Abstract：
:The different barriers that slow the penetration of active ingredients administered by the ocular route are described, and some novel dosage forms designed for this route are discussed. Both precorneal and corneal factors considerably restrict ocular penetration. The low bioavailability of classical ophthalmic dosage forms can be improved by several approaches, particularly by increasing the time the active ingredients remain in contact with the eye tissues. The new dosage forms are reviewed according to their type and their drug release mechanisms. The characteristics, advantages, and limitations of each are outlined. The potential of these dosage forms can be expected to enhance development. They offer prolonged effectiveness, reproducibility, fewer unwanted side effects, and improved tolerance.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Aiache JM,el Meski S,Beyssac E,Serpin Gdoi
10.1177/088532829701100305subject
Has Abstractpub_date
1997-01-01 00:00:00pages
329-48issue
3eissn
0885-3282issn
1530-8022journal_volume
11pub_type
杂志文章abstract：:Eight different chemicals were investigated as potential candidate coupling agents for phosphate glass fibre reinforced polylactic acid composites. Evidence of reaction of the coupling agents with phosphate glass and their effect on surface wettability and glass degradation were studied along with their principle role...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212453634
更新日期：2013-09-01 00:00:00
abstract：:Antenna coupling microwave plasma enables a highly oxidative treatment of the outmost surface of polypropylene (PP) nonwoven fabric within a short time period. Subsequently, grafting copolymerization with acrylic acid (AAc) makes the plasma-treated fabric durably hydrophilic and excellent in water absorbency. With hig...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/088532802030478
更新日期：2002-10-01 00:00:00
abstract：:To develop biocompatible composite microspheres for novel hemostatic use, we designed and prepared a novel biomaterial, composite microspheres consisting of carboxymethyl chitosan, sodium alginate, and collagen (CSCM). The ultra-structure of CSCM was investigated by scanning electron microscopy assay. In hemostatic fu...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215618354
更新日期：2016-02-01 00:00:00
abstract：:In this study, the effects of sodium carbonate (Na(2)CO(3) ) solution with different concentrations (10, 15, 20, and 25 wt%) as liquid phase on the setting time and compressive strength of tricalcium silicate bone cements are investigated. The in vitro bioactivity and degradability of the resultant Ca(3)SiO(5)-Na(2)CO...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208088714
更新日期：2008-11-01 00:00:00
abstract：:The process of molecular self-assembly plays a crucial role in formulation of polymeric nanoparticulated drug delivery carriers as it creates the possibility for enhanced drug encapsulation and carrier surface engineering. This study aimed to develop a novel self-assembled polymeric micelles for targeted delivery in t...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214549612
更新日期：2015-01-01 00:00:00
abstract：:Magnesium-based alloys exhibit biodegradable, biocompatible and excellent mechanical properties which enable them to serve as ideal candidate biomedical materials. In particular, their biodegradable ability helps patients to avoid a second surgery. The corrosion rate, however, is too rapid to sustain the healing proce...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章,评审
doi：10.1177/0885328219834656
更新日期：2019-05-01 00:00:00
abstract：:Bone tissue engineering, which relies on the interactions between stem cells and suitable scaffold materials, represents a highly desirable alternative to currently used allograft or autograft strategies for the treatment of bone defects caused by injury or disease, with one of the major challenges being to generate s...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213515734
更新日期：2014-07-01 00:00:00
abstract：:The aim of the in vitro study was a comparison of an allogenic (ABSM) and a xenogenic bone substitute material (XBSM) with and without injectable platelet-rich fibrin (ABSM-i-PRF & XBSM-i-PRF) on cell characteristics of human osteoblasts (HOB). Here, ABSM and XBSM (+ i-PRF = test; - i-PRF = control) were incubated wit...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220914407
更新日期：2020-07-01 00:00:00
abstract：:Sternotomy and sternal closure occur prior to and post cardiac surgery, respectively. Although post-operative complications associated with poor sternal fixation can result in morbidity, mortality, and considerable resource utilization, sternotomy is preferred over other methods such as lateral thoracotomy. Rigid ster...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章,评审
doi：10.1177/0885328213495426
更新日期：2013-11-01 00:00:00
abstract：:Aluminum-free glass ionomer cements (GICs) are under development for orthopedic applications, but are limited by their insufficient handling properties. Here, the addition of calcium polyphosphate (CPP) was investigated as an additive to an experimental zinc-silicate glass ionomer cement. A 50% maximum increase in wor...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215568985
更新日期：2015-07-01 00:00:00
abstract：:Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211427774
更新日期：2013-03-01 00:00:00
abstract：:The controlled release of insulin from a series of biodegradable hybrid hydrogel network containing dextran derivative of allyl isocyanate (dex-AI) and poly (D,L) lactide diacrylate macromer (PDLLAM) over a wide range of composition ratio was investigated. Laser confocal scanning microscope was used to understand the ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/088532802024248
更新日期：2002-04-01 00:00:00
abstract：:The aim of this work was to study the cytotoxicity of different fractions of gold nanoparticles prepared by ultrasonic spray pyrolysis from gold scrap. The target cells were rat thymocytes, as a type of nonproliferating cells, and L929 mouse fibroblasts, as a type of continuous proliferating cells. Fractions 1 and 2, ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328210377536
更新日期：2012-01-01 00:00:00
abstract：:Polymer biocomposites based on segmented poly(ester urethane) and extracellular matrix components have been prepared for the development of tissue engineering applications with improved biological characteristics of the materials in contact with blood and tissues for long periods. Thermal, dynamical, and dielectrical ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328210394468
更新日期：2012-08-01 00:00:00
abstract：:Nanohydroxyapatite (nanoHA), due to its chemical properties, has appeared as an exceptionally promising bioceramic to be used as bone regeneration material. Staphylococcus epidermidis have emerged as major nosocomial pathogens associated with infections of implanted medical devices. In this work, the purpose was to st...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213507300
更新日期：2014-05-01 00:00:00
abstract：:Reconstruction of critical sized bone injuries is a major problem that continues to inspire the design of new materials and grafts. Natural ceramics (hydroxyapatite (HA) coralline HA, or synthetic HA) and β-tricalcium phosphate (β-TCP) are being explored for use as scaffolds in bone tissue engineering, among several o...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211415132
更新日期：2013-01-01 00:00:00
abstract：:Three types of commercially available ultra-high molecular weight polyethylene (UHMWPE) acetabular cups currently used in total hip arthroplasty have been studied by means of Raman micro-spectroscopy to unfold the microstructural modification induced by the oxidative degradation after accelerated aging with and withou...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214548693
更新日期：2015-01-01 00:00:00
abstract：:Biomaterials and devices have been used in a variety of applications ranging from disposable extracorporeal devices and soft and hard tissue augmentation, to total artificial internal organs. However, there are risks and failures in each application which are a result of undesirable biological interactions. This artic...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829300800104
更新日期：1993-07-01 00:00:00
abstract：:This study's aim consists of evaluating the adhesion and proliferation of mesenchymal stem cells (MSCs) derived from rat bone marrow on nanoparticle Titanium (Ti) surface. Hence, passage 3 MSCs were, respectively, seeded on nanoparticle Ti and pure Ti surfaces and then cultured for 32 h. Cell morphology and viability ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211414750
更新日期：2013-01-01 00:00:00
abstract：:The surface quality of coronary stents has a significant influence on its biocompatibility. Therefore, surface polishing is of paramount importance in the production and application of stents. In the present study, electropolishing is performed on 316LVM steel slotted tube coronary stents. Additionally, acid pickling,...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328205046564
更新日期：2005-01-01 00:00:00
abstract：:The aim of this study was to investigate if newly developed polyurethane (PU) scaffolds are suitable as scaffold for cell-seeded meniscus tissue engineered constructs. Scaffolds were seeded with goat meniscal fibrochondrocytes and cultured to assess changes in biological and mechanical properties. Furthermore, the eff...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211417317
更新日期：2013-01-01 00:00:00
abstract：:Devices such as contact lenses and collagen shields have been used to improve the antibiotic bioavailability of eye drops formulations in the treatment of ulcerative keratitis. Nevertheless, these devices are not sustained drug delivery systems, and a combination with eye drops is necessary. In animal patients, it req...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220931733
更新日期：2020-09-01 00:00:00
abstract：:Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any promise of a cure in the near future. Although islet transplantation has proven to be an effective means of treating type 1 diabetes mell...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章,评审
doi：10.1177/0885328219831391
更新日期：2019-04-01 00:00:00
abstract：:The incidence of fractures increases with age. This is partly due to extraosseous factors and partly to the increased fragility of the bone material itself. Ageing adversely affects the "quality" of human bone material, its elastic and ultimate properties. The hypothesis here is that these effects are caused by factor...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/5JUJ-TFJ3-JVVA-3RJ0
更新日期：2001-01-01 00:00:00
abstract：:The development of an effective wound dressing with the ability to induce skin wound healing is a great challenge in medicine. Nanofibers are highly attractive for wound dressing preparation due to their properties such as hemostasis induction, good absorption of wound exudates, and facilitation of cell growth. Chitos...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217739562
更新日期：2018-01-01 00:00:00
abstract：:Cellulose acetate phthalate and Pluronic F-127 combined together (70:30 wt:wt) create a rigid, surface-eroding association polymer. To impart flexibility into the polymer system and allow for a drug delivery film that can contour to varying wound shapes, plasticizers were added. Triethyl citrate or tributyl citrate wa...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213480979
更新日期：2014-01-01 00:00:00
abstract：:Poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) copolymers have been widely used for various biomedical applications. However, their hemocompatibility has not been clarified, which would lag their developments and clinical applications. In this work, we studied the effect of PEG-PLA copolymers on key human blood com...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215627404
更新日期：2016-05-01 00:00:00
abstract：:In order to induce esophageal muscle cells' orientation, the silicon wafer with prototype 1 and prototype 2 was designed. Prototype 1 has micro-channels of 200 µm width and 30 µm depth with 30 µm wide wall as the interval. Prototype 2 has channels of 100 µm width and 30 µm depth with a discontinuous wall which has 30 ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215627585
更新日期：2016-04-01 00:00:00
abstract：:Transarterial embolization is an established minimally invasive treatment for solid tumors. Unintended inflammation, foreign body reactions and ischemia-triggered neoangiogenesis are clinical drawbacks of permanent embolic materials. The aim of the current study was to characterize a new type of biodegradable starch m...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217746674
更新日期：2018-02-01 00:00:00
abstract：:Tendon tears are a relevant concern for today's national health systems because of their social impact and high recurrence rate. The current gold standard for fixing tendon tears is surgical repair; however, this strategy is not able to fully re-establish tendon integrity and functionality. Tissue engineering approach...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218779846
更新日期：2018-07-01 00:00:00
