Abstract：
PURPOSE:A functionalized graphene oxide-based thermosensitive hydrogel loaded with docetaxel for intratumoral delivery was designed to enhance therapeutic efficacy and alleviate system toxicity. METHODS:First, graphene oxide was functionalized with chitosan to acquire high stability in physiological solutions. And then docetaxel-graphene oxide/chitosan gel was formed by mixed docetaxel-graphene oxide/chitosan suspension with hydrogel which was made from Poloxamer 407 and Poloxamer 188. Cellular uptake, antitumor effect in vitro and in vivo, cell apoptosis, and biodistribution of docetaxel-graphene oxide/chitosan gel were investigated, compared with the docetaxel solution. RESULTS:Graphene oxide/chitosan was stable in physiological solution, and docetaxel released much slower from docetaxel-graphene oxide/chitosan gel with a pH-responsive feature. Compared with free docetaxel, docetaxel-graphene oxide/chitosan could afford higher antitumor efficacy in Michigan Cancer Foundation-7 (MCF-7) cells in vitro. Furthermore, docetaxel-grapheme oxide/chitosan gel which was injected within tumor could afford higher concentration and longer resident time in tumor tissues of mice in vivo, without obvious toxic effects to normal organs. Meanwhile, the combination of near-infrared laser irradiation at 808 nm significantly enhanced tumor inhibition in vitro and in vivo. CONCLUSIONS:Docetaxel-graphene oxide/chitosan gel in combination with 808 nm near-infrared laser irradiation had great potential for cancer chemo-photothermal therapy.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Zhu X,Zhang Y,Huang H,Zhang H,Hou L,Zhang Zdoi
10.1177/0885328215619583subject
Has Abstractpub_date
2016-03-01 00:00:00pages
1230-41issue
8eissn
0885-3282issn
1530-8022pii
0885328215619583journal_volume
30pub_type
杂志文章abstract：:Melt electrowriting (MEW) can print high-resolution scaffolds with the ultrafine fibers from 800 nm to 20 µm. However, the cell seeding efficiency relatively low due to the large pore size of the MEW scaffold. Here, we reported a method to solve this dilemma by electrospinning a gelatin methacrylate (GelMA) hydrogel f...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220962606
更新日期：2021-01-01 00:00:00
abstract：:Staphylococcus epidermidis plays a major role in capsular contractures of silicone breast implants. This in vitro study evaluates the antibacterial effect of copper on S. epidermidis in silicone implants. Specimens of a silicone material used for breast augmentation (Cu0) and specimens coated with different copper con...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212441957
更新日期：2013-08-01 00:00:00
abstract：:Among biomaterials used as implants in human body, sutures constitute the largest groups of materials having a huge market exceeding $1.3 billion annually. Sutures are the most widely used materials in wound closure and have been in use for many centuries. With the development of the synthetic absorbable polymer, poly...
journal_title：Journal of biomaterials applications
pub_type： 历史文章,杂志文章,评审
doi：10.1177/0885328210384890
更新日期：2010-11-01 00:00:00
abstract：:The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/su...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829200700105
更新日期：1992-07-01 00:00:00
abstract：:A biodegradable polylactic acid composite containing tricalcium phosphate microsphere was fabricated. The composite exhibited enhanced biocompatibility and a well-interconnected porous structure that enabled tissue ingrowth after degradation. The tricalcium phosphate microspheres had an average size of 106 ± 43 μm and...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218763660
更新日期：2018-05-01 00:00:00
abstract：:Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218759043
更新日期：2018-05-01 00:00:00
abstract：:Antenna coupling microwave plasma enables a highly oxidative treatment of the outmost surface of polypropylene (PP) nonwoven fabric within a short time period. Subsequently, grafting copolymerization with acrylic acid (AAc) makes the plasma-treated fabric durably hydrophilic and excellent in water absorbency. With hig...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/088532802030478
更新日期：2002-10-01 00:00:00
abstract：:Hydrogels were prepared from 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate as cross-linking agent. Two different polymerization techniques were followed, namely bulk polymerization initiated by dibenzoyl peroxide and solution polymerization, in water, using a redox initiator system. Differences in the...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829801200402
更新日期：1998-04-01 00:00:00
abstract：:The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defec...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218765847
更新日期：2018-07-01 00:00:00
abstract：:In this work, we report brushite-based calcium phosphate cement (CPC) system to enhance the in vivo biodegradation and tissue in-growth by incorporation of micro-channeled hydroxyapatite (HAp) granule and silicon and sodium addition in calcium phosphate precursor powder. Sodium- and silicon-rich calcium phosphate powd...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215601938
更新日期：2016-01-01 00:00:00
abstract：:Transarterial embolization is an established minimally invasive treatment for solid tumors. Unintended inflammation, foreign body reactions and ischemia-triggered neoangiogenesis are clinical drawbacks of permanent embolic materials. The aim of the current study was to characterize a new type of biodegradable starch m...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217746674
更新日期：2018-02-01 00:00:00
abstract：:The aim of this study was to compare the osteogenic effects of periodontal ligament stem cells (PDLSCs) versus bone marrow mesenchymal stem cells (BMMSCs) in combination with Bio-Oss scaffolds on subcutaneous and critical-size defects in the immunodeficient rat calvarium. PDLSCs and BMMSCs were obtained from the same ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214521846
更新日期：2014-08-01 00:00:00
abstract：:The layer-by-layer technique, which allows simple preparation of polyelectrolyte multilayers, came into the focus of research for development of functionalized medical devices. Numerous literature exist that concentrate on the film build-up and the behaviour of cells on polyelectrolyte multilayers. However, in case of...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212437610
更新日期：2013-07-01 00:00:00
abstract：:This study aims the in vivo biological characterization of an innovative minocycline delivery system, based on polymethylmethacrylate bone cement. Bone cements containing 1% or 2.5% (w/w) minocycline were formulated and evaluated through solid-state characterization. Biological evaluation was conducted in vivo, within...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218795290
更新日期：2018-09-01 00:00:00
abstract：:A biosensor for the analysis of D-amino acids is described. Carbon paste (graphite/paraffin oil) was chemically modified with immobilized D-amino acid oxidase and either horse-radish peroxidase or fungal peroxidase from Arthromyces ramosus. The two enzymes dissolved in buffer, together with an amine containing oligome...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829300800204
更新日期：1993-10-01 00:00:00
abstract：:The purpose of this investigation is to study the effect of long-term subcutaneous aluminum polymeric implants on aluminum release and accumulation in various tissues in rats. The implants were formulated using silicone rubber and polyurethane polymers and three different aluminum salts. The polymeric matrices were ev...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829601100103
更新日期：1996-07-01 00:00:00
abstract：:Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any promise of a cure in the near future. Although islet transplantation has proven to be an effective means of treating type 1 diabetes mell...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章,评审
doi：10.1177/0885328219831391
更新日期：2019-04-01 00:00:00
abstract：:Using a hydraulic stress simulator, the mechanical behavior of the porcine pericardium used in the construction of cardiac valve leaflets was characterized following the same procedure employed with calf pericardium in Part 1 of this study. One hundred fifty pairs of tissue samples were subjected to tensile testing to...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/3JXM-UTPN-PXTG-72DT
更新日期：2001-07-01 00:00:00
abstract：:The aim of the paper is to obtain and characterize k-carrageenan-chitosan dual hydrogel multilayers shell BSA gel microcapsules, as a carrier for curcumin, and as a possible antitumoral agent in biological studies. We used the CaCO3 template to synthesize non-toxic CaCO3/BSA particles as microtemplates by coprecipitat...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215603797
更新日期：2016-01-01 00:00:00
abstract：:The manufacture of a polyester vascular prosthesis in the southern hemisphere is a new development in the global dissemination of this maturing technology. Hence the recent introduction of the Barone Microvelour arterial graft from Argentina has highlighted the need for a comparative in vitro and in vivo study to comp...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532828800300302
更新日期：1989-01-01 00:00:00
abstract：:Silicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217715428
更新日期：2017-08-01 00:00:00
abstract：:The process of molecular self-assembly plays a crucial role in formulation of polymeric nanoparticulated drug delivery carriers as it creates the possibility for enhanced drug encapsulation and carrier surface engineering. This study aimed to develop a novel self-assembled polymeric micelles for targeted delivery in t...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214549612
更新日期：2015-01-01 00:00:00
abstract：:The aim of this study was to investigate if newly developed polyurethane (PU) scaffolds are suitable as scaffold for cell-seeded meniscus tissue engineered constructs. Scaffolds were seeded with goat meniscal fibrochondrocytes and cultured to assess changes in biological and mechanical properties. Furthermore, the eff...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211417317
更新日期：2013-01-01 00:00:00
abstract：:The aim of this study was to examine the release of silica (Si), calcium (Ca), phosphorous (P), and fluoride (F) from conventional glass ionomer cement (GI) and resin-modified glass ionomer cement (LCGI), containing different quantities of bioactive glass (BAG). Further aim was to evaluate in vitro biomineralization o...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0085328204044538
更新日期：2004-07-01 00:00:00
abstract：:Phase-sensitive in situ gel-forming controlled release formulations of insulin were prepared using poly(lactide-co-glycolide) and a solvent system consisting of various proportions of benzyl benzoate and benzyl alcohol. The in vitro release samples of formulations were assayed for insulin content by enzyme linked immu...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328209359959
更新日期：2011-03-01 00:00:00
abstract：:In this work, the role of shock wave-induced increase of bone morphogenetic proteins in modulating the osteogenic properties of osteoblast-like cells seeded on a bioactive scaffold was investigated using gremlin as a bone morphogenetic protein antagonist. Bone-like glass-ceramic scaffolds, based on a silicate experime...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214541974
更新日期：2014-11-01 00:00:00
abstract：:The aim of this study was to design a new natural/synthetic bioactive bone scaffold for potential use in bone replacement applications. We developed a tri-component osteogenic composite scaffold made of collagen (Coll), hydroxyapatite (HA) and poly(l-lactide-co-ε-caprolactone) (PLCL). This Coll/HA/PLCL composite scaff...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213486705
更新日期：2014-02-01 00:00:00
abstract：:A range of crystalline and nano-sized carbonate- and silicate-substituted hydroxyapatite has been successfully produced by using continuous hydrothermal flow synthesis technology. Ion-substituted calcium phosphates are better candidates for bone replacement applications (due to improved bioactivity) as compared to pha...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212460289
更新日期：2013-09-01 00:00:00
abstract：:The surface quality of coronary stents has a significant influence on its biocompatibility. Therefore, surface polishing is of paramount importance in the production and application of stents. In the present study, electropolishing is performed on 316LVM steel slotted tube coronary stents. Additionally, acid pickling,...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328205046564
更新日期：2005-01-01 00:00:00
abstract：:Hydroxyapatite (Ca10(PO4)6(OH)2) is widely investigated as an implantable material for hard tissue restoration due to its osteoconductive properties. However, hydroxyapatite in bulk form is limited as its mechanical properties are insufficient for load-bearing orthopedic applications. Attempts have been made to improv...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215592866
更新日期：2015-11-01 00:00:00
