当前位置： SCI文献检索 > Cell Stem Cell期刊下所有文献 > Profiling identifies precursor suspects: notch family again!

Profiling identifies precursor suspects: notch family again!

Abstract：

:Newborn neurons in the adult dentate gyrus pass through several distinct precursor and progenitor classes prior to differentiation. In this issue of Cell Stem Cell, Lugert et al. (2010) characterized their strikingly different proliferative behaviors after neurogenic stimuli or aging.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Breunig JJ,Rakic P

doi

10.1016/j.stem.2010.04.006

subject

Has Abstract

pub_date

2010-05-07 00:00:00

pages

401-2

issue

5

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(10)00161-X

journal_volume

6

pub_type

评论,杂志文章

相关文献

Cell Stem Cell文献大全
  • Looking Back: Cancer Stem Cells.

    abstract：:Over the past decade, our growing understanding of cancer stem cell characteristics and function continues to guide innovative new treatments to eradicate cancer. For our tenth anniversary, we asked authors who cited a selection of our most popular papers in this area about the broad influences these studies have had....

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2017.05.005

    authors：

    更新日期：2017-06-01 00:00:00

  • AMPK Keeps Tumor Cells from Starving to Death.

    abstract：:In this issue of Cell Stem Cell, Saito et al. (2015) examine how leukemia-initiating cells react to metabolic stress imposed by different tissue environments. They find that inhibition of the metabolic stress sensor AMP-activated protein kinase (AMPK) led to deranged glucose metabolism and redox homeostasis, resulting...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2015.10.007

    authors： Shaw RJ

    更新日期：2015-11-05 00:00:00

  • Multiple epigenetic modifiers induce aggressive viral extinction in extraembryonic endoderm stem cells.

    abstract：:To prevent insertional mutagenesis arising from retroviral reactivation, cells of embryonic origin possess a unique capacity to silence retroviruses. Given the distinct modes of X chromosome inactivation between embryonic and extraembryonic lineages, we investigated paradigms of viral extinction. We show that trophect...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2010.03.014

    authors： Golding MC,Zhang L,Mann MR

    更新日期：2010-05-07 00:00:00

  • Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.

    abstract：:Chronic myeloid leukemia (CML) originates in a hematopoietic stem cell (HSC) transformed by the breakpoint cluster region (BCR)-abelson (ABL) oncogene and is effectively treated with tyrosine kinase inhibitors (TKIs). TKIs do not eliminate disease-propagating leukemic stem cells (LSCs), suggesting a deeper understandi...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2019.02.018

    authors： Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R

    更新日期：2019-05-02 00:00:00

  • Blood cells need glia, too: a new role for the nervous system in the bone marrow niche.

    abstract：:Regulation of hematopoietic stem cell (HSC) dormancy by specific cell types in the hematopoietic niche remains poorly understood. Yamazaki et al. (2011) now report that nerve-associated nonmyelinating Schwann cells activate TGF-β to maintain dormant HSCs, suggesting that glia are novel players in the bone marrow niche...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2011.11.016

    authors： Brückner K

    更新日期：2011-12-02 00:00:00

  • Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.

    abstract：:Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer; however, their clinical application has been hindered by their low numbers in cancer patients. Here, we developed a proof-of-concept for hematopoietic stem cell-engineered iNKT (HSC-iNKT) cell therapy with the potential to provide th...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2019.08.004

    authors： Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Ma

    更新日期：2019-10-03 00:00:00

  • The nuclear lamina regulates germline stem cell niche organization via modulation of EGFR signaling.

    abstract：:Stem cell niche interactions have been studied extensively with regard to cell polarity and extracellular signaling. Less is known about the way in which signals and polarity cues integrate with intracellular structures to ensure appropriate niche organization and function. Here, we report that nuclear lamins function...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2013.05.003

    authors： Chen H,Chen X,Zheng Y

    更新日期：2013-07-03 00:00:00

  • Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.

    abstract：:Somatic cells can be induced into pluripotent stem cells (iPSCs) with a combination of four transcription factors, Oct4/Sox2/Klf4/c-Myc or Oct4/Sox2/Nanog/LIN28. This provides an enabling platform to obtain patient-specific cells for various therapeutic and research applications. However, several problems remain for t...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2008.10.004

    authors： Shi Y,Desponts C,Do JT,Hahm HS,Schöler HR,Ding S

    更新日期：2008-11-06 00:00:00

  • When fibroblasts MET iPSCs.

    abstract：:Two independent studies by Li et al. (2010) and Samavarchi-Tehrani et al. (2010) in this issue of Cell Stem Cell suggest that a mesenchymal-to-epithelial transition is a critical initiating event during the derivation of induced pluripotent stem cells (iPSCs) from fibroblasts, indicating remarkable similarities betwee...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2010.05.018

    authors： Polo JM,Hochedlinger K

    更新日期：2010-07-02 00:00:00

  • Dosage Counts: Correcting Trisomy-21-Related Phenotypes in Human Organoids and Xenografts.

    abstract：:Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2019.05.009

    authors： Manley WF,Anderson SA

    更新日期：2019-06-06 00:00:00

  • Of Mice and Man: Differential DNMT Dependence in Mammalian ESCs.

    abstract：:Liao et al. (2015) recently reported on the effects of disrupting DNA methyltransferase activity in human embryonic stem cells (hESCs). This work highlights key differences between mammalian ESC models upon the loss of these essential proteins and provides comprehensive base resolution methylome maps of DNMT targets d...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2015.04.009

    authors： Bogdanović O,Lister R

    更新日期：2015-05-07 00:00:00

  • Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma.

    abstract：:Functionally relevant markers of glioblastoma stem-like cells (GSCs) have potential for therapeutic targeting to treat this aggressive disease. Here we used generation and screening of thousands of monoclonal antibodies to search for receptors and signaling pathways preferentially enriched in GSCs. We identified integ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2017.04.009

    authors： Haas TL,Sciuto MR,Brunetto L,Valvo C,Signore M,Fiori ME,di Martino S,Giannetti S,Morgante L,Boe A,Patrizii M,Warnken U,Schnölzer M,Ciolfi A,Di Stefano C,Biffoni M,Ricci-Vitiani L,Pallini R,De Maria R

    更新日期：2017-07-06 00:00:00

  • Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.

    abstract：:Defects in brain development are believed to contribute toward the onset of neuropsychiatric disorders, but identifying specific underlying mechanisms has proven difficult. Here, we took a multifaceted approach to investigate why 15q11.2 copy number variants are prominent risk factors for schizophrenia and autism. Fir...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2014.05.003

    authors： Yoon KJ,Nguyen HN,Ursini G,Zhang F,Kim NS,Wen Z,Makri G,Nauen D,Shin JH,Park Y,Chung R,Pekle E,Zhang C,Towe M,Hussaini SM,Lee Y,Rujescu D,St Clair D,Kleinman JE,Hyde TM,Krauss G,Christian KM,Rapoport JL,Wein

    更新日期：2014-07-03 00:00:00

  • Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells.

    abstract：:Dysfunction and loss of retinal pigment epithelium (RPE) leads to degeneration of photoreceptors in age-related macular degeneration and subtypes of retinitis pigmentosa. Human embryonic stem cells (hESCs) may serve as an unlimited source of RPE cells for transplantation in these blinding conditions. Here we show the ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2009.07.002

    authors： Idelson M,Alper R,Obolensky A,Ben-Shushan E,Hemo I,Yachimovich-Cohen N,Khaner H,Smith Y,Wiser O,Gropp M,Cohen MA,Even-Ram S,Berman-Zaken Y,Matzrafi L,Rechavi G,Banin E,Reubinoff B

    更新日期：2009-10-02 00:00:00

  • On the streets of San Francisco: highlights from the ISSCR Annual Meeting 2010.

    abstract：:The 2010 Annual Meeting of the International Society for Stem Cell Research (ISSCR) was held in San Francisco in June with an exciting program covering a wealth of stem cell research from basic science to clinical research. ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2010.09.002

    authors： Elefanty AG,Blelloch R,Passegué E,Wernig M,Mummery CL

    更新日期：2010-10-08 00:00:00

  • Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.

    abstract：:Individuals with neurofibromatosis type 1 (NF1) develop abnormalities of both neuronal and glial cell lineages, suggesting that the NF1 protein neurofibromin is an essential regulator of neuroglial progenitor function. In this regard, Nf1-deficient embryonic telencephalic neurospheres exhibit increased self-renewal an...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2007.07.008

    authors： Hegedus B,Dasgupta B,Shin JE,Emnett RJ,Hart-Mahon EK,Elghazi L,Bernal-Mizrachi E,Gutmann DH

    更新日期：2007-10-11 00:00:00

  • Targeting epigenetics to speed up repair.

    abstract：:In this issue of Cell Stem Cell, Palii et al. reveal that TAL1 is a master regulator of adhesion and migration networks in human endothelial progenitors and that ex vivo treatment with the histone deacetylase inhibitor TSA enables their faster vascularization after ischemic injury. ...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2014.04.018

    authors： Soler E,Grosveld F

    更新日期：2014-05-01 00:00:00

  • Tales from the Cryptkeeper: New Roles for Lats1/2 in Wnt-driven Homeostasis.

    abstract：:In this issue of Cell Stem Cell, Li et al. (2020) reveal pivotal roles for Lats1/2 in adult, Wnt-mediated intestinal homeostasis through TEAD-dependent and -independent transcription. Loss of Lats1/2 mobilizes a previously unrecognized YAP/TAZ-Groucho/TLE interaction to suppress Wnt/TCF-mediated transcription, thereby...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2020.04.011

    authors： Fu V,Guan KL

    更新日期：2020-05-07 00:00:00

  • Banking human induced pluripotent stem cells: lessons learned from embryonic stem cells?

    abstract：:The generation of human embryonic stem cell banking networks has ensured that well-characterized and quality controlled stem cell lines are broadly accessible to researchers worldwide. Here, we provide recommendations for engaging these established networks in efforts to build similar resources for the distribution an...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2013.09.007

    authors： Stacey GN,Crook JM,Hei D,Ludwig T

    更新日期：2013-10-03 00:00:00

  • Metabolic makeover for HSCs.

    abstract：:Hematopoietic stem cells (HSCs) must at times exit quiescence to divide and produce differentiated blood cells. In this issue of Cell Stem Cell, Takubo et al. (2013) and Yu et al. (2013) show that these opposing actions require distinct metabolic programs to meet the changing energy demands of self-renewing HSCs. ...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2012.12.005

    authors： Warr MR,Passegué E

    更新日期：2013-01-03 00:00:00

  • A high-efficiency system for the generation and study of human induced pluripotent stem cells.

    abstract：:Direct reprogramming of human fibroblasts to a pluripotent state has been achieved through ectopic expression of the transcription factors OCT4, SOX2, and either cMYC and KLF4 or NANOG and LIN28. Little is known, however, about the mechanisms by which reprogramming occurs, which is in part limited by the low efficienc...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2008.08.003

    authors： Maherali N,Ahfeldt T,Rigamonti A,Utikal J,Cowan C,Hochedlinger K

    更新日期：2008-09-11 00:00:00

  • Glucose and glutamine metabolism regulate human hematopoietic stem cell lineage specification.

    abstract：:The metabolic state of quiescent hematopoietic stem cells (HSCs) is an important regulator of self-renewal, but it is unclear whether or how metabolic parameters contribute to HSC lineage specification and commitment. Here, we show that the commitment of human and murine HSCs to the erythroid lineage is dependent upon...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2014.06.002

    authors： Oburoglu L,Tardito S,Fritz V,de Barros SC,Merida P,Craveiro M,Mamede J,Cretenet G,Mongellaz C,An X,Klysz D,Touhami J,Boyer-Clavel M,Battini JL,Dardalhon V,Zimmermann VS,Mohandas N,Gottlieb E,Sitbon M,Kinet S,Taylo

    更新日期：2014-08-07 00:00:00

  • Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.

    abstract：:Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work suggests that quiescen...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2019.12.011

    authors： Murata K,Jadhav U,Madha S,van Es J,Dean J,Cavazza A,Wucherpfennig K,Michor F,Clevers H,Shivdasani RA

    更新日期：2020-03-05 00:00:00

  • Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.

    abstract：:Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the ...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2015.06.006

    authors： Kwon HY,Bajaj J,Ito T,Blevins A,Konuma T,Weeks J,Lytle NK,Koechlein CS,Rizzieri D,Chuah C,Oehler VG,Sasik R,Hardiman G,Reya T

    更新日期：2015-08-06 00:00:00

  • TGF-β Pathway Inhibition Signals New Hope for Fanconi Anemia.

    abstract：:An improved understanding of the bone marrow failure (BMF) mechanisms in Fanconi anemia (FA) may improve current therapeutic strategies. Zhang et al. identify hyperactive TGF-β signaling as an underlying cause of BMF in FA mice and patient cells, whose inhibition promotes DNA repair and hematopoietic stem and progenit...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2016.04.008

    authors： Tummala H,Dokal I

    更新日期：2016-05-05 00:00:00

  • Future AAVenues for In Utero Gene Therapy.

    abstract：:Fetal gene therapy using safe and effective viral vectors no longer remains a distant prospect. Recently in Nature Medicine, Massaro et al. (2018) demonstrated that prenatal intracranial injection of a viral vector results in improved neurologic function, raising the intriguing possibility that in utero gene therapy m...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2018.08.010

    authors： MacKenzie TC

    更新日期：2018-09-06 00:00:00

  • A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.

    abstract：:Leukemia stem cells (LSCs) play a pivotal role in the resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors (TKIs) and its progression to blast crisis (BC), in part, through the alternative splicing of self-renewal and survival genes. To elucidate splice-isoform regulators of human BC LSC maintena...

    journal_title：Cell stem cell

    pub_type： 杂志文章

    doi：10.1016/j.stem.2012.12.011

    authors： Goff DJ,Court Recart A,Sadarangani A,Chun HJ,Barrett CL,Krajewska M,Leu H,Low-Marchelli J,Ma W,Shih AY,Wei J,Zhai D,Geron I,Pu M,Bao L,Chuang R,Balaian L,Gotlib J,Minden M,Martinelli G,Rusert J,Dao KH,Shazand

    更新日期：2013-03-07 00:00:00

  • Won't You Be My Neighbor? Muscle Stem Cells Recruit Endothelial Cells to Their Niche.

    abstract：:The maintenance of a pool of quiescent satellite cells (muscle stem cells) is necessary for long-term muscle health. In this issue of Cell Stem Cell, Verma et al. (2018) show that satellite cells recruit endothelial cells to create a vascular niche and that cross-talk between endothelial and satellite cells is vital f...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2018.09.013

    authors： Collins BC,Kardon G

    更新日期：2018-10-04 00:00:00

  • Growth signaling at the nexus of stem cell life and death.

    abstract：:Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with age. In this issue of Cell Stem Cell and in Nature, Castilho et al. (2009) and Harrison et al. (2009) highlight the importance of mTOR signaling in stem cell exhaustion and mammalian aging, respectively. ...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2009.08.008

    authors： Wood KC,Sabatini DM

    更新日期：2009-09-04 00:00:00

  • A Little Bit of Guidance: Mini Brains on Their Route to Adolescence.

    abstract：:Cerebral organoids represent a new model in which to study human brain development outside the human body. Recently in Nature Biotechnology, Lancaster et al. (2017) tackled the lack of reproducibility, tissue homogeneity, and complexity of this system by bioengineering organoids to establish the next generation of hum...

    journal_title：Cell stem cell

    pub_type： 评论,杂志文章

    doi：10.1016/j.stem.2017.07.001

    authors： Koch P,Ladewig J

    更新日期：2017-08-03 00:00:00