Abstract：
:In this issue of Cell Stem Cell, Li et al. (2020) reveal pivotal roles for Lats1/2 in adult, Wnt-mediated intestinal homeostasis through TEAD-dependent and -independent transcription. Loss of Lats1/2 mobilizes a previously unrecognized YAP/TAZ-Groucho/TLE interaction to suppress Wnt/TCF-mediated transcription, thereby resulting in intestinal stem cell depletion and Wnt-uncoupled progenitor expansion.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Fu V,Guan KLdoi
10.1016/j.stem.2020.04.011subject
Has Abstractpub_date
2020-05-07 00:00:00pages
612-614issue
5eissn
1934-5909issn
1875-9777pii
S1934-5909(20)30150-8journal_volume
26pub_type
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