A "complex" issue: deciphering the role of variant PRC1 in ESCs.

Abstract:

:Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et al. (2012a) and Wu et al. (2013) define functionally distinct roles for canonical and noncanonical PRC1 in ESCs.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Turner SA,Bracken AP

doi

10.1016/j.stem.2013.01.014

subject

Has Abstract

pub_date

2013-02-07 00:00:00

pages

145-6

issue

2

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(13)00017-9

journal_volume

12

pub_type

评论,杂志文章
  • Correction of a genetic disease in mouse via use of CRISPR-Cas9.

    abstract::The CRISPR-Cas9 system has been employed to generate mutant alleles in a range of different organisms. However, so far there have not been reports of use of this system for efficient correction of a genetic disease. Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2013.10.016

    authors: Wu Y,Liang D,Wang Y,Bai M,Tang W,Bao S,Yan Z,Li D,Li J

    更新日期:2013-12-05 00:00:00

  • A 3D Tissue-wide Digital Imaging Pipeline for Quantitation of Secreted Molecules Shows Absence of CXCL12 Gradients in Bone Marrow.

    abstract::Technological limitations have hampered understanding of how individual molecules, including putative stem cell regulators, are distributed throughout tissues and stem cell niches. Here, we report adaptation of the proximity ligation assay (PLA) for large-volume, in situ imaging of individual proteins with multiple ad...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.10.003

    authors: Kunz L,Schroeder T

    更新日期:2019-12-05 00:00:00

  • Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming.

    abstract::Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from a cardiac fibroblast toward an induced cardiomyocyte, we performed c...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.06.012

    authors: Stone NR,Gifford CA,Thomas R,Pratt KJB,Samse-Knapp K,Mohamed TMA,Radzinsky EM,Schricker A,Ye L,Yu P,van Bemmel JG,Ivey KN,Pollard KS,Srivastava D

    更新日期:2019-07-03 00:00:00

  • Single-Cell RNA-Seq Analysis Maps Development of Human Germline Cells and Gonadal Niche Interactions.

    abstract::Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for maintenance of the species. However, the developmental trajectories and heterogeneity of human FGCs remain largely unknown. Here we performed single-cell RNA-seq analysis of over 2,000 FGCs and their gonadal niche cells in female and ma...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2017.03.007

    authors: Li L,Dong J,Yan L,Yong J,Liu X,Hu Y,Fan X,Wu X,Guo H,Wang X,Zhu X,Li R,Yan J,Wei Y,Zhao Y,Wang W,Ren Y,Yuan P,Yan Z,Hu B,Guo F,Wen L,Tang F,Qiao J

    更新日期:2017-06-01 00:00:00

  • Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development.

    abstract::Human disease phenotypes associated with haploinsufficient gene requirements are often not recapitulated well in animal models. Here, we have investigated the association between human GATA6 haploinsufficiency and a wide range of clinical phenotypes that include neonatal and adult-onset diabetes using CRISPR (clustere...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2017.01.001

    authors: Shi ZD,Lee K,Yang D,Amin S,Verma N,Li QV,Zhu Z,Soh CL,Kumar R,Evans T,Chen S,Huangfu D

    更新日期:2017-05-04 00:00:00

  • Policy uncertainty and the conduct of stem cell research.

    abstract::A survey of U.S. stem cell scientists shows that uncertainty following the legal challenge to the Obama Administration's hESC research policy has negative scientific and economic impacts and affects a range of stem cell scientists, not just those working with hESCs. The international implications of these results are ...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2011.01.002

    authors: Levine AD

    更新日期:2011-02-04 00:00:00

  • High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping.

    abstract::Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation. Here, we present a fully automated, HTS-compatible platform for enhanced differentiation and...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2018.04.022

    authors: Czerniecki SM,Cruz NM,Harder JL,Menon R,Annis J,Otto EA,Gulieva RE,Islas LV,Kim YK,Tran LM,Martins TJ,Pippin JW,Fu H,Kretzler M,Shankland SJ,Himmelfarb J,Moon RT,Paragas N,Freedman BS

    更新日期:2018-06-01 00:00:00

  • Hair follicle epithelial stem cells get their sox on.

    abstract::Sox family transcription factors have emerged as key regulators of multiple developmental processes, including fate determination and differentiation in multiple tissues. In this issue of Cell Stem Cell, Nowak et al. (2008) implicate Sox9 in the specification of early hair follicle stem cells and subsequent epithelial...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2008.06.014

    authors: Christiano AM

    更新日期:2008-07-03 00:00:00

  • Profiling identifies precursor suspects: notch family again!

    abstract::Newborn neurons in the adult dentate gyrus pass through several distinct precursor and progenitor classes prior to differentiation. In this issue of Cell Stem Cell, Lugert et al. (2010) characterized their strikingly different proliferative behaviors after neurogenic stimuli or aging. ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2010.04.006

    authors: Breunig JJ,Rakic P

    更新日期:2010-05-07 00:00:00

  • Illuminating the Properties of Prostate Luminal Progenitors.

    abstract::The identification of tumor-initiating cells represents a significant challenge for studies of prostate cancer. In a recent issue of Cell Reports, Agarwal and colleagues use organoid culture to ascertain two distinct luminal progenitors in a mouse model of prostate cancer, shedding new light on lineage relationships i...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2015.11.018

    authors: Shen MM

    更新日期:2015-12-03 00:00:00

  • Erosion of dosage compensation impacts human iPSC disease modeling.

    abstract::Although distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear whether such variability impacts their utility for disease modeling. Here, we show that although low-passage female hiPSCs retain the inactive X chromosome of the somatic cell they are...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2012.02.014

    authors: Mekhoubad S,Bock C,de Boer AS,Kiskinis E,Meissner A,Eggan K

    更新日期:2012-05-04 00:00:00

  • In epigenetic therapy, less is more.

    abstract::How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells. ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2012.03.012

    authors: Shen H,Laird PW

    更新日期:2012-04-06 00:00:00

  • Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts.

    abstract::Trophoblast stem cells (TSCs) arise from the first cell fate decision in the developing embryo and generate extra-embryonic lineages, giving rise to the fetal portion of the placenta. Mouse embryonic and extra-embryonic lineages are strictly separated by a distinct epigenetic barrier, which is not fully overcome follo...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2015.08.005

    authors: Kubaczka C,Senner CE,Cierlitza M,Araúzo-Bravo MJ,Kuckenberg P,Peitz M,Hemberger M,Schorle H

    更新日期:2015-11-05 00:00:00

  • Engineering Hematopoietic Stem Cells: Lessons from Development.

    abstract::Cell engineering has brought us tantalizingly close to the goal of deriving patient-specific hematopoietic stem cells (HSCs). While directed differentiation and transcription factor-mediated conversion strategies have generated progenitor cells with multilineage potential, to date, therapy-grade engineered HSCs remain...

    journal_title:Cell stem cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.stem.2016.05.016

    authors: Rowe RG,Mandelbaum J,Zon LI,Daley GQ

    更新日期:2016-06-02 00:00:00

  • Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification.

    abstract::The metabolic state of quiescent hematopoietic stem cells (HSCs) is an important regulator of self-renewal, but it is unclear whether or how metabolic parameters contribute to HSC lineage specification and commitment. Here, we show that the commitment of human and murine HSCs to the erythroid lineage is dependent upon...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2014.06.002

    authors: Oburoglu L,Tardito S,Fritz V,de Barros SC,Merida P,Craveiro M,Mamede J,Cretenet G,Mongellaz C,An X,Klysz D,Touhami J,Boyer-Clavel M,Battini JL,Dardalhon V,Zimmermann VS,Mohandas N,Gottlieb E,Sitbon M,Kinet S,Taylo

    更新日期:2014-08-07 00:00:00

  • Growth signaling at the nexus of stem cell life and death.

    abstract::Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with age. In this issue of Cell Stem Cell and in Nature, Castilho et al. (2009) and Harrison et al. (2009) highlight the importance of mTOR signaling in stem cell exhaustion and mammalian aging, respectively. ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2009.08.008

    authors: Wood KC,Sabatini DM

    更新日期:2009-09-04 00:00:00

  • Coordination of satellite cell activation and self-renewal by Par-complex-dependent asymmetric activation of p38α/β MAPK.

    abstract::In response to muscle injury, satellite cells activate the p38α/β MAPK pathway to exit quiescence, then proliferate, repair skeletal muscle, and self-renew, replenishing the quiescent satellite cell pool. Although satellite cells are capable of asymmetric division, the mechanisms regulating satellite cell self-renewal...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2012.05.025

    authors: Troy A,Cadwallader AB,Fedorov Y,Tyner K,Tanaka KK,Olwin BB

    更新日期:2012-10-05 00:00:00

  • Stress Can Be a Good Thing for Blood Formation.

    abstract::Like politics, most developmental signals are local. However, in this issue of Cell Stem Cell, Kwan et al. (2016) and colleagues describe how a stress-induced signal that originates in the zebrafish brain promotes the formation of blood at a distant site, the dorsal aorta. ...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2016.08.011

    authors: Speck NA

    更新日期:2016-09-01 00:00:00

  • A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening.

    abstract::Gastric cancer displays marked molecular heterogeneity with aggressive behavior and treatment resistance. Therefore, good in vitro models that encompass unique subtypes are urgently needed for precision medicine development. Here, we have established a primary gastric cancer organoid (GCO) biobank that comprises norma...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2018.09.016

    authors: Yan HHN,Siu HC,Law S,Ho SL,Yue SSK,Tsui WY,Chan D,Chan AS,Ma S,Lam KO,Bartfeld S,Man AHY,Lee BCH,Chan ASY,Wong JWH,Cheng PSW,Chan AKW,Zhang J,Shi J,Fan X,Kwong DLW,Mak TW,Yuen ST,Clevers H,Leung SY

    更新日期:2018-12-06 00:00:00

  • Adult neural stem cells bridge their niche.

    abstract::Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranula...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2012.05.012

    authors: Fuentealba LC,Obernier K,Alvarez-Buylla A

    更新日期:2012-06-14 00:00:00

  • Self-Organizing 3D Human Trunk Neuromuscular Organoids.

    abstract::Neuromuscular networks assemble during early human embryonic development and are essential for the control of body movement. Previous neuromuscular junction modeling efforts using human pluripotent stem cells (hPSCs) generated either spinal cord neurons or skeletal muscles in monolayer culture. Here, we use hPSC-deriv...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2019.12.007

    authors: Faustino Martins JM,Fischer C,Urzi A,Vidal R,Kunz S,Ruffault PL,Kabuss L,Hube I,Gazzerro E,Birchmeier C,Spuler S,Sauer S,Gouti M

    更新日期:2020-02-06 00:00:00

  • Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification.

    abstract::During embryonic development, multipotent cardiovascular progenitor cells are specified from early mesoderm. Using mouse ESCs in which gene expression can be temporally regulated, we have found that transient expression of Mesp1 dramatically accelerates and enhances multipotent cardiovascular progenitor specification ...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2008.06.009

    authors: Bondue A,Lapouge G,Paulissen C,Semeraro C,Iacovino M,Kyba M,Blanpain C

    更新日期:2008-07-03 00:00:00

  • Chromatin and transcription transitions of mammalian adult germline stem cells and spermatogenesis.

    abstract::Adult germline stem cells (AGSCs) self-renew (Thy1(+) enriched) or commit to gametogenesis (Kit(+) enriched). To better understand how chromatin regulates AGSC biology and gametogenesis, we derived stage-specific high-resolution profiles of DNA methylation, 5hmC, histone modifications/variants, and RNA-seq in AGSCs an...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2014.04.006

    authors: Hammoud SS,Low DH,Yi C,Carrell DT,Guccione E,Cairns BR

    更新日期:2014-08-07 00:00:00

  • Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

    abstract::Despite widespread interest in using human induced pluripotent stem cells (hiPSCs) in neurological disease modeling, a suitable model system to study human neuronal connectivity is lacking. Here, we report a comprehensive and efficient differentiation paradigm for hiPSCs that generate multiple CA3 pyramidal neuron sub...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2018.04.009

    authors: Sarkar A,Mei A,Paquola ACM,Stern S,Bardy C,Klug JR,Kim S,Neshat N,Kim HJ,Ku M,Shokhirev MN,Adamowicz DH,Marchetto MC,Jappelli R,Erwin JA,Padmanabhan K,Shtrahman M,Jin X,Gage FH

    更新日期:2018-05-03 00:00:00

  • Wnt-related molecules and signaling pathway equilibrium in hematopoiesis.

    abstract::There is near consensus that Wnt family molecules establish important gradients within niches where hematopoietic stem cells (HSC) reside. We review recent papers suggesting that a delicate balance is required between competing Wnt ligands and corresponding signaling pathways to maintain HSC integrity. Some steps in t...

    journal_title:Cell stem cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.stem.2008.12.004

    authors: Malhotra S,Kincade PW

    更新日期:2009-01-09 00:00:00

  • Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma.

    abstract::Functionally relevant markers of glioblastoma stem-like cells (GSCs) have potential for therapeutic targeting to treat this aggressive disease. Here we used generation and screening of thousands of monoclonal antibodies to search for receptors and signaling pathways preferentially enriched in GSCs. We identified integ...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2017.04.009

    authors: Haas TL,Sciuto MR,Brunetto L,Valvo C,Signore M,Fiori ME,di Martino S,Giannetti S,Morgante L,Boe A,Patrizii M,Warnken U,Schnölzer M,Ciolfi A,Di Stefano C,Biffoni M,Ricci-Vitiani L,Pallini R,De Maria R

    更新日期:2017-07-06 00:00:00

  • Capturing Totipotent Stem Cells.

    abstract::Minority subpopulations within embryonic stem cell cultures display an expanded developmental potential similar to that of early embryo blastomeres or the early inner cell mass. The ability to isolate and culture totipotent cells capable of giving rise to the entire conceptus would enhance our capacity to study early ...

    journal_title:Cell stem cell

    pub_type: 杂志文章,评审

    doi:10.1016/j.stem.2017.12.011

    authors: Baker CL,Pera MF

    更新日期:2018-01-04 00:00:00

  • Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.

    abstract::Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. This provides an enabling platform to obtain patient-specific cells for various therapeutic and research applications. However, several problems remain for t...

    journal_title:Cell stem cell

    pub_type: 杂志文章

    doi:10.1016/j.stem.2008.10.004

    authors: Shi Y,Desponts C,Do JT,Hahm HS,Schöler HR,Ding S

    更新日期:2008-11-06 00:00:00

  • Synthetic Embryos: Windows into Mammalian Development.

    abstract::Mammalian embryonic stem cells (ESCs) can self-organize in vitro, but whether they can recreate early embryonic morphogenesis is unclear. Harrison et al. recently demonstrate in Science that 3D co-cultures of mouse ESCs and trophoblast stem cells self-organize into embryo-like structures that recreate many features of...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2017.04.001

    authors: Warmflash A

    更新日期:2017-05-04 00:00:00

  • Stem Cells Expand Insights into Human Brain Evolution.

    abstract::Substantial expansion in the number of cerebral cortex neurons is thought to underlie cognitive differences between humans and other primates, although the mechanisms underlying this expansion are unclear. Otani et al. (2016) utilize PSC-derived brain organoids to study how species-specific differences in cortical pro...

    journal_title:Cell stem cell

    pub_type: 评论,杂志文章

    doi:10.1016/j.stem.2016.03.017

    authors: Dyer MA

    更新日期:2016-04-07 00:00:00