Preparation and in vivo evaluation of a silicate-based composite bone cement.

Abstract:

:Silicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study, a pilot in vivo evaluation of a silicate-based composite bone cement (CSC) was carried out in a rabbit femur defect model. The cement was composed of tricalcium silicate, 45S5 bioglass and calcium sulfate, and the self-setting properties of the material were established. The in vivo bone integration and biodegradability of CSC were investigated and compared with those of bioactive glass particulates, and a calcium phosphate cement. The results showed that CSC underwent a relatively slower in vivo degradation as compared with bioactive glass and calcium phosphate cement. Histological observation demonstrated that bone contact area at the interface between the surrounding bone and CSC gradually increased with time proceeding. CSC kept its structural integrity during implantation in vivo because of its acceptable mechanical strength. These results provide evidence of effectiveness in vivo and suggest potential clinical applications of the silicate-based composite bone cements.

journal_name

J Biomater Appl

authors

Ma B,Huan Z,Xu C,Ma N,Zhu H,Zhong J,Chang J

doi

10.1177/0885328217715428

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

257-264

issue

2

eissn

0885-3282

issn

1530-8022

journal_volume

32

pub_type

杂志文章
  • Characterization of a new composite PMMA-HA/Brushite bone cement for spinal augmentation.

    abstract::Calcium phosphate fillers have been shown to increase cement osteoconductivity, but have caused drawbacks in cement properties. Hydroxyapatite and Brushite were introduced in an acrylic two-solution cement at varying concentrations. Novel composite bone cements were developed and characterized using rheology, injectab...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214544770

    authors: Aghyarian S,Rodriguez LC,Chari J,Bentley E,Kosmopoulos V,Lieberman IH,Rodrigues DC

    更新日期:2014-11-01 00:00:00

  • In vivo testing of a biostable polyurethane.

    abstract::At present all the commercially available "medical grade" urethane elastomers exhibit a phenomenon known as environmental stress cracking (ESC). This phenomenon is characterized by surface microcracking when the elastomer is elongated while in vivo. The degree of strain that is required to initiate microcracking varie...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829100600202

    authors: Szycher M,Reed AM,Siciliano AA

    更新日期:1991-10-01 00:00:00

  • Chitosan crosslinked microparticles with encapsulated polyphenols: Water sorption and release properties.

    abstract::Chitosan-glutaraldehyde microparticles were produced by emulsion crosslinking method to be used as drug delivery system for polyphenols from Thymus serpyllum L. aqueous extract. The effect of preparation conditions, chitosan concentration (1.5-3% w/v), and glutaraldehyde/chitosan (GA/Ch) mass ratio (0.15-1.20) on wate...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215598940

    authors: Trifković K,Milašinović N,Djordjević V,Zdunić G,Kalagasidis Krušić M,Knežević-Jugović Z,Šavikin K,Nedović V,Bugarski B

    更新日期:2015-11-01 00:00:00

  • Polymer-based material containing calcium phosphate particles functionalized with a dimethacrylate monomer for use in restorative dentistry.

    abstract::Dicalcium phosphate dihydrate particles functionalized with triethyleneglycol dimethacrylate were synthesized and added to a photocurable mixture of bisphenol-A glycidyl dimethacrylate and triethyleneglycol dimethacrylate with the purpose of developing a resin composite capable of releasing calcium and phosphate ions ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328216680116

    authors: Rodrigues MC,Xavier TA,Arana-Chavez VE,Braga RR

    更新日期:2017-01-01 00:00:00

  • Vitamin E (α-tocopherol) addition modifies P(D,L)LA sponge degradation and protein release.

    abstract::Polylactic acid (PLA)-derived polymers are widely used in many biotechnological fields, thanks to their biocompatibility and resorbability through natural pathways. Moreover, PLA is one of the few polymers in which both the properties and the stereochemical structure can be easily modified, making possible a specific ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328211398298

    authors: Renò F,Rizzi M,Cannas M

    更新日期:2012-08-01 00:00:00

  • Plastics in medical applications.

    abstract::Plastics are fulfilling a number of critical roles in a variety of medical applications. While some of these are low-technology, throw-away products, many of the applications impose critical requirements as to mechanical performance, chemical resistance, biocompatibility, ability to be sterilized and to remain sterile...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532828700200305

    authors: Lantos PR

    更新日期:1988-01-01 00:00:00

  • The adhesion and proliferation of bone marrow-derived mesenchymal stem cells promoted by nanoparticle surface.

    abstract::This study's aim consists of evaluating the adhesion and proliferation of mesenchymal stem cells (MSCs) derived from rat bone marrow on nanoparticle Titanium (Ti) surface. Hence, passage 3 MSCs were, respectively, seeded on nanoparticle Ti and pure Ti surfaces and then cultured for 32 h. Cell morphology and viability ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328211414750

    authors: Chen L,Sun J,Zhu Z,Wu K,Li W,Liu H,Xu S

    更新日期:2013-01-01 00:00:00

  • In vitro evaluation of quaternized polydimethylaminoethylmethacrylate sub-microparticles for oral insulin delivery.

    abstract::This investigation describes the synthesis and in vitro evaluation of cationic hydrogel sub-microparticles based on polydimethylaminoethylmethacrylate for oral insulin delivery. Polymerization of dimethylaminoethylmethacrylate was carried out in aqueous medium with potassium persulfate as the initiator. Quaternization...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212437392

    authors: Sonia TA,Sharma CP

    更新日期:2013-07-01 00:00:00

  • Ageing human bone: factors affecting its biomechanical properties and the role of collagen.

    abstract::The incidence of fractures increases with age. This is partly due to extraosseous factors and partly to the increased fragility of the bone material itself. Ageing adversely affects the "quality" of human bone material, its elastic and ultimate properties. The hypothesis here is that these effects are caused by factor...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1106/5JUJ-TFJ3-JVVA-3RJ0

    authors: Zioupos P

    更新日期:2001-01-01 00:00:00

  • Thermal, dynamic mechanical, and dielectric analyses of some polyurethane biocomposites.

    abstract::Polymer biocomposites based on segmented poly(ester urethane) and extracellular matrix components have been prepared for the development of tissue engineering applications with improved biological characteristics of the materials in contact with blood and tissues for long periods. Thermal, dynamical, and dielectrical ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328210394468

    authors: Macocinschi D,Filip D,Vlad S,Cristea M,Musteata V,Ibanescu S

    更新日期:2012-08-01 00:00:00

  • In vivo efficacy for novel combined anticalcification treatment of glutaraldehyde-fixed cardiac xenograft using humanized mice.

    abstract::The animal immune response against Galα1,3-Galβ1-4GlcNAc-R(α-Gal) epitopes gives an important cause for the failure of glutaraldehyde(GA)-fixed cardiac xenografts. This study aimed to assess the in vivo effect of our novel combined anticalcification treatment, which includes immunologic modification, using α1,3-galact...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214552710

    authors: Lim HG,Choi SY,Jeong S,Shin JS,Park CG,Kim YJ

    更新日期:2015-02-01 00:00:00

  • In vitro and in vivo evaluation of polylactic acid-based composite with tricalcium phosphate microsphere for enhanced biodegradability and osseointegration.

    abstract::A biodegradable polylactic acid composite containing tricalcium phosphate microsphere was fabricated. The composite exhibited enhanced biocompatibility and a well-interconnected porous structure that enabled tissue ingrowth after degradation. The tricalcium phosphate microspheres had an average size of 106 ± 43 μm and...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328218763660

    authors: Shin DY,Kang MH,Kang IG,Kim HE,Jeong SH

    更新日期:2018-05-01 00:00:00

  • Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging.

    abstract::In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220952594

    authors: Ma K,Cheng Y,Wei X,Chen D,Zhao X,Jia P

    更新日期:2020-08-27 00:00:00

  • Effectiveness of antibacterial copper additives in silicone implants.

    abstract::Staphylococcus epidermidis plays a major role in capsular contractures of silicone breast implants. This in vitro study evaluates the antibacterial effect of copper on S. epidermidis in silicone implants. Specimens of a silicone material used for breast augmentation (Cu0) and specimens coated with different copper con...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212441957

    authors: Gosau M,Bürgers R,Vollkommer T,Holzmann T,Prantl L

    更新日期:2013-08-01 00:00:00

  • The influence of solvent processing on polyester bioabsorbable polymers.

    abstract::Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lact...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328210376997

    authors: Manson J,Dixon D

    更新日期:2012-01-01 00:00:00

  • Development of a microporous compliant small bore vascular graft.

    abstract:PURPOSE:To produce biodurable small diameter microporous vascular grafts with self-sealing properties for vascular access, for peripheral vascular and potentially for coronary artery bypass. The prosthesis should retain compliance and pulsatile flow in situ using a unique modus operandi permitting wall compression whic...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829501000207

    authors: Edwards A,Carson RJ,Bowald S,Quist WC

    更新日期:1995-10-01 00:00:00

  • Fabrication and characterization of polysulfone-dicalcium silicate composite films.

    abstract::Polysulfone (PSU) composite films filled with Beta-dicalcium silicate (Beta-Ca(2)SiO(4)) particles are prepared by the solvent casting-evaporation method. The surface morphologies and mechanical properties of the films are determined. The bioactivity of the composite films is evaluated by soaking them in simulated bod...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328206054712

    authors: Cheng W,Chang J

    更新日期:2006-04-01 00:00:00

  • Investigating the use of coupling agents to improve the interfacial properties between a resorbable phosphate glass and polylactic acid matrix.

    abstract::Eight different chemicals were investigated as potential candidate coupling agents for phosphate glass fibre reinforced polylactic acid composites. Evidence of reaction of the coupling agents with phosphate glass and their effect on surface wettability and glass degradation were studied along with their principle role...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212453634

    authors: Hasan MS,Ahmed I,Parsons AJ,Rudd CD,Walker GS,Scotchford CA

    更新日期:2013-09-01 00:00:00

  • Cell survival and proliferation after encapsulation in a chemically modified Pluronic(R) F127 hydrogel.

    abstract::Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328211427774

    authors: Lippens E,Swennen I,Gironès J,Declercq H,Vertenten G,Vlaminck L,Gasthuys F,Schacht E,Cornelissen R

    更新日期:2013-03-01 00:00:00

  • Polymers for use in controlled release systems: the effect of surfactants on their swelling properties.

    abstract::The effect of an ampholytic surfactant on the swelling properties of polymeric materials was studied, using various swelling liquids. Tablets were prepared consisting of hydroxypropyl methylcellulose, poly(oxyethylene) and sodium alginate. Tego betain was the non-ionic surfactant used as an additive in a series of sam...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1106/GX1T-2JC6-QWC6-69GC

    authors: Vlachou M,Hani N,Efentakis M,Tarantili PA,Andreopoulos AG

    更新日期:2000-07-01 00:00:00

  • Anisotropic cytocompatible electrospun scaffold for tendon tissue engineering elicits limited inflammatory response in vitro.

    abstract::Tendon tears are a relevant concern for today's national health systems because of their social impact and high recurrence rate. The current gold standard for fixing tendon tears is surgical repair; however, this strategy is not able to fully re-establish tendon integrity and functionality. Tissue engineering approach...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328218779846

    authors: Fotticchia A,Musson D,Lenardi C,Demirci E,Liu Y

    更新日期:2018-07-01 00:00:00

  • Engineered polymeric amphiphiles self-assembling into nanostructures and acting as efficient gene and drug carriers.

    abstract::Nonviral gene delivery systems are finding widespread use due to their safety, rapid and economical production, and ease of modification. In this work, series of N-alkyl-substituted linear polyethylenimine (CP) polymers have been synthesized, characterized, and investigated about how degree of substitution (hydrophobi...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328217710125

    authors: Bansal R,Kumar P

    更新日期:2017-07-01 00:00:00

  • Brushite-based calcium phosphate cement with multichannel hydroxyapatite granule loading for improved bone regeneration.

    abstract::In this work, we report brushite-based calcium phosphate cement (CPC) system to enhance the in vivo biodegradation and tissue in-growth by incorporation of micro-channeled hydroxyapatite (HAp) granule and silicon and sodium addition in calcium phosphate precursor powder. Sodium- and silicon-rich calcium phosphate powd...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215601938

    authors: Sarkar SK,Lee BY,Padalhin AR,Sarker A,Carpena N,Kim B,Paul K,Choi HJ,Bae SH,Lee BT

    更新日期:2016-01-01 00:00:00

  • Biocompatibility properties of surface-modified poly(dimethylsiloxane) for urinary applications.

    abstract::An electronic sensor system for urinary bladder pressure monitoring requires an imbedding into a biocompatible, flexible, and liquid-impermeable material. Poly(dimethylsiloxane) (PDMS) was selected in the present set-up as packaging material because it fulfills the abovementioned requirements. However, the surface of ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328211422119

    authors: Lippens E,De Smet N,Schauvliege S,Martens A,Gasthuys F,Schacht E,Cornelissen R

    更新日期:2013-02-01 00:00:00

  • Strontium-based glass polyalkenoate cements for luting applications in the skeleton.

    abstract::Glass Polyalkenoate Cements (GPCs) based on strontium calcium zinc silicate (Sr-Ca-Zn-SiO2) glasses and high molecular weight poly(acrylic acid) (PAA) have been shown to exhibit suitable mechanical properties for orthopaedic arthroplasty applications, however for vertebroplasty and other medical luting applications th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328208099085

    authors: Clarkin O,Boyd D,Towler MR

    更新日期:2010-02-01 00:00:00

  • In vitro construction and in vivo regeneration of esophageal bilamellar muscle tissue.

    abstract::In order to induce esophageal muscle cells' orientation, the silicon wafer with prototype 1 and prototype 2 was designed. Prototype 1 has micro-channels of 200 µm width and 30 µm depth with 30 µm wide wall as the interval. Prototype 2 has channels of 100 µm width and 30 µm depth with a discontinuous wall which has 30 ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215627585

    authors: Hou L,Gong C,Zhu Y

    更新日期:2016-04-01 00:00:00

  • Properties of zinc releasing surfaces for clinical applications.

    abstract::Two series of glasses of general formula (2-p) SiO2.1.1Na2O.CaO.pP2O5.xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. Th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328207079731

    authors: Lusvardi G,Malavasi G,Menabue L,Menziani MC,Pedone A,Segre U,Aina V,Perardi A,Morterra C,Boccafoschi F,Gatti S,Bosetti M,Cannas M

    更新日期:2008-05-01 00:00:00

  • Hematological aspects of biocompatibility--review article.

    abstract::The development and improvement of medical devices and artificial organs is critically dependent on the realisation of the importance of the interactions between materials and body tissues. In this regard, the evaluation of biocompatibility assumes paramount importance. This paper reviews the hematological aspects of ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章,评审

    doi:10.1177/088532829701200104

    authors: Banerjee R,Nageswari K,Puniyani RR

    更新日期:1997-07-01 00:00:00

  • Biological interactions: causes for risks and failures of biomaterials and devices.

    abstract::Biomaterials and devices have been used in a variety of applications ranging from disposable extracorporeal devices and soft and hard tissue augmentation, to total artificial internal organs. However, there are risks and failures in each application which are a result of undesirable biological interactions. This artic...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829300800104

    authors: Jayabalan M

    更新日期:1993-07-01 00:00:00

  • Melanin-containing hydrogel intraocular lenses: a histopathological study in animal eyes.

    abstract::Poly(2-hydroxyethyl methacrylate) hydrogel intraocular lenses, containing adrenochrome-melanin, were manufactured and implanted in animal eyes in order to assess the effect of melanin upon (a) biocompatibility of implants with the eye tissues, and (b) fibrous proliferation of lens epithelium responsible for the opacif...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829500900305

    authors: Chirila TV,Constable IJ,Vijayasekaran S,Ben-Hun J

    更新日期:1995-01-01 00:00:00