Abstract：
:The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/support ratio, time, volume of solvent), as well as the mathematical model correlating the amount of coupled drug with these parameters is established. Maximum amounts of drug (28%) are chemically bound when employing maximum values of the parameters mentioned (i.e., AcAA/PAcA-S ratio = 2 mole/mole; time = 50 h; THF volume = 60 ml). Physicochemical and spectral analyses evidence the existence of some chemical bonds of the -CO-NH-SO2-type between the macromolecular support and the drug. In vivo tests have demonstrated the gradual hydrolysis of the chemical bonds as well as the release of the drug, due to the diuretic effect produced.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Dumitriu S,Popa M,Dărângă M,Dumitriu Cdoi
10.1177/088532829200700105subject
Has Abstractpub_date
1992-07-01 00:00:00pages
76-92issue
1eissn
0885-3282issn
1530-8022journal_volume
7pub_type
杂志文章abstract：:Biodegradable magnesium-based implants are currently being developed for use in orthopedic applications. The aim of this study was to investigate the acute, subacute, and chronic local effects on bone tissue as well as the systemic reactions to a magnesium-based (MgYREZr-alloy) screw containing rare earth elements. Th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212472215
更新日期：2014-01-01 00:00:00
abstract：:Single nanofibers with chemical and functional properties consistent with artery extracellular matrix nanofibers were produced by electrospinning. Using weight ratios to mimic artery extracellular matrix, five materials were tested: (1) Collagen type I, (2) Collagen type I + Collagen type III, (3) Collagen type I + po...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213477893
更新日期：2014-01-01 00:00:00
abstract：:Nonviral gene delivery systems are finding widespread use due to their safety, rapid and economical production, and ease of modification. In this work, series of N-alkyl-substituted linear polyethylenimine (CP) polymers have been synthesized, characterized, and investigated about how degree of substitution (hydrophobi...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217710125
更新日期：2017-07-01 00:00:00
abstract：:Melt electrowriting (MEW) can print high-resolution scaffolds with the ultrafine fibers from 800 nm to 20 µm. However, the cell seeding efficiency relatively low due to the large pore size of the MEW scaffold. Here, we reported a method to solve this dilemma by electrospinning a gelatin methacrylate (GelMA) hydrogel f...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220962606
更新日期：2021-01-01 00:00:00
abstract：:Bone tissue is dependent on an efficient blood supply to ensure delivery of nutrients and oxygen. One method to acquire a vascular-engineered bone tissue could be the use of an angiogenic gene-activated scaffold. In the current study, porous chitosan/hydroxyapatite (C/HA) scaffolds were fabricated via freeze-drying wi...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214544769
更新日期：2014-11-01 00:00:00
abstract：:The controlled release of insulin from a series of biodegradable hybrid hydrogel network containing dextran derivative of allyl isocyanate (dex-AI) and poly (D,L) lactide diacrylate macromer (PDLLAM) over a wide range of composition ratio was investigated. Laser confocal scanning microscope was used to understand the ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/088532802024248
更新日期：2002-04-01 00:00:00
abstract：:The purpose of this research was to develop novel nanoparticles (NPs) of star-like copolymer mannitol-functionalized poly(lactide)-vitamin E TPGS (M-PLA-TPGS) for paclitaxel delivery for prostate cancer treatment, and evaluate their therapeutic effects in prostate cancer cell line and animal model in comparison with t...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214527486
更新日期：2014-09-01 00:00:00
abstract：:The development and improvement of medical devices and artificial organs is critically dependent on the realisation of the importance of the interactions between materials and body tissues. In this regard, the evaluation of biocompatibility assumes paramount importance. This paper reviews the hematological aspects of ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章,评审
doi：10.1177/088532829701200104
更新日期：1997-07-01 00:00:00
abstract：:Sustained intestinal delivery of thiamine hydrochloride (Vitamin B(1); VB(1)) and pyridoxine hydrochloride (Vitamin B(6); VB(6)) seems to be a feasible alternative to existing therapy. The vitamins (VB(1)/VB(6)) intercalated in montmorillonite (MMT) and intercalated VB(1)/VB(6)-MMT hybrid is further used for synthesis...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328209344003
更新日期：2010-08-01 00:00:00
abstract：:Functionalization of a porous orthopedic implant with dexamethasone, a widely used anti-inflammatory drug, encapsulated within a biodegradable polymer for controlled release could help reduce or eliminate the inflammation response by the local tissue. In this research, we investigated the possibility of using supercri...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328209354365
更新日期：2011-01-01 00:00:00
abstract：:The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Quest...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212473510
更新日期：2014-01-01 00:00:00
abstract：:The synthesis, tensile strength, thermostability and hydrophilicity of the poly(urethaneamideimide) and the poly(urethaneureas) with N-aliphatic side chains are presented. These elastomers were compared in blood compatibility with determination of the common indices and with immunologic tests of the beta-thromboglobul...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/TBUW-TWW9-EC7X-YA3H
更新日期：2000-10-01 00:00:00
abstract：:A rapid and continuous hydrothermal route for the synthesis of nano-sized hydroxyapatite rods co-precipitated with calcium-doped zirconia nanoparticles using a superheated water flow at 450°C and 24.1 MPa as a crystallizing medium is described. Hydroxyapatite and calcium-doped zirconia phases in the powder mixtures co...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212444483
更新日期：2012-07-01 00:00:00
abstract：:This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)-pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS-pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microen...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328206056771
更新日期：2007-01-01 00:00:00
abstract：:Understanding the structure-function relationship in biomaterial constructs is critical in optimizing biological outcomes. For ensheathed structures such as peripheral nerve, engineering implantable tissue substitutes has been challenging. This is due to a unique geometry of thin-walled microtube arrays composed mostl...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218804338
更新日期：2018-10-01 00:00:00
abstract：:The objective of the study was to produce three-dimensional and porous nanofiber reinforced hydrogel scaffolds that can mimic the hydrated composite structure of the cartilage extracellular matrix. In this regard, wet-electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofiber reinforced carboxymethyl ch...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220930714
更新日期：2020-10-01 00:00:00
abstract：:In the present study, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabric was prepared by graft copolymerization of N-isopropylacrylamide and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was pr...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213509503
更新日期：2014-05-01 00:00:00
abstract：:The incidence of fractures increases with age. This is partly due to extraosseous factors and partly to the increased fragility of the bone material itself. Ageing adversely affects the "quality" of human bone material, its elastic and ultimate properties. The hypothesis here is that these effects are caused by factor...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/5JUJ-TFJ3-JVVA-3RJ0
更新日期：2001-01-01 00:00:00
abstract：:A series of cellulose/soy protein isolate (SPI) sponges was prepared using a freeze-drying process. The effect of the SPI content on the structure of the sponges was characterized by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction analysis (XRD) and scanning electron microscopy (SEM). It showed that...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208099337
更新日期：2010-02-01 00:00:00
abstract：:The aim of the in vitro study was a comparison of an allogenic (ABSM) and a xenogenic bone substitute material (XBSM) with and without injectable platelet-rich fibrin (ABSM-i-PRF & XBSM-i-PRF) on cell characteristics of human osteoblasts (HOB). Here, ABSM and XBSM (+ i-PRF = test; - i-PRF = control) were incubated wit...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220914407
更新日期：2020-07-01 00:00:00
abstract：:The different barriers that slow the penetration of active ingredients administered by the ocular route are described, and some novel dosage forms designed for this route are discussed. Both precorneal and corneal factors considerably restrict ocular penetration. The low bioavailability of classical ophthalmic dosage ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829701100305
更新日期：1997-01-01 00:00:00
abstract：:Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211427774
更新日期：2013-03-01 00:00:00
abstract：:Phase-sensitive in situ gel-forming controlled release formulations of insulin were prepared using poly(lactide-co-glycolide) and a solvent system consisting of various proportions of benzyl benzoate and benzyl alcohol. The in vitro release samples of formulations were assayed for insulin content by enzyme linked immu...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328209359959
更新日期：2011-03-01 00:00:00
abstract：:Polysulfone (PSU) composite films filled with Beta-dicalcium silicate (Beta-Ca(2)SiO(4)) particles are prepared by the solvent casting-evaporation method. The surface morphologies and mechanical properties of the films are determined. The bioactivity of the composite films is evaluated by soaking them in simulated bod...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328206054712
更新日期：2006-04-01 00:00:00
abstract：:Central venous access devices play an important role in patients with prolonged intravenous administration requirements. In the last years, the coating of these devices with bactericidal compounds has emerged as a potential tool to prevent bacterial colonization. Our study describes the modification of 3D-printed rese...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217739199
更新日期：2018-01-01 00:00:00
abstract：:In this paper, the authors describe a novel type of hydrogel coating prepared from the copolymer of human serum albumin and oxidized dextran. The material was designed as a hydrogel sealant for polyester (Dacron®)-based vascular grafts. Dextran was chosen as a coating material due to its anti-thrombogenic properties. ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213509676
更新日期：2014-05-01 00:00:00
abstract：:The aim of this work was to study the cytotoxicity of different fractions of gold nanoparticles prepared by ultrasonic spray pyrolysis from gold scrap. The target cells were rat thymocytes, as a type of nonproliferating cells, and L929 mouse fibroblasts, as a type of continuous proliferating cells. Fractions 1 and 2, ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328210377536
更新日期：2012-01-01 00:00:00
abstract：:Aluminum-free glass ionomer cements (GICs) are under development for orthopedic applications, but are limited by their insufficient handling properties. Here, the addition of calcium polyphosphate (CPP) was investigated as an additive to an experimental zinc-silicate glass ionomer cement. A 50% maximum increase in wor...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215568985
更新日期：2015-07-01 00:00:00
abstract：:The process of molecular self-assembly plays a crucial role in formulation of polymeric nanoparticulated drug delivery carriers as it creates the possibility for enhanced drug encapsulation and carrier surface engineering. This study aimed to develop a novel self-assembled polymeric micelles for targeted delivery in t...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214549612
更新日期：2015-01-01 00:00:00
abstract：:The production of large quantities of functional vascularized bone tissue ex vivo still represent an unmet clinical challenge. Microcarriers offer a potential solution to scalable manufacture of bone tissue due to their high surface area-to-volume ratio and the capacity to be assembled using a modular approach. Microc...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217720812
更新日期：2017-09-01 00:00:00
