Abstract：
:The objective of the present study was to incorporate strontium into calcium phosphate cement combined with a lower single-dose local administration of bone morphogenetic protein-2 to enhance its in vivo biodegradation and bone tissue growth. After the creation of a rodent critical-sized femoral metaphyseal bone defect, strontium-modified calcium phosphate cement was prepared by mixing sieved granules of calcium phosphate cement and 5% SrCO3 for medical use, and then strontium-modified calcium phosphate cement with dripped bone morphogenetic protein-2 solution (5 µg) was implanted into the defect of OVX rats until death at eight weeks. The defected area in distal femurs of rats was harvested for evaluation by histology, micro-CT, and biomechanics. The results of our study show that a lower single-dose local administration of bone morphogenetic protein-2 combined local usage of strontium-modified calcium phosphate cement can increase the healing of defects in OVX rats. Furthermore, treatments with single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement showed a stronger effect on accelerating the local bone formation than calcium phosphate cement and strontium-modified calcium phosphate cement used alone. The results from our study demonstrate that combination of a lower single-dose local administration of bone morphogenetic protein-2 and strontium-modified calcium phosphate cement had an additive effect on local bone formation in osteoporosis rats.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Tao Z,Zhou W,Jiang Y,Wu X,Xu Z,Yang M,Xie Jdoi
10.1177/0885328218765847subject
Has Abstractpub_date
2018-07-01 00:00:00pages
3-10issue
1eissn
0885-3282issn
1530-8022journal_volume
33pub_type
杂志文章abstract：:The quality and quantity of bone are crucial to the success of dental implant treatment. Recently, bone grafting materials have reached some limitations. This study aimed to evaluate the biocompatibility of novel drug delivery material, injectable methacrylated hyaluronic acid hydrogel incorporated with different rati...
journal_title：Journal of biomaterials applications
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abstract：:Polylactic acid (PLA)-derived polymers are widely used in many biotechnological fields, thanks to their biocompatibility and resorbability through natural pathways. Moreover, PLA is one of the few polymers in which both the properties and the stereochemical structure can be easily modified, making possible a specific ...
journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/088532802030478
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abstract：:Composite hydrogel systems consisting of oxidized alginate, gelatin, and biphasic calcium phosphate were fabricated by the Schiff-base reaction and the effect of oxidation of alginate on the microstructure, material properties, and biocompatibility were evaluated. Alginate was modified by oxidizing the attached -OH gr...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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journal_title：Journal of biomaterials applications
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