Illuminating the Properties of Prostate Luminal Progenitors.

abstract：:It has been proposed that human embryonic stem cells could be used to provide an inexhaustible supply of differentiated cell types for the study of disease processes. Although methods for differentiating embryonic stem cells into specific cell types have become increasingly sophisticated, the utility of the resulting ...

journal_title：Cell stem cell

authors： Di Giorgio FP,Boulting GL,Bobrowicz S,Eggan KC

更新日期：2008-12-04 00:00:00

abstract：:The transcription factors Tcf3 and Nanog regulate many genes in embryonic stem cells, but according to two reports in this issue of Cell Stem Cell (Festuccia et al., 2012, Martello et al., 2012), only one, Esrrb, encoding an orphan nuclear hormone receptor, truly matters in the maintenance of self-renewal. ...

journal_title：Cell stem cell

authors： Zwaka TP

更新日期：2012-10-05 00:00:00

abstract：:Several cell populations have been reported to possess intestinal stem cell (ISC) activity during homeostasis and injury-induced regeneration. Here, we explored inter-relationships between putative mouse ISC populations by comparative RNA-sequencing (RNA-seq). The transcriptomes of multiple cycling ISC populations clo...

journal_title：Cell stem cell

authors： Yan KS,Gevaert O,Zheng GXY,Anchang B,Probert CS,Larkin KA,Davies PS,Cheng ZF,Kaddis JS,Han A,Roelf K,Calderon RI,Cynn E,Hu X,Mandleywala K,Wilhelmy J,Grimes SM,Corney DC,Boutet SC,Terry JM,Belgrader P,Ziraldo SB

更新日期：2017-07-06 00:00:00

abstract：:To assess the genetic consequences of induced pluripotent stem cell (iPSC) reprogramming, we sequenced the genomes of ten murine iPSC clones derived from three independent reprogramming experiments, and compared them to their parental cell genomes. We detected hundreds of single nucleotide variants (SNVs) in every clo...

journal_title：Cell stem cell

authors： Young MA,Larson DE,Sun CW,George DR,Ding L,Miller CA,Lin L,Pawlik KM,Chen K,Fan X,Schmidt H,Kalicki-Veizer J,Cook LL,Swift GW,Demeter RT,Wendl MC,Sands MS,Mardis ER,Wilson RK,Townes TM,Ley TJ

更新日期：2012-05-04 00:00:00

abstract：:The mechanisms that regulate the establishment of adult stem cell pools during normal and perturbed mammalian development are still largely unknown. Here, we asked whether a maternal cytokine surge, which occurs during human maternal infections and has been implicated in cognitive disorders, might have long-lasting co...

journal_title：Cell stem cell

authors： Gallagher D,Norman AA,Woodard CL,Yang G,Gauthier-Fisher A,Fujitani M,Vessey JP,Cancino GI,Sachewsky N,Woltjen K,Fatt MP,Morshead CM,Kaplan DR,Miller FD

更新日期：2013-11-07 00:00:00

abstract：:Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranula...

journal_title：Cell stem cell

authors： Fuentealba LC,Obernier K,Alvarez-Buylla A

更新日期：2012-06-14 00:00:00

abstract：:In this issue of Cell Stem Cell, Li et al. (2020) reveal pivotal roles for Lats1/2 in adult, Wnt-mediated intestinal homeostasis through TEAD-dependent and -independent transcription. Loss of Lats1/2 mobilizes a previously unrecognized YAP/TAZ-Groucho/TLE interaction to suppress Wnt/TCF-mediated transcription, thereby...

journal_title：Cell stem cell

authors： Fu V,Guan KL

更新日期：2020-05-07 00:00:00

abstract：:In a recent issue of Nature, Mayack et al. (2010) use young and old parabiotic mice to show that systemic signals from the young parabiont rejuvenate hematopoietic stem cell function via the microenvironmental niche. ...

journal_title：Cell stem cell

authors： Oakley EJ,Van Zant G

更新日期：2010-02-05 00:00:00

abstract：:The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during hematopoietic development are unclear. Using an irreversible lineage-trac...

journal_title：Cell stem cell

authors： Beaudin AE,Boyer SW,Perez-Cunningham J,Hernandez GE,Derderian SC,Jujjavarapu C,Aaserude E,MacKenzie T,Forsberg EC

更新日期：2016-12-01 00:00:00

abstract：:Oocyte defects lie at the heart of some forms of infertility and could potentially be addressed therapeutically by alternative routes for oocyte formation. Here, we describe the generation of functional human oocytes following nuclear transfer of first polar body (PB1) genomes from metaphase II (MII) oocytes into enuc...

journal_title：Cell stem cell

authors： Ma H,O'Neil RC,Marti Gutierrez N,Hariharan M,Zhang ZZ,He Y,Cinnioglu C,Kayali R,Kang E,Lee Y,Hayama T,Koski A,Nery J,Castanon R,Tippner-Hedges R,Ahmed R,Van Dyken C,Li Y,Olson S,Battaglia D,Lee DM,Wu DH,Amato

更新日期：2017-01-05 00:00:00

abstract：:Somatic cell nuclear transfer (SCNT) enables cloning of differentiated cells by reprogramming their nuclei to a totipotent state. However, successful full-term development of SCNT embryos is a low-efficiency process and arrested embryos frequently exhibit epigenetic abnormalities. Here, we generated genome-wide DNA me...

journal_title：Cell stem cell

authors： Gao R,Wang C,Gao Y,Xiu W,Chen J,Kou X,Zhao Y,Liao Y,Bai D,Qiao Z,Yang L,Wang M,Zang R,Liu X,Jia Y,Li Y,Zhang Y,Yin J,Wang H,Wan X,Liu W,Zhang Y,Gao S

更新日期：2018-09-06 00:00:00

abstract：:The study of gastric epithelial homeostasis and cancer has been hampered by the lack of stem cell markers and in vitro culture methods. The Wnt target gene Lgr5 marks stem cells in the small intestine, colon, and hair follicle. Here, we investigated Lgr5 expression in the stomach and assessed the stem cell potential o...

journal_title：Cell stem cell

authors： Barker N,Huch M,Kujala P,van de Wetering M,Snippert HJ,van Es JH,Sato T,Stange DE,Begthel H,van den Born M,Danenberg E,van den Brink S,Korving J,Abo A,Peters PJ,Wright N,Poulsom R,Clevers H

更新日期：2010-01-08 00:00:00

abstract：:An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive TGF-β signaling as an underlying cause of BMF in FA mice and patient cells, whose inhibition promotes DNA repair and hematopoietic stem and progenit...

journal_title：Cell stem cell

authors： Tummala H,Dokal I

更新日期：2016-05-05 00:00:00

abstract：VIDEO ABSTRACT:Although endogenous recruitment of adult neural stem cells has been proposed as a therapeutic strategy, clinical approaches for achieving this are lacking. Here, we show that metformin, a widely used drug, promotes neurogenesis and enhances spatial memory formation. Specifically, we show that an atypical...

journal_title：Cell stem cell

authors： Wang J,Gallagher D,DeVito LM,Cancino GI,Tsui D,He L,Keller GM,Frankland PW,Kaplan DR,Miller FD

更新日期：2012-07-06 00:00:00

abstract：:Muscle stem cell regenerative capacity is rapidly lost during ex vivo culture. In this issue of Cell Stem Cell, Judson et al. (2018) show that inhibition of cytoplasmic SETD7, a lysine methyltransferase, potently expands naive, undifferentiated mouse and human muscle stem cells by restricting their progression through...

journal_title：Cell stem cell

authors： Fujita R,Crist C

更新日期：2018-02-01 00:00:00

abstract：:Patients with type 1 diabetes (T1D) often experience gastrointestinal enteropathy (DE) of unclear etiology. Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and...

journal_title：Cell stem cell

authors： Cheng CW,Yilmaz ÖH

更新日期：2015-10-01 00:00:00

abstract：:Direct reprogramming of human fibroblasts to a pluripotent state has been achieved through ectopic expression of the transcription factors OCT4, SOX2, and either cMYC and KLF4 or NANOG and LIN28. Little is known, however, about the mechanisms by which reprogramming occurs, which is in part limited by the low efficienc...

journal_title：Cell stem cell

authors： Maherali N,Ahfeldt T,Rigamonti A,Utikal J,Cowan C,Hochedlinger K

更新日期：2008-09-11 00:00:00

abstract：:The identification of mechanisms that regulate stem cell renewal has led to the development of innovative approaches to expand hematopoietic stem cells ex vivo. One approach reported by Wagner et al. (2016) in this issue of Cell Stem Cell has demonstrated dramatic expansion of umbilical cord blood stem cells that prom...

journal_title：Cell stem cell

authors： Nikiforow S,Ritz J

更新日期：2016-01-07 00:00:00

abstract：:Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice (pregastrulation lethality) and humans (Seckel syndrome). Here we show that eliminating ATR in adult mice leads to de...

journal_title：Cell stem cell

authors： Ruzankina Y,Pinzon-Guzman C,Asare A,Ong T,Pontano L,Cotsarelis G,Zediak VP,Velez M,Bhandoola A,Brown EJ

更新日期：2007-06-07 00:00:00

abstract：:Human disease phenotypes associated with haploinsufficient gene requirements are often not recapitulated well in animal models. Here, we have investigated the association between human GATA6 haploinsufficiency and a wide range of clinical phenotypes that include neonatal and adult-onset diabetes using CRISPR (clustere...

journal_title：Cell stem cell

authors： Shi ZD,Lee K,Yang D,Amin S,Verma N,Li QV,Zhu Z,Soh CL,Kumar R,Evans T,Chen S,Huangfu D

更新日期：2017-05-04 00:00:00

abstract：:Human induced pluripotent stem cells (HiPSCs) appear to be highly similar to human embryonic stem cells (HESCs). Using two genetic lineage-tracing systems, we demonstrate the generation of iPSC lines from human pancreatic islet beta cells. These reprogrammed cells acquired markers of pluripotent cells and differentiat...

journal_title：Cell stem cell

authors： Bar-Nur O,Russ HA,Efrat S,Benvenisty N

更新日期：2011-07-08 00:00:00

abstract：:In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 genes. We were able to predict causal variants for these expression quantitative trait loci (e...

journal_title：Cell stem cell

authors： DeBoever C,Li H,Jakubosky D,Benaglio P,Reyna J,Olson KM,Huang H,Biggs W,Sandoval E,D'Antonio M,Jepsen K,Matsui H,Arias A,Ren B,Nariai N,Smith EN,D'Antonio-Chronowska A,Farley EK,Frazer KA

更新日期：2017-04-06 00:00:00

abstract：:Pluripotent stem cells are defined by their capacity to differentiate into all three tissue layers that comprise the body. Chimera formation, generated by stem cell transplantation to the embryo, is a stringent assessment of stem cell pluripotency. However, the ability of human pluripotent stem cells (hPSCs) to form e...

journal_title：Cell stem cell

authors： Mascetti VL,Pedersen RA

更新日期：2016-01-07 00:00:00

abstract：:SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present an experimental pl...

journal_title：Cell stem cell

authors： Yang L,Han Y,Nilsson-Payant BE,Gupta V,Wang P,Duan X,Tang X,Zhu J,Zhao Z,Jaffré F,Zhang T,Kim TW,Harschnitz O,Redmond D,Houghton S,Liu C,Naji A,Ciceri G,Guttikonda S,Bram Y,Nguyen DT,Cioffi M,Chandar V,Hoagl

更新日期：2020-07-02 00:00:00

abstract：:Adult neurogenesis regulates plasticity and function in the hippocampus, which is critical for memory and vulnerable to Alzheimer's disease (AD). Promoting neurogenesis may improve hippocampal function in AD brains. However, how amyloid beta (Abeta), the key AD pathogen, affects the development and function of adult-b...

journal_title：Cell stem cell

authors： Sun B,Halabisky B,Zhou Y,Palop JJ,Yu G,Mucke L,Gan L

更新日期：2009-12-04 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a rapidly progressing neurodegenerative disease, characterized by motor neuron (MN) death, for which there are no truly effective treatments. Here, we describe a new small molecule survival screen carried out using MNs from both wild-type and mutant SOD1 mouse embryonic stem cell...

journal_title：Cell stem cell

authors： Yang YM,Gupta SK,Kim KJ,Powers BE,Cerqueira A,Wainger BJ,Ngo HD,Rosowski KA,Schein PA,Ackeifi CA,Arvanites AC,Davidow LS,Woolf CJ,Rubin LL

更新日期：2013-06-06 00:00:00

abstract：:Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...

journal_title：Cell stem cell

authors： Hobbs RM,Polo JM

更新日期：2014-03-06 00:00:00

abstract：:The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and in many other adult organs. The transcription factor Ascl2 (a Wnt target gene) is a master regulator of intestinal stem cell identity. It is unclear how the continuous Wnt gradient along the crypt axis is translated into discrete ex...

journal_title：Cell stem cell

authors： Schuijers J,Junker JP,Mokry M,Hatzis P,Koo BK,Sasselli V,van der Flier LG,Cuppen E,van Oudenaarden A,Clevers H

更新日期：2015-02-05 00:00:00

abstract：:The 2009 ISSCR Annual Meeting in Barcelona will draw stem cell scientists from around the world to Europe, to connect to each other and to the local community. With record abstract submissions, we are sure to have an exciting meeting. ...

journal_title：Cell stem cell

authors： McKay RD

更新日期：2009-06-05 00:00:00

abstract：:Adoptive immunotherapy with functional T cells is potentially an effective therapeutic strategy for combating many types of cancer and viral infection. However, exhaustion of antigen-specific T cells represents a major challenge to this type of approach. In an effort to overcome this problem, we reprogrammed clonally ...

journal_title：Cell stem cell

authors： Nishimura T,Kaneko S,Kawana-Tachikawa A,Tajima Y,Goto H,Zhu D,Nakayama-Hosoya K,Iriguchi S,Uemura Y,Shimizu T,Takayama N,Yamada D,Nishimura K,Ohtaka M,Watanabe N,Takahashi S,Iwamoto A,Koseki H,Nakanishi M,Eto K,Na

更新日期：2013-01-03 00:00:00