Abstract：
:Regulation of hematopoietic stem cell (HSC) dormancy by specific cell types in the hematopoietic niche remains poorly understood. Yamazaki et al. (2011) now report that nerve-associated nonmyelinating Schwann cells activate TGF-β to maintain dormant HSCs, suggesting that glia are novel players in the bone marrow niche.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Brückner Kdoi
10.1016/j.stem.2011.11.016subject
Has Abstractpub_date
2011-12-02 00:00:00pages
493-5issue
6eissn
1934-5909issn
1875-9777pii
S1934-5909(11)00544-3journal_volume
9pub_type
评论,杂志文章相关文献
Cell Stem Cell文献大全abstract：:Individuals with neurofibromatosis type 1 (NF1) develop abnormalities of both neuronal and glial cell lineages, suggesting that the NF1 protein neurofibromin is an essential regulator of neuroglial progenitor function. In this regard, Nf1-deficient embryonic telencephalic neurospheres exhibit increased self-renewal an...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2007.07.008
更新日期：2007-10-11 00:00:00
abstract：:Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) should provide a robust means to assess whether the genomes of these cells have similar pluripotent states. Recent studies have suggested that ESCs and iPSCs...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2010.06.015
更新日期：2010-08-06 00:00:00
abstract：:Erythropoietin, the red blood cell-making cytokine, is also a potential cytoprotective agent in heart disease. In this issue of Cell Stem Cell, Hoch et al. (2011) use two heart failure models, including chemotherapeutic cardiotoxicity, to reveal a mechanistic connection between reduced cardiomyocyte production of eryt...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2011.07.008
更新日期：2011-08-05 00:00:00
abstract：:Mouse embryonic stem cells (mESCs) cultured under serum/LIF conditions exhibit heterogeneous expression of pluripotency-associated factors that can be overcome by two inhibitors (2i) of the MEK and GSK3 pathways. Several studies have shown that the "ground state" induced by 2i is characterized by global hypomethylatio...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.07.005
更新日期：2015-10-01 00:00:00
abstract：:In this issue of Cell Stem Cell, Wang et al. (2014) describe a signaling axis present in bone marrow stromal cells that suppresses inflammation and myeloid expansions. Loss of endothelial Notch signaling leads to deregulation of miR-155 expression, activation of NF-kB, and increased proinflammatory cytokine production...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2014.06.010
更新日期：2014-07-03 00:00:00
abstract：:Steroid hormones are known systemic regulators of multiple normal and cancerous tissues; however, whether or how they impact the fate and function of adult stem cells is unclear. In the Drosophila ovary, insulin signals modulate the proliferation and self-renewal of germline stem cells (GSCs), yet despite evidence tha...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2010.10.001
更新日期：2010-11-05 00:00:00
abstract：:Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation. Here, we present a fully automated, HTS-compatible platform for enhanced differentiation and...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2018.04.022
更新日期：2018-06-01 00:00:00
abstract：:Technological limitations have hampered understanding of how individual molecules, including putative stem cell regulators, are distributed throughout tissues and stem cell niches. Here, we report adaptation of the proximity ligation assay (PLA) for large-volume, in situ imaging of individual proteins with multiple ad...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2019.10.003
更新日期：2019-12-05 00:00:00
abstract：:Understanding the development and maintenance of dopamine neurons is essential to establish novel stem cell therapies and animal models of Parkinson's disease. A recent PLoS Biology report (Kittappa et al., 2007) reveals that Foxa2 regulates dopamine neuron generation and differentiation, and that aging foxa2(+/-) mic...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2008.01.012
更新日期：2008-02-07 00:00:00
abstract：:To assess the genetic consequences of induced pluripotent stem cell (iPSC) reprogramming, we sequenced the genomes of ten murine iPSC clones derived from three independent reprogramming experiments, and compared them to their parental cell genomes. We detected hundreds of single nucleotide variants (SNVs) in every clo...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2012.03.002
更新日期：2012-05-04 00:00:00
abstract：VIDEO ABSTRACT:Although endogenous recruitment of adult neural stem cells has been proposed as a therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that metformin, a widely used drug, promotes neurogenesis and enhances spatial memory formation. Specifically, we show that an atypical...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2012.03.016
更新日期：2012-07-06 00:00:00
abstract：:Rapid progress has recently been made regarding how the niche controls stem cell function, but little is yet known about how stem cells in the same niche interact with one another. In this study, we show that differentiation-defective Drosophila ovarian germline stem cells (GSCs) can outcompete normal ones for niche o...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2007.10.021
更新日期：2008-01-10 00:00:00
abstract：:The CRISPR-Cas9 system has been employed to generate mutant alleles in a range of different organisms. However, so far there have not been reports of use of this system for efficient correction of a genetic disease. Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2013.10.016
更新日期：2013-12-05 00:00:00
abstract：:Over the past decade, our growing understanding of cancer stem cell characteristics and function continues to guide innovative new treatments to eradicate cancer. For our tenth anniversary, we asked authors who cited a selection of our most popular papers in this area about the broad influences these studies have had....
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2017.05.005
更新日期：2017-06-01 00:00:00
abstract：:Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et al. (2012a) and Wu et al. (2013) define functionally distinct roles for canonical and noncanonica...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2013.01.014
更新日期：2013-02-07 00:00:00
abstract：:Renal pathology suggests that tubular repair results from tubular proliferation. In contrast, recent studies propose that postnatal kidney repair may involve renal stem cells. In this issue of Cell Stem Cell, Humphreys et al. (2008) use lineage tracing to genetically assess contribution of adult nontubular cells (pote...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2008.02.007
更新日期：2008-03-06 00:00:00
abstract：:In Nature Medicine, Pollyea et al. (2018) recently reported a remarkable overall response of newly diagnosed elderly acute myeloid leukemia patients to a venetoclax and azacitidine combination in a new clinical trial. This treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cyc...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2018.12.005
更新日期：2019-01-03 00:00:00
abstract：:The emerging field of regenerative rehabilitation integrates biological and bioengineering advances in regenerative medicine with rehabilitative sciences. Here we highlight recent stem cell-based examples of the regenerative rehabilitation paradigm to promote tissue repair and regeneration, and we discuss remaining ch...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2018.02.003
更新日期：2018-03-01 00:00:00
abstract：:Substantial expansion in the number of cerebral cortex neurons is thought to underlie cognitive differences between humans and other primates, although the mechanisms underlying this expansion are unclear. Otani et al. (2016) utilize PSC-derived brain organoids to study how species-specific differences in cortical pro...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2016.03.017
更新日期：2016-04-07 00:00:00
abstract：:Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer; however, their clinical application has been hindered by their low numbers in cancer patients. Here, we developed a proof-of-concept for hematopoietic stem cell-engineered iNKT (HSC-iNKT) cell therapy with the potential to provide th...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2019.08.004
更新日期：2019-10-03 00:00:00
abstract：:Adult germline stem cells (AGSCs) self-renew (Thy1(+) enriched) or commit to gametogenesis (Kit(+) enriched). To better understand how chromatin regulates AGSC biology and gametogenesis, we derived stage-specific high-resolution profiles of DNA methylation, 5hmC, histone modifications/variants, and RNA-seq in AGSCs an...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2014.04.006
更新日期：2014-08-07 00:00:00
abstract：:Developing technologies for efficient and scalable disruption of gene expression will provide powerful tools for studying gene function, developmental pathways, and disease mechanisms. Here, we develop clustered regularly interspaced short palindromic repeat interference (CRISPRi) to repress gene expression in human i...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2016.01.022
更新日期：2016-04-07 00:00:00
abstract：:Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit fr...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2014.11.011
更新日期：2014-12-04 00:00:00
abstract：:Trophoblast stem cells (TSCs) arise from the first cell fate decision in the developing embryo and generate extra-embryonic lineages, giving rise to the fetal portion of the placenta. Mouse embryonic and extra-embryonic lineages are strictly separated by a distinct epigenetic barrier, which is not fully overcome follo...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.08.005
更新日期：2015-11-05 00:00:00
abstract：:Chimeras are individuals with tissues derived from more than one zygote. Interspecific chimeras have tissues derived from different species. The biological consequences of human-animal chimeras have become an issue of ethical debate. Ironically, human-animal chimeras with human blood, neurons, germ cells, and other ti...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2007.07.021
更新日期：2007-09-13 00:00:00
abstract：:Fetal gene therapy using safe and effective viral vectors no longer remains a distant prospect. Recently in Nature Medicine, Massaro et al. (2018) demonstrated that prenatal intracranial injection of a viral vector results in improved neurologic function, raising the intriguing possibility that in utero gene therapy m...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2018.08.010
更新日期：2018-09-06 00:00:00
abstract：:Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determina...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2015.06.011
更新日期：2015-07-02 00:00:00
abstract：:As a response against serious infection, there is often a need to produce more leukocytes to defend the organism against the infectious agent. In this issue of Cell Stem Cell, Goodell and colleagues (Feng et al., 2008) find a link between regulators of host defense and hematopoietic stem cells. ...
journal_title：Cell stem cell
pub_type： 评论,社论
doi：10.1016/j.stem.2007.12.002
更新日期：2008-01-10 00:00:00
abstract：:We have recently demonstrated that reactive glial cells can be directly reprogrammed into functional neurons by a single neural transcription factor, NeuroD1. Here we report that a combination of small molecules can also reprogram human astrocytes in culture into fully functional neurons. We demonstrate that sequentia...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.09.012
更新日期：2015-12-03 00:00:00
abstract：:Recurrent mutations in cohesin complex proteins have been identified in pre-leukemic hematopoietic stem cells and during the early development of acute myeloid leukemia and other myeloid malignancies. Although cohesins are involved in chromosome separation and DNA damage repair, cohesin complex functions during hemato...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.09.017
更新日期：2015-12-03 00:00:00
