Polyelectrolyte based molecular carriers: the role of self-assembled proteins in permeability properties.

Abstract:

:Polyelectrolyte capsules are seen as promising nanotechnology based drug delivery systems. In previous works, we have demonstrated the possibility to fabricate bio-activated surface layer containing capsules with improved features in terms of biocompatibility. In this study, we have characterized the permeability properties of such capsules towards low and high molecular weight molecules, including proteins. The results indicated that the presence of the surface layer strongly affects the permeability properties of the capsules in terms of loading capacity which was found to be higher compared to that of plain capsules. These properties make such systems interesting candidates as drug delivery platforms.

journal_name

J Biomater Appl

authors

Habibi N,Pastorino L,Sandoval OH,Ruggiero C

doi

10.1177/0885328212446358

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

262-9

issue

2

eissn

0885-3282

issn

1530-8022

pii

0885328212446358

journal_volume

28

pub_type

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