Drug release from PLGA microspheres attached to solids using supercritical CO₂.

Abstract:

:Functionalization of a porous orthopedic implant with dexamethasone, a widely used anti-inflammatory drug, encapsulated within a biodegradable polymer for controlled release could help reduce or eliminate the inflammation response by the local tissue. In this research, we investigated the possibility of using supercritical carbon dioxide (CO₂) for attaching dexamethasone-loaded PLGA (polylactic-co-glycolic acid) microspheres to porous CoCrMo alloy for continuous delivery of dexamethasone. Supercritical CO₂ has been shown to be effective for attachment of PLGA microspheres to glass plates and porous CoCrMo alloy. Attached microspheres showed similar dexamethasone release profiles but different magnitude of burst release. Microspheres attached to the porous alloy samples using supercritical CO₂ at 10 bar and 40 °C for 30 min showed a release profile similar to that of the nonattached microspheres. The microsphere morphology and the release profiles of microspheres attached to the glass plates and to the porous alloy samples suggest that dexamethasone burst release is enhanced by PLGA swelling at higher CO₂ pressures and better dispersion of microspheres. This study shows that microspheres can be incorporated into porous solids using supercritical CO₂, allowing for a wide variety of drug-biodegradable polymer formulations prepared using the proven emulsion/solvent evaporation method to be tested.

journal_name

J Biomater Appl

authors

Mulia K,Witkamp GJ,Dawes GJ,Fratila-Apachitei LE,Apachitei I,Duszczyk J,Pellikaan H

doi

10.1177/0885328209354365

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

401-12

issue

5

eissn

0885-3282

issn

1530-8022

pii

0885328209354365

journal_volume

25

pub_type

杂志文章
  • Bovine bone screws: metrology and effects of chemical processing and ethylene oxide sterilization on bone surface and mechanical properties.

    abstract::We assess the effects of chemical processing, ethylene oxide sterilization, and threading on bone surface and mechanical properties of bovine undecalcified bone screws. In addition, we evaluate the possibility of manufacturing bone screws with predefined dimensions. Scanning electronic microscopic images show that che...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328208092110

    authors: Haje DP,Volpon JB,Moro CA

    更新日期:2009-03-01 00:00:00

  • Biomimetic bone-like composites as osteo-odonto-keratoprosthesis skirt substitutes.

    abstract::Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years. However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexi...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220972219

    authors: Avadhanam V,Ingavle G,Zheng Y,Kumar S,Liu C,Sandeman S

    更新日期:2020-11-11 00:00:00

  • In vitro evaluation of quaternized polydimethylaminoethylmethacrylate sub-microparticles for oral insulin delivery.

    abstract::This investigation describes the synthesis and in vitro evaluation of cationic hydrogel sub-microparticles based on polydimethylaminoethylmethacrylate for oral insulin delivery. Polymerization of dimethylaminoethylmethacrylate was carried out in aqueous medium with potassium persulfate as the initiator. Quaternization...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212437392

    authors: Sonia TA,Sharma CP

    更新日期:2013-07-01 00:00:00

  • Effectiveness of antibacterial copper additives in silicone implants.

    abstract::Staphylococcus epidermidis plays a major role in capsular contractures of silicone breast implants. This in vitro study evaluates the antibacterial effect of copper on S. epidermidis in silicone implants. Specimens of a silicone material used for breast augmentation (Cu0) and specimens coated with different copper con...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212441957

    authors: Gosau M,Bürgers R,Vollkommer T,Holzmann T,Prantl L

    更新日期:2013-08-01 00:00:00

  • Plastics in medical applications.

    abstract::Plastics are fulfilling a number of critical roles in a variety of medical applications. While some of these are low-technology, throw-away products, many of the applications impose critical requirements as to mechanical performance, chemical resistance, biocompatibility, ability to be sterilized and to remain sterile...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532828700200305

    authors: Lantos PR

    更新日期:1988-01-01 00:00:00

  • Evaluation of adenoviral vascular endothelial growth factor-activated chitosan/hydroxyapatite scaffold for engineering vascularized bone tissue using human osteoblasts: In vitro and in vivo studies.

    abstract::Bone tissue is dependent on an efficient blood supply to ensure delivery of nutrients and oxygen. One method to acquire a vascular-engineered bone tissue could be the use of an angiogenic gene-activated scaffold. In the current study, porous chitosan/hydroxyapatite (C/HA) scaffolds were fabricated via freeze-drying wi...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214544769

    authors: Koç A,Finkenzeller G,Elçin AE,Stark GB,Elçin YM

    更新日期:2014-11-01 00:00:00

  • Polyelectrolyte based molecular carriers: the role of self-assembled proteins in permeability properties.

    abstract::Polyelectrolyte capsules are seen as promising nanotechnology based drug delivery systems. In previous works, we have demonstrated the possibility to fabricate bio-activated surface layer containing capsules with improved features in terms of biocompatibility. In this study, we have characterized the permeability prop...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212446358

    authors: Habibi N,Pastorino L,Sandoval OH,Ruggiero C

    更新日期:2013-08-01 00:00:00

  • In vivo study of a biodegradable orthopedic screw (MgYREZr-alloy) in a rabbit model for up to 12 months.

    abstract::Biodegradable magnesium-based implants are currently being developed for use in orthopedic applications. The aim of this study was to investigate the acute, subacute, and chronic local effects on bone tissue as well as the systemic reactions to a magnesium-based (MgYREZr-alloy) screw containing rare earth elements. Th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212472215

    authors: Waizy H,Diekmann J,Weizbauer A,Reifenrath J,Bartsch I,Neubert V,Schavan R,Windhagen H

    更新日期:2014-01-01 00:00:00

  • Towards modular bone tissue engineering using Ti-Co-doped phosphate glass microspheres: cytocompatibility and dynamic culture studies.

    abstract::The production of large quantities of functional vascularized bone tissue ex vivo still represent an unmet clinical challenge. Microcarriers offer a potential solution to scalable manufacture of bone tissue due to their high surface area-to-volume ratio and the capacity to be assembled using a modular approach. Microc...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328217720812

    authors: Peticone C,De Silva Thompson D,Owens GJ,Kim HW,Micheletti M,Knowles JC,Wall I

    更新日期:2017-09-01 00:00:00

  • Effects of low concentration BMP-7 on human osteoarthritic chondrocytes: comparison of different applications.

    abstract::While BMP-7 (OP-1) is one of the most potent growth factors in cartilage tissue engineering, the effects of exogenous low concentration BMP-7 on osteoarthritic chondrocytes are still unknown. Human osteoarthritic chondrocytes obtained from the femoral condyles of 10 patients were grown either in monolayer or in 3D col...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328210388439

    authors: Gavenis K,Heussen N,Schmidt-Rohlfing B

    更新日期:2012-03-01 00:00:00

  • Engineered polymeric amphiphiles self-assembling into nanostructures and acting as efficient gene and drug carriers.

    abstract::Nonviral gene delivery systems are finding widespread use due to their safety, rapid and economical production, and ease of modification. In this work, series of N-alkyl-substituted linear polyethylenimine (CP) polymers have been synthesized, characterized, and investigated about how degree of substitution (hydrophobi...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328217710125

    authors: Bansal R,Kumar P

    更新日期:2017-07-01 00:00:00

  • Nanoparticles of star-like copolymer mannitol-functionalized poly(lactide)-vitamin E TPGS for delivery of paclitaxel to prostate cancer cells.

    abstract::The purpose of this research was to develop novel nanoparticles (NPs) of star-like copolymer mannitol-functionalized poly(lactide)-vitamin E TPGS (M-PLA-TPGS) for paclitaxel delivery for prostate cancer treatment, and evaluate their therapeutic effects in prostate cancer cell line and animal model in comparison with t...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214527486

    authors: Wang K,Guo L,Xiong W,Sun L,Zheng Y

    更新日期:2014-09-01 00:00:00

  • 3D printed high-resolution scaffold with hydrogel microfibers for providing excellent biocompatibility.

    abstract::Melt electrowriting (MEW) can print high-resolution scaffolds with the ultrafine fibers from 800 nm to 20 µm. However, the cell seeding efficiency relatively low due to the large pore size of the MEW scaffold. Here, we reported a method to solve this dilemma by electrospinning a gelatin methacrylate (GelMA) hydrogel f...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220962606

    authors: Ye W,Xie C,Liu Y,He Y,Gao Q,Ouyang A

    更新日期:2021-01-01 00:00:00

  • Targeted gold nanoshelled hybrid nanocapsules encapsulating doxorubicin for bimodal imaging and near-infrared triggered synergistic therapy of Her2-positve breast cancer.

    abstract::A multifunctional targeted nanoplatform combining photothermal therapy and chemotherapy has emerged as a promising strategy for comprehensive therapies of breast cancer. In this study, we constructed human epidermal growth factor receptor 2 (Her2)-targeted gold nanoshelled poly(lactic-co-glycolic acid) hybrid nanocaps...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220929616

    authors: Dong Q,Wan C,Yang H,Zheng D,Xu L,Zhou Z,Xie S,Du J,Li F

    更新日期:2020-09-01 00:00:00

  • Optimization of alginate purification using polyvinylidene difluoride membrane filtration: Effects on immunogenicity and biocompatibility of three-dimensional alginate scaffolds.

    abstract::Sodium alginate is an effective biomaterial for tissue engineering applications. Non-purified alginate is contaminated with protein, lipopolysaccharide, DNA, and RNA, which could elicit adverse immunological reactions. We developed a purification protocol to generate biocompatible alginate based on (a) activated charc...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328216645952

    authors: Sondermeijer HP,Witkowski P,Woodland D,Seki T,Aangenendt FJ,van der Laarse A,Itescu S,Hardy MA

    更新日期:2016-10-01 00:00:00

  • In vitro and in vivo evaluation of polylactic acid-based composite with tricalcium phosphate microsphere for enhanced biodegradability and osseointegration.

    abstract::A biodegradable polylactic acid composite containing tricalcium phosphate microsphere was fabricated. The composite exhibited enhanced biocompatibility and a well-interconnected porous structure that enabled tissue ingrowth after degradation. The tricalcium phosphate microspheres had an average size of 106 ± 43 μm and...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328218763660

    authors: Shin DY,Kang MH,Kang IG,Kim HE,Jeong SH

    更新日期:2018-05-01 00:00:00

  • Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (L-lactide-co-ε-caprolactone) scaffold.

    abstract::The aim of this study was to design a new natural/synthetic bioactive bone scaffold for potential use in bone replacement applications. We developed a tri-component osteogenic composite scaffold made of collagen (Coll), hydroxyapatite (HA) and poly(l-lactide-co-ε-caprolactone) (PLCL). This Coll/HA/PLCL composite scaff...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328213486705

    authors: Akkouch A,Zhang Z,Rouabhia M

    更新日期:2014-02-01 00:00:00

  • Properties of maxillofacial silicone elastomers reinforced with silica powder.

    abstract::Compounds of a silicone elastomer suitable for preparing maxillofacial prostheses, reinforced with various amounts of silica powder, have been studied for their mechanical response and wetting properties in terms of contact angle. Tensile strength and elongation at break showed an increase with increasing silica volum...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829801300104

    authors: Andreopoulos AG,Evangelatou M,Tarantili PA

    更新日期:1998-07-01 00:00:00

  • In vitro thermomechanical ageing of Ni-Ti alloys.

    abstract::NiTi alloy is used as a biomaterial due to its pseudoelastic behaviour. It exhibits a great potential in dental and orthopedic applications where constant correcting loads are required. In order to use such materials, it is necessary to investigate the effect of the cyclic straining upon the transformation stresses an...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829801200304

    authors: Gil FJ,Planell JA

    更新日期:1998-01-01 00:00:00

  • Preparation and in vivo evaluation of a novel gel-based wound dressing using arginine-alginate surface-modified chitosan nanofibers.

    abstract::The development of an effective wound dressing with the ability to induce skin wound healing is a great challenge in medicine. Nanofibers are highly attractive for wound dressing preparation due to their properties such as hemostasis induction, good absorption of wound exudates, and facilitation of cell growth. Chitos...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328217739562

    authors: Hoseinpour Najar M,Minaiyan M,Taheri A

    更新日期:2018-01-01 00:00:00

  • Effects of strontium-modified calcium phosphate cement combined with bone morphogenetic protein-2 on osteoporotic bone defects healing in rats.

    abstract::The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defec...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328218765847

    authors: Tao Z,Zhou W,Jiang Y,Wu X,Xu Z,Yang M,Xie J

    更新日期:2018-07-01 00:00:00

  • Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications.

    abstract::Gold nanomaterials possess unique physical and chemical properties, which attracted much attention in recent years. As a new type of gold nanomaterials, gold nanostars (GNSTs) have been prepared and characterized in this study. GNSTs under near-infrared (NIR) light irradiation can exert not only cancer photothermal th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215594481

    authors: Wang L,Meng D,Hao Y,Zhao Y,Li D,Zhang B,Zhang Y,Zhang Z

    更新日期:2015-11-01 00:00:00

  • Factor analysis in the evaluation of the relationship between bacterial adherence to biomaterials and changes in free energy.

    abstract::The relative surface charge and free energy of forty-one coagulase-negative staphylococci were found to be normally distributed; therefore, they can be considered a homogeneous group under strict statistical criteria. The adherence of these bacteria to eight different biomaterials (seven synthetic and one biologic) wa...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829200700203

    authors: Carballo J,Ferreirós CM,Criado MT

    更新日期:1992-10-01 00:00:00

  • Periodontal ligament versus bone marrow mesenchymal stem cells in combination with Bio-Oss scaffolds for ectopic and in situ bone formation: A comparative study in the rat.

    abstract::The aim of this study was to compare the osteogenic effects of periodontal ligament stem cells (PDLSCs) versus bone marrow mesenchymal stem cells (BMMSCs) in combination with Bio-Oss scaffolds on subcutaneous and critical-size defects in the immunodeficient rat calvarium. PDLSCs and BMMSCs were obtained from the same ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214521846

    authors: Yu BH,Zhou Q,Wang ZL

    更新日期:2014-08-01 00:00:00

  • An arterial prosthesis from Argentina: the Barone Microvelour arterial graft.

    abstract::The manufacture of a polyester vascular prosthesis in the southern hemisphere is a new development in the global dissemination of this maturing technology. Hence the recent introduction of the Barone Microvelour arterial graft from Argentina has highlighted the need for a comparative in vitro and in vivo study to comp...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532828800300302

    authors: Torché D,Guidoin R,Boyer D,Marceau D,Marois Y,Debille E,Lacombe J,King M

    更新日期:1989-01-01 00:00:00

  • In vitro proliferation and osteogenic differentiation of human dental pulp stem cells in injectable thermo-sensitive chitosan/β-glycerophosphate/hydroxyapatite hydrogel.

    abstract::Injectable thermo-sensitive hydrogels have a potential application in bone tissue engineering for their sensitivities and minimal invasive properties. Human dental pulp stem cells have been considered a promising tool for tissue reconstruction. The objective of this study was to investigate the proliferation and osteo...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328216661566

    authors: Chen Y,Zhang F,Fu Q,Liu Y,Wang Z,Qi N

    更新日期:2016-09-01 00:00:00

  • Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue.

    abstract::Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215597818

    authors: O'Rourke C,Drake RA,Cameron GW,Loughlin AJ,Phillips JB

    更新日期:2015-11-01 00:00:00

  • Release of silica, calcium, phosphorus, and fluoride from glass ionomer cement containing bioactive glass.

    abstract::The aim of this study was to examine the release of silica (Si), calcium (Ca), phosphorous (P), and fluoride (F) from conventional glass ionomer cement (GI) and resin-modified glass ionomer cement (LCGI), containing different quantities of bioactive glass (BAG). Further aim was to evaluate in vitro biomineralization o...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0085328204044538

    authors: Yli-Urpo H,Vallittu PK,Närhi TO,Forsback AP,Väkiparta M

    更新日期:2004-07-01 00:00:00

  • Self-tapping ability of carbon fibre reinforced polyetheretherketone suture anchors.

    abstract::An experimental and computational investigation of the self-tapping ability of carbon fibre reinforced polyetheretherketone (CFR-PEEK) has been conducted. Six CFR-PEEK suture anchor designs were investigated using PEEK-OPTIMA® Reinforced, a medical grade of CFR-PEEK. Experimental tests were conducted to investigate th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214535274

    authors: Feerick EM,Wilson J,Jarman-Smith M,Ó'Brádaigh CM,McGarry JP

    更新日期:2014-10-01 00:00:00

  • Review paper: absorbable polymeric surgical sutures: chemistry, production, properties, biodegradability, and performance.

    abstract::Among biomaterials used as implants in human body, sutures constitute the largest groups of materials having a huge market exceeding $1.3 billion annually. Sutures are the most widely used materials in wound closure and have been in use for many centuries. With the development of the synthetic absorbable polymer, poly...

    journal_title:Journal of biomaterials applications

    pub_type: 历史文章,杂志文章,评审

    doi:10.1177/0885328210384890

    authors: Pillai CK,Sharma CP

    更新日期:2010-11-01 00:00:00