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Modulating Cell Fate as a Therapeutic Strategy.

Abstract：

:In injured tissues, regeneration is often associated with cell fate plasticity, in that cells deviate from their normal lineage paths. It is becoming increasingly clear that this plasticity often creates alternative strategies to restore damaged or lost cells. Alternatively, cell fate plasticity is also part and parcel of pathologic tissue transformations that accompany disease. In this Perspective, we summarize a few illustrative examples of physiologic and aberrant cellular plasticity. Then, we speculate on how one could enhance endogenous plasticity to promote regeneration and reverse pathologic plasticity, perhaps inspiring interest in a new class of therapies targeting cell fate modulation.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Lin B,Srikanth P,Castle AC,Nigwekar S,Malhotra R,Galloway JL,Sykes DB,Rajagopal J

doi

10.1016/j.stem.2018.05.009

subject

Has Abstract

pub_date

2018-09-06 00:00:00

pages

329-341

issue

3

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(18)30227-3

journal_volume

23

pub_type

杂志文章,评审

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