Abstract:
:Significant development in the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) has been achieved by retroviral infection of defined genes. Several recent reports, including one in this issue of Cell Stem Cell (Marson et al., 2008), have started to replace these genetic changes with specific chemical stimulation.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Tada Tdoi
10.1016/j.stem.2008.07.005subject
Has Abstractpub_date
2008-08-07 00:00:00pages
121-2issue
2eissn
1934-5909issn
1875-9777pii
S1934-5909(08)00339-1journal_volume
3pub_type
评论相关文献
Cell Stem Cell文献大全abstract::In injured tissues, regeneration is often associated with cell fate plasticity, in that cells deviate from their normal lineage paths. It is becoming increasingly clear that this plasticity often creates alternative strategies to restore damaged or lost cells. Alternatively, cell fate plasticity is also part and parce...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2018.05.009
更新日期:2018-09-06 00:00:00
abstract::Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone marrow environment, and their metabolic status is distinct from that of their differentiated progeny. HSCs generate energy mainly via anaer...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2011.09.010
更新日期:2011-10-04 00:00:00
abstract::In a pioneering study in New England Journal of Medicine, Schweitzer et al. (2020) report on a patient with Parkinson's disease who received a graft of dopamine neurons obtained from in vitro differentiated induced pluripotent stem cells, derived from the patient's own skin fibroblasts, showing the feasibility of auto...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.06.008
更新日期:2020-07-02 00:00:00
abstract::N6-methyladenosine (m6A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m6A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was reported to be frequently deleted, implying a ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.04.009
更新日期:2020-07-02 00:00:00
abstract::In a study of young adults chosen as unrelated hematopoietic stem cell donors for patients with hematological malignancies, leukemia-associated mutations were detectable in cells from 44% of donors. Donor-origin mutant clones engrafted in recipients and expanded during the first 100 days after transplant, but donor-de...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2020.01.022
更新日期:2020-03-05 00:00:00
abstract::The identification of tumor-initiating cells represents a significant challenge for studies of prostate cancer. In a recent issue of Cell Reports, Agarwal and colleagues use organoid culture to ascertain two distinct luminal progenitors in a mouse model of prostate cancer, shedding new light on lineage relationships i...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.11.018
更新日期:2015-12-03 00:00:00
abstract::Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we explored inter-relationships between putative mouse ISC populations by comparative RNA-sequencing (RNA-seq). The transcriptomes of multiple cycling ISC populations clo...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2017.06.014
更新日期:2017-07-06 00:00:00
abstract::Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations f...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2017.09.014
更新日期:2017-11-02 00:00:00
abstract::Two recent papers outline improvements in gene editing technology that may facilitate the analysis of signaling networks important for development. The systems developed by both Thyagarajan and coworkers (Thyagarajan et al., 2007) in Nature Biotechnology, and Lombardo and colleagues (Lombardo et al., 2007) in Stem Cel...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2007.11.004
更新日期:2007-12-13 00:00:00
abstract::Increasing evidence suggests tumors are maintained by cancer stem cells; however, their nature remains controversial. In a HoxA9-Meis1 (H9M) model of acute myeloid leukemia (AML), we found that tumor-initiating activity existed in three, immunophenotypically distinct compartments, corresponding to disparate lineages o...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.01.004
更新日期:2012-02-03 00:00:00
abstract::Patients with type 1 diabetes (T1D) often experience gastrointestinal enteropathy (DE) of unclear etiology. Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.09.008
更新日期:2015-10-01 00:00:00
abstract::Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit fr...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.11.011
更新日期:2014-12-04 00:00:00
abstract::Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice (pregastrulation lethality) and humans (Seckel syndrome). Here we show that eliminating ATR in adult mice leads to de...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2007.03.002
更新日期:2007-06-07 00:00:00
abstract::Organoids derived from human pluripotent stem cells are a potentially powerful tool for high-throughput screening (HTS), but the complexity of organoid cultures poses a significant challenge for miniaturization and automation. Here, we present a fully automated, HTS-compatible platform for enhanced differentiation and...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2018.04.022
更新日期:2018-06-01 00:00:00
abstract::Similarities between basal cell carcinoma (BCC) tumor cells and hair follicle keratinocytes had previously suggested that BCC originates within the hair follicle bulge stem cell niche. However, in the current Nature Cell Biology, Youssef et al. (2010) show that BCC instead originates in the interfollicular epidermis. ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2010.03.009
更新日期:2010-04-02 00:00:00
abstract::Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et al. (2012a) and Wu et al. (2013) define functionally distinct roles for canonical and noncanonica...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2013.01.014
更新日期:2013-02-07 00:00:00
abstract::Substantial expansion in the number of cerebral cortex neurons is thought to underlie cognitive differences between humans and other primates, although the mechanisms underlying this expansion are unclear. Otani et al. (2016) utilize PSC-derived brain organoids to study how species-specific differences in cortical pro...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2016.03.017
更新日期:2016-04-07 00:00:00
abstract::The CRISPR-Cas9 system has been employed to generate mutant alleles in a range of different organisms. However, so far there have not been reports of use of this system for efficient correction of a genetic disease. Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2013.10.016
更新日期:2013-12-05 00:00:00
abstract::Sox family transcription factors have emerged as key regulators of multiple developmental processes, including fate determination and differentiation in multiple tissues. In this issue of Cell Stem Cell, Nowak et al. (2008) implicate Sox9 in the specification of early hair follicle stem cells and subsequent epithelial...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2008.06.014
更新日期:2008-07-03 00:00:00
abstract::Twist1 promotes epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and cancer stem cell (CSC) properties. However, it remains unclear whether Twist1 is also required for tumor initiation and whether Twist1-induced cancer stemness and EMT are functionally linked. Using a conditional deletion of Twist1 at...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2014.12.002
更新日期:2015-01-08 00:00:00
abstract::Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from a cardiac fibroblast toward an induced cardiomyocyte, we performed c...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.06.012
更新日期:2019-07-03 00:00:00
abstract::Understanding the basis of the unrestricted multilineage differentiation potential of pluripotent cells will be of developmental and translational consequence. We propose that pluripotency transcription factors are lineage specifiers that direct commitment to specific fetal lineages. Individual factors bestow the abil...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.03.013
更新日期:2011-04-08 00:00:00
abstract::Cellular metabolism plays important functions in dictating stem cell behaviors, although its role in stomach epithelial homeostasis has not been evaluated in depth. Here, we show that the energy sensor AMP kinase (AMPK) governs gastric epithelial progenitor differentiation. Administering the AMPK activator metformin d...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.03.006
更新日期:2020-06-04 00:00:00
abstract::In this issue of Cell Stem Cell, Csaszar et al. (2012) develop a culture method that overcomes current limitations in ex vivo hematopoietic stem/progenitor cell expansion by continuously diluting inhibitory signaling factors and maintaining stem cell density. This approach enhances the generation of precursors with po...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2012.01.012
更新日期:2012-02-03 00:00:00
abstract::Adult germline stem cells (AGSCs) self-renew (Thy1(+) enriched) or commit to gametogenesis (Kit(+) enriched). To better understand how chromatin regulates AGSC biology and gametogenesis, we derived stage-specific high-resolution profiles of DNA methylation, 5hmC, histone modifications/variants, and RNA-seq in AGSCs an...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2014.04.006
更新日期:2014-08-07 00:00:00
abstract::Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.02.003
更新日期:2014-03-06 00:00:00
abstract::Neuromuscular networks assemble during early human embryonic development and are essential for the control of body movement. Previous neuromuscular junction modeling efforts using human pluripotent stem cells (hPSCs) generated either spinal cord neurons or skeletal muscles in monolayer culture. Here, we use hPSC-deriv...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2019.12.007
更新日期:2020-02-06 00:00:00
abstract::All animals must excrete the waste products of metabolism. Excretion is performed by the kidney in vertebrates and by the Malpighian tubules in Drosophila. The mammalian kidney has an inherent ability for recovery and regeneration after ischemic injury. Stem cells and progenitor cells have been proposed to be responsi...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2007.07.003
更新日期:2007-08-16 00:00:00
abstract::Emerging evidence strongly suggests that stem cells and their differentiated progeny display distinct metabolic profiles, but how metabolic changes are coupled with organogenesis has remained unclear. Homem et al. (2014) now reveal a hormone-dependent pathway that couples metabolic changes with stem cell differentiati...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.08.006
更新日期:2014-09-04 00:00:00
abstract::The metabolic state of quiescent hematopoietic stem cells (HSCs) is an important regulator of self-renewal, but it is unclear whether or how metabolic parameters contribute to HSC lineage specification and commitment. Here, we show that the commitment of human and murine HSCs to the erythroid lineage is dependent upon...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2014.06.002
更新日期:2014-08-07 00:00:00