Bioactive polymers 55. Synthesis and characterization of a macromolecular drug based on 5-acetylamino-2-sulfamoyl-1,3,4-thiodiazole.


:The paper studies the coupling reaction by covalent bonding of acetylamino-2-sulfamoyl-1,3,4-thiodiazole (AcAA) on the poly(acrylic acid-costyrene) copolymer (PAcA-S) in homogeneous system, in the presence of dicyclohexylcarbodiimide (DCC) as activator. The influence of some factors on coupling efficiency (the drug/support ratio, time, volume of solvent), as well as the mathematical model correlating the amount of coupled drug with these parameters is established. Maximum amounts of drug (28%) are chemically bound when employing maximum values of the parameters mentioned (i.e., AcAA/PAcA-S ratio = 2 mole/mole; time = 50 h; THF volume = 60 ml). Physicochemical and spectral analyses evidence the existence of some chemical bonds of the -CO-NH-SO2-type between the macromolecular support and the drug. In vivo tests have demonstrated the gradual hydrolysis of the chemical bonds as well as the release of the drug, due to the diuretic effect produced.


J Biomater Appl


Dumitriu S,Popa M,Dărângă M,Dumitriu C




Has Abstract


1992-07-01 00:00:00












  • A clinical report of bone regeneration in maxillofacial surgery using bonelike synthetic bone graft.

    abstract::The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocol...

    journal_title:Journal of biomaterials applications

    pub_type: 临床试验,杂志文章


    authors: Sousa RC,Lobato JV,Maurício AC,Hussain NS,Botelho CM,Lopes MA,Santos JD

    更新日期:2008-01-01 00:00:00

  • Poly (γ-glutamic acid)/beta-TCP nanocomposites via in situ copolymerization: Preparation and characterization.

    abstract::A series biodegradable poly (γ-glutamic acid)/beta-tricalcium phosphate (γ-PGA/TCP) nanocomposites were prepared which were composed of poly-γ-glutamic acid polymerized in situ with β-tricalcium phosphate and physiochemically characterized as bone graft substitutes. The particle size via dynamic light scattering, the ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Shu XL,Shi QS,Feng J,Yang YH,Zhou G,Li WR

    更新日期:2016-07-01 00:00:00

  • Gold embedded chitosan nanoparticles with cell membrane mimetic polymer coating for pH-sensitive controlled drug release and cellular fluorescence imaging.

    abstract::In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Ma K,Cheng Y,Wei X,Chen D,Zhao X,Jia P

    更新日期:2020-08-27 00:00:00

  • A nerve cuff electrode for controlled reshaping of nerve geometry.

    abstract::The purpose of this study is the development of a nerve electrode that reorganizes nerve geometry slowly and controllably. The Flat Interface Nerve Electrode (FINE) can reshape the nerve into an elongated oval and provide selective stimulation. However, the rate of closure of this electrode is difficult to control. Th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Caparso AV,Durand DM,Mansour JM

    更新日期:2009-09-01 00:00:00

  • Review paper: absorbable polymeric surgical sutures: chemistry, production, properties, biodegradability, and performance.

    abstract::Among biomaterials used as implants in human body, sutures constitute the largest groups of materials having a huge market exceeding $1.3 billion annually. Sutures are the most widely used materials in wound closure and have been in use for many centuries. With the development of the synthetic absorbable polymer, poly...

    journal_title:Journal of biomaterials applications

    pub_type: 历史文章,杂志文章,评审


    authors: Pillai CK,Sharma CP

    更新日期:2010-11-01 00:00:00

  • Combination of an allogenic and a xenogenic bone substitute material with injectable platelet-rich fibrin - A comparative in vitro study.

    abstract::The aim of the in vitro study was a comparison of an allogenic (ABSM) and a xenogenic bone substitute material (XBSM) with and without injectable platelet-rich fibrin (ABSM-i-PRF & XBSM-i-PRF) on cell characteristics of human osteoblasts (HOB). Here, ABSM and XBSM (+ i-PRF = test; - i-PRF = control) were incubated wit...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Kyyak S,Blatt S,Pabst A,Thiem D,Al-Nawas B,Kämmerer PW

    更新日期:2020-07-01 00:00:00

  • Properties of tableted high-amylose corn starch-pectin blend microparticles intended for controlled delivery of diclofenac sodium.

    abstract::This study reports the properties of tableted microparticles based on high-amylose corn starch (HACS)-pectin blend polymers as the controlled release system for diclofenac sodium (DS). HACS-pectin blend microparticles are prepared through a modified process by the spray drying technique, which is a widely used microen...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Desai KG

    更新日期:2007-01-01 00:00:00

  • Influence of the selection of the suture material on the mechanical behavior of a biomaterial to be employed in the construction of implants. Part 2: Porcine pericardium.

    abstract::Using a hydraulic stress simulator, the mechanical behavior of the porcine pericardium used in the construction of cardiac valve leaflets was characterized following the same procedure employed with calf pericardium in Part 1 of this study. One hundred fifty pairs of tissue samples were subjected to tensile testing to...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: García Páez JM,Carrera A,Herrero EJ,Millán I,Rocha A,Cordón A,Sainz N,Mendez J,Castillo-Olivares JL

    更新日期:2001-07-01 00:00:00

  • Engineered polymeric amphiphiles self-assembling into nanostructures and acting as efficient gene and drug carriers.

    abstract::Nonviral gene delivery systems are finding widespread use due to their safety, rapid and economical production, and ease of modification. In this work, series of N-alkyl-substituted linear polyethylenimine (CP) polymers have been synthesized, characterized, and investigated about how degree of substitution (hydrophobi...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Bansal R,Kumar P

    更新日期:2017-07-01 00:00:00

  • Effect of controlled local acetylsalicylic acid release on in vitro platelet adhesion to vascular grafts.

    abstract::Thrombosis is the most serious acute problem for small diameter arterial bypass grafts. In this research, small diameter expanded polytetrafluoroethylene (e-PTFE) vascular grafts were coated with acetylsalicylic acid (ASA) loaded poly (d,l-lactide) (PLA) by a solvent casting method. The feasibility and efficacy of thi...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Hall JD,Rittgers SE,Schmidt SP

    更新日期:1994-04-01 00:00:00

  • Cell survival and proliferation after encapsulation in a chemically modified Pluronic(R) F127 hydrogel.

    abstract::Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Lippens E,Swennen I,Gironès J,Declercq H,Vertenten G,Vlaminck L,Gasthuys F,Schacht E,Cornelissen R

    更新日期:2013-03-01 00:00:00

  • Effectiveness of antibacterial copper additives in silicone implants.

    abstract::Staphylococcus epidermidis plays a major role in capsular contractures of silicone breast implants. This in vitro study evaluates the antibacterial effect of copper on S. epidermidis in silicone implants. Specimens of a silicone material used for breast augmentation (Cu0) and specimens coated with different copper con...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Gosau M,Bürgers R,Vollkommer T,Holzmann T,Prantl L

    更新日期:2013-08-01 00:00:00

  • Rapid hydrothermal flow synthesis and characterisation of carbonate- and silicate-substituted calcium phosphates.

    abstract::A range of crystalline and nano-sized carbonate- and silicate-substituted hydroxyapatite has been successfully produced by using continuous hydrothermal flow synthesis technology. Ion-substituted calcium phosphates are better candidates for bone replacement applications (due to improved bioactivity) as compared to pha...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Chaudhry AA,Knowles JC,Rehman I,Darr JA

    更新日期:2013-09-01 00:00:00

  • Effects of low concentration BMP-7 on human osteoarthritic chondrocytes: comparison of different applications.

    abstract::While BMP-7 (OP-1) is one of the most potent growth factors in cartilage tissue engineering, the effects of exogenous low concentration BMP-7 on osteoarthritic chondrocytes are still unknown. Human osteoarthritic chondrocytes obtained from the femoral condyles of 10 patients were grown either in monolayer or in 3D col...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Gavenis K,Heussen N,Schmidt-Rohlfing B

    更新日期:2012-03-01 00:00:00

  • In vivo efficacy for novel combined anticalcification treatment of glutaraldehyde-fixed cardiac xenograft using humanized mice.

    abstract::The animal immune response against Galα1,3-Galβ1-4GlcNAc-R(α-Gal) epitopes gives an important cause for the failure of glutaraldehyde(GA)-fixed cardiac xenografts. This study aimed to assess the in vivo effect of our novel combined anticalcification treatment, which includes immunologic modification, using α1,3-galact...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Lim HG,Choi SY,Jeong S,Shin JS,Park CG,Kim YJ

    更新日期:2015-02-01 00:00:00

  • Microspheres of carboxymethyl chitosan, sodium alginate and collagen for a novel hemostatic in vitro study.

    abstract::To develop biocompatible composite microspheres for novel hemostatic use, we designed and prepared a novel biomaterial, composite microspheres consisting of carboxymethyl chitosan, sodium alginate, and collagen (CSCM). The ultra-structure of CSCM was investigated by scanning electron microscopy assay. In hemostatic fu...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Shi X,Fang Q,Ding M,Wu J,Ye F,Lv Z,Jin J

    更新日期:2016-02-01 00:00:00

  • Investigating the use of coupling agents to improve the interfacial properties between a resorbable phosphate glass and polylactic acid matrix.

    abstract::Eight different chemicals were investigated as potential candidate coupling agents for phosphate glass fibre reinforced polylactic acid composites. Evidence of reaction of the coupling agents with phosphate glass and their effect on surface wettability and glass degradation were studied along with their principle role...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Hasan MS,Ahmed I,Parsons AJ,Rudd CD,Walker GS,Scotchford CA

    更新日期:2013-09-01 00:00:00

  • Influence of MMP inhibitor GM6001 loading of fibre coated polypropylene meshes on wound healing: Implications for hernia repair.

    abstract::Polypropylene meshes are standard for hernia repair. Matrix metalloproteinases play a central role in inflammation. To reduce the inflammatory response and improve remodelling with an associated reduction of hernia recurrence, we modified polypropylene meshes by nanofibre coating and saturation with the broad-spectrum...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Böhm G,Groll J,Heffels KH,Heussen N,Ink P,Alizai HP,Neumann UP,Schnabel R,Mirastschijski U

    更新日期:2018-05-01 00:00:00

  • Properties of maxillofacial silicone elastomers reinforced with silica powder.

    abstract::Compounds of a silicone elastomer suitable for preparing maxillofacial prostheses, reinforced with various amounts of silica powder, have been studied for their mechanical response and wetting properties in terms of contact angle. Tensile strength and elongation at break showed an increase with increasing silica volum...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Andreopoulos AG,Evangelatou M,Tarantili PA

    更新日期:1998-07-01 00:00:00

  • C-Graft in regeneration of periodontal tissue in intrabony periodontal defect in dog.

    abstract::The aim of this study was to investigate the effect of C-Graft particles on formation of new cementum and bone in periodontal bone defects in dog. Healing and tissue change were histologically determined at 2, 4, 8, and 16 weeks. Little bone or cementum formation was observed in the control group. A statistically sign...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Nakanishi S,Ota M,Shibukawa Y,Yamada S

    更新日期:2009-08-01 00:00:00

  • Optimising contraction and alignment of cellular collagen hydrogels to achieve reliable and consistent engineered anisotropic tissue.

    abstract::Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: O'Rourke C,Drake RA,Cameron GW,Loughlin AJ,Phillips JB

    更新日期:2015-11-01 00:00:00

  • Nanoparticles based on phenylalanine ethyl ester-alginate conjugate as vitamin B2 delivery system.

    abstract::Phenylalanine ethyl ester (PAE)-alginate (Alg) conjugate (PAE-Alg, PEA) was synthesized and formation of an amide bond between PAE and Alg was confirmed by Fourier transformed-infrared and (1)H nuclear magnetic resonance spectroscopy. The degree of PAE substitution was 3.5-4.7 (PAE group per hundred sugar residues of ...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Zhang P,Zhao SR,Li JX,Hong L,Raja MA,Yu LJ,Liu CG

    更新日期:2016-07-01 00:00:00

  • In vitro proliferation and osteogenic differentiation of human dental pulp stem cells in injectable thermo-sensitive chitosan/β-glycerophosphate/hydroxyapatite hydrogel.

    abstract::Injectable thermo-sensitive hydrogels have a potential application in bone tissue engineering for their sensitivities and minimal invasive properties. Human dental pulp stem cells have been considered a promising tool for tissue reconstruction. The objective of this study was to investigate the proliferation and osteo...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Chen Y,Zhang F,Fu Q,Liu Y,Wang Z,Qi N

    更新日期:2016-09-01 00:00:00

  • Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (L-lactide-co-ε-caprolactone) scaffold.

    abstract::The aim of this study was to design a new natural/synthetic bioactive bone scaffold for potential use in bone replacement applications. We developed a tri-component osteogenic composite scaffold made of collagen (Coll), hydroxyapatite (HA) and poly(l-lactide-co-ε-caprolactone) (PLCL). This Coll/HA/PLCL composite scaff...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Akkouch A,Zhang Z,Rouabhia M

    更新日期:2014-02-01 00:00:00

  • Properties of single electrospun poly (diol citrate)-collagen-proteoglycan nanofibers for arterial repair and in applications requiring viscoelasticity.

    abstract::Single nanofibers with chemical and functional properties consistent with artery extracellular matrix nanofibers were produced by electrospinning. Using weight ratios to mimic artery extracellular matrix, five materials were tested: (1) Collagen type I, (2) Collagen type I + Collagen type III, (3) Collagen type I + po...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Liu J,Argenta L,Morykwas M,Wagner WD

    更新日期:2014-01-01 00:00:00

  • Properties of zinc releasing surfaces for clinical applications.

    abstract::Two series of glasses of general formula (2-p) SiO2.1.1Na2O.CaO.pP2O5.xZnO (p=0.10, 0.20; x=0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblast-like cells behavior when cultured on them. Th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Lusvardi G,Malavasi G,Menabue L,Menziani MC,Pedone A,Segre U,Aina V,Perardi A,Morterra C,Boccafoschi F,Gatti S,Bosetti M,Cannas M

    更新日期:2008-05-01 00:00:00

  • Novel contributions on luminescent apatite-based colloids intended for medical imaging.

    abstract::The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Quest...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Al-Kattan A,Santran V,Dufour P,Dexpert-Ghys J,Drouet C

    更新日期:2014-01-01 00:00:00

  • In vitro apatite formation on porous anodic alumina induced by a phosphorylation treatment.

    abstract::In this study, a phosphorylation treatment of porous anodic alumina (PAA) was performed by wet impregnation in phosphoric acid and a subsequent heat treatment. The PAA and phosphorylated PAA specimens were analyzed using a field emission scanning electron microscope, an energy-dispersive X-ray spectrometer, and Fourie...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Li X,Ni S,Webster TJ

    更新日期:2014-09-01 00:00:00

  • Bovine bone screws: metrology and effects of chemical processing and ethylene oxide sterilization on bone surface and mechanical properties.

    abstract::We assess the effects of chemical processing, ethylene oxide sterilization, and threading on bone surface and mechanical properties of bovine undecalcified bone screws. In addition, we evaluate the possibility of manufacturing bone screws with predefined dimensions. Scanning electronic microscopic images show that che...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Haje DP,Volpon JB,Moro CA

    更新日期:2009-03-01 00:00:00

  • In vivo study of a biodegradable orthopedic screw (MgYREZr-alloy) in a rabbit model for up to 12 months.

    abstract::Biodegradable magnesium-based implants are currently being developed for use in orthopedic applications. The aim of this study was to investigate the acute, subacute, and chronic local effects on bone tissue as well as the systemic reactions to a magnesium-based (MgYREZr-alloy) screw containing rare earth elements. Th...

    journal_title:Journal of biomaterials applications

    pub_type: 杂志文章


    authors: Waizy H,Diekmann J,Weizbauer A,Reifenrath J,Bartsch I,Neubert V,Schavan R,Windhagen H

    更新日期:2014-01-01 00:00:00