Abstract:
:Two independent studies by Li et al. (2010) and Samavarchi-Tehrani et al. (2010) in this issue of Cell Stem Cell suggest that a mesenchymal-to-epithelial transition is a critical initiating event during the derivation of induced pluripotent stem cells (iPSCs) from fibroblasts, indicating remarkable similarities between cellular reprogramming, development, and cancer.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Polo JM,Hochedlinger Kdoi
10.1016/j.stem.2010.05.018subject
Has Abstractpub_date
2010-07-02 00:00:00pages
5-6issue
1eissn
1934-5909issn
1875-9777pii
S1934-5909(10)00278-Xjournal_volume
7pub_type
评论,杂志文章相关文献
Cell Stem Cell文献大全abstract::Long noncoding RNAs (lncRNAs) have been described in cell lines and various whole tissues, but lncRNA analysis of development in vivo is limited. Here, we comprehensively analyze lncRNA expression for the adult mouse subventricular zone neural stem cell lineage. We utilize complementary genome-wide techniques includin...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2013.03.003
更新日期:2013-05-02 00:00:00
abstract::Epithelial-to-mesenchymal transition (EMT) is a developmental process important for cell fate determination. Fibroblasts, a product of EMT, can be reset into induced pluripotent stem cells (iPSCs) via exogenous transcription factors but the underlying mechanism is unclear. Here we show that the generation of iPSCs fro...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.04.014
更新日期:2010-07-02 00:00:00
abstract::Radiation is one of the most effective cancer treatments. However, gastrointestinal (GI) syndrome is a major limiting factor in abdominal and pelvic radiotherapy. The loss of crypt stem cells or villus endothelial cells has been suggested to be responsible for radiation-induced intestinal damage. We report here a crit...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2008.03.009
更新日期:2008-06-05 00:00:00
abstract::In Nature Medicine, Pollyea et al. (2018) recently reported a remarkable overall response of newly diagnosed elderly acute myeloid leukemia patients to a venetoclax and azacitidine combination in a new clinical trial. This treatment reduced succinate dehydrogenase glutathionylation, impaired the tricarboxylic acid cyc...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2018.12.005
更新日期:2019-01-03 00:00:00
abstract::Systems biology studies have revealed transcriptional networks and proteomic signatures critical for embryonic stem cell (ESC) function. In this issue of Cell Stem Cell, Sampath et al. (2008) demonstrate that translation is also differentially controlled in undifferentiated versus differentiated ESCs. ...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2008.04.009
更新日期:2008-05-08 00:00:00
abstract::Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in huma...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2016.03.002
更新日期:2016-05-05 00:00:00
abstract::Mesenchymal stem/stromal cells (MSCs) can either suppress or promote tumors. We found previously that incubation of human bone marrow MSCs (hMSCs) with TNF-α upregulated multiple genes including TRAIL, which has cancer apoptotic activity. Here, we show that weekly infusions into mice of hMSCs preactivated with TNF-α i...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.10.001
更新日期:2012-12-07 00:00:00
abstract::Patients with type 1 diabetes (T1D) often experience gastrointestinal enteropathy (DE) of unclear etiology. Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.09.008
更新日期:2015-10-01 00:00:00
abstract::Epidermal integrity is a complex process established during embryogenesis and maintained throughout the organism lifespan by epithelial stem cells. Although Wnt regulates normal epithelial stem cell renewal, aberrant Wnt signaling can contribute to cancerous growth. Here, we explored the consequences of persistent exp...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2009.06.017
更新日期:2009-09-04 00:00:00
abstract::Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit fr...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.11.011
更新日期:2014-12-04 00:00:00
abstract::Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to ...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2009.03.005
更新日期:2009-04-03 00:00:00
abstract::Liao et al. (2015) recently reported on the effects of disrupting DNA methyltransferase activity in human embryonic stem cells (hESCs). This work highlights key differences between mammalian ESC models upon the loss of these essential proteins and provides comprehensive base resolution methylome maps of DNMT targets d...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.04.009
更新日期:2015-05-07 00:00:00
abstract::Dysfunction and loss of retinal pigment epithelium (RPE) leads to degeneration of photoreceptors in age-related macular degeneration and subtypes of retinitis pigmentosa. Human embryonic stem cells (hESCs) may serve as an unlimited source of RPE cells for transplantation in these blinding conditions. Here we show the ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2009.07.002
更新日期:2009-10-02 00:00:00
abstract::Cardiac stem/progenitor cells hold great potential for regenerative therapies; however, the mechanisms regulating their expansion and differentiation remain insufficiently defined. Here we show that Ldb1 is a central regulator of genome organization in cardiac progenitor cells, which is crucial for cardiac lineage dif...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2015.08.007
更新日期:2015-09-03 00:00:00
abstract::Cell engineering has brought us tantalizingly close to the goal of deriving patient-specific hematopoietic stem cells (HSCs). While directed differentiation and transcription factor-mediated conversion strategies have generated progenitor cells with multilineage potential, to date, therapy-grade engineered HSCs remain...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2016.05.016
更新日期:2016-06-02 00:00:00
abstract::Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determina...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2015.06.011
更新日期:2015-07-02 00:00:00
abstract::In this study, we explore endoderm cell fate regulation through the expression of lineage-determining transcription factors. We demonstrate that stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 or SOX17, producing extraembryonic endoderm and definitive endoderm prog...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2008.06.018
更新日期:2008-08-07 00:00:00
abstract::The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to promote regeneration of damaged tissue, to treat inflammation, and to promote angiogenesis. However, these studies are complicated by the diverse methods used to culture, characterize, and deliver MSCs and by the variety of meth...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2009.02.001
更新日期:2009-03-06 00:00:00
abstract::Knowledge of both the global chromatin structure and the gene expression programs of human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) should provide a robust means to assess whether the genomes of these cells have similar pluripotent states. Recent studies have suggested that ESCs and iPSCs...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2010.06.015
更新日期:2010-08-06 00:00:00
abstract::Although distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear whether such variability impacts their utility for disease modeling. Here, we show that although low-passage female hiPSCs retain the inactive X chromosome of the somatic cell they are...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2012.02.014
更新日期:2012-05-04 00:00:00
abstract::Stem cells have the capacity to both self-renew and generate postmitotic cells. Long-term tracking of individual clones in their natural environment constitutes the ultimate way to validate postembryonic stem cells. We identify retinal stem cells (RSCs) using the spatiotemporal organization of the fish retina and foll...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.11.004
更新日期:2011-12-02 00:00:00
abstract::The re-emergence of Zika virus (ZIKV) and its suspected link with various disorders in newborns and adults led the World Health Organization to declare a global health emergency. In response, the stem cell field quickly established platforms for modeling ZIKV exposure using human pluripotent stem cell-derived neural p...
journal_title:Cell stem cell
pub_type: 杂志文章,评审
doi:10.1016/j.stem.2016.11.014
更新日期:2016-12-01 00:00:00
abstract::The current widespread outbreak of Zika virus (ZIKV) infection has been linked to severe clinical birth defects, particularly microcephaly, warranting urgent study of the molecular mechanisms underlying ZIKV pathogenesis. Akt-mTOR signaling is one of the key cellular pathways essential for brain development and autoph...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2016.07.019
更新日期:2016-11-03 00:00:00
abstract::Functionally relevant markers of glioblastoma stem-like cells (GSCs) have potential for therapeutic targeting to treat this aggressive disease. Here we used generation and screening of thousands of monoclonal antibodies to search for receptors and signaling pathways preferentially enriched in GSCs. We identified integ...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2017.04.009
更新日期:2017-07-06 00:00:00
abstract::In a pioneering study in New England Journal of Medicine, Schweitzer et al. (2020) report on a patient with Parkinson's disease who received a graft of dopamine neurons obtained from in vitro differentiated induced pluripotent stem cells, derived from the patient's own skin fibroblasts, showing the feasibility of auto...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2020.06.008
更新日期:2020-07-02 00:00:00
abstract::Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...
journal_title:Cell stem cell
pub_type: 评论,杂志文章
doi:10.1016/j.stem.2014.02.003
更新日期:2014-03-06 00:00:00
abstract::Rapid progress has recently been made regarding how the niche controls stem cell function, but little is yet known about how stem cells in the same niche interact with one another. In this study, we show that differentiation-defective Drosophila ovarian germline stem cells (GSCs) can outcompete normal ones for niche o...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2007.10.021
更新日期:2008-01-10 00:00:00
abstract::The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum. However, a pluripotent "ground state," bearing resemblance to preimplantation mouse epiblasts, can be established through dual inhibition (2i) of both prodifferentiation Mek/Erk and Gsk3/Tcf3 pathways. While Gsk3 inhibition has been attribut...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2014.04.015
更新日期:2014-06-05 00:00:00
abstract::Defects in brain development are believed to contribute toward the onset of neuropsychiatric disorders, but identifying specific underlying mechanisms has proven difficult. Here, we took a multifaceted approach to investigate why 15q11.2 copy number variants are prominent risk factors for schizophrenia and autism. Fir...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2014.05.003
更新日期:2014-07-03 00:00:00
abstract::Understanding the basis of the unrestricted multilineage differentiation potential of pluripotent cells will be of developmental and translational consequence. We propose that pluripotency transcription factors are lineage specifiers that direct commitment to specific fetal lineages. Individual factors bestow the abil...
journal_title:Cell stem cell
pub_type: 杂志文章
doi:10.1016/j.stem.2011.03.013
更新日期:2011-04-08 00:00:00