced by emulsion crosslinking method to be used as drug delivery system for polyphenols from Thymus serpyllum L. aqueous extract. The effect of preparation conditions, chitosan concentration (1.5-3% w/v), and glutaraldehyde/chitosan (GA/Ch) mass ratio (0.15-1.20) on wate...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215598940
更新日期:2015-11-01 00:00:00
abstract::The surface quality of coronary stents has a significant influence on its biocompatibility. Therefore, surface polishing is of paramount importance in the production and application of stents. In the present study, electropolishing is performed on 316LVM steel slotted tube coronary stents. Additionally, acid pickling,...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328205046564
更新日期:2005-01-01 00:00:00
abstract::Phenylalanine ethyl ester (PAE)-alginate (Alg) conjugate (PAE-Alg, PEA) was synthesized and formation of an amide bond between PAE and Alg was confirmed by Fourier transformed-infrared and (1)H nuclear magnetic resonance spectroscopy. The degree of PAE substitution was 3.5-4.7 (PAE group per hundred sugar residues of ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216630497
更新日期:2016-07-01 00:00:00
abstract::The controlled release of insulin from a series of biodegradable hybrid hydrogel network containing dextran derivative of allyl isocyanate (dex-AI) and poly (D,L) lactide diacrylate macromer (PDLLAM) over a wide range of composition ratio was investigated. Laser confocal scanning microscope was used to understand the ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1106/088532802024248
更新日期:2002-04-01 00:00:00
abstract::Novel in situ polymerizable liquid three-arm biodegradable oligomeric polyesters based upon glycolic acid (GA), L-lactic acid (LLA), and their copolymers are synthesized and characterized. Injectable and in situ curable polymer neat resins and their composites formulated with bioabsorbable beta-tricalcium phosphate ar...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328206068691
更新日期:2007-07-01 00:00:00
abstract::This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)-pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS-pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microen...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328206056771
更新日期:2007-01-01 00:00:00
abstract::Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing proce...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/0885328219834656
更新日期:2019-05-01 00:00:00
abstract::The synthesis, tensile strength, thermostability and hydrophilicity of the poly(urethaneamideimide) and the poly(urethaneureas) with N-aliphatic side chains are presented. These elastomers were compared in blood compatibility with determination of the common indices and with immunologic tests of the beta-thromboglobul...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1106/TBUW-TWW9-EC7X-YA3H
更新日期:2000-10-01 00:00:00
abstract::In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220952594
更新日期:2020-08-27 00:00:00
abstract::Appropriate design of dialysis membranes requires correct values of structural parameters such as pore radius, surface porosity, water content and tortuosity. It is impossible, however, to find the pore radius of dialysis membranes using a mercury porosimeter or an electron microscope because the pores are only severa...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532828900400201
更新日期:1989-10-01 00:00:00
abstract::The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds we...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212471409
更新日期:2014-01-01 00:00:00
abstract::Bone tissue engineering, which relies on the interactions between stem cells and suitable scaffold materials, represents a highly desirable alternative to currently used allograft or autograft strategies for the treatment of bone defects caused by injury or disease, with one of the major challenges being to generate s...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213515734
更新日期:2014-07-01 00:00:00
abstract::The aim of the in vitro study was a comparison of an allogenic (ABSM) and a xenogenic bone substitute material (XBSM) with and without injectable platelet-rich fibrin (ABSM-i-PRF & XBSM-i-PRF) on cell characteristics of human osteoblasts (HOB). Here, ABSM and XBSM (+ i-PRF = test; - i-PRF = control) were incubated wit...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220914407
更新日期:2020-07-01 00:00:00
abstract::In this work, the role of shock wave-induced increase of bone morphogenetic proteins in modulating the osteogenic properties of osteoblast-like cells seeded on a bioactive scaffold was investigated using gremlin as a bone morphogenetic protein antagonist. Bone-like glass-ceramic scaffolds, based on a silicate experime...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214541974
更新日期:2014-11-01 00:00:00
abstract::A rapid and continuous hydrothermal route for the synthesis of nano-sized hydroxyapatite rods co-precipitated with calcium-doped zirconia nanoparticles using a superheated water flow at 450°C and 24.1 MPa as a crystallizing medium is described. Hydroxyapatite and calcium-doped zirconia phases in the powder mixtures co...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212444483
更新日期:2012-07-01 00:00:00
abstract::Single nanofibers with chemical and functional properties consistent with artery extracellular matrix nanofibers were produced by electrospinning. Using weight ratios to mimic artery extracellular matrix, five materials were tested: (1) Collagen type I, (2) Collagen type I + Collagen type III, (3) Collagen type I + po...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213477893
更新日期:2014-01-01 00:00:00
abstract::Nonviral gene delivery systems are finding widespread use due to their safety, rapid and economical production, and ease of modification. In this work, series of N-alkyl-substituted linear polyethylenimine (CP) polymers have been synthesized, characterized, and investigated about how degree of substitution (hydrophobi...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217710125
更新日期:2017-07-01 00:00:00
abstract::Phase-sensitive in situ gel-forming controlled release formulations of insulin were prepared using poly(lactide-co-glycolide) and a solvent system consisting of various proportions of benzyl benzoate and benzyl alcohol. The in vitro release samples of formulations were assayed for insulin content by enzyme linked immu...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328209359959
更新日期:2011-03-01 00:00:00
abstract::Transarterial embolization is an established minimally invasive treatment for solid tumors. Unintended inflammation, foreign body reactions and ischemia-triggered neoangiogenesis are clinical drawbacks of permanent embolic materials. The aim of the current study was to characterize a new type of biodegradable starch m...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217746674
更新日期:2018-02-01 00:00:00
abstract::The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocol...
journal_title:Journal of biomaterials applications
pub_type: 临床试验,杂志文章
doi:10.1177/0885328207078260
更新日期:2008-01-01 00:00:00
abstract::The carcinogenic potential of asbestos has led to the development of non-asbestos materials for use as casting ring liners. Cellulose paper are replacing asbestos paper. The brass die and crown were made to produce full crowns. The standardized wax pattern was replicated twenty-nine times. Two grooves were marked on t...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532820001400406
更新日期:2000-04-01 00:00:00
abstract::A new diol, bis[2-(2-hydroxyethyldimethylammonio)ethyl] butylenediphosphate, that contains two phosphatidylcholine analogous moieties in one diol molecule, was synthesized and characterized. The diol together with 1,4-butanediol as chain extender was further incorporated into the propolymer of poly(ethylene oxide) (Mn...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829701200205
更新日期:1997-10-01 00:00:00
abstract::A series of cellulose/soy protein isolate (SPI) sponges was prepared using a freeze-drying process. The effect of the SPI content on the structure of the sponges was characterized by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). It showed that...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328208099337
更新日期:2010-02-01 00:00:00