Abstract:
:Calcium phosphate fillers have been shown to increase cement osteoconductivity, but have caused drawbacks in cement properties. Hydroxyapatite and Brushite were introduced in an acrylic two-solution cement at varying concentrations. Novel composite bone cements were developed and characterized using rheology, injectability, and mechanical tests. It was hypothesized that the ample swelling time allowed by the premixed two-solution cement would enable thorough dispersion of the additives in the solutions, resulting in no detrimental effects after polymerization. The addition of Hydroxyapatite and Brushite both caused an increase in cement viscosity; however, these cements exhibited high shear-thinning, which facilitated injection. In gel point studies, the composite cements showed no detectable change in gel point time compared to an all-acrylic control cement. Hydroxyapatite and Brushite composite cements were observed to have high mechanical strengths even at high loads of calcium phosphate fillers. These cements showed an average compressive strength of 85 MPa and flexural strength of 65 MPa. A calcium phosphate-containing cement exhibiting a combination of high viscosity, pseudoplasticity and high mechanical strength can provide the essential bioactivity factor for osseointegration without sacrificing load-bearing capability.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Aghyarian S,Rodriguez LC,Chari J,Bentley E,Kosmopoulos V,Lieberman IH,Rodrigues DCdoi
10.1177/0885328214544770subject
Has Abstractpub_date
2014-11-01 00:00:00pages
688-98issue
5eissn
0885-3282issn
1530-8022pii
0885328214544770journal_volume
29pub_type
杂志文章abstract::Bone tissue engineering, which relies on the interactions between stem cells and suitable scaffold materials, represents a highly desirable alternative to currently used allograft or autograft strategies for the treatment of bone defects caused by injury or disease, with one of the major challenges being to generate s...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213515734
更新日期:2014-07-01 00:00:00
abstract::Carbon-fibre-reinforced polyether ether ketone (CFR-PEEK) exhibits excellent biomechanical properties as it has an elastic modulus similar to bone. However, CFR-PEEK displays inferior biocompatibility compared with titanium alloy and coating techniques are therefore of interest in order to improve integration. In this...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214521669
更新日期:2014-08-01 00:00:00
abstract::Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood-brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the ben...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218799551
更新日期:2018-10-01 00:00:00
abstract::Biodegradable sponges, as a promising hemostatic biomaterial, has been clinically required over the past decades. Current hemostatic sponges are generally prepared by crosslinking and freeze-drying, but the quality control or biocompatibility is often unsatisfactory due to the freezing-caused morphological non-uniform...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216687663
更新日期:2017-03-01 00:00:00
abstract::Functionalization of a porous orthopedic implant with dexamethasone, a widely used anti-inflammatory drug, encapsulated within a biodegradable polymer for controlled release could help reduce or eliminate the inflammation response by the local tissue. In this research, we investigated the possibility of using supercri...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328209354365
更新日期:2011-01-01 00:00:00
abstract::Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211427774
更新日期:2013-03-01 00:00:00
abstract::To develop biocompatible composite microspheres for novel hemostatic use, we designed and prepared a novel biomaterial, composite microspheres consisting of carboxymethyl chitosan, sodium alginate, and collagen (CSCM). The ultra-structure of CSCM was investigated by scanning electron microscopy assay. In hemostatic fu...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215618354
更新日期:2016-02-01 00:00:00
abstract::The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocol...
journal_title:Journal of biomaterials applications
pub_type: 临床试验,杂志文章
doi:10.1177/0885328207078260
更新日期:2008-01-01 00:00:00
abstract::Hydrogels were prepared from 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate as cross-linking agent. Two different polymerization techniques were followed, namely bulk polymerization initiated by dibenzoyl peroxide and solution polymerization, in water, using a redox initiator system. Differences in the...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829801200402
更新日期:1998-04-01 00:00:00
abstract::Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215597818
更新日期:2015-11-01 00:00:00
abstract::The layer-by-layer technique, which allows simple preparation of polyelectrolyte multilayers, came into the focus of research for development of functionalized medical devices. Numerous literature exist that concentrate on the film build-up and the behaviour of cells on polyelectrolyte multilayers. However, in case of...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212437610
更新日期:2013-07-01 00:00:00
abstract::A multifunctional targeted nanoplatform combining photothermal therapy and chemotherapy has emerged as a promising strategy for comprehensive therapies of breast cancer. In this study, we constructed human epidermal growth factor receptor 2 (Her2)-targeted gold nanoshelled poly(lactic-co-glycolic acid) hybrid nanocaps...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220929616
更新日期:2020-09-01 00:00:00
abstract::Nanodrug delivery systems have been widely researched to achieve efficient antitumor drug delivery. However, the controlled drug delivery at tumor cells remains the main challenge for antitumor therapy. Herein, a pH and reduction-responsive nanocarrier based on green tea polyphenols was employed as a smart excipient f...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220924539
更新日期:2020-08-01 00:00:00
abstract::Silicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217715428
更新日期:2017-08-01 00:00:00
abstract::The effect of an ampholytic surfactant on the swelling properties of polymeric materials was studied, using various swelling liquids. Tablets were prepared consisting of hydroxypropyl methylcellulose, poly(oxyethylene) and sodium alginate. Tego betain was the non-ionic surfactant used as an additive in a series of sam...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1106/GX1T-2JC6-QWC6-69GC
更新日期:2000-07-01 00:00:00
abstract::The purpose of this research was to develop novel nanoparticles (NPs) of star-like copolymer mannitol-functionalized poly(lactide)-vitamin E TPGS (M-PLA-TPGS) for paclitaxel delivery for prostate cancer treatment, and evaluate their therapeutic effects in prostate cancer cell line and animal model in comparison with t...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214527486
更新日期:2014-09-01 00:00:00
abstract::The quality and quantity of bone are crucial to the success of dental implant treatment. Recently, bone grafting materials have reached some limitations. This study aimed to evaluate the biocompatibility of novel drug delivery material, injectable methacrylated hyaluronic acid hydrogel incorporated with different rati...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220971746
更新日期:2020-11-04 00:00:00
abstract::The synthesis, tensile strength, thermostability and hydrophilicity of the poly(urethaneamideimide) and the poly(urethaneureas) with N-aliphatic side chains are presented. These elastomers were compared in blood compatibility with determination of the common indices and with immunologic tests of the beta-thromboglobul...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1106/TBUW-TWW9-EC7X-YA3H
更新日期:2000-10-01 00:00:00
abstract::Cellulose acetate phthalate and Pluronic F-127 combined together (70:30 wt:wt) create a rigid, surface-eroding association polymer. To impart flexibility into the polymer system and allow for a drug delivery film that can contour to varying wound shapes, plasticizers were added. Triethyl citrate or tributyl citrate wa...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213480979
更新日期:2014-01-01 00:00:00
abstract::Antenna coupling microwave plasma enables a highly oxidative treatment of the outmost surface of polypropylene (PP) nonwoven fabric within a short time period. Subsequently, grafting copolymerization with acrylic acid (AAc) makes the plasma-treated fabric durably hydrophilic and excellent in water absorbency. With hig...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1106/088532802030478
更新日期:2002-10-01 00:00:00
abstract::Phase-sensitive in situ gel-forming controlled release formulations of insulin were prepared using poly(lactide-co-glycolide) and a solvent system consisting of various proportions of benzyl benzoate and benzyl alcohol. The in vitro release samples of formulations were assayed for insulin content by enzyme linked immu...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328209359959
更新日期:2011-03-01 00:00:00
abstract::The aim of this study was to examine the release of silica (Si), calcium (Ca), phosphorous (P), and fluoride (F) from conventional glass ionomer cement (GI) and resin-modified glass ionomer cement (LCGI), containing different quantities of bioactive glass (BAG). Further aim was to evaluate in vitro biomineralization o...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0085328204044538
更新日期:2004-07-01 00:00:00
abstract::The development and improvement of medical devices and artificial organs is critically dependent on the realisation of the importance of the interactions between materials and body tissues. In this regard, the evaluation of biocompatibility assumes paramount importance. This paper reviews the hematological aspects of ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/088532829701200104
更新日期:1997-07-01 00:00:00
abstract::The different barriers that slow the penetration of active ingredients administered by the ocular route are described, and some novel dosage forms designed for this route are discussed. Both precorneal and corneal factors considerably restrict ocular penetration. The low bioavailability of classical ophthalmic dosage ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829701100305
更新日期:1997-01-01 00:00:00
abstract::This investigation describes the synthesis and in vitro evaluation of cationic hydrogel sub-microparticles based on polydimethylaminoethylmethacrylate for oral insulin delivery. Polymerization of dimethylaminoethylmethacrylate was carried out in aqueous medium with potassium persulfate as the initiator. Quaternization...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212437392
更新日期:2013-07-01 00:00:00
abstract::The present article deals with the development of 3D porous scaffolds for bone grafting. They were prepared based on rapid fluid infiltration of Al2O3-SiO2 sol into a polyethylene non-woven fabric template structure. Titanium dioxide in concentration equal to 5 wt% was added to the Al2O3-SiO2 mixture to produce Al2O3-...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213483634
更新日期:2014-02-01 00:00:00
abstract::Composite hydrogel systems consisting of oxidized alginate, gelatin, and biphasic calcium phosphate were fabricated by the Schiff-base reaction and the effect of oxidation of alginate on the microstructure, material properties, and biocompatibility were evaluated. Alginate was modified by oxidizing the attached -OH gr...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211404265
更新日期:2012-09-01 00:00:00
abstract::Calcium polyphosphate is a biodegradable bone substitute. It remains a challenge to prepare porous calcium polyphosphate with desired gradient porous structures. In this study, a modified one-step gravity sintering method was used to prepare calcium polyphosphate scaffolds with desired-gradient-pore-size distribution....
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215608335
更新日期:2016-02-01 00:00:00
abstract::Nanohydroxyapatite (nanoHA), due to its chemical properties, has appeared as an exceptionally promising bioceramic to be used as bone regeneration material. Staphylococcus epidermidis have emerged as major nosocomial pathogens associated with infections of implanted medical devices. In this work, the purpose was to st...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213507300
更新日期:2014-05-01 00:00:00
abstract::In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220952594
更新日期:2020-08-27 00:00:00