Abstract:
:Two series of glasses of general formula (2-p) SiO2.1.1Na2O.CaO.pP2O5.xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. The resulted good cell adhesion and growth, along with nonsignificant changes of the focal contacts, allow the authors to indicate HZ5 and HP5Z5 glasses as the ones having optimal ratio of Zn/P to maintain acceptable cell behavior, comparable to the bioactive glass (Bioglass) used as a control; results are also rationalized by means of three-dimensional models derived by molecular dynamic simulations, with decomposition and conversion rates optimized with respect to the parent Hench's Bioglass.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Lusvardi G,Malavasi G,Menabue L,Menziani MC,Pedone A,Segre U,Aina V,Perardi A,Morterra C,Boccafoschi F,Gatti S,Bosetti M,Cannas Mdoi
10.1177/0885328207079731subject
Has Abstractpub_date
2008-05-01 00:00:00pages
505-26issue
6eissn
0885-3282issn
1530-8022pii
0885328207079731journal_volume
22pub_type
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