Abstract：
:The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/support ratio, time, volume of solvent), as well as the mathematical model correlating the amount of coupled drug with these parameters is established. Maximum amounts of drug (28%) are chemically bound when employing maximum values of the parameters mentioned (i.e., AcAA/PAcA-S ratio = 2 mole/mole; time = 50 h; THF volume = 60 ml). Physicochemical and spectral analyses evidence the existence of some chemical bonds of the -CO-NH-SO2-type between the macromolecular support and the drug. In vivo tests have demonstrated the gradual hydrolysis of the chemical bonds as well as the release of the drug, due to the diuretic effect produced.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Dumitriu S,Popa M,Dărângă M,Dumitriu Cdoi
10.1177/088532829200700105subject
Has Abstractpub_date
1992-07-01 00:00:00pages
76-92issue
1eissn
0885-3282issn
1530-8022journal_volume
7pub_type
杂志文章abstract：:The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocol...
journal_title：Journal of biomaterials applications
pub_type： 临床试验,杂志文章
doi：10.1177/0885328207078260
更新日期：2008-01-01 00:00:00
abstract：:A series biodegradable poly (γ-glutamic acid)/beta-tricalcium phosphate (γ-PGA/TCP) nanocomposites were prepared which were composed of poly-γ-glutamic acid polymerized in situ with β-tricalcium phosphate and physiochemically characterized as bone graft substitutes. The particle size via dynamic light scattering, the ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328216632444
更新日期：2016-07-01 00:00:00
abstract：:In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220952594
更新日期：2020-08-27 00:00:00
abstract：:The purpose of this study is the development of a nerve electrode that reorganizes nerve geometry slowly and controllably. The Flat Interface Nerve Electrode (FINE) can reshape the nerve into an elongated oval and provide selective stimulation. However, the rate of closure of this electrode is difficult to control. Th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208097426
更新日期：2009-09-01 00:00:00
abstract：:Among biomaterials used as implants in human body, sutures constitute the largest groups of materials having a huge market exceeding $1.3 billion annually. Sutures are the most widely used materials in wound closure and have been in use for many centuries. With the development of the synthetic absorbable polymer, poly...
journal_title：Journal of biomaterials applications
pub_type： 历史文章,杂志文章,评审
doi：10.1177/0885328210384890
更新日期：2010-11-01 00:00:00
abstract：:The aim of the in vitro study was a comparison of an allogenic (ABSM) and a xenogenic bone substitute material (XBSM) with and without injectable platelet-rich fibrin (ABSM-i-PRF & XBSM-i-PRF) on cell characteristics of human osteoblasts (HOB). Here, ABSM and XBSM (+ i-PRF = test; - i-PRF = control) were incubated wit...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220914407
更新日期：2020-07-01 00:00:00
abstract：:This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)-pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS-pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microen...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328206056771
更新日期：2007-01-01 00:00:00
abstract：:Using a hydraulic stress simulator, the mechanical behavior of the porcine pericardium used in the construction of cardiac valve leaflets was characterized following the same procedure employed with calf pericardium in Part 1 of this study. One hundred fifty pairs of tissue samples were subjected to tensile testing to...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1106/3JXM-UTPN-PXTG-72DT
更新日期：2001-07-01 00:00:00
abstract：:Nonviral gene delivery systems are finding widespread use due to their safety, rapid and economical production, and ease of modification. In this work, series of N-alkyl-substituted linear polyethylenimine (CP) polymers have been synthesized, characterized, and investigated about how degree of substitution (hydrophobi...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217710125
更新日期：2017-07-01 00:00:00
abstract：:Thrombosis is the most serious acute problem for small diameter arterial bypass grafts. In this research, small diameter expanded polytetrafluoroethylene (e-PTFE) vascular grafts were coated with acetylsalicylic acid (ASA) loaded poly (d,l-lactide) (PLA) by a solvent casting method. The feasibility and efficacy of thi...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829400800404
更新日期：1994-04-01 00:00:00
abstract：:Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211427774
更新日期：2013-03-01 00:00:00
abstract：:Staphylococcus epidermidis plays a major role in capsular contractures of silicone breast implants. This in vitro study evaluates the antibacterial effect of copper on S. epidermidis in silicone implants. Specimens of a silicone material used for breast augmentation (Cu0) and specimens coated with different copper con...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212441957
更新日期：2013-08-01 00:00:00
abstract：:A range of crystalline and nano-sized carbonate- and silicate-substituted hydroxyapatite has been successfully produced by using continuous hydrothermal flow synthesis technology. Ion-substituted calcium phosphates are better candidates for bone replacement applications (due to improved bioactivity) as compared to pha...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212460289
更新日期：2013-09-01 00:00:00
abstract：:While BMP-7 (OP-1) is one of the most potent growth factors in cartilage tissue engineering, the effects of exogenous low concentration BMP-7 on osteoarthritic chondrocytes are still unknown. Human osteoarthritic chondrocytes obtained from the femoral condyles of 10 patients were grown either in monolayer or in 3D col...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328210388439
更新日期：2012-03-01 00:00:00
abstract：:The animal immune response against Galα1,3-Galβ1-4GlcNAc-R(α-Gal) epitopes gives an important cause for the failure of glutaraldehyde(GA)-fixed cardiac xenografts. This study aimed to assess the in vivo effect of our novel combined anticalcification treatment, which includes immunologic modification, using α1,3-galact...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214552710
更新日期：2015-02-01 00:00:00
abstract：:To develop biocompatible composite microspheres for novel hemostatic use, we designed and prepared a novel biomaterial, composite microspheres consisting of carboxymethyl chitosan, sodium alginate, and collagen (CSCM). The ultra-structure of CSCM was investigated by scanning electron microscopy assay. In hemostatic fu...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215618354
更新日期：2016-02-01 00:00:00
abstract：:Eight different chemicals were investigated as potential candidate coupling agents for phosphate glass fibre reinforced polylactic acid composites. Evidence of reaction of the coupling agents with phosphate glass and their effect on surface wettability and glass degradation were studied along with their principle role...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212453634
更新日期：2013-09-01 00:00:00
abstract：:Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218759043
更新日期：2018-05-01 00:00:00
abstract：:Compounds of a silicone elastomer suitable for preparing maxillofacial prostheses, reinforced with various amounts of silica powder, have been studied for their mechanical response and wetting properties in terms of contact angle. Tensile strength and elongation at break showed an increase with increasing silica volum...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829801300104
更新日期：1998-07-01 00:00:00
abstract：:The aim of this study was to investigate the effect of C-Graft particles on formation of new cementum and bone in periodontal bone defects in dog. Healing and tissue change were histologically determined at 2, 4, 8, and 16 weeks. Little bone or cementum formation was observed in the control group. A statistically sign...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208094427
更新日期：2009-08-01 00:00:00
abstract：:Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215597818
更新日期：2015-11-01 00:00:00
abstract：:Phenylalanine ethyl ester (PAE)-alginate (Alg) conjugate (PAE-Alg, PEA) was synthesized and formation of an amide bond between PAE and Alg was confirmed by Fourier transformed-infrared and (1)H nuclear magnetic resonance spectroscopy. The degree of PAE substitution was 3.5-4.7 (PAE group per hundred sugar residues of ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328216630497
更新日期：2016-07-01 00:00:00
abstract：:Injectable thermo-sensitive hydrogels have a potential application in bone tissue engineering for their sensitivities and minimal invasive properties. Human dental pulp stem cells have been considered a promising tool for tissue reconstruction. The objective of this study was to investigate the proliferation and osteo...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328216661566
更新日期：2016-09-01 00:00:00
abstract：:The aim of this study was to design a new natural/synthetic bioactive bone scaffold for potential use in bone replacement applications. We developed a tri-component osteogenic composite scaffold made of collagen (Coll), hydroxyapatite (HA) and poly(l-lactide-co-ε-caprolactone) (PLCL). This Coll/HA/PLCL composite scaff...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213486705
更新日期：2014-02-01 00:00:00
abstract：:Single nanofibers with chemical and functional properties consistent with artery extracellular matrix nanofibers were produced by electrospinning. Using weight ratios to mimic artery extracellular matrix, five materials were tested: (1) Collagen type I, (2) Collagen type I + Collagen type III, (3) Collagen type I + po...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213477893
更新日期：2014-01-01 00:00:00
abstract：:Two series of glasses of general formula (2-p) SiO2.1.1Na2O.CaO.pP2O5.xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. Th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328207079731
更新日期：2008-05-01 00:00:00
abstract：:The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Quest...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212473510
更新日期：2014-01-01 00:00:00
abstract：:In this study, a phosphorylation treatment of porous anodic alumina (PAA) was performed by wet impregnation in phosphoric acid and a subsequent heat treatment. The PAA and phosphorylated PAA specimens were analyzed using a field emission scanning electron microscope, an energy-dispersive X-ray spectrometer, and Fourie...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214526765
更新日期：2014-09-01 00:00:00
abstract：:We assess the effects of chemical processing, ethylene oxide sterilization, and threading on bone surface and mechanical properties of bovine undecalcified bone screws. In addition, we evaluate the possibility of manufacturing bone screws with predefined dimensions. Scanning electronic microscopic images show that che...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208092110
更新日期：2009-03-01 00:00:00
abstract：:Biodegradable magnesium-based implants are currently being developed for use in orthopedic applications. The aim of this study was to investigate the acute, subacute, and chronic local effects on bone tissue as well as the systemic reactions to a magnesium-based (MgYREZr-alloy) screw containing rare earth elements. Th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212472215
更新日期：2014-01-01 00:00:00
