Abstract:
:A new diol, bis[2-(2-hydroxyethyldimethylammonio)ethyl] butylenediphosphate, that contains two phosphatidylcholine analogous moieties in one diol molecule, was synthesized and characterized. The diol together with 1,4-butanediol as chain extender was further incorporated into the propolymer of poly(ethylene oxide) (Mn = 1000, 2000, 6000) and 4,4'-methylenediphenyl diisocyanate. The resulting phospholipid poly(ether urethane)s show viscosity behavior of common polyelectrolytes. The bulk and surface characteristics of the new phospholipid poly(ether urethane)s were investigated by IR, GPC, ATR-FTIR, ESCA and contact angle measurements. The new polymers possessed relatively hydrophilic surface revealed by contact angle measurements. The blood compatibilities of the polyurethanes were evaluated by platelet rich plasma contacting studies and scanning electron microscopy observation using medical grade PVC as the reference. No platelet adhesion was observed for all new phospholipid polyurethane casting films. This new type of phospholipid polyurethane is expected to have potential biomedical applications.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Li YJ,Nakaya T,Zhang Z,Kodama Mdoi
10.1177/088532829701200205subject
Has Abstractpub_date
1997-10-01 00:00:00pages
167-91issue
2eissn
0885-3282issn
1530-8022journal_volume
12pub_type
杂志文章abstract::A biosensor for the analysis of D-amino acids is described. Carbon paste (graphite/paraffin oil) was chemically modified with immobilized D-amino acid oxidase and either horse-radish peroxidase or fungal peroxidase from Arthromyces ramosus. The two enzymes dissolved in buffer, together with an amine containing oligome...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829300800204
更新日期:1993-10-01 00:00:00
abstract::In this work, the role of shock wave-induced increase of bone morphogenetic proteins in modulating the osteogenic properties of osteoblast-like cells seeded on a bioactive scaffold was investigated using gremlin as a bone morphogenetic protein antagonist. Bone-like glass-ceramic scaffolds, based on a silicate experime...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214541974
更新日期:2014-11-01 00:00:00
abstract::Sodium alginate is an effective biomaterial for tissue engineering applications. Non-purified alginate is contaminated with protein, lipopolysaccharide, DNA, and RNA, which could elicit adverse immunological reactions. We developed a purification protocol to generate biocompatible alginate based on (a) activated charc...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216645952
更新日期:2016-10-01 00:00:00
abstract::Devices such as contact lenses and collagen shields have been used to improve the antibiotic bioavailability of eye drops formulations in the treatment of ulcerative keratitis. Nevertheless, these devices are not sustained drug delivery systems, and a combination with eye drops is necessary. In animal patients, it req...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220931733
更新日期:2020-09-01 00:00:00
abstract::The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix. In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl ch...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220930714
更新日期:2020-10-01 00:00:00
abstract::Bone tissue engineering, which relies on the interactions between stem cells and suitable scaffold materials, represents a highly desirable alternative to currently used allograft or autograft strategies for the treatment of bone defects caused by injury or disease, with one of the major challenges being to generate s...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213515734
更新日期:2014-07-01 00:00:00
abstract::Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lact...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328210376997
更新日期:2012-01-01 00:00:00
abstract::Polymer biocomposites based on segmented poly(ester urethane) and extracellular matrix components have been prepared for the development of tissue engineering applications with improved biological characteristics of the materials in contact with blood and tissues for long periods. Thermal, dynamical, and dielectrical ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328210394468
更新日期:2012-08-01 00:00:00
abstract::Osteo-odonto-keratoprostheses, incorporating dental laminate material as an anchoring skirt around a central poly(methyl methacrylate) (PMMA) optic, have been used to replace the cornea for many years. However, there are many intricacies associated with the use of autologous dental laminate material, surgical complexi...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220972219
更新日期:2020-11-11 00:00:00
abstract::The aim of this study was to investigate if newly developed polyurethane (PU) scaffolds are suitable as scaffold for cell-seeded meniscus tissue engineered constructs. Scaffolds were seeded with goat meniscal fibrochondrocytes and cultured to assess changes in biological and mechanical properties. Furthermore, the eff...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211417317
更新日期:2013-01-01 00:00:00
abstract::Hydrogels were prepared from 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate as cross-linking agent. Two different polymerization techniques were followed, namely bulk polymerization initiated by dibenzoyl peroxide and solution polymerization, in water, using a redox initiator system. Differences in the...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829801200402
更新日期:1998-04-01 00:00:00
abstract::Fracture resistance of provisional restorations is an important clinical concern. This property is directly related to transverse strength. Strengthening of provisional fixed partial dentures may result from reinforcement with various fiber types. This study evaluated the effect of fiber type and water storage on the ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328203017004003
更新日期:2003-04-01 00:00:00
abstract::Polyelectrolyte capsules are seen as promising nanotechnology based drug delivery systems. In previous works, we have demonstrated the possibility to fabricate bio-activated surface layer containing capsules with improved features in terms of biocompatibility. In this study, we have characterized the permeability prop...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212446358
更新日期:2013-08-01 00:00:00
abstract::Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215597818
更新日期:2015-11-01 00:00:00
abstract::The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defec...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218765847
更新日期:2018-07-01 00:00:00
abstract::Carbon-fibre-reinforced polyether ether ketone (CFR-PEEK) exhibits excellent biomechanical properties as it has an elastic modulus similar to bone. However, CFR-PEEK displays inferior biocompatibility compared with titanium alloy and coating techniques are therefore of interest in order to improve integration. In this...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214521669
更新日期:2014-08-01 00:00:00
abstract::Calcium phosphate fillers have been shown to increase cement osteoconductivity, but have caused drawbacks in cement properties. Hydroxyapatite and Brushite were introduced in an acrylic two-solution cement at varying concentrations. Novel composite bone cements were developed and characterized using rheology, injectab...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214544770
更新日期:2014-11-01 00:00:00
abstract::In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220952594
更新日期:2020-08-27 00:00:00
abstract::Plastics are fulfilling a number of critical roles in a variety of medical applications. While some of these are low-technology, throw-away products, many of the applications impose critical requirements as to mechanical performance, chemical resistance, biocompatibility, ability to be sterilized and to remain sterile...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532828700200305
更新日期:1988-01-01 00:00:00
abstract::Transarterial embolization is an established minimally invasive treatment for solid tumors. Unintended inflammation, foreign body reactions and ischemia-triggered neoangiogenesis are clinical drawbacks of permanent embolic materials. The aim of the current study was to characterize a new type of biodegradable starch m...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328217746674
更新日期:2018-02-01 00:00:00
abstract::The different barriers that slow the penetration of active ingredients administered by the ocular route are described, and some novel dosage forms designed for this route are discussed. Both precorneal and corneal factors considerably restrict ocular penetration. The low bioavailability of classical ophthalmic dosage ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829701100305
更新日期:1997-01-01 00:00:00
abstract::Appropriate design of dialysis membranes requires correct values of structural parameters such as pore radius, surface porosity, water content and tortuosity. It is impossible, however, to find the pore radius of dialysis membranes using a mercury porosimeter or an electron microscope because the pores are only severa...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532828900400201
更新日期:1989-10-01 00:00:00
abstract::Poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) copolymers have been widely used for various biomedical applications. However, their hemocompatibility has not been clarified, which would lag their developments and clinical applications. In this work, we studied the effect of PEG-PLA copolymers on key human blood com...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215627404
更新日期:2016-05-01 00:00:00
abstract:PURPOSE:A functionalized graphene oxide-based thermosensitive hydrogel loaded with docetaxel for intratumoral delivery was designed to enhance therapeutic efficacy and alleviate system toxicity. METHODS:First, graphene oxide was functionalized with chitosan to acquire high stability in physiological solutions. And the...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215619583
更新日期:2016-03-01 00:00:00
abstract::The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Quest...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328212473510
更新日期:2014-01-01 00:00:00
abstract::Sternotomy and sternal closure occur prior to and post cardiac surgery, respectively. Although post-operative complications associated with poor sternal fixation can result in morbidity, mortality, and considerable resource utilization, sternotomy is preferred over other methods such as lateral thoracotomy. Rigid ster...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/0885328213495426
更新日期:2013-11-01 00:00:00
abstract::Fabrication of osteoconductive scaffold with osteoinductive capability and appropriate resorption rate is of great significance for treating bone defects. To achieve this aim, strontium-substituted calcium sulfate hemihydrate (Sr-CSH) and hydroxyapatite (HA) were mixed to develop a novel composite. Sr-CSH containing 5...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220915816
更新日期:2020-07-01 00:00:00
abstract::NiTi alloy is used as a biomaterial due to its pseudoelastic behaviour. It exhibits a great potential in dental and orthopedic applications where constant correcting loads are required. In order to use such materials, it is necessary to investigate the effect of the cyclic straining upon the transformation stresses an...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829801200304
更新日期:1998-01-01 00:00:00
abstract::Gold nanomaterials possess unique physical and chemical properties, which attracted much attention in recent years. As a new type of gold nanomaterials, gold nanostars (GNSTs) have been prepared and characterized in this study. GNSTs under near-infrared (NIR) light irradiation can exert not only cancer photothermal th...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215594481
更新日期:2015-11-01 00:00:00
abstract::The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/su...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829200700105
更新日期:1992-07-01 00:00:00