Abstract：
:During embryonic development, multipotent cardiovascular progenitor cells are specified from early mesoderm. Using mouse ESCs in which gene expression can be temporally regulated, we have found that transient expression of Mesp1 dramatically accelerates and enhances multipotent cardiovascular progenitor specification through an intrinsic and cell autonomous mechanism. Genome-wide transcriptional analysis indicates that Mesp1 rapidly activates and represses a discrete set of genes, and chromatin immunoprecipitation shows that Mesp1 directly binds to regulatory DNA sequences located in the promoter of many key genes in the core cardiac transcriptional machinery, resulting in their rapid upregulation. Mesp1 also directly represses the expression of key genes regulating other early mesoderm and endoderm cell fates. Our results demonstrate that Mesp1 acts as a key regulatory switch during cardiovascular specification, residing at the top of the hierarchy of the gene network responsible for cardiovascular cell-fate determination.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Bondue A,Lapouge G,Paulissen C,Semeraro C,Iacovino M,Kyba M,Blanpain Cdoi
10.1016/j.stem.2008.06.009subject
Has Abstractpub_date
2008-07-03 00:00:00pages
69-84issue
1eissn
1934-5909issn
1875-9777pii
S1934-5909(08)00288-9journal_volume
3pub_type
杂志文章相关文献
Cell Stem Cell文献大全abstract：:In injured tissues, regeneration is often associated with cell fate plasticity, in that cells deviate from their normal lineage paths. It is becoming increasingly clear that this plasticity often creates alternative strategies to restore damaged or lost cells. Alternatively, cell fate plasticity is also part and parce...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2018.05.009
更新日期：2018-09-06 00:00:00
abstract：:Twist1 promotes epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and cancer stem cell (CSC) properties. However, it remains unclear whether Twist1 is also required for tumor initiation and whether Twist1-induced cancer stemness and EMT are functionally linked. Using a conditional deletion of Twist1 at...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2014.12.002
更新日期：2015-01-08 00:00:00
abstract：:Significant development in the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has been achieved by retroviral infection of defined genes. Several recent reports, including one in this issue of Cell Stem Cell (Marson et al., 2008), have started to replace these genetic changes with specific ...
journal_title：Cell stem cell
pub_type： 评论
doi：10.1016/j.stem.2008.07.005
更新日期：2008-08-07 00:00:00
abstract：:Cells of adult mammals can be converted (reprogrammed) to new cells. In one approach, adult cells are converted to pluripotent stem cells, followed by differentiation to regenerate new cell types. Alternatively, adult cells may be directly converted into other mature cells or progenitors. We discuss and compare these ...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2008.09.015
更新日期：2008-10-09 00:00:00
abstract：:In this issue of Cell Stem Cell, Feng et al. (2013) report that the gene mutated in human CHARGE syndrome, ATP-dependent chromatin remodeling factor CHD7, contributes to the control of neurogenesis. The authors also report that exercise ameliorates these defects and suggest it as an intervention worthy of study in CHA...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2013.06.010
更新日期：2013-07-03 00:00:00
abstract：:Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progenitor...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2013.04.026
更新日期：2013-06-06 00:00:00
abstract：:The CRISPR-Cas9 system has been employed to generate mutant alleles in a range of different organisms. However, so far there have not been reports of use of this system for efficient correction of a genetic disease. Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2013.10.016
更新日期：2013-12-05 00:00:00
abstract：:Cellular metabolism plays important functions in dictating stem cell behaviors, although its role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation. Administering the AMPK activator metformin d...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2020.03.006
更新日期：2020-06-04 00:00:00
abstract：:Large cutaneous and non-healing ulcers exhibit impaired epithelialization, which represents a major therapeutic challenge. Recently in Nature, Kurita et al. (2018) reported a surprising potential source of epithelial cells. The authors demonstrate that wound-resident mesenchymal cells can be reprogrammed to generate e...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2018.10.014
更新日期：2018-11-01 00:00:00
abstract：:In a study of young adults chosen as unrelated hematopoietic stem cell donors for patients with hematological malignancies, leukemia-associated mutations were detectable in cells from 44% of donors. Donor-origin mutant clones engrafted in recipients and expanded during the first 100 days after transplant, but donor-de...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2020.01.022
更新日期：2020-03-05 00:00:00
abstract：:The 2009 ISSCR Annual Meeting in Barcelona will draw stem cell scientists from around the world to Europe, to connect to each other and to the local community. With record abstract submissions, we are sure to have an exciting meeting. ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2009.05.009
更新日期：2009-06-05 00:00:00
abstract：:Regulated blood production is achieved through the hierarchical organization of dormant hematopoietic stem cell (HSC) subsets that differ in self-renewal potential and division frequency, with long-term (LT)-HSCs dividing the least. The molecular mechanisms underlying this variability in HSC division kinetics are unkn...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.01.017
更新日期：2015-03-05 00:00:00
abstract：:While studies of organ development have traditionally relied on model organisms, recent advances in embryonic stem cell (ESC) culture allow investigation of organogenesis in human cells. Wang et al. (2015) employ this system to map the dynamic enhancer landscape during ESC differentiation to the endoderm derivatives p...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2015.03.006
更新日期：2015-04-02 00:00:00
abstract：:There is intense contemporary interest in the identity, stability, and potential of stem cells, in the body or in the lab. The unusually comprehensive view provided by the 7th annual meeting of the ISSCR provides a framework to summarize recent progress. ...
journal_title：Cell stem cell
pub_type：
doi：10.1016/j.stem.2009.10.012
更新日期：2009-11-06 00:00:00
abstract：:Cellular barcoding offers a powerful approach to characterize the growth and differentiation activity of large numbers of cotransplanted stem cells. Here, we describe a lentiviral genomic-barcoding and analysis strategy and its use to compare the clonal outputs of transplants of purified mouse and human basal mammary ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2013.12.011
更新日期：2014-02-06 00:00:00
abstract：:We have recently demonstrated that reactive glial cells can be directly reprogrammed into functional neurons by a single neural transcription factor, NeuroD1. Here we report that a combination of small molecules can also reprogram human astrocytes in culture into fully functional neurons. We demonstrate that sequentia...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.09.012
更新日期：2015-12-03 00:00:00
abstract：:Gastric cancer displays marked molecular heterogeneity with aggressive behavior and treatment resistance. Therefore, good in vitro models that encompass unique subtypes are urgently needed for precision medicine development. Here, we have established a primary gastric cancer organoid (GCO) biobank that comprises norma...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2018.09.016
更新日期：2018-12-06 00:00:00
abstract：:How DNA methylation inhibitors exert their anticancer effects in patients is not well understood. In the latest issue of Cancer Cell, Tsai et al. (2012) use low-dose drug treatment to induce persistent attenuation of tumorigenicity by targeting tumor-initiating cells. ...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2012.03.012
更新日期：2012-04-06 00:00:00
abstract：:Exit from the naive pluripotent state occurs through a series of changes in the gene regulatory circuitry, allowing cells to become primed for lineage commitment. In this issue of Cell Stem Cell, Kalkan et al. (2019) show that three transcription regulators are required for naive mouse embryonic stem cells (ESCs) to e...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2019.04.008
更新日期：2019-05-02 00:00:00
abstract：:Steroid hormones are known systemic regulators of multiple normal and cancerous tissues; however, whether or how they impact the fate and function of adult stem cells is unclear. In the Drosophila ovary, insulin signals modulate the proliferation and self-renewal of germline stem cells (GSCs), yet despite evidence tha...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2010.10.001
更新日期：2010-11-05 00:00:00
abstract：:Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the ...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2015.06.006
更新日期：2015-08-06 00:00:00
abstract：:To prevent insertional mutagenesis arising from retroviral reactivation, cells of embryonic origin possess a unique capacity to silence retroviruses. Given the distinct modes of X chromosome inactivation between embryonic and extraembryonic lineages, we investigated paradigms of viral extinction. We show that trophect...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2010.03.014
更新日期：2010-05-07 00:00:00
abstract：:Centralized banking of human embryonic stem (hES) cells is an endeavor that can benefit individual research efforts and enhance international collaboration but is complicated by the fact that the science is rapidly evolving in an environment of heterogeneous laws, guidelines, and ethical standards. Written from the va...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2008.03.018
更新日期：2008-04-10 00:00:00
abstract：:The generation of induced pluripotent stem cells (iPSCs) provides a novel method to facilitate investigations into the mechanisms that control stem cell pluripotency and self-renewal. Myc has previously been shown to be critical for murine embryonic stem cell (mESC) maintenance, while also enhancing directed reprogram...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2010.06.023
更新日期：2010-09-03 00:00:00
abstract：:Nodal and Activin belong to the TGF-β superfamily and are important regulators of embryonic stem cell fate. Here we investigated whether Nodal and Activin regulate self-renewal of pancreatic cancer stem cells. Nodal and Activin were hardly detectable in more differentiated pancreatic cancer cells, while cancer stem ce...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2011.10.001
更新日期：2011-11-04 00:00:00
abstract：:There is near consensus that Wnt family molecules establish important gradients within niches where hematopoietic stem cells (HSC) reside. We review recent papers suggesting that a delicate balance is required between competing Wnt ligands and corresponding signaling pathways to maintain HSC integrity. Some steps in t...
journal_title：Cell stem cell
pub_type： 杂志文章,评审
doi：10.1016/j.stem.2008.12.004
更新日期：2009-01-09 00:00:00
abstract：:Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). Promoting neurogenesis may improve hippocampal function in AD brains. However, how amyloid beta (Abeta), the key AD pathogen, affects the development and function of adult-b...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2009.10.003
更新日期：2009-12-04 00:00:00
abstract：:Animal cloning can be achieved through somatic cell nuclear transfer (SCNT), although the live birth rate is relatively low. Recent studies have identified H3K9me3 in donor cells and abnormal Xist activation as epigenetic barriers that impede SCNT. Here we overcome these barriers using a combination of Xist knockout d...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2018.06.008
更新日期：2018-09-06 00:00:00
abstract：:In Nature Medicine, Pollyea et al. (2018) recently reported a remarkable overall response of newly diagnosed elderly acute myeloid leukemia patients to a venetoclax and azacitidine combination in a new clinical trial. This treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cyc...
journal_title：Cell stem cell
pub_type： 评论,杂志文章
doi：10.1016/j.stem.2018.12.005
更新日期：2019-01-03 00:00:00
abstract：:Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in huma...
journal_title：Cell stem cell
pub_type： 杂志文章
doi：10.1016/j.stem.2016.03.002
更新日期：2016-05-05 00:00:00
