Wnt-related molecules and signaling pathway equilibrium in hematopoiesis.

abstract：:Radiation is one of the most effective cancer treatments. However, gastrointestinal (GI) syndrome is a major limiting factor in abdominal and pelvic radiotherapy. The loss of crypt stem cells or villus endothelial cells has been suggested to be responsible for radiation-induced intestinal damage. We report here a crit...

journal_title：Cell stem cell

authors： Qiu W,Carson-Walter EB,Liu H,Epperly M,Greenberger JS,Zambetti GP,Zhang L,Yu J

更新日期：2008-06-05 00:00:00

abstract：:The Notch signaling pathway is activated in the majority of T cell acute lymphoblastic leukemias (T-ALL). Adding to the complexity of Notch signaling in hematopoiesis, recently in Nature, Klinakis et al. (2011) demonstrate a tumor-suppressor function for the Notch pathway in myeloid malignancy. ...

journal_title：Cell stem cell

authors： Walkley CR,Izon DJ,Purton LE

更新日期：2011-06-03 00:00:00

abstract：:Similarities between basal cell carcinoma (BCC) tumor cells and hair follicle keratinocytes had previously suggested that BCC originates within the hair follicle bulge stem cell niche. However, in the current Nature Cell Biology, Youssef et al. (2010) show that BCC instead originates in the interfollicular epidermis. ...

journal_title：Cell stem cell

authors： Ridky TW,Khavari PA

更新日期：2010-04-02 00:00:00

abstract：:Epidermal integrity is a complex process established during embryogenesis and maintained throughout the organism lifespan by epithelial stem cells. Although Wnt regulates normal epithelial stem cell renewal, aberrant Wnt signaling can contribute to cancerous growth. Here, we explored the consequences of persistent exp...

journal_title：Cell stem cell

authors： Castilho RM,Squarize CH,Chodosh LA,Williams BO,Gutkind JS

更新日期：2009-09-04 00:00:00

abstract：:Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from a cardiac fibroblast toward an induced cardiomyocyte, we performed c...

journal_title：Cell stem cell

authors： Stone NR,Gifford CA,Thomas R,Pratt KJB,Samse-Knapp K,Mohamed TMA,Radzinsky EM,Schricker A,Ye L,Yu P,van Bemmel JG,Ivey KN,Pollard KS,Srivastava D

更新日期：2019-07-03 00:00:00

abstract：:Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond to DNA damage, identify various common and distinct mechanisms utilized by tissue-specific SCs to a...

journal_title：Cell stem cell

authors： Blanpain C,Mohrin M,Sotiropoulou PA,Passegué E

更新日期：2011-01-07 00:00:00

abstract：:Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work suggests that quiescen...

journal_title：Cell stem cell

authors： Murata K,Jadhav U,Madha S,van Es J,Dean J,Cavazza A,Wucherpfennig K,Michor F,Clevers H,Shivdasani RA

更新日期：2020-03-05 00:00:00

abstract：:About half of the human genome consists of highly repetitive elements, most of which are considered dispensable for human life. Here, we report that repetitive elements originating from endogenous retroviruses (ERVs) are systematically transcribed during human early embryogenesis in a stage-specific manner. Our analys...

journal_title：Cell stem cell

authors： Göke J,Lu X,Chan YS,Ng HH,Ly LH,Sachs F,Szczerbinska I

更新日期：2015-02-05 00:00:00

abstract：:Organ growth requires a careful balance between stem cell self-renewal and lineage commitment to ensure proper tissue expansion. The cellular and molecular mechanisms that mediate this balance are unresolved in most organs, including skeletal muscle. Here we identify a long-lived stem cell pool that mediates growth of...

journal_title：Cell stem cell

authors： Nguyen PD,Gurevich DB,Sonntag C,Hersey L,Alaei S,Nim HT,Siegel A,Hall TE,Rossello FJ,Boyd SE,Polo JM,Currie PD

更新日期：2017-07-06 00:00:00

abstract：:The mechanisms that regulate the establishment of adult stem cell pools during normal and perturbed mammalian development are still largely unknown. Here, we asked whether a maternal cytokine surge, which occurs during human maternal infections and has been implicated in cognitive disorders, might have long-lasting co...

journal_title：Cell stem cell

authors： Gallagher D,Norman AA,Woodard CL,Yang G,Gauthier-Fisher A,Fujitani M,Vessey JP,Cancino GI,Sachewsky N,Woltjen K,Fatt MP,Morshead CM,Kaplan DR,Miller FD

更新日期：2013-11-07 00:00:00

abstract：:While studies of organ development have traditionally relied on model organisms, recent advances in embryonic stem cell (ESC) culture allow investigation of organogenesis in human cells. Wang et al. (2015) employ this system to map the dynamic enhancer landscape during ESC differentiation to the endoderm derivatives p...

journal_title：Cell stem cell

authors： Kaestner KH

更新日期：2015-04-02 00:00:00

abstract：:3D organoids enable in vitro human brain development models, but they have not yet recapitulated some essential features of brain circuit formation. Recently, several studies appearing in Nature, Nature Methods, and Cell Stem Cell generated fused organoid models of inhibitory and excitatory neuron development, which c...

journal_title：Cell stem cell

authors： Mich JK,Close JL,Levi BP

更新日期：2017-09-07 00:00:00

abstract：:We are only beginning to understand the higher-order chromatin structure of pluripotent stem cells and its relevance to cell fate. Three recent studies used different approaches to reconstruct the 3D chromatin landscape of naive and primed pluripotent cells, unveiling common features as well as differences between the...

journal_title：Cell stem cell

authors： Wei Z,Lu W

更新日期：2016-02-04 00:00:00

abstract：:Human induced pluripotent stem cells (HiPSCs) appear to be highly similar to human embryonic stem cells (HESCs). Using two genetic lineage-tracing systems, we demonstrate the generation of iPSC lines from human pancreatic islet beta cells. These reprogrammed cells acquired markers of pluripotent cells and differentiat...

journal_title：Cell stem cell

authors： Bar-Nur O,Russ HA,Efrat S,Benvenisty N

更新日期：2011-07-08 00:00:00

abstract：:In the mouse embryo, the aorta-gonad-mesonephros (AGM) region is considered to be the sole location for intraembryonic emergence of hematopoietic stem cells (HSCs). Here we report that, in parallel to the AGM region, the E10.5-E11.5 mouse head harbors bona fide HSCs, as defined by long-term, high-level, multilineage r...

journal_title：Cell stem cell

authors： Li Z,Lan Y,He W,Chen D,Wang J,Zhou F,Wang Y,Sun H,Chen X,Xu C,Li S,Pang Y,Zhang G,Yang L,Zhu L,Fan M,Shang A,Ju Z,Luo L,Ding Y,Guo W,Yuan W,Yang X,Liu B

更新日期：2012-11-02 00:00:00

abstract：:Regulation of hematopoietic stem cell (HSC) dormancy by specific cell types in the hematopoietic niche remains poorly understood. Yamazaki et al. (2011) now report that nerve-associated nonmyelinating Schwann cells activate TGF-β to maintain dormant HSCs, suggesting that glia are novel players in the bone marrow niche...

journal_title：Cell stem cell

authors： Brückner K

更新日期：2011-12-02 00:00:00

abstract：:The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways. While Gsk3 inhibition has been attribut...

journal_title：Cell stem cell

authors： Yeo JC,Jiang J,Tan ZY,Yim GR,Ng JH,Göke J,Kraus P,Liang H,Gonzales KA,Chong HC,Tan CP,Lim YS,Tan NS,Lufkin T,Ng HH

更新日期：2014-06-05 00:00:00

abstract：:It has been proposed that human embryonic stem cells could be used to provide an inexhaustible supply of differentiated cell types for the study of disease processes. Although methods for differentiating embryonic stem cells into specific cell types have become increasingly sophisticated, the utility of the resulting ...

journal_title：Cell stem cell

authors： Di Giorgio FP,Boulting GL,Bobrowicz S,Eggan KC

更新日期：2008-12-04 00:00:00

abstract：:Establishing tissue-specific adult stem cells during organogenesis is important for maintenance of tissue homeostasis throughout the lifetime of the organism. In a recent study in Science, Mathur et al. (2010) describe how progenitor cells in the Drosophila larval midgut create a temporary niche to maintain stem cell ...

journal_title：Cell stem cell

authors： Issigonis M,Matunis E

更新日期：2010-03-05 00:00:00

abstract：:In a study of young adults chosen as unrelated hematopoietic stem cell donors for patients with hematological malignancies, leukemia-associated mutations were detectable in cells from 44% of donors. Donor-origin mutant clones engrafted in recipients and expanded during the first 100 days after transplant, but donor-de...

journal_title：Cell stem cell

authors： Steensma DP

更新日期：2020-03-05 00:00:00

abstract：:Large cutaneous and non-healing ulcers exhibit impaired epithelialization, which represents a major therapeutic challenge. Recently in Nature, Kurita et al. (2018) reported a surprising potential source of epithelial cells. The authors demonstrate that wound-resident mesenchymal cells can be reprogrammed to generate e...

journal_title：Cell stem cell

authors： Ankawa R,Fuchs Y

更新日期：2018-11-01 00:00:00

abstract：:In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 genes. We were able to predict causal variants for these expression quantitative trait loci (e...

journal_title：Cell stem cell

authors： DeBoever C,Li H,Jakubosky D,Benaglio P,Reyna J,Olson KM,Huang H,Biggs W,Sandoval E,D'Antonio M,Jepsen K,Matsui H,Arias A,Ren B,Nariai N,Smith EN,D'Antonio-Chronowska A,Farley EK,Frazer KA

更新日期：2017-04-06 00:00:00

abstract：:Stem cell niche interactions have been studied extensively with regard to cell polarity and extracellular signaling. Less is known about the way in which signals and polarity cues integrate with intracellular structures to ensure appropriate niche organization and function. Here, we report that nuclear lamins function...

journal_title：Cell stem cell

authors： Chen H,Chen X,Zheng Y

更新日期：2013-07-03 00:00:00

abstract：:Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine dec...

journal_title：Cell stem cell

authors： Chen X,Deng H,Churchill MJ,Luchsinger LL,Du X,Chu TH,Friedman RA,Middelhoff M,Ding H,Tailor YH,Wang ALE,Liu H,Niu Z,Wang H,Jiang Z,Renders S,Ho SH,Shah SV,Tishchenko P,Chang W,Swayne TC,Munteanu L,Califano A,

更新日期：2017-12-07 00:00:00

abstract：:Systems biology studies have revealed transcriptional networks and proteomic signatures critical for embryonic stem cell (ESC) function. In this issue of Cell Stem Cell, Sampath et al. (2008) demonstrate that translation is also differentially controlled in undifferentiated versus differentiated ESCs. ...

journal_title：Cell stem cell

authors： Chang WY,Stanford WL

更新日期：2008-05-08 00:00:00

abstract：:The kidney's complex spatial organization and poorly defined lineage specification programs have impeded derivation of kidney progenitors from pluripotent stem cells (PSCs). Now in Cell Stem Cell, Taguchi et al. (2014) redefine the identity of embryonic kidney progenitors in vivo to obtain PSC-derived kidney progenito...

journal_title：Cell stem cell

authors： Gouon-Evans V

更新日期：2014-01-02 00:00:00

abstract：:The maintenance of a pool of quiescent satellite cells (muscle stem cells) is necessary for long-term muscle health. In this issue of Cell Stem Cell, Verma et al. (2018) show that satellite cells recruit endothelial cells to create a vascular niche and that cross-talk between endothelial and satellite cells is vital f...

journal_title：Cell stem cell

authors： Collins BC,Kardon G

更新日期：2018-10-04 00:00:00

abstract：:Aging is characterized by a decrease in genome integrity, impaired organ maintenance, and an increased risk of cancer, which coincide with clonal dominance of expanded mutant stem and progenitor cell populations in aging tissues, such as the intestinal epithelium, the hematopoietic system, and the male germline. Here ...

journal_title：Cell stem cell

authors： Adams PD,Jasper H,Rudolph KL

更新日期：2015-06-04 00:00:00

abstract：:The re-emergence of Zika virus (ZIKV) and its suspected link with various disorders in newborns and adults led the World Health Organization to declare a global health emergency. In response, the stem cell field quickly established platforms for modeling ZIKV exposure using human pluripotent stem cell-derived neural p...

journal_title：Cell stem cell

authors： Ming GL,Tang H,Song H

更新日期：2016-12-01 00:00:00

abstract：:Although distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear whether such variability impacts their utility for disease modeling. Here, we show that although low-passage female hiPSCs retain the inactive X chromosome of the somatic cell they are...

journal_title：Cell stem cell

authors： Mekhoubad S,Bock C,de Boer AS,Kiskinis E,Meissner A,Eggan K

更新日期：2012-05-04 00:00:00