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Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary.

Abstract：

:Rapid progress has recently been made regarding how the niche controls stem cell function, but little is yet known about how stem cells in the same niche interact with one another. In this study, we show that differentiation-defective Drosophila ovarian germline stem cells (GSCs) can outcompete normal ones for niche occupancy in a cadherin-dependent manner. The differentiation-defective bam or bgcn mutant GSCs invade the niche space of neighboring wild-type GSCs and gradually push them out of the niche by upregulating E-cadherin expression. Furthermore, the bam/bgcn-mediated GSC competition requires E-cadherin and normal GSC division, but not the self-renewal-promoting BMP niche signal, while different E-cadherin levels can sufficiently stimulate GSC competition. Therefore, we propose that GSCs have a competitive relationship for niche occupancy, which may serve as a quality control mechanism to ensure that accidentally differentiated stem cells are rapidly removed from the niche and replaced by functional ones.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Jin Z,Kirilly D,Weng C,Kawase E,Song X,Smith S,Schwartz J,Xie T

doi

10.1016/j.stem.2007.10.021

subject

Has Abstract

pub_date

2008-01-10 00:00:00

pages

39-49

issue

1

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(07)00238-X

journal_volume

2

pub_type

杂志文章

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