Novel porous Al2O3-SiO2-TiO2 bone grafting materials: formation and characterization.

Abstract:

:The present article deals with the development of 3D porous scaffolds for bone grafting. They were prepared based on rapid fluid infiltration of Al2O3-SiO2 sol into a polyethylene non-woven fabric template structure. Titanium dioxide in concentration equal to 5 wt% was added to the Al2O3-SiO2 mixture to produce Al2O3-SiO2-TiO2 composite scaffolds. The prepared scaffolds are characterized by means of X-ray diffraction, scanning electron microscopy and three-point bending test techniques. The bioactivity of the produced bodies is discussed, including the in vitro and in vivo assessments. The produced scaffolds exhibit mean total porosity of 66.0% and three-point bending strength of 7.1 MPa. In vitro studies showed that MG-63 osteoblast-like cells attach and spread on the scaffolds surfaces. Furthermore, cells grew through the scaffolds and start to produce extra-cellular matrix. Additionally, in vivo studies revealed the ability of the porous scaffolds to regenerate bone tissue in femur defects of albino rats 5 months post surgery. Histological analysis showed that the defect is almost entirely filled with new bone. The formed bone is characterized as a mature bone. The produced bone grafts are intended to be used as bone substitute or bone filler as their degradation products caused no inflammatory effects.

journal_name

J Biomater Appl

authors

Naga SM,El-Kady AM,El-Maghraby HF,Awaad M,Detsch R,Boccaccini AR

doi

10.1177/0885328213483634

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

813-24

issue

6

eissn

0885-3282

issn

1530-8022

pii

0885328213483634

journal_volume

28

pub_type

杂志文章
  • Melanin-containing hydrogel intraocular lenses: a histopathological study in animal eyes.

    abstract::Poly(2-hydroxyethyl methacrylate) hydrogel intraocular lenses, containing adrenochrome-melanin, were manufactured and implanted in animal eyes in order to assess the effect of melanin upon (a) biocompatibility of implants with the eye tissues, and (b) fibrous proliferation of lens epithelium responsible for the opacif...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829500900305

    authors: Chirila TV,Constable IJ,Vijayasekaran S,Ben-Hun J

    更新日期:1995-01-01 00:00:00

  • Chitosan-based coatings in the prevention of intravascular catheter-associated infections.

    abstract::Central venous access devices play an important role in patients with prolonged intravenous administration requirements. In the last years, the coating of these devices with bactericidal compounds has emerged as a potential tool to prevent bacterial colonization. Our study describes the modification of 3D-printed rese...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328217739199

    authors: Mendoza G,Regiel-Futyra A,Tamayo A,Monzon M,Irusta S,de Gregorio MA,Kyzioł A,Arruebo M

    更新日期:2018-01-01 00:00:00

  • Investigating the use of coupling agents to improve the interfacial properties between a resorbable phosphate glass and polylactic acid matrix.

    abstract::Eight different chemicals were investigated as potential candidate coupling agents for phosphate glass fibre reinforced polylactic acid composites. Evidence of reaction of the coupling agents with phosphate glass and their effect on surface wettability and glass degradation were studied along with their principle role...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328212453634

    authors: Hasan MS,Ahmed I,Parsons AJ,Rudd CD,Walker GS,Scotchford CA

    更新日期:2013-09-01 00:00:00

  • Effects of low concentration BMP-7 on human osteoarthritic chondrocytes: comparison of different applications.

    abstract::While BMP-7 (OP-1) is one of the most potent growth factors in cartilage tissue engineering, the effects of exogenous low concentration BMP-7 on osteoarthritic chondrocytes are still unknown. Human osteoarthritic chondrocytes obtained from the femoral condyles of 10 patients were grown either in monolayer or in 3D col...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328210388439

    authors: Gavenis K,Heussen N,Schmidt-Rohlfing B

    更新日期:2012-03-01 00:00:00

  • Targeted gold nanoshelled hybrid nanocapsules encapsulating doxorubicin for bimodal imaging and near-infrared triggered synergistic therapy of Her2-positve breast cancer.

    abstract::A multifunctional targeted nanoplatform combining photothermal therapy and chemotherapy has emerged as a promising strategy for comprehensive therapies of breast cancer. In this study, we constructed human epidermal growth factor receptor 2 (Her2)-targeted gold nanoshelled poly(lactic-co-glycolic acid) hybrid nanocaps...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220929616

    authors: Dong Q,Wan C,Yang H,Zheng D,Xu L,Zhou Z,Xie S,Du J,Li F

    更新日期:2020-09-01 00:00:00

  • The influence of solvent processing on polyester bioabsorbable polymers.

    abstract::Solvent-based methods are commonly employed for the production of polyester-based samples and coatings in both medical device production and research. The influence of solvent casting and subsequent drying time was studied using thermal analysis, spectroscopy and weight measurement for four grades of 50 : 50 poly(lact...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328210376997

    authors: Manson J,Dixon D

    更新日期:2012-01-01 00:00:00

  • Drug release from PLGA microspheres attached to solids using supercritical CO₂.

    abstract::Functionalization of a porous orthopedic implant with dexamethasone, a widely used anti-inflammatory drug, encapsulated within a biodegradable polymer for controlled release could help reduce or eliminate the inflammation response by the local tissue. In this research, we investigated the possibility of using supercri...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328209354365

    authors: Mulia K,Witkamp GJ,Dawes GJ,Fratila-Apachitei LE,Apachitei I,Duszczyk J,Pellikaan H

    更新日期:2011-01-01 00:00:00

  • Aluminum polymeric implants: in vitro-in vivo evaluations.

    abstract::The purpose of this investigation is to study the effect of long-term subcutaneous aluminum polymeric implants on aluminum release and accumulation in various tissues in rats. The implants were formulated using silicone rubber and polyurethane polymers and three different aluminum salts. The polymeric matrices were ev...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829601100103

    authors: Pathak YV,Vanmeeteren R,Dwivedi C

    更新日期:1996-07-01 00:00:00

  • In vitro proliferation and osteogenic differentiation of human dental pulp stem cells in injectable thermo-sensitive chitosan/β-glycerophosphate/hydroxyapatite hydrogel.

    abstract::Injectable thermo-sensitive hydrogels have a potential application in bone tissue engineering for their sensitivities and minimal invasive properties. Human dental pulp stem cells have been considered a promising tool for tissue reconstruction. The objective of this study was to investigate the proliferation and osteo...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328216661566

    authors: Chen Y,Zhang F,Fu Q,Liu Y,Wang Z,Qi N

    更新日期:2016-09-01 00:00:00

  • Calcium polyphosphate as an additive to zinc-silicate glass ionomer cements.

    abstract::Aluminum-free glass ionomer cements (GICs) are under development for orthopedic applications, but are limited by their insufficient handling properties. Here, the addition of calcium polyphosphate (CPP) was investigated as an additive to an experimental zinc-silicate glass ionomer cement. A 50% maximum increase in wor...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215568985

    authors: Valliant EM,Gagnier D,Dickey BT,Boyd D,Filiaggi MJ

    更新日期:2015-07-01 00:00:00

  • Curcumin delivered through bovine serum albumin/polysaccharides multilayered microcapsules.

    abstract::The aim of the paper is to obtain and characterize k-carrageenan-chitosan dual hydrogel multilayers shell BSA gel microcapsules, as a carrier for curcumin, and as a possible antitumoral agent in biological studies. We used the CaCO3 template to synthesize non-toxic CaCO3/BSA particles as microtemplates by coprecipitat...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215603797

    authors: Paşcalău V,Soritau O,Popa F,Pavel C,Coman V,Perhaita I,Borodi G,Dirzu N,Tabaran F,Popa C

    更新日期:2016-01-01 00:00:00

  • Functionalized graphene oxide-based thermosensitive hydrogel for near-infrared chemo-photothermal therapy on tumor.

    abstract:PURPOSE:A functionalized graphene oxide-based thermosensitive hydrogel loaded with docetaxel for intratumoral delivery was designed to enhance therapeutic efficacy and alleviate system toxicity. METHODS:First, graphene oxide was functionalized with chitosan to acquire high stability in physiological solutions. And the...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215619583

    authors: Zhu X,Zhang Y,Huang H,Zhang H,Hou L,Zhang Z

    更新日期:2016-03-01 00:00:00

  • Properties of zinc releasing surfaces for clinical applications.

    abstract::Two series of glasses of general formula (2-p) SiO2.1.1Na2O.CaO.pP2O5.xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. Th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328207079731

    authors: Lusvardi G,Malavasi G,Menabue L,Menziani MC,Pedone A,Segre U,Aina V,Perardi A,Morterra C,Boccafoschi F,Gatti S,Bosetti M,Cannas M

    更新日期:2008-05-01 00:00:00

  • Dextran/Albumin hydrogel sealant for Dacron(R) vascular prosthesis.

    abstract::In this paper, the authors describe a novel type of hydrogel coating prepared from the copolymer of human serum albumin and oxidized dextran. The material was designed as a hydrogel sealant for polyester (Dacron®)-based vascular grafts. Dextran was chosen as a coating material due to its anti-thrombogenic properties. ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328213509676

    authors: Lisman A,Butruk B,Wasiak I,Ciach T

    更新日期:2014-05-01 00:00:00

  • A review of sternal closure techniques.

    abstract::Sternotomy and sternal closure occur prior to and post cardiac surgery, respectively. Although post-operative complications associated with poor sternal fixation can result in morbidity, mortality, and considerable resource utilization, sternotomy is preferred over other methods such as lateral thoracotomy. Rigid ster...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章,评审

    doi:10.1177/0885328213495426

    authors: Alhalawani AM,Towler MR

    更新日期:2013-11-01 00:00:00

  • Properties of single electrospun poly (diol citrate)-collagen-proteoglycan nanofibers for arterial repair and in applications requiring viscoelasticity.

    abstract::Single nanofibers with chemical and functional properties consistent with artery extracellular matrix nanofibers were produced by electrospinning. Using weight ratios to mimic artery extracellular matrix, five materials were tested: (1) Collagen type I, (2) Collagen type I + Collagen type III, (3) Collagen type I + po...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328213477893

    authors: Liu J,Argenta L,Morykwas M,Wagner WD

    更新日期:2014-01-01 00:00:00

  • Biocompatibility properties of surface-modified poly(dimethylsiloxane) for urinary applications.

    abstract::An electronic sensor system for urinary bladder pressure monitoring requires an imbedding into a biocompatible, flexible, and liquid-impermeable material. Poly(dimethylsiloxane) (PDMS) was selected in the present set-up as packaging material because it fulfills the abovementioned requirements. However, the surface of ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328211422119

    authors: Lippens E,De Smet N,Schauvliege S,Martens A,Gasthuys F,Schacht E,Cornelissen R

    更新日期:2013-02-01 00:00:00

  • Silk fibroin-based vascular repairing sheet with angiogenic-promoting activity of SVVYGLR peptide regenerated the damaged vascular in rats.

    abstract::Medical sheets are useful in surgically repair vascular disease. To avoid long-term side effects, they are to be replaced with regenerated tissue after implantation. Silk fibroin is a fibrous protein secreted by silkworm. The advantage of silk fibroin is its biocompatibility and has been used as regenerative artificia...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220928660

    authors: Shimada K,Honda T,Kato K,Hori R,Ujike N,Uemura A,Murakami T,Kitpipatkun P,Nakazawa Y,Tanaka R

    更新日期:2020-06-02 00:00:00

  • Enhancement of CRF-PEEK osseointegration by plasma-sprayed hydroxyapatite: A rabbit model.

    abstract::Carbon-fibre-reinforced polyether ether ketone (CFR-PEEK) exhibits excellent biomechanical properties as it has an elastic modulus similar to bone. However, CFR-PEEK displays inferior biocompatibility compared with titanium alloy and coating techniques are therefore of interest in order to improve integration. In this...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214521669

    authors: Suska F,Omar O,Emanuelsson L,Taylor M,Gruner P,Kinbrum A,Hunt D,Hunt T,Taylor A,Palmquist A

    更新日期:2014-08-01 00:00:00

  • Degradable magnesium-based alloys for biomedical applications: The role of critical alloying elements.

    abstract::Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing proce...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章,评审

    doi:10.1177/0885328219834656

    authors: Chen Y,Dou J,Yu H,Chen C

    更新日期:2019-05-01 00:00:00

  • Biodegradable polyurethanes: biodegradable low adherence films for the prevention of adhesions after surgery.

    abstract::Adhesions commonly occur after internal disease or surgery. The natural healing response leads to the formation of vascular and avascular adhesions after inflammatory diseases and surgical interventions. A barrier film could be incorporated during surgery between layers of tissues that must not adhere to one another. ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829601100203

    authors: Rehman IU

    更新日期:1996-10-01 00:00:00

  • Biological interactions: causes for risks and failures of biomaterials and devices.

    abstract::Biomaterials and devices have been used in a variety of applications ranging from disposable extracorporeal devices and soft and hard tissue augmentation, to total artificial internal organs. However, there are risks and failures in each application which are a result of undesirable biological interactions. This artic...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532829300800104

    authors: Jayabalan M

    更新日期:1993-07-01 00:00:00

  • Flow perfusion culture of MC3T3-E1 osteogenic cells on gradient calcium polyphosphate scaffolds with different pore sizes.

    abstract::Calcium polyphosphate is a biodegradable bone substitute. It remains a challenge to prepare porous calcium polyphosphate with desired gradient porous structures. In this study, a modified one-step gravity sintering method was used to prepare calcium polyphosphate scaffolds with desired-gradient-pore-size distribution....

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215608335

    authors: Chen L,Song W,Markel DC,Shi T,Muzik O,Matthew H,Ren W

    更新日期:2016-02-01 00:00:00

  • An arterial prosthesis from Argentina: the Barone Microvelour arterial graft.

    abstract::The manufacture of a polyester vascular prosthesis in the southern hemisphere is a new development in the global dissemination of this maturing technology. Hence the recent introduction of the Barone Microvelour arterial graft from Argentina has highlighted the need for a comparative in vitro and in vivo study to comp...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/088532828800300302

    authors: Torché D,Guidoin R,Boyer D,Marceau D,Marois Y,Debille E,Lacombe J,King M

    更新日期:1989-01-01 00:00:00

  • Comparative evaluation of in vivo biocompatibility and biodegradability of regenerated silk scaffolds reinforced with/without natural silk fibers.

    abstract::Nowadays, exceptional advantages of silk fibroin over synthetic and natural polymers have impelled the scientists to application of this biomaterial for tissue engineering purposes. Recently, we showed that embedding natural degummed silk fibers in regenerated Bombyx mori silk-based scaffold significantly increases th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328215601925

    authors: Mobini S,Taghizadeh-Jahed M,Khanmohammadi M,Moshiri A,Naderi MM,Heidari-Vala H,Ashrafi Helan J,Khanjani S,Springer A,Akhondi MM,Kazemnejad S

    更新日期:2016-01-01 00:00:00

  • In vitro and in vivo evaluation of polylactic acid-based composite with tricalcium phosphate microsphere for enhanced biodegradability and osseointegration.

    abstract::A biodegradable polylactic acid composite containing tricalcium phosphate microsphere was fabricated. The composite exhibited enhanced biocompatibility and a well-interconnected porous structure that enabled tissue ingrowth after degradation. The tricalcium phosphate microspheres had an average size of 106 ± 43 μm and...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328218763660

    authors: Shin DY,Kang MH,Kang IG,Kim HE,Jeong SH

    更新日期:2018-05-01 00:00:00

  • Self-tapping ability of carbon fibre reinforced polyetheretherketone suture anchors.

    abstract::An experimental and computational investigation of the self-tapping ability of carbon fibre reinforced polyetheretherketone (CFR-PEEK) has been conducted. Six CFR-PEEK suture anchor designs were investigated using PEEK-OPTIMA® Reinforced, a medical grade of CFR-PEEK. Experimental tests were conducted to investigate th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328214535274

    authors: Feerick EM,Wilson J,Jarman-Smith M,Ó'Brádaigh CM,McGarry JP

    更新日期:2014-10-01 00:00:00

  • Influence of MMP inhibitor GM6001 loading of fibre coated polypropylene meshes on wound healing: Implications for hernia repair.

    abstract::Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328218759043

    authors: Böhm G,Groll J,Heffels KH,Heussen N,Ink P,Alizai HP,Neumann UP,Schnabel R,Mirastschijski U

    更新日期:2018-05-01 00:00:00

  • Wet-electrospun PHBV nanofiber reinforced carboxymethyl chitosan-silk hydrogel composite scaffolds for articular cartilage repair.

    abstract::The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix. In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl ch...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328220930714

    authors: Gunes OC,Albayrak AZ,Tasdemir S,Sendemir A

    更新日期:2020-10-01 00:00:00

  • Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6.

    abstract::Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章

    doi:10.1177/0885328209344003

    authors: Kevadiya BD,Joshi GV,Patel HA,Ingole PG,Mody HM,Bajaj HC

    更新日期:2010-08-01 00:00:00