Abstract:
:The aim of this study was to design a new natural/synthetic bioactive bone scaffold for potential use in bone replacement applications. We developed a tri-component osteogenic composite scaffold made of collagen (Coll), hydroxyapatite (HA) and poly(l-lactide-co-ε-caprolactone) (PLCL). This Coll/HA/PLCL composite scaffold was combined with human osteoblast-like cells obtained by differentiation of dental pulp stem cells (DPSCs) to engineer bone tissue in vitro. Results show that the 3D Coll/HA/PLCL composite scaffold was highly porous, thereby enabling osteoblast-like cell adhesion and growth. Cultured in the Coll/HA/PLCL scaffold, the osteoblast-like cells expressed different osteogenic genes, produced alkaline phosphatase and formed nodules more than did PLCL alone. Micro-CT analyses revealed a significant (30%) increase of tissue mineralisation on the surface as well as inside of the Coll/HA/PLCL scaffold, thus confirming its effectiveness as a bone regeneration platform.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Akkouch A,Zhang Z,Rouabhia Mdoi
10.1177/0885328213486705subject
Has Abstractpub_date
2014-02-01 00:00:00pages
922-36issue
6eissn
0885-3282issn
1530-8022pii
0885328213486705journal_volume
28pub_type
杂志文章abstract::The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/su...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829200700105
更新日期:1992-07-01 00:00:00
abstract::Reconstruction of critical sized bone injuries is a major problem that continues to inspire the design of new materials and grafts. Natural ceramics (hydroxyapatite (HA) coralline HA, or synthetic HA) and β-tricalcium phosphate (β-TCP) are being explored for use as scaffolds in bone tissue engineering, among several o...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211415132
更新日期:2013-01-01 00:00:00
abstract::Fabrication of osteoconductive scaffold with osteoinductive capability and appropriate resorption rate is of great significance for treating bone defects. To achieve this aim, strontium-substituted calcium sulfate hemihydrate (Sr-CSH) and hydroxyapatite (HA) were mixed to develop a novel composite. Sr-CSH containing 5...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220915816
更新日期:2020-07-01 00:00:00
abstract::Understanding the structure-function relationship in biomaterial constructs is critical in optimizing biological outcomes. For ensheathed structures such as peripheral nerve, engineering implantable tissue substitutes has been challenging. This is due to a unique geometry of thin-walled microtube arrays composed mostl...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218804338
更新日期:2018-10-01 00:00:00
abstract::Excessive demineralization in osteoporotic bones impairs its self-regeneration potential following a defect/fracture and is of great concern among the aged population. In this context, implants with inherent osteogenic ability loaded with therapeutic ions like Strontium (Sr2+) may bring forth promising outcomes. Micro...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216647197
更新日期:2016-10-01 00:00:00
abstract::Two series of glasses of general formula (2-p) SiO2.1.1Na2O.CaO.pP2O5.xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. Th...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328207079731
更新日期:2008-05-01 00:00:00
abstract::Silicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217715428
更新日期:2017-08-01 00:00:00
abstract::A new diol, bis[2-(2-hydroxyethyldimethylammonio)ethyl] butylenediphosphate, that contains two phosphatidylcholine analogous moieties in one diol molecule, was synthesized and characterized. The diol together with 1,4-butanediol as chain extender was further incorporated into the propolymer of poly(ethylene oxide) (Mn...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829701200205
更新日期:1997-10-01 00:00:00
abstract::In this work, we report brushite-based calcium phosphate cement (CPC) system to enhance the in vivo biodegradation and tissue in-growth by incorporation of micro-channeled hydroxyapatite (HAp) granule and silicon and sodium addition in calcium phosphate precursor powder. Sodium- and silicon-rich calcium phosphate powd...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215601938
更新日期:2016-01-01 00:00:00
abstract::In this study, the effects of sodium carbonate (Na(2)CO(3) ) solution with different concentrations (10, 15, 20, and 25 wt%) as liquid phase on the setting time and compressive strength of tricalcium silicate bone cements are investigated. The in vitro bioactivity and degradability of the resultant Ca(3)SiO(5)-Na(2)CO...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328208088714
更新日期:2008-11-01 00:00:00
abstract::Novel in situ polymerizable liquid three-arm biodegradable oligomeric polyesters based upon glycolic acid (GA), L-lactic acid (LLA), and their copolymers are synthesized and characterized. Injectable and in situ curable polymer neat resins and their composites formulated with bioabsorbable beta-tricalcium phosphate ar...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328206068691
更新日期:2007-07-01 00:00:00
abstract::In this study, a novel bilayer scaffold composed of electrospun polycaprolactone and poly(lacto-co-glycolic acid) (PCL/PLGA) membrane and glutaraldehyde (3.5% v/v) cross-linked chitosan/gelatin hydrogel was fabricated using two methods: electrospinning of the membrane onto the lyophilized hydrogel (BS-1) and membrane ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211416527
更新日期:2013-01-01 00:00:00
abstract::Eight different chemicals were investigated as potential candidate coupling agents for phosphate glass fibre reinforced polylactic acid composites. Evidence of reaction of the coupling agents with phosphate glass and their effect on surface wettability and glass degradation were studied along with their principle role...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212453634
更新日期:2013-09-01 00:00:00
abstract::In this study, a phosphorylation treatment of porous anodic alumina (PAA) was performed by wet impregnation in phosphoric acid and a subsequent heat treatment. The PAA and phosphorylated PAA specimens were analyzed using a field emission scanning electron microscope, an energy-dispersive X-ray spectrometer, and Fourie...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214526765
更新日期:2014-09-01 00:00:00
abstract::Injectable thermo-sensitive hydrogels have a potential application in bone tissue engineering for their sensitivities and minimal invasive properties. Human dental pulp stem cells have been considered a promising tool for tissue reconstruction. The objective of this study was to investigate the proliferation and osteo...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216661566
更新日期:2016-09-01 00:00:00
abstract::Plastics are fulfilling a number of critical roles in a variety of medical applications. While some of these are low-technology, throw-away products, many of the applications impose critical requirements as to mechanical performance, chemical resistance, biocompatibility, ability to be sterilized and to remain sterile...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532828700200305
更新日期:1988-01-01 00:00:00
abstract::Gold nanomaterials possess unique physical and chemical properties, which attracted much attention in recent years. As a new type of gold nanomaterials, gold nanostars (GNSTs) have been prepared and characterized in this study. GNSTs under near-infrared (NIR) light irradiation can exert not only cancer photothermal th...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215594481
更新日期:2015-11-01 00:00:00
abstract::The adhesion of platelets, red blood cells, and lymphocytes onto various polymer substrates, hydrophobic to hydrophilic in nature, has been studied. Cell adhesion is found to be higher on hydrophilic substrates. The stability of these adhered cells has also been studied under a flow rate of 20 ml/min. Further the effe...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829100600105
更新日期:1991-07-01 00:00:00
abstract::Sodium alginate is an effective biomaterial for tissue engineering applications. Non-purified alginate is contaminated with protein, lipopolysaccharide, DNA, and RNA, which could elicit adverse immunological reactions. We developed a purification protocol to generate biocompatible alginate based on (a) activated charc...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216645952
更新日期:2016-10-01 00:00:00
abstract::Cellulose acetate phthalate and Pluronic F-127 combined together (70:30 wt:wt) create a rigid, surface-eroding association polymer. To impart flexibility into the polymer system and allow for a drug delivery film that can contour to varying wound shapes, plasticizers were added. Triethyl citrate or tributyl citrate wa...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213480979
更新日期:2014-01-01 00:00:00
abstract::Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years. However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexi...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220972219
更新日期:2020-11-11 00:00:00
abstract::Single nanofibers with chemical and functional properties consistent with artery extracellular matrix nanofibers were produced by electrospinning. Using weight ratios to mimic artery extracellular matrix, five materials were tested: (1) Collagen type I, (2) Collagen type I + Collagen type III, (3) Collagen type I + po...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213477893
更新日期:2014-01-01 00:00:00
abstract::Glass Polyalkenoate Cements (GPCs) based on strontium calcium zinc silicate (Sr-Ca-Zn-SiO2) glasses and high molecular weight poly(acrylic acid) (PAA) have been shown to exhibit suitable mechanical properties for orthopaedic arthroplasty applications, however for vertebroplasty and other medical luting applications th...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328208099085
更新日期:2010-02-01 00:00:00
abstract::Biomaterials and devices have been used in a variety of applications ranging from disposable extracorporeal devices and soft and hard tissue augmentation, to total artificial internal organs. However, there are risks and failures in each application which are a result of undesirable biological interactions. This artic...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829300800104
更新日期:1993-07-01 00:00:00
abstract::The purpose of this study was to develop a specific targeting magnetic nanoparticle probe for magnetic resonance imaging and therapy in the form of local hyperthermia. Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-asparti...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213493486
更新日期:2014-03-01 00:00:00
abstract::Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328209344003
更新日期:2010-08-01 00:00:00
abstract::Fracture resistance of provisional restorations is an important clinical concern. This property is directly related to transverse strength. Strengthening of provisional fixed partial dentures may result from reinforcement with various fiber types. This study evaluated the effect of fiber type and water storage on the ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328203017004003
更新日期:2003-04-01 00:00:00
abstract::The controlled release of insulin from a series of biodegradable hybrid hydrogel network containing dextran derivative of allyl isocyanate (dex-AI) and poly (D,L) lactide diacrylate macromer (PDLLAM) over a wide range of composition ratio was investigated. Laser confocal scanning microscope was used to understand the ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1106/088532802024248
更新日期:2002-04-01 00:00:00
abstract::Carbon-fibre-reinforced polyether ether ketone (CFR-PEEK) exhibits excellent biomechanical properties as it has an elastic modulus similar to bone. However, CFR-PEEK displays inferior biocompatibility compared with titanium alloy and coating techniques are therefore of interest in order to improve integration. In this...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214521669
更新日期:2014-08-01 00:00:00
abstract::An electronic sensor system for urinary bladder pressure monitoring requires an imbedding into a biocompatible, flexible, and liquid-impermeable material. Poly(dimethylsiloxane) (PDMS) was selected in the present set-up as packaging material because it fulfills the abovementioned requirements. However, the surface of ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211422119
更新日期:2013-02-01 00:00:00