Abstract:
:The purpose of this investigation is to study the effect of long-term subcutaneous aluminum polymeric implants on aluminum release and accumulation in various tissues in rats. The implants were formulated using silicone rubber and polyurethane polymers and three different aluminum salts. The polymeric matrices were evaluated for in vitro release studies. These matrices released aluminum in vitro up to the period of four months. The aluminum matrices were implanted in rats and animals were sacrificed at various time intervals. Various tissues such as brain, kidney, liver, intestine, and heart were isolated. Aluminum in dried tissues was analyzed by Neutron Activation Analysis. Results from this investigation suggest that polymeric aluminum implants raise the aluminum concentration in the brain and liver. However, these implants did not increase aluminum levels in intestine, heart, and kidney. The polymeric aluminum implants could be used to establish an animal model for the neuropathology of dementia.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Pathak YV,Vanmeeteren R,Dwivedi Cdoi
10.1177/088532829601100103subject
Has Abstractpub_date
1996-07-01 00:00:00pages
62-75issue
1eissn
0885-3282issn
1530-8022journal_volume
11pub_type
杂志文章abstract::Polylactic acid (PLA)-derived polymers are widely used in many biotechnological fields, thanks to their biocompatibility and resorbability through natural pathways. Moreover, PLA is one of the few polymers in which both the properties and the stereochemical structure can be easily modified, making possible a specific ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211398298
更新日期:2012-08-01 00:00:00
abstract::In this study, a phosphorylation treatment of porous anodic alumina (PAA) was performed by wet impregnation in phosphoric acid and a subsequent heat treatment. The PAA and phosphorylated PAA specimens were analyzed using a field emission scanning electron microscope, an energy-dispersive X-ray spectrometer, and Fourie...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214526765
更新日期:2014-09-01 00:00:00
abstract::In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was pr...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213509503
更新日期:2014-05-01 00:00:00
abstract::In this study, a novel bilayer scaffold composed of electrospun polycaprolactone and poly(lacto-co-glycolic acid) (PCL/PLGA) membrane and glutaraldehyde (3.5% v/v) cross-linked chitosan/gelatin hydrogel was fabricated using two methods: electrospinning of the membrane onto the lyophilized hydrogel (BS-1) and membrane ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211416527
更新日期:2013-01-01 00:00:00
abstract::Calcium phosphate fillers have been shown to increase cement osteoconductivity, but have caused drawbacks in cement properties. Hydroxyapatite and Brushite were introduced in an acrylic two-solution cement at varying concentrations. Novel composite bone cements were developed and characterized using rheology, injectab...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214544770
更新日期:2014-11-01 00:00:00
abstract::The controlled release of insulin from a series of biodegradable hybrid hydrogel network containing dextran derivative of allyl isocyanate (dex-AI) and poly (D,L) lactide diacrylate macromer (PDLLAM) over a wide range of composition ratio was investigated. Laser confocal scanning microscope was used to understand the ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1106/088532802024248
更新日期:2002-04-01 00:00:00
abstract::Sternotomy and sternal closure occur prior to and post cardiac surgery, respectively. Although post-operative complications associated with poor sternal fixation can result in morbidity, mortality, and considerable resource utilization, sternotomy is preferred over other methods such as lateral thoracotomy. Rigid ster...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/0885328213495426
更新日期:2013-11-01 00:00:00
abstract::Hydroxyapatite (Ca10(PO4)6(OH)2) is widely investigated as an implantable material for hard tissue restoration due to its osteoconductive properties. However, hydroxyapatite in bulk form is limited as its mechanical properties are insufficient for load-bearing orthopedic applications. Attempts have been made to improv...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215592866
更新日期:2015-11-01 00:00:00
abstract::This study aims the in vivo biological characterization of an innovative minocycline delivery system, based on polymethylmethacrylate bone cement. Bone cements containing 1% or 2.5% (w/w) minocycline were formulated and evaluated through solid-state characterization. Biological evaluation was conducted in vivo, within...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218795290
更新日期:2018-09-01 00:00:00
abstract::Reconstruction of critical sized bone injuries is a major problem that continues to inspire the design of new materials and grafts. Natural ceramics (hydroxyapatite (HA) coralline HA, or synthetic HA) and β-tricalcium phosphate (β-TCP) are being explored for use as scaffolds in bone tissue engineering, among several o...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328211415132
更新日期:2013-01-01 00:00:00
abstract::A biosensor for the analysis of D-amino acids is described. Carbon paste (graphite/paraffin oil) was chemically modified with immobilized D-amino acid oxidase and either horse-radish peroxidase or fungal peroxidase from Arthromyces ramosus. The two enzymes dissolved in buffer, together with an amine containing oligome...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829300800204
更新日期:1993-10-01 00:00:00
abstract::The purpose of this research was to develop novel nanoparticles (NPs) of star-like copolymer mannitol-functionalized poly(lactide)-vitamin E TPGS (M-PLA-TPGS) for paclitaxel delivery for prostate cancer treatment, and evaluate their therapeutic effects in prostate cancer cell line and animal model in comparison with t...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214527486
更新日期:2014-09-01 00:00:00
abstract::Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328218759043
更新日期:2018-05-01 00:00:00
abstract::The aim of this study was to compare the osteogenic effects of periodontal ligament stem cells (PDLSCs) versus bone marrow mesenchymal stem cells (BMMSCs) in combination with Bio-Oss scaffolds on subcutaneous and critical-size defects in the immunodeficient rat calvarium. PDLSCs and BMMSCs were obtained from the same ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214521846
更新日期:2014-08-01 00:00:00
abstract::The surface quality of coronary stents has a significant influence on its biocompatibility. Therefore, surface polishing is of paramount importance in the production and application of stents. In the present study, electropolishing is performed on 316LVM steel slotted tube coronary stents. Additionally, acid pickling,...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328205046564
更新日期:2005-01-01 00:00:00
abstract::The different barriers that slow the penetration of active ingredients administered by the ocular route are described, and some novel dosage forms designed for this route are discussed. Both precorneal and corneal factors considerably restrict ocular penetration. The low bioavailability of classical ophthalmic dosage ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829701100305
更新日期:1997-01-01 00:00:00
abstract::To develop biocompatible composite microspheres for novel hemostatic use, we designed and prepared a novel biomaterial, composite microspheres consisting of carboxymethyl chitosan, sodium alginate, and collagen (CSCM). The ultra-structure of CSCM was investigated by scanning electron microscopy assay. In hemostatic fu...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328215618354
更新日期:2016-02-01 00:00:00
abstract::Novel in situ polymerizable liquid three-arm biodegradable oligomeric polyesters based upon glycolic acid (GA), L-lactic acid (LLA), and their copolymers are synthesized and characterized. Injectable and in situ curable polymer neat resins and their composites formulated with bioabsorbable beta-tricalcium phosphate ar...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328206068691
更新日期:2007-07-01 00:00:00
abstract::Cellulose acetate phthalate and Pluronic F-127 combined together (70:30 wt:wt) create a rigid, surface-eroding association polymer. To impart flexibility into the polymer system and allow for a drug delivery film that can contour to varying wound shapes, plasticizers were added. Triethyl citrate or tributyl citrate wa...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213480979
更新日期:2014-01-01 00:00:00
abstract::A multifunctional targeted nanoplatform combining photothermal therapy and chemotherapy has emerged as a promising strategy for comprehensive therapies of breast cancer. In this study, we constructed human epidermal growth factor receptor 2 (Her2)-targeted gold nanoshelled poly(lactic-co-glycolic acid) hybrid nanocaps...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220929616
更新日期:2020-09-01 00:00:00
abstract::The development and improvement of medical devices and artificial organs is critically dependent on the realisation of the importance of the interactions between materials and body tissues. In this regard, the evaluation of biocompatibility assumes paramount importance. This paper reviews the hematological aspects of ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章,评审
doi:10.1177/088532829701200104
更新日期:1997-07-01 00:00:00
abstract::While BMP-7 (OP-1) is one of the most potent growth factors in cartilage tissue engineering, the effects of exogenous low concentration BMP-7 on osteoarthritic chondrocytes are still unknown. Human osteoarthritic chondrocytes obtained from the femoral condyles of 10 patients were grown either in monolayer or in 3D col...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328210388439
更新日期:2012-03-01 00:00:00
abstract::Bone tissue is dependent on an efficient blood supply to ensure delivery of nutrients and oxygen. One method to acquire a vascular-engineered bone tissue could be the use of an angiogenic gene-activated scaffold. In the current study, porous chitosan/hydroxyapatite (C/HA) scaffolds were fabricated via freeze-drying wi...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328214544769
更新日期:2014-11-01 00:00:00
abstract::Devices such as contact lenses and collagen shields have been used to improve the antibiotic bioavailability of eye drops formulations in the treatment of ulcerative keratitis. Nevertheless, these devices are not sustained drug delivery systems, and a combination with eye drops is necessary. In animal patients, it req...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328220931733
更新日期:2020-09-01 00:00:00
abstract::The present article deals with the development of 3D porous scaffolds for bone grafting. They were prepared based on rapid fluid infiltration of Al2O3-SiO2 sol into a polyethylene non-woven fabric template structure. Titanium dioxide in concentration equal to 5 wt% was added to the Al2O3-SiO2 mixture to produce Al2O3-...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213483634
更新日期:2014-02-01 00:00:00
abstract::Sodium alginate is an effective biomaterial for tissue engineering applications. Non-purified alginate is contaminated with protein, lipopolysaccharide, DNA, and RNA, which could elicit adverse immunological reactions. We developed a purification protocol to generate biocompatible alginate based on (a) activated charc...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328216645952
更新日期:2016-10-01 00:00:00
abstract::The relative surface charge and free energy of forty-one coagulase-negative staphylococci were found to be normally distributed; therefore, they can be considered a homogeneous group under strict statistical criteria. The adherence of these bacteria to eight different biomaterials (seven synthetic and one biologic) wa...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/088532829200700203
更新日期:1992-10-01 00:00:00
abstract::Titanium and hydroxyapatite (HA) are widely used as biomaterials for dental and medical applications. HA-coated titanium implants have excellent biocompatibility and mechanical properties. However, the adherence of HA film formed on titanium substrate is weak because of the lack of chemical interaction between HA and ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328209340334
更新日期:2010-03-01 00:00:00
abstract::In this paper, the authors describe a novel type of hydrogel coating prepared from the copolymer of human serum albumin and oxidized dextran. The material was designed as a hydrogel sealant for polyester (Dacron®)-based vascular grafts. Dextran was chosen as a coating material due to its anti-thrombogenic properties. ...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328213509676
更新日期:2014-05-01 00:00:00
abstract::Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis...
journal_title:Journal of biomaterials applications
pub_type: 杂志文章
doi:10.1177/0885328209344003
更新日期:2010-08-01 00:00:00