Abstract：
:In order to induce esophageal muscle cells' orientation, the silicon wafer with prototype 1 and prototype 2 was designed. Prototype 1 has micro-channels of 200 µm width and 30 µm depth with 30 µm wide wall as the interval. Prototype 2 has channels of 100 µm width and 30 µm depth with a discontinuous wall which has 30 µm gap for each 100 µm channel. The poly(ester urethane) scaffolds with pattern prototype 1 and prototype 2 were fabricated using solution casting method and abbreviated as PU1 and PU2, respectively. Silk fibroin was grafted individually on PU1 and PU2 surface (PU1-SF, PU2-SF) using our previous protocol, aiming at improving scaffolds' biocompatibility. The primary esophageal smooth muscle cell was seeded to evaluate the scaffolds' cytocompatibility in vitro. Characterizations like MTT assay, immunocytochemistry, scanning electron microscope, and Western blotting were applied. After that, poly(ester urethane) scaffolds with double patterns, prototype 1 on the exterior, and prototype 2 in the lumen were implanted into the rabbit esophagous to test the regeneration of the muscle tissue. Results from these preliminary tests showed that the growth and differentiation of primary smooth muscle cells were promoted, but also the muscle tissue with endocircular and exolongitudinal architecture was in regenerating, against non-constitution in the animals without the patterned scaffold or with poly(ester urethane) plane membrane at the defaulted sites. This micro-channel pattern together with silk fibroin grafting and vascular endothelial growth factor coating greatly promoted the regeneration of esophageal muscle with normal histological structure.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Hou L,Gong C,Zhu Ydoi
10.1177/0885328215627585subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1373-84issue
9eissn
0885-3282issn
1530-8022pii
0885328215627585journal_volume
30pub_type
杂志文章abstract：:In this study, the effects of sodium carbonate (Na(2)CO(3) ) solution with different concentrations (10, 15, 20, and 25 wt%) as liquid phase on the setting time and compressive strength of tricalcium silicate bone cements are investigated. The in vitro bioactivity and degradability of the resultant Ca(3)SiO(5)-Na(2)CO...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208088714
更新日期：2008-11-01 00:00:00
abstract：:This investigation describes the synthesis and in vitro evaluation of cationic hydrogel sub-microparticles based on polydimethylaminoethylmethacrylate for oral insulin delivery. Polymerization of dimethylaminoethylmethacrylate was carried out in aqueous medium with potassium persulfate as the initiator. Quaternization...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212437392
更新日期：2013-07-01 00:00:00
abstract：:The purpose of this study was to develop a specific targeting magnetic nanoparticle probe for magnetic resonance imaging and therapy in the form of local hyperthermia. Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-asparti...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213493486
更新日期：2014-03-01 00:00:00
abstract：:The layer-by-layer technique, which allows simple preparation of polyelectrolyte multilayers, came into the focus of research for development of functionalized medical devices. Numerous literature exist that concentrate on the film build-up and the behaviour of cells on polyelectrolyte multilayers. However, in case of...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212437610
更新日期：2013-07-01 00:00:00
abstract：:The purpose of this investigation is to study the effect of long-term subcutaneous aluminum polymeric implants on aluminum release and accumulation in various tissues in rats. The implants were formulated using silicone rubber and polyurethane polymers and three different aluminum salts. The polymeric matrices were ev...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829601100103
更新日期：1996-07-01 00:00:00
abstract：:Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years. However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexi...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220972219
更新日期：2020-11-11 00:00:00
abstract：:Titanium and hydroxyapatite (HA) are widely used as biomaterials for dental and medical applications. HA-coated titanium implants have excellent biocompatibility and mechanical properties. However, the adherence of HA film formed on titanium substrate is weak because of the lack of chemical interaction between HA and ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328209340334
更新日期：2010-03-01 00:00:00
abstract：:Medical sheets are useful in surgically repair vascular disease. To avoid long-term side effects, they are to be replaced with regenerated tissue after implantation. Silk fibroin is a fibrous protein secreted by silkworm. The advantage of silk fibroin is its biocompatibility and has been used as regenerative artificia...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220928660
更新日期：2020-06-02 00:00:00
abstract：:At present all the commercially available "medical grade" urethane elastomers exhibit a phenomenon known as environmental stress cracking (ESC). This phenomenon is characterized by surface microcracking when the elastomer is elongated while in vivo. The degree of strain that is required to initiate microcracking varie...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829100600202
更新日期：1991-10-01 00:00:00
abstract：:Dicalcium phosphate dihydrate particles functionalized with triethyleneglycol dimethacrylate were synthesized and added to a photocurable mixture of bisphenol-A glycidyl dimethacrylate and triethyleneglycol dimethacrylate with the purpose of developing a resin composite capable of releasing calcium and phosphate ions ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328216680116
更新日期：2017-01-01 00:00:00
abstract：:Reconstruction of critical sized bone injuries is a major problem that continues to inspire the design of new materials and grafts. Natural ceramics (hydroxyapatite (HA) coralline HA, or synthetic HA) and β-tricalcium phosphate (β-TCP) are being explored for use as scaffolds in bone tissue engineering, among several o...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211415132
更新日期：2013-01-01 00:00:00
abstract：:Silicate-based cements have been developed as a class of bioactive and biodegradable bone cements owing to their good in vitro bioactivity and ability to dissolve in a simulated body fluid. Until recently, however, the in vivo evidence of their ability to support bone regeneration is still scarce. In the present study...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217715428
更新日期：2017-08-01 00:00:00
abstract：:Aluminum-free glass ionomer cements (GICs) are under development for orthopedic applications, but are limited by their insufficient handling properties. Here, the addition of calcium polyphosphate (CPP) was investigated as an additive to an experimental zinc-silicate glass ionomer cement. A 50% maximum increase in wor...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215568985
更新日期：2015-07-01 00:00:00
abstract：:Excessive demineralization in osteoporotic bones impairs its self-regeneration potential following a defect/fracture and is of great concern among the aged population. In this context, implants with inherent osteogenic ability loaded with therapeutic ions like Strontium (Sr2+) may bring forth promising outcomes. Micro...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328216647197
更新日期：2016-10-01 00:00:00
abstract：:Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215597818
更新日期：2015-11-01 00:00:00
abstract：:Central venous access devices play an important role in patients with prolonged intravenous administration requirements. In the last years, the coating of these devices with bactericidal compounds has emerged as a potential tool to prevent bacterial colonization. Our study describes the modification of 3D-printed rese...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217739199
更新日期：2018-01-01 00:00:00
abstract：:An electronic sensor system for urinary bladder pressure monitoring requires an imbedding into a biocompatible, flexible, and liquid-impermeable material. Poly(dimethylsiloxane) (PDMS) was selected in the present set-up as packaging material because it fulfills the abovementioned requirements. However, the surface of ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211422119
更新日期：2013-02-01 00:00:00
abstract：:The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocol...
journal_title：Journal of biomaterials applications
pub_type： 临床试验,杂志文章
doi：10.1177/0885328207078260
更新日期：2008-01-01 00:00:00
abstract：:The quality and quantity of bone are crucial to the success of dental implant treatment. Recently, bone grafting materials have reached some limitations. This study aimed to evaluate the biocompatibility of novel drug delivery material, injectable methacrylated hyaluronic acid hydrogel incorporated with different rati...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220971746
更新日期：2020-11-04 00:00:00
abstract：:Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211427774
更新日期：2013-03-01 00:00:00
abstract：:We assess the effects of chemical processing, ethylene oxide sterilization, and threading on bone surface and mechanical properties of bovine undecalcified bone screws. In addition, we evaluate the possibility of manufacturing bone screws with predefined dimensions. Scanning electronic microscopic images show that che...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208092110
更新日期：2009-03-01 00:00:00
abstract：:Fracture resistance of provisional restorations is an important clinical concern. This property is directly related to transverse strength. Strengthening of provisional fixed partial dentures may result from reinforcement with various fiber types. This study evaluated the effect of fiber type and water storage on the ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328203017004003
更新日期：2003-04-01 00:00:00
abstract：:Hydroxyapatite (Ca10(PO4)6(OH)2) is widely investigated as an implantable material for hard tissue restoration due to its osteoconductive properties. However, hydroxyapatite in bulk form is limited as its mechanical properties are insufficient for load-bearing orthopedic applications. Attempts have been made to improv...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215592866
更新日期：2015-11-01 00:00:00
abstract：:The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/su...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829200700105
更新日期：1992-07-01 00:00:00
abstract：:Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218759043
更新日期：2018-05-01 00:00:00
abstract：:An experimental and computational investigation of the self-tapping ability of carbon fibre reinforced polyetheretherketone (CFR-PEEK) has been conducted. Six CFR-PEEK suture anchor designs were investigated using PEEK-OPTIMA® Reinforced, a medical grade of CFR-PEEK. Experimental tests were conducted to investigate th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214535274
更新日期：2014-10-01 00:00:00
abstract：:The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds we...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
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更新日期：2014-01-01 00:00:00
abstract：:Hydrogels were prepared from 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate as cross-linking agent. Two different polymerization techniques were followed, namely bulk polymerization initiated by dibenzoyl peroxide and solution polymerization, in water, using a redox initiator system. Differences in the...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
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更新日期：1998-04-01 00:00:00
abstract：:Novel in situ polymerizable liquid three-arm biodegradable oligomeric polyesters based upon glycolic acid (GA), L-lactic acid (LLA), and their copolymers are synthesized and characterized. Injectable and in situ curable polymer neat resins and their composites formulated with bioabsorbable beta-tricalcium phosphate ar...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328206068691
更新日期：2007-07-01 00:00:00
abstract：:Calcium polyphosphate is a biodegradable bone substitute. It remains a challenge to prepare porous calcium polyphosphate with desired gradient porous structures. In this study, a modified one-step gravity sintering method was used to prepare calcium polyphosphate scaffolds with desired-gradient-pore-size distribution....
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215608335
更新日期：2016-02-01 00:00:00
