Abstract：
:The incidence of fractures increases with age. This is partly due to extraosseous factors and partly to the increased fragility of the bone material itself. Ageing adversely affects the "quality" of human bone material, its elastic and ultimate properties. The hypothesis here is that these effects are caused by factors such as architectural changes, compositional changes, physicochemical changes, changes at the micromechanical level, and the degree of prior in vivo microdamage. Examination of the extent of the secondary osteonal area, the porosity level, the calcium content, the mineral/wet weight fraction, the dry density, the condition of the collagen and its content in mature x-links, the elasticity of osteonal and interstitial lamellae at the microscopic level and the numerical- and surface-density of the in vivo fatigue microcracks has been undertaken. The findings show that some factors simply affect the stiffness and the strength of bone, while others soley affect its toughness. We discuss the implications of these findings in the context of the composite nature of the ageing bone material matrix.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Zioupos Pdoi
10.1106/5JUJ-TFJ3-JVVA-3RJ0subject
Has Abstractpub_date
2001-01-01 00:00:00pages
187-229issue
3eissn
0885-3282issn
1530-8022journal_volume
15pub_type
杂志文章abstract：:Aluminum-free glass ionomer cements (GICs) are under development for orthopedic applications, but are limited by their insufficient handling properties. Here, the addition of calcium polyphosphate (CPP) was investigated as an additive to an experimental zinc-silicate glass ionomer cement. A 50% maximum increase in wor...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215568985
更新日期：2015-07-01 00:00:00
abstract：:Functionalization of a porous orthopedic implant with dexamethasone, a widely used anti-inflammatory drug, encapsulated within a biodegradable polymer for controlled release could help reduce or eliminate the inflammation response by the local tissue. In this research, we investigated the possibility of using supercri...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328209354365
更新日期：2011-01-01 00:00:00
abstract：:The synthesis, tensile strength, thermostability and hydrophilicity of the poly(urethaneamideimide) and the poly(urethaneureas) with N-aliphatic side chains are presented. These elastomers were compared in blood compatibility with determination of the common indices and with immunologic tests of the beta-thromboglobul...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/TBUW-TWW9-EC7X-YA3H
更新日期：2000-10-01 00:00:00
abstract：:The in vitro effect of platelet-rich plasma (PRP) on cell loading, proliferation, and osteogenic differentiation of human mesenchymal stem cells (MSC) is assessed on distinct resorbable and synthetic calcium phosphate scaffolds. A high specific surface area scaffold composed of calcium-deficient hydroxyapatite (CDHA; ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328207088269
更新日期：2008-09-01 00:00:00
abstract：:The aim of this study was to investigate if newly developed polyurethane (PU) scaffolds are suitable as scaffold for cell-seeded meniscus tissue engineered constructs. Scaffolds were seeded with goat meniscal fibrochondrocytes and cultured to assess changes in biological and mechanical properties. Furthermore, the eff...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211417317
更新日期：2013-01-01 00:00:00
abstract：:Biomaterials and devices have been used in a variety of applications ranging from disposable extracorporeal devices and soft and hard tissue augmentation, to total artificial internal organs. However, there are risks and failures in each application which are a result of undesirable biological interactions. This artic...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829300800104
更新日期：1993-07-01 00:00:00
abstract：:Poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) copolymers have been widely used for various biomedical applications. However, their hemocompatibility has not been clarified, which would lag their developments and clinical applications. In this work, we studied the effect of PEG-PLA copolymers on key human blood com...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215627404
更新日期：2016-05-01 00:00:00
abstract：:The surface quality of coronary stents has a significant influence on its biocompatibility. Therefore, surface polishing is of paramount importance in the production and application of stents. In the present study, electropolishing is performed on 316LVM steel slotted tube coronary stents. Additionally, acid pickling,...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328205046564
更新日期：2005-01-01 00:00:00
abstract：:Even though Ti-based implants are the most used materials for hard tissue replacement, they may present lack of osseointegration on the long term, due to their inertness. Hydrothermal treatment (HT) is a useful technique for the synthesis of firmly attached, highly crystalline coatings made of anatase titanium dioxide...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215569091
更新日期：2015-07-01 00:00:00
abstract：:In this work, the role of shock wave-induced increase of bone morphogenetic proteins in modulating the osteogenic properties of osteoblast-like cells seeded on a bioactive scaffold was investigated using gremlin as a bone morphogenetic protein antagonist. Bone-like glass-ceramic scaffolds, based on a silicate experime...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214541974
更新日期：2014-11-01 00:00:00
abstract：:Polysulfone (PSU) composite films filled with Beta-dicalcium silicate (Beta-Ca(2)SiO(4)) particles are prepared by the solvent casting-evaporation method. The surface morphologies and mechanical properties of the films are determined. The bioactivity of the composite films is evaluated by soaking them in simulated bod...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328206054712
更新日期：2006-04-01 00:00:00
abstract：:Using a hydraulic stress simulator, the mechanical behavior of the porcine pericardium used in the construction of cardiac valve leaflets was characterized following the same procedure employed with calf pericardium in Part 1 of this study. One hundred fifty pairs of tissue samples were subjected to tensile testing to...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/3JXM-UTPN-PXTG-72DT
更新日期：2001-07-01 00:00:00
abstract：:The development of an effective wound dressing with the ability to induce skin wound healing is a great challenge in medicine. Nanofibers are highly attractive for wound dressing preparation due to their properties such as hemostasis induction, good absorption of wound exudates, and facilitation of cell growth. Chitos...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217739562
更新日期：2018-01-01 00:00:00
abstract：:In order to find hemodynamic parameters that can accurately predict whether patients can be successfully weaned from ventricular assist devices (VADs), we studied data from 17 patients supported with Pierce-Donachy VADs [11 left VAD (LVAD); 6 right VAD (RVAD)] following cardiogenic shock for periods from 1.3 to 22 day...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829000400403
更新日期：1990-04-01 00:00:00
abstract：:Calcium polyphosphate is a biodegradable bone substitute. It remains a challenge to prepare porous calcium polyphosphate with desired gradient porous structures. In this study, a modified one-step gravity sintering method was used to prepare calcium polyphosphate scaffolds with desired-gradient-pore-size distribution....
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215608335
更新日期：2016-02-01 00:00:00
abstract：:At present all the commercially available "medical grade" urethane elastomers exhibit a phenomenon known as environmental stress cracking (ESC). This phenomenon is characterized by surface microcracking when the elastomer is elongated while in vivo. The degree of strain that is required to initiate microcracking varie...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829100600202
更新日期：1991-10-01 00:00:00
abstract：:Two series of glasses of general formula (2-p) SiO2.1.1Na2O.CaO.pP2O5.xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. Th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328207079731
更新日期：2008-05-01 00:00:00
abstract：:Poor blood circulation makes it difficult for antitubercular drugs to achieve effective bactericidal concentration at tuberculose focus. The residual Mycobacterium tuberculosis around surgical wound would multiply, resulting in nonunion or sinus formation. Carbon nanotubes have strong tissue penetration and can cross ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218814988
更新日期：2019-02-01 00:00:00
abstract：:Cellulose acetate phthalate and Pluronic F-127 combined together (70:30 wt:wt) create a rigid, surface-eroding association polymer. To impart flexibility into the polymer system and allow for a drug delivery film that can contour to varying wound shapes, plasticizers were added. Triethyl citrate or tributyl citrate wa...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213480979
更新日期：2014-01-01 00:00:00
abstract：:The aim of this study was to design a new natural/synthetic bioactive bone scaffold for potential use in bone replacement applications. We developed a tri-component osteogenic composite scaffold made of collagen (Coll), hydroxyapatite (HA) and poly(l-lactide-co-ε-caprolactone) (PLCL). This Coll/HA/PLCL composite scaff...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213486705
更新日期：2014-02-01 00:00:00
abstract：:In this study, a phosphorylation treatment of porous anodic alumina (PAA) was performed by wet impregnation in phosphoric acid and a subsequent heat treatment. The PAA and phosphorylated PAA specimens were analyzed using a field emission scanning electron microscope, an energy-dispersive X-ray spectrometer, and Fourie...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214526765
更新日期：2014-09-01 00:00:00
abstract：:A biosensor for the analysis of D-amino acids is described. Carbon paste (graphite/paraffin oil) was chemically modified with immobilized D-amino acid oxidase and either horse-radish peroxidase or fungal peroxidase from Arthromyces ramosus. The two enzymes dissolved in buffer, together with an amine containing oligome...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829300800204
更新日期：1993-10-01 00:00:00
abstract：:This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)-pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS-pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microen...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328206056771
更新日期：2007-01-01 00:00:00
abstract：:A series of cellulose/soy protein isolate (SPI) sponges was prepared using a freeze-drying process. The effect of the SPI content on the structure of the sponges was characterized by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). It showed that...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208099337
更新日期：2010-02-01 00:00:00
abstract：:Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing proce...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章,评审
doi：10.1177/0885328219834656
更新日期：2019-05-01 00:00:00
abstract：:While BMP-7 (OP-1) is one of the most potent growth factors in cartilage tissue engineering, the effects of exogenous low concentration BMP-7 on osteoarthritic chondrocytes are still unknown. Human osteoarthritic chondrocytes obtained from the femoral condyles of 10 patients were grown either in monolayer or in 3D col...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328210388439
更新日期：2012-03-01 00:00:00
abstract：:The purpose of this study was to develop a specific targeting magnetic nanoparticle probe for magnetic resonance imaging and therapy in the form of local hyperthermia. Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-asparti...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213493486
更新日期：2014-03-01 00:00:00
abstract：:Hydroxyapatite (Ca10(PO4)6(OH)2) is widely investigated as an implantable material for hard tissue restoration due to its osteoconductive properties. However, hydroxyapatite in bulk form is limited as its mechanical properties are insufficient for load-bearing orthopedic applications. Attempts have been made to improv...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215592866
更新日期：2015-11-01 00:00:00
abstract：:Melt electrowriting (MEW) can print high-resolution scaffolds with the ultrafine fibers from 800 nm to 20 µm. However, the cell seeding efficiency relatively low due to the large pore size of the MEW scaffold. Here, we reported a method to solve this dilemma by electrospinning a gelatin methacrylate (GelMA) hydrogel f...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220962606
更新日期：2021-01-01 00:00:00
abstract：:Appropriate design of dialysis membranes requires correct values of structural parameters such as pore radius, surface porosity, water content and tortuosity. It is impossible, however, to find the pore radius of dialysis membranes using a mercury porosimeter or an electron microscope because the pores are only severa...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532828900400201
更新日期：1989-10-01 00:00:00
