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Mitochondrial Shapeshifting Impacts AML Stemness and Differentiation.

Abstract：

:In this issue of Cell Stem Cell, Pei et al. (2018) demonstrate that leukemic stem cells (LSCs) have enhanced mitochondrial fission, which is positively regulated by FIS1. FIS1 is necessary to maintain LSC function; thus, targeting its expression and mitochondrial fission is a novel approach to decrease stemness and increase differentiation in Acute Myeloid Leukemia.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Schimmer AD

doi

10.1016/j.stem.2018.05.026

subject

Has Abstract

pub_date

2018-07-05 00:00:00

pages

3-4

issue

1

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(18)30281-9

journal_volume

23

pub_type

评论,杂志文章

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