Blood compatible phospholipid-containing polyurethanes: synthesis characterization and blood compatibility evaluation.

Abstract:

:A new diol, bis[2-(2-hydroxyethyldimethylammonio)ethyl] butylenediphosphate, that contains two phosphatidylcholine analogous moieties in one diol molecule, was synthesized and characterized. The diol together with 1,4-butanediol as chain extender was further incorporated into the propolymer of poly(ethylene oxide) (Mn = 1000, 2000, 6000) and 4,4'-methylenediphenyl diisocyanate. The resulting phospholipid poly(ether urethane)s show viscosity behavior of common polyelectrolytes. The bulk and surface characteristics of the new phospholipid poly(ether urethane)s were investigated by IR, GPC, ATR-FTIR, ESCA and contact angle measurements. The new polymers possessed relatively hydrophilic surface revealed by contact angle measurements. The blood compatibilities of the polyurethanes were evaluated by platelet rich plasma contacting studies and scanning electron microscopy observation using medical grade PVC as the reference. No platelet adhesion was observed for all new phospholipid polyurethane casting films. This new type of phospholipid polyurethane is expected to have potential biomedical applications.

journal_name

J Biomater Appl

authors

Li YJ,Nakaya T,Zhang Z,Kodama M

doi

10.1177/088532829701200205

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

167-91

issue

2

eissn

0885-3282

issn

1530-8022

journal_volume

12

pub_type

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