Nanoparticles based on phenylalanine ethyl ester-alginate conjugate as vitamin B2 delivery system.

Abstract:

:Phenylalanine ethyl ester (PAE)-alginate (Alg) conjugate (PAE-Alg, PEA) was synthesized and formation of an amide bond between PAE and Alg was confirmed by Fourier transformed-infrared and (1)H nuclear magnetic resonance spectroscopy. The degree of PAE substitution was 3.5-4.7 (PAE group per hundred sugar residues of Alg) which was determined by elemental analysis. The critical aggregation concentration values determined for PEA conjugates PEA1, PEA2, and PEA3 were 0.20, 0.12, and 0.10 mg/ml, respectively. The particle size of PEA nanoparticles (PEA-NPs) decreased from 425 nm to 226 nm with the increasing degree of PAE substitution. Vitamin B2 (VB2), as a model nutrient, was encapsulated into the nanoparticles. The drug-loading content increased with increasing degree of PAE substitution. The maximum VB2 loading capacity and loading efficiency of PEA3 nanoparticles were 3.53 ± 0.03% and 91.48 ± 0.80%, respectively. The in vitro release behavior of VB2 from the PEA-NPs showed a biphasic release profile with an initial burst release of about 40-50% of VB2 in the first 10 h followed by a steady and continuous release phase for the following 50 h in PBS, pH 7.4. The human colorectal carcinoma cell line was used to investigate the cytotoxicity of PEA-NPs. Our results showed that various concentrations of nanoparticles did not cause significant cytotoxicity against cell lines at normal concentrations.

journal_name

J Biomater Appl

authors

Zhang P,Zhao SR,Li JX,Hong L,Raja MA,Yu LJ,Liu CG

doi

10.1177/0885328216630497

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

13-22

issue

1

eissn

0885-3282

issn

1530-8022

pii

0885328216630497

journal_volume

31

pub_type

杂志文章
  • Cell survival and proliferation after encapsulation in a chemically modified Pluronic(R) F127 hydrogel.

    abstract::Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328211427774

    authors: Lippens E,Swennen I,Gironès J,Declercq H,Vertenten G,Vlaminck L,Gasthuys F,Schacht E,Cornelissen R

    更新日期:2013-03-01 00:00:00

  • Polymers for use in controlled release systems: the effect of surfactants on their swelling properties.

    abstract::The effect of an ampholytic surfactant on the swelling properties of polymeric materials was studied, using various swelling liquids. Tablets were prepared consisting of hydroxypropyl methylcellulose, poly(oxyethylene) and sodium alginate. Tego betain was the non-ionic surfactant used as an additive in a series of sam...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1106/GX1T-2JC6-QWC6-69GC

    authors: Vlachou M,Hani N,Efentakis M,Tarantili PA,Andreopoulos AG

    更新日期:2000-07-01 00:00:00

  • Sodium-phosphorylated chitosan/zinc oxide complexes and evaluation of their cytocompatibility: an approach for periodontal dressing.

    abstract::The aim of this study was to evaluate the possibility of metal complex formation between sodium-phosphorylated chitosan (PCTS) and ZnO. The polymer-metal complex formation was investigated in terms of thermal degradation. The structure deduction of the PCTS/ZnO complex was investigated by means of Fourier transform in...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328211408371

    authors: Srakaew V,Ruangsri P,Suthin K,Thunyakitpisal P,Tachaboonyakiat W

    更新日期:2012-11-01 00:00:00

  • 3D printed high-resolution scaffold with hydrogel microfibers for providing excellent biocompatibility.

    abstract::Melt electrowriting (MEW) can print high-resolution scaffolds with the ultrafine fibers from 800 nm to 20 µm. However, the cell seeding efficiency relatively low due to the large pore size of the MEW scaffold. Here, we reported a method to solve this dilemma by electrospinning a gelatin methacrylate (GelMA) hydrogel f...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220962606

    authors: Ye W,Xie C,Liu Y,He Y,Gao Q,Ouyang A

    更新日期:2021-01-01 00:00:00

  • Polyelectrolyte based molecular carriers: the role of self-assembled proteins in permeability properties.

    abstract::Polyelectrolyte capsules are seen as promising nanotechnology based drug delivery systems. In previous works, we have demonstrated the possibility to fabricate bio-activated surface layer containing capsules with improved features in terms of biocompatibility. In this study, we have characterized the permeability prop...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212446358

    authors: Habibi N,Pastorino L,Sandoval OH,Ruggiero C

    更新日期:2013-08-01 00:00:00

  • Isoniazid-loaded chitosan/carbon nanotubes microspheres promote secondary wound healing of bone tuberculosis.

    abstract::Poor blood circulation makes it difficult for antitubercular drugs to achieve effective bactericidal concentration at tuberculose focus. The residual Mycobacterium tuberculosis around surgical wound would multiply, resulting in nonunion or sinus formation. Carbon nanotubes have strong tissue penetration and can cross ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328218814988

    authors: Chen G,Wu Y,Yu D,Li R,Luo W,Ma G,Zhang C

    更新日期:2019-02-01 00:00:00

  • Cellular interactions with biodegradable polyurethanes formulated from L-tyrosine.

    abstract::L-Tyrosine polyurethanes (LTUs) have been synthesized by structural modification of the poly (amino acid) backbone to circumvent the problems associated with the processing of poly (amino acids) arising from their high crystallinity, insolubility in common organic solvents, and high glass-transition and melting temper...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328211432325

    authors: Shah PN,Yun YH

    更新日期:2013-05-01 00:00:00

  • Influence of MMP inhibitor GM6001 loading of fibre coated polypropylene meshes on wound healing: Implications for hernia repair.

    abstract::Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328218759043

    authors: Böhm G,Groll J,Heffels KH,Heussen N,Ink P,Alizai HP,Neumann UP,Schnabel R,Mirastschijski U

    更新日期:2018-05-01 00:00:00

  • Effect of GO-Fe3O4 and rotating magnetic field on cellular metabolic activity of mammalian cells.

    abstract::The effect of hybrid material-graphene flakes with Fe3O4 nanospheres (GO-Fe3O4), graphene oxide (GO) and magnetite nanospheres (Fe3O4) in rotating magnetic field on mammalian cells metabolism has been studied. Several reports shown that exposure to magnetic field may have influence on cellular membrane permeability. T...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328216628762

    authors: Urbas K,Jedrzejczak-Silicka M,Rakoczy R,Zaborski D,Mijowska E

    更新日期:2016-04-01 00:00:00

  • Targeted gold nanoshelled hybrid nanocapsules encapsulating doxorubicin for bimodal imaging and near-infrared triggered synergistic therapy of Her2-positve breast cancer.

    abstract::A multifunctional targeted nanoplatform combining photothermal therapy and chemotherapy has emerged as a promising strategy for comprehensive therapies of breast cancer. In this study, we constructed human epidermal growth factor receptor 2 (Her2)-targeted gold nanoshelled poly(lactic-co-glycolic acid) hybrid nanocaps...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220929616

    authors: Dong Q,Wan C,Yang H,Zheng D,Xu L,Zhou Z,Xie S,Du J,Li F

    更新日期:2020-09-01 00:00:00

  • Osteogenic efficacy of strontium hydroxyapatite micro-granules in osteoporotic rat model.

    abstract::Excessive demineralization in osteoporotic bones impairs its self-regeneration potential following a defect/fracture and is of great concern among the aged population. In this context, implants with inherent osteogenic ability loaded with therapeutic ions like Strontium (Sr2+) may bring forth promising outcomes. Micro...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328216647197

    authors: Chandran S,Babu S S,Vs HK,Varma HK,John A

    更新日期:2016-10-01 00:00:00

  • Novel porous Al2O3-SiO2-TiO2 bone grafting materials: formation and characterization.

    abstract::The present article deals with the development of 3D porous scaffolds for bone grafting. They were prepared based on rapid fluid infiltration of Al2O3-SiO2 sol into a polyethylene non-woven fabric template structure. Titanium dioxide in concentration equal to 5 wt% was added to the Al2O3-SiO2 mixture to produce Al2O3-...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328213483634

    authors: Naga SM,El-Kady AM,El-Maghraby HF,Awaad M,Detsch R,Boccaccini AR

    更新日期:2014-02-01 00:00:00

  • Preparation, characterization, and in vitro and in vivo evaluation of cellulose/soy protein isolate composite sponges.

    abstract::A series of cellulose/soy protein isolate (SPI) sponges was prepared using a freeze-drying process. The effect of the SPI content on the structure of the sponges was characterized by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). It showed that...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328208099337

    authors: Luo LH,Zhang YF,Wang XM,Wan Y,Chang PR,Anderson DP,Chen Y

    更新日期:2010-02-01 00:00:00

  • In vivo efficacy for novel combined anticalcification treatment of glutaraldehyde-fixed cardiac xenograft using humanized mice.

    abstract::The animal immune response against Galα1,3-Galβ1-4GlcNAc-R(α-Gal) epitopes gives an important cause for the failure of glutaraldehyde(GA)-fixed cardiac xenografts. This study aimed to assess the in vivo effect of our novel combined anticalcification treatment, which includes immunologic modification, using α1,3-galact...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214552710

    authors: Lim HG,Choi SY,Jeong S,Shin JS,Park CG,Kim YJ

    更新日期:2015-02-01 00:00:00

  • Effect of controlled local acetylsalicylic acid release on in vitro platelet adhesion to vascular grafts.

    abstract::Thrombosis is the most serious acute problem for small diameter arterial bypass grafts. In this research, small diameter expanded polytetrafluoroethylene (e-PTFE) vascular grafts were coated with acetylsalicylic acid (ASA) loaded poly (d,l-lactide) (PLA) by a solvent casting method. The feasibility and efficacy of thi...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829400800404

    authors: Hall JD,Rittgers SE,Schmidt SP

    更新日期:1994-04-01 00:00:00

  • Healing properties of surface-coated polycaprolactone-co-lactide scaffolds: a pilot study in sheep.

    abstract::The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds we...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212471409

    authors: Rentsch C,Schneiders W,Hess R,Rentsch B,Bernhardt R,Spekl K,Schneider K,Scharnweber D,Biewener A,Rammelt S

    更新日期:2014-01-01 00:00:00

  • Bovine bone screws: metrology and effects of chemical processing and ethylene oxide sterilization on bone surface and mechanical properties.

    abstract::We assess the effects of chemical processing, ethylene oxide sterilization, and threading on bone surface and mechanical properties of bovine undecalcified bone screws. In addition, we evaluate the possibility of manufacturing bone screws with predefined dimensions. Scanning electronic microscopic images show that che...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328208092110

    authors: Haje DP,Volpon JB,Moro CA

    更新日期:2009-03-01 00:00:00

  • Fabrication and characterization of 3D microtubular collagen scaffolds for peripheral nerve repair.

    abstract::Understanding the structure-function relationship in biomaterial constructs is critical in optimizing biological outcomes. For ensheathed structures such as peripheral nerve, engineering implantable tissue substitutes has been challenging. This is due to a unique geometry of thin-walled microtube arrays composed mostl...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328218804338

    authors: Li J,Gao W

    更新日期:2018-10-01 00:00:00

  • Enhancement of CRF-PEEK osseointegration by plasma-sprayed hydroxyapatite: A rabbit model.

    abstract::Carbon-fibre-reinforced polyether ether ketone (CFR-PEEK) exhibits excellent biomechanical properties as it has an elastic modulus similar to bone. However, CFR-PEEK displays inferior biocompatibility compared with titanium alloy and coating techniques are therefore of interest in order to improve integration. In this...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214521669

    authors: Suska F,Omar O,Emanuelsson L,Taylor M,Gruner P,Kinbrum A,Hunt D,Hunt T,Taylor A,Palmquist A

    更新日期:2014-08-01 00:00:00

  • In vitro proliferation and osteogenic differentiation of human dental pulp stem cells in injectable thermo-sensitive chitosan/β-glycerophosphate/hydroxyapatite hydrogel.

    abstract::Injectable thermo-sensitive hydrogels have a potential application in bone tissue engineering for their sensitivities and minimal invasive properties. Human dental pulp stem cells have been considered a promising tool for tissue reconstruction. The objective of this study was to investigate the proliferation and osteo...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328216661566

    authors: Chen Y,Zhang F,Fu Q,Liu Y,Wang Z,Qi N

    更新日期:2016-09-01 00:00:00

  • In vitro apatite formation on porous anodic alumina induced by a phosphorylation treatment.

    abstract::In this study, a phosphorylation treatment of porous anodic alumina (PAA) was performed by wet impregnation in phosphoric acid and a subsequent heat treatment. The PAA and phosphorylated PAA specimens were analyzed using a field emission scanning electron microscope, an energy-dispersive X-ray spectrometer, and Fourie...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214526765

    authors: Li X,Ni S,Webster TJ

    更新日期:2014-09-01 00:00:00

  • Bioactive polymers 55. Synthesis and characterization of a macromolecular drug based on 5-acetylamino-2-sulfamoyl-1,3,4-thiodiazole.

    abstract::The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/su...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829200700105

    authors: Dumitriu S,Popa M,Dărângă M,Dumitriu C

    更新日期:1992-07-01 00:00:00

  • Self-tapping ability of carbon fibre reinforced polyetheretherketone suture anchors.

    abstract::An experimental and computational investigation of the self-tapping ability of carbon fibre reinforced polyetheretherketone (CFR-PEEK) has been conducted. Six CFR-PEEK suture anchor designs were investigated using PEEK-OPTIMA® Reinforced, a medical grade of CFR-PEEK. Experimental tests were conducted to investigate th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214535274

    authors: Feerick EM,Wilson J,Jarman-Smith M,Ó'Brádaigh CM,McGarry JP

    更新日期:2014-10-01 00:00:00

  • Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (L-lactide-co-ε-caprolactone) scaffold.

    abstract::The aim of this study was to design a new natural/synthetic bioactive bone scaffold for potential use in bone replacement applications. We developed a tri-component osteogenic composite scaffold made of collagen (Coll), hydroxyapatite (HA) and poly(l-lactide-co-ε-caprolactone) (PLCL). This Coll/HA/PLCL composite scaff...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328213486705

    authors: Akkouch A,Zhang Z,Rouabhia M

    更新日期:2014-02-01 00:00:00

  • Strontium-substituted calcium sulfate hemihydrate/hydroxyapatite scaffold enhances bone regeneration by recruiting bone mesenchymal stromal cells.

    abstract::Fabrication of osteoconductive scaffold with osteoinductive capability and appropriate resorption rate is of great significance for treating bone defects. To achieve this aim, strontium-substituted calcium sulfate hemihydrate (Sr-CSH) and hydroxyapatite (HA) were mixed to develop a novel composite. Sr-CSH containing 5...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220915816

    authors: Chang H,Xiang H,Yao Z,Yang S,Tu M,Zhang X,Yu B

    更新日期:2020-07-01 00:00:00

  • Gold nanostars mediated combined photothermal and photodynamic therapy and X-ray imaging for cancer theranostic applications.

    abstract::Gold nanomaterials possess unique physical and chemical properties, which attracted much attention in recent years. As a new type of gold nanomaterials, gold nanostars (GNSTs) have been prepared and characterized in this study. GNSTs under near-infrared (NIR) light irradiation can exert not only cancer photothermal th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215594481

    authors: Wang L,Meng D,Hao Y,Zhao Y,Li D,Zhang B,Zhang Y,Zhang Z

    更新日期:2015-11-01 00:00:00

  • Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging.

    abstract::In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220952594

    authors: Ma K,Cheng Y,Wei X,Chen D,Zhao X,Jia P

    更新日期:2020-08-27 00:00:00

  • Review paper: absorbable polymeric surgical sutures: chemistry, production, properties, biodegradability, and performance.

    abstract::Among biomaterials used as implants in human body, sutures constitute the largest groups of materials having a huge market exceeding $1.3 billion annually. Sutures are the most widely used materials in wound closure and have been in use for many centuries. With the development of the synthetic absorbable polymer, poly...

    journal_title:Journal of biomaterials applications

    pub_type: 历史文章,杂志文章,评审

    doi:10.1177/0885328210384890

    authors: Pillai CK,Sharma CP

    更新日期:2010-11-01 00:00:00

  • Melanin-containing hydrogel intraocular lenses: a histopathological study in animal eyes.

    abstract::Poly(2-hydroxyethyl methacrylate) hydrogel intraocular lenses, containing adrenochrome-melanin, were manufactured and implanted in animal eyes in order to assess the effect of melanin upon (a) biocompatibility of implants with the eye tissues, and (b) fibrous proliferation of lens epithelium responsible for the opacif...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829500900305

    authors: Chirila TV,Constable IJ,Vijayasekaran S,Ben-Hun J

    更新日期:1995-01-01 00:00:00

  • Factor analysis in the evaluation of the relationship between bacterial adherence to biomaterials and changes in free energy.

    abstract::The relative surface charge and free energy of forty-one coagulase-negative staphylococci were found to be normally distributed; therefore, they can be considered a homogeneous group under strict statistical criteria. The adherence of these bacteria to eight different biomaterials (seven synthetic and one biologic) wa...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829200700203

    authors: Carballo J,Ferreirós CM,Criado MT

    更新日期:1992-10-01 00:00:00