Abstract：
:The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during hematopoietic development are unclear. Using an irreversible lineage-tracing model, we identify a definitive hematopoietic stem cell (HSC) that supports long-term multilineage reconstitution upon transplantation into adult recipients but does not persist into adulthood in situ. These HSCs are fully multipotent, yet they display both higher lymphoid cell production and greater capacity to generate innate-like B and T lymphocytes as compared to coexisting fetal HSCs and adult HSCs. Thus, these developmentally restricted HSCs (drHSCs) define the origin and generation of early lymphoid cells that play essential roles in establishing self-recognition and tolerance, with important implications for understanding autoimmune disease, allergy, and rejection of transplanted organs.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Beaudin AE,Boyer SW,Perez-Cunningham J,Hernandez GE,Derderian SC,Jujjavarapu C,Aaserude E,MacKenzie T,Forsberg ECdoi
10.1016/j.stem.2016.08.013subject
Has Abstractpub_date
2016-12-01 00:00:00pages
768-783issue
6eissn
1934-5909issn
1875-9777pii
S1934-5909(16)30260-0journal_volume
19pub_type
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