Abstract：
:In this study, we explore endoderm cell fate regulation through the expression of lineage-determining transcription factors. We demonstrate that stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 or SOX17, producing extraembryonic endoderm and definitive endoderm progenitors, respectively. In teratoma assays and growth factor-mediated differentiation, SOX7 cells appear restricted to the extraembryonic endoderm, and SOX17 cells demonstrate a mesendodermal phenotype in teratomas and the ability to undergo endoderm maturation in vitro in the absence of cytokine-mediated endoderm induction. These endoderm progenitor cells maintain a stable phenotype through many passages in culture, thereby providing new tools to explore the pathways of endoderm differentiation.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Séguin CA,Draper JS,Nagy A,Rossant Jdoi
10.1016/j.stem.2008.06.018subject
Has Abstractpub_date
2008-08-07 00:00:00pages
182-95issue
2eissn
1934-5909issn
1875-9777pii
S1934-5909(08)00327-5journal_volume
3pub_type
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