Abstract:
:Biodegradable magnesium-based implants are currently being developed for use in orthopedic applications. The aim of this study was to investigate the acute, subacute, and chronic local effects on bone tissue as well as the systemic reactions to a magnesium-based (MgYREZr-alloy) screw containing rare earth elements. The upper part of the screw was implanted into the marrow cavity of the left femora of 15 adult rabbits (New Zealand White), and animals were euthanized 1 week, 12 weeks, and 52 weeks postoperatively. Blood samples were analyzed at set times, and radiographic examinations were performed to evaluate gas formation. There were no significant increased changes in blood values compared to normal levels. Histological examination revealed moderate bone formation with direct implant contact without a fibrous capsule. Histopathological evaluation of lung, liver, intestine, kidneys, pancreas, and spleen tissue samples showed no abnormalities. In summary, our data indicate that these magnesium-based screws containing rare earth elements have good biocompatibility and osteoconductivity without acute, subacute, or chronic toxicity.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Waizy H,Diekmann J,Weizbauer A,Reifenrath J,Bartsch I,Neubert V,Schavan R,Windhagen Hdoi
10.1177/0885328212472215subject
Has Abstractpub_date
2014-01-01 00:00:00pages
667-75issue
5eissn
0885-3282issn
1530-8022pii
0885328212472215journal_volume
28pub_type
杂志文章abstract::Nanohydroxyapatite (nanoHA), due to its chemical properties, has appeared as an exceptionally promising bioceramic to be used as bone regeneration material. Staphylococcus epidermidis have emerged as major nosocomial pathogens associated with infections of implanted medical devices. In this work, the purpose was to st...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213507300
更新日期:2014-05-01 00:00:00
abstract::Biomaterials and devices have been used in a variety of applications ranging from disposable extracorporeal devices and soft and hard tissue augmentation, to total artificial internal organs. However, there are risks and failures in each application which are a result of undesirable biological interactions. This artic...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829300800104
更新日期:1993-07-01 00:00:00
abstract::Gold nanomaterials possess unique physical and chemical properties, which attracted much attention in recent years. As a new type of gold nanomaterials, gold nanostars (GNSTs) have been prepared and characterized in this study. GNSTs under near-infrared (NIR) light irradiation can exert not only cancer photothermal th...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215594481
更新日期:2015-11-01 00:00:00
abstract::At present all the commercially available "medical grade" urethane elastomers exhibit a phenomenon known as environmental stress cracking (ESC). This phenomenon is characterized by surface microcracking when the elastomer is elongated while in vivo. The degree of strain that is required to initiate microcracking varie...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829100600202
更新日期:1991-10-01 00:00:00
abstract::NiTi alloy is used as a biomaterial due to its pseudoelastic behaviour. It exhibits a great potential in dental and orthopedic applications where constant correcting loads are required. In order to use such materials, it is necessary to investigate the effect of the cyclic straining upon the transformation stresses an...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829801200304
更新日期:1998-01-01 00:00:00
abstract::The relative surface charge and free energy of forty-one coagulase-negative staphylococci were found to be normally distributed; therefore, they can be considered a homogeneous group under strict statistical criteria. The adherence of these bacteria to eight different biomaterials (seven synthetic and one biologic) wa...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829200700203
更新日期:1992-10-01 00:00:00
abstract::In this paper, the authors describe a novel type of hydrogel coating prepared from the copolymer of human serum albumin and oxidized dextran. The material was designed as a hydrogel sealant for polyester (Dacron®)-based vascular grafts. Dextran was chosen as a coating material due to its anti-thrombogenic properties. ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213509676
更新日期:2014-05-01 00:00:00
abstract::Cellulose acetate phthalate and Pluronic F-127 combined together (70:30 wt:wt) create a rigid, surface-eroding association polymer. To impart flexibility into the polymer system and allow for a drug delivery film that can contour to varying wound shapes, plasticizers were added. Triethyl citrate or tributyl citrate wa...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213480979
更新日期:2014-01-01 00:00:00
abstract::Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lact...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328210376997
更新日期:2012-01-01 00:00:00
abstract::Polysulfone (PSU) composite films filled with Beta-dicalcium silicate (Beta-Ca(2)SiO(4)) particles are prepared by the solvent casting-evaporation method. The surface morphologies and mechanical properties of the films are determined. The bioactivity of the composite films is evaluated by soaking them in simulated bod...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328206054712
更新日期:2006-04-01 00:00:00
abstract::The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocol...
journal_title:Journal of biomaterials applications
pub_type: 临床试验,杂志文章
doi:10.1177/0885328207078260
更新日期:2008-01-01 00:00:00
abstract::While BMP-7 (OP-1) is one of the most potent growth factors in cartilage tissue engineering, the effects of exogenous low concentration BMP-7 on osteoarthritic chondrocytes are still unknown. Human osteoarthritic chondrocytes obtained from the femoral condyles of 10 patients were grown either in monolayer or in 3D col...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328210388439
更新日期:2012-03-01 00:00:00
abstract::The effect of hybrid material-graphene flakes with Fe3O4 nanospheres (GO-Fe3O4), graphene oxide (GO) and magnetite nanospheres (Fe3O4) in rotating magnetic field on mammalian cells metabolism has been studied. Several reports shown that exposure to magnetic field may have influence on cellular membrane permeability. T...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216628762
更新日期:2016-04-01 00:00:00
abstract::In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220952594
更新日期:2020-08-27 00:00:00
abstract::The development and improvement of medical devices and artificial organs is critically dependent on the realisation of the importance of the interactions between materials and body tissues. In this regard, the evaluation of biocompatibility assumes paramount importance. This paper reviews the hematological aspects of ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/088532829701200104
更新日期:1997-07-01 00:00:00
abstract::Eight different chemicals were investigated as potential candidate coupling agents for phosphate glass fibre reinforced polylactic acid composites. Evidence of reaction of the coupling agents with phosphate glass and their effect on surface wettability and glass degradation were studied along with their principle role...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212453634
更新日期:2013-09-01 00:00:00
abstract::Nowadays, exceptional advantages of silk fibroin over synthetic and natural polymers have impelled the scientists to application of this biomaterial for tissue engineering purposes. Recently, we showed that embedding natural degummed silk fibers in regenerated Bombyx mori silk-based scaffold significantly increases th...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215601925
更新日期:2016-01-01 00:00:00
abstract::A series biodegradable poly (γ-glutamic acid)/beta-tricalcium phosphate (γ-PGA/TCP) nanocomposites were prepared which were composed of poly-γ-glutamic acid polymerized in situ with β-tricalcium phosphate and physiochemically characterized as bone graft substitutes. The particle size via dynamic light scattering, the ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216632444
更新日期:2016-07-01 00:00:00
abstract::In order to find hemodynamic parameters that can accurately predict whether patients can be successfully weaned from ventricular assist devices (VADs), we studied data from 17 patients supported with Pierce-Donachy VADs [11 left VAD (LVAD); 6 right VAD (RVAD)] following cardiogenic shock for periods from 1.3 to 22 day...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829000400403
更新日期:1990-04-01 00:00:00
abstract::Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215597818
更新日期:2015-11-01 00:00:00
abstract::Sternotomy and sternal closure occur prior to and post cardiac surgery, respectively. Although post-operative complications associated with poor sternal fixation can result in morbidity, mortality, and considerable resource utilization, sternotomy is preferred over other methods such as lateral thoracotomy. Rigid ster...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/0885328213495426
更新日期:2013-11-01 00:00:00
abstract::Silicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217715428
更新日期:2017-08-01 00:00:00
abstract::Tendon tears are a relevant concern for today's national health systems because of their social impact and high recurrence rate. The current gold standard for fixing tendon tears is surgical repair; however, this strategy is not able to fully re-establish tendon integrity and functionality. Tissue engineering approach...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218779846
更新日期:2018-07-01 00:00:00
abstract::The production of large quantities of functional vascularized bone tissue ex vivo still represent an unmet clinical challenge. Microcarriers offer a potential solution to scalable manufacture of bone tissue due to their high surface area-to-volume ratio and the capacity to be assembled using a modular approach. Microc...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217720812
更新日期:2017-09-01 00:00:00
abstract::A biosensor for the analysis of D-amino acids is described. Carbon paste (graphite/paraffin oil) was chemically modified with immobilized D-amino acid oxidase and either horse-radish peroxidase or fungal peroxidase from Arthromyces ramosus. The two enzymes dissolved in buffer, together with an amine containing oligome...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829300800204
更新日期:1993-10-01 00:00:00
abstract::We assess the effects of chemical processing, ethylene oxide sterilization, and threading on bone surface and mechanical properties of bovine undecalcified bone screws. In addition, we evaluate the possibility of manufacturing bone screws with predefined dimensions. Scanning electronic microscopic images show that che...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328208092110
更新日期:2009-03-01 00:00:00
abstract::Reconstruction of critical sized bone injuries is a major problem that continues to inspire the design of new materials and grafts. Natural ceramics (hydroxyapatite (HA) coralline HA, or synthetic HA) and β-tricalcium phosphate (β-TCP) are being explored for use as scaffolds in bone tissue engineering, among several o...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211415132
更新日期:2013-01-01 00:00:00
abstract::This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)-pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS-pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microen...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328206056771
更新日期:2007-01-01 00:00:00
abstract::The layer-by-layer technique, which allows simple preparation of polyelectrolyte multilayers, came into the focus of research for development of functionalized medical devices. Numerous literature exist that concentrate on the film build-up and the behaviour of cells on polyelectrolyte multilayers. However, in case of...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212437610
更新日期:2013-07-01 00:00:00
abstract::Single nanofibers with chemical and functional properties consistent with artery extracellular matrix nanofibers were produced by electrospinning. Using weight ratios to mimic artery extracellular matrix, five materials were tested: (1) Collagen type I, (2) Collagen type I + Collagen type III, (3) Collagen type I + po...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213477893
更新日期:2014-01-01 00:00:00