Abstract:
:Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood-brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the benefits of vitamin E d-ɑ-tocopheryl poly(ethylene glycol) succinate (E-TPGS) (or TPGS) and guar gum to get TPGS-g-guar gum as a drug delivery system to carry borneol, which could improve the solubility of borneol and increase the drug-loading capacity efficiently. The results showed that TPGS-g-guar gum nanoparticles delivery system was suitable to carry borneol and release the drug effectively, and TPGS-g-guar gum/borneol nanoparticles would be a potential platform for improving the treatment of central nervous system illness and cerebrovascular disease.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Liu Y,Rao L,Zhang H,Cen Y,Cheng Kdoi
10.1177/0885328218799551subject
Has Abstractpub_date
2018-10-01 00:00:00pages
590-598issue
4eissn
0885-3282issn
1530-8022journal_volume
33pub_type
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journal_title:Journal of biomaterials applications
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