Conjugation of vitamin E-TPGS and guar gum to carry borneol for enhancing blood-brain barrier permeability.

Abstract:

:Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood-brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the benefits of vitamin E d-ɑ-tocopheryl poly(ethylene glycol) succinate (E-TPGS) (or TPGS) and guar gum to get TPGS-g-guar gum as a drug delivery system to carry borneol, which could improve the solubility of borneol and increase the drug-loading capacity efficiently. The results showed that TPGS-g-guar gum nanoparticles delivery system was suitable to carry borneol and release the drug effectively, and TPGS-g-guar gum/borneol nanoparticles would be a potential platform for improving the treatment of central nervous system illness and cerebrovascular disease.

journal_name

J Biomater Appl

authors

Liu Y,Rao L,Zhang H,Cen Y,Cheng K

doi

10.1177/0885328218799551

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

590-598

issue

4

eissn

0885-3282

issn

1530-8022

journal_volume

33

pub_type

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