Abstract：
:The re-emergence of Zika virus (ZIKV) and its suspected link with various disorders in newborns and adults led the World Health Organization to declare a global health emergency. In response, the stem cell field quickly established platforms for modeling ZIKV exposure using human pluripotent stem cell-derived neural progenitors and brain organoids, fetal tissues, and animal models. These efforts provided significant insight into cellular targets, pathogenesis, and underlying biological mechanisms of ZIKV infection as well as platforms for drug testing. Here we review the remarkable progress in stem cell-based ZIKV research and discuss current challenges and future opportunities.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Ming GL,Tang H,Song Hdoi
10.1016/j.stem.2016.11.014subject
Has Abstractpub_date
2016-12-01 00:00:00pages
690-702issue
6eissn
1934-5909issn
1875-9777pii
S1934-5909(16)30415-5journal_volume
19pub_type
杂志文章,评审相关文献
Cell Stem Cell文献大全abstract：:Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit fr...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2014.11.011
更新日期：2014-12-04 00:00:00
abstract：:In a study of young adults chosen as unrelated hematopoietic stem cell donors for patients with hematological malignancies, leukemia-associated mutations were detectable in cells from 44% of donors. Donor-origin mutant clones engrafted in recipients and expanded during the first 100 days after transplant, but donor-de...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2020.01.022
更新日期：2020-03-05 00:00:00
abstract：:The kidney's complex spatial organization and poorly defined lineage specification programs have impeded derivation of kidney progenitors from pluripotent stem cells (PSCs). Now in Cell Stem Cell, Taguchi et al. (2014) redefine the identity of embryonic kidney progenitors in vivo to obtain PSC-derived kidney progenito...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2013.12.004
更新日期：2014-01-02 00:00:00
abstract：:To prevent insertional mutagenesis arising from retroviral reactivation, cells of embryonic origin possess a unique capacity to silence retroviruses. Given the distinct modes of X chromosome inactivation between embryonic and extraembryonic lineages, we investigated paradigms of viral extinction. We show that trophect...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2010.03.014
更新日期：2010-05-07 00:00:00
abstract：:Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2014.02.003
更新日期：2014-03-06 00:00:00
abstract：:Scientists are rarely immoral and seldom even amoral. The ethical principles that underlie much of their own work are shared with scientists in other countries to a much greater degree than the cultural and religious differences among those countries would lead one to expect. Like me, few will have had any formal trai...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2007.05.003
更新日期：2007-06-07 00:00:00
abstract：:There is near consensus that Wnt family molecules establish important gradients within niches where hematopoietic stem cells (HSC) reside. We review recent papers suggesting that a delicate balance is required between competing Wnt ligands and corresponding signaling pathways to maintain HSC integrity. Some steps in t...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2008.12.004
更新日期：2009-01-09 00:00:00
abstract：:The suspected link between infection by Zika virus (ZIKV), a re-emerging flavivirus, and microcephaly is an urgent global health concern. The direct target cells of ZIKV in the developing human fetus are not clear. Here we show that a strain of the ZIKV, MR766, serially passaged in monkey and mosquito cells efficientl...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2016.02.016
更新日期：2016-05-05 00:00:00
abstract：:Internal tandem duplication (ITD) mutations within the FMS-like tyrosine kinase-3 (FLT3) render the receptor constitutively active driving proliferation and survival in leukemic blasts. Expression of FLT3-ITD from the endogenous promoter in a murine knockin model results in progenitor expansion and a myeloproliferativ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2012.05.027
更新日期：2012-09-07 00:00:00
abstract：:Neural precursor cells (NPCs) reside in the subventricular zone in association with blood vessels and ependymal cells. In this issue of Cell Stem Cell, Kokovay et al. (2010) show that SDF1 directs the association of NPCs with this niche and regulates their lineage progression in a stage-specific manner. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2010.07.001
更新日期：2010-08-06 00:00:00
abstract：:Hematopoiesis is a complex process that requires a high degree of transcriptional diversification during lineage commitment and differentiation. de Graaf et al. (2016) have now generated a comprehensive gene expression dataset that allows cell-type-specific genes as well as associated transcription factor expression p...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2016.07.010
更新日期：2016-08-04 00:00:00
abstract：:Mammalian embryonic stem cells (ESCs) can self-organize in vitro, but whether they can recreate early embryonic morphogenesis is unclear. Harrison et al. recently demonstrate in Science that 3D co-cultures of mouse ESCs and trophoblast stem cells self-organize into embryo-like structures that recreate many features of...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2017.04.001
更新日期：2017-05-04 00:00:00
abstract：:In this issue of Cell Stem Cell, Palii et al. reveal that TAL1 is a master regulator of adhesion and migration networks in human endothelial progenitors and that ex vivo treatment with the histone deacetylase inhibitor TSA enables their faster vascularization after ischemic injury. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2014.04.018
更新日期：2014-05-01 00:00:00
abstract：:The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during hematopoietic development are unclear. Using an irreversible lineage-trac...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2016.08.013
更新日期：2016-12-01 00:00:00
abstract：:Substantial expansion in the number of cerebral cortex neurons is thought to underlie cognitive differences between humans and other primates, although the mechanisms underlying this expansion are unclear. Otani et al. (2016) utilize PSC-derived brain organoids to study how species-specific differences in cortical pro...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2016.03.017
更新日期：2016-04-07 00:00:00
abstract：:Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations f...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2017.09.014
更新日期：2017-11-02 00:00:00
abstract：:In this issue of Cell Stem Cell, Belema-Bedada et al. (2008) describe a novel mechanism by which bone marrow-derived adult mesenchymal stem cells migrate to sites of damaged heart tissue. This process is dependent on the intracellular adaptor molecule FROUNT, which interacts with the chemokine receptor CCR2. ...
journal_title：Cell stem cell
pub_type： 评论
doi：10.1016/j.stem.2008.05.012
更新日期：2008-06-05 00:00:00
abstract：:In a recent issue of Nature, Mayack et al. (2010) use young and old parabiotic mice to show that systemic signals from the young parabiont rejuvenate hematopoietic stem cell function via the microenvironmental niche. ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2010.01.008
更新日期：2010-02-05 00:00:00
abstract：:Cell types more advanced in development than embryonic stem cells, such as EpiSCs, fail to contribute to chimeras when injected into pre-implantation-stage blastocysts, apparently because the injected cells undergo apoptosis. Here we show that transient promotion of cell survival through expression of the anti-apoptot...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2016.10.013
更新日期：2016-11-03 00:00:00
abstract：:The identification of tumor-initiating cells represents a significant challenge for studies of prostate cancer. In a recent issue of Cell Reports, Agarwal and colleagues use organoid culture to ascertain two distinct luminal progenitors in a mouse model of prostate cancer, shedding new light on lineage relationships i...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2015.11.018
更新日期：2015-12-03 00:00:00
abstract：:Fetal gene therapy using safe and effective viral vectors no longer remains a distant prospect. Recently in Nature Medicine, Massaro et al. (2018) demonstrated that prenatal intracranial injection of a viral vector results in improved neurologic function, raising the intriguing possibility that in utero gene therapy m...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2018.08.010
更新日期：2018-09-06 00:00:00
abstract：:How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2012.03.012
更新日期：2012-04-06 00:00:00
abstract：:Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. Here, we utilized a porcine model of acute...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2014.11.009
更新日期：2014-12-04 00:00:00
abstract：:In-depth analysis of the cellular and molecular mechanisms regulating human HSC function will require a surrogate host that supports robust maintenance of transplanted human HSCs in vivo, but the currently available options are problematic. Previously we showed that mutations in the Kit receptor enhance engraftment of...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2014.06.001
更新日期：2014-08-07 00:00:00
abstract：:The transcription factors Tcf3 and Nanog regulate many genes in embryonic stem cells, but according to two reports in this issue of Cell Stem Cell (Festuccia et al., 2012, Martello et al., 2012), only one, Esrrb, encoding an orphan nuclear hormone receptor, truly matters in the maintenance of self-renewal. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2012.09.005
更新日期：2012-10-05 00:00:00
abstract：:Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.06.006
更新日期：2015-08-06 00:00:00
abstract：:Cellular metabolism plays important functions in dictating stem cell behaviors, although its role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation. Administering the AMPK activator metformin d...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2020.03.006
更新日期：2020-06-04 00:00:00
abstract：:Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanisms underlying this variability in HSC division kinetics are unkn...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.01.017
更新日期：2015-03-05 00:00:00
abstract：:The mechanisms that regulate the establishment of adult stem cell pools during normal and perturbed mammalian development are still largely unknown. Here, we asked whether a maternal cytokine surge, which occurs during human maternal infections and has been implicated in cognitive disorders, might have long-lasting co...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2013.10.002
更新日期：2013-11-07 00:00:00
abstract：:Cellular reprogramming converts differentiated cells into induced pluripotent stem cells (iPSCs). However, this process is typically very inefficient, complicating mechanistic studies. We identified and molecularly characterized rare, early intermediates poised to reprogram with up to 95% efficiency, without perturbin...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2018.06.013
更新日期：2018-08-02 00:00:00
