Abstract：
:Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in human FA fibroblasts, we identify transforming growth factor-β (TGF-β) pathway-mediated growth suppression as a cause of BMF in FA. Blocking the TGF-β pathway improves the survival of FA cells and rescues the proliferative and functional defects of HSPCs derived from FA mice and FA patients. Inhibition of TGF-β signaling in FA HSPCs results in elevated homologous recombination (HR) repair with a concomitant decrease in non-homologous end-joining (NHEJ), accounting for the improvement in cellular growth. Together, our results suggest that elevated TGF-β signaling contributes to BMF in FA by impairing HSPC function and may be a potential therapeutic target for the treatment of FA.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Zhang H,Kozono DE,O'Connor KW,Vidal-Cardenas S,Rousseau A,Hamilton A,Moreau L,Gaudiano EF,Greenberger J,Bagby G,Soulier J,Grompe M,Parmar K,D'Andrea ADdoi
10.1016/j.stem.2016.03.002subject
Has Abstractpub_date
2016-05-05 00:00:00pages
668-81issue
5eissn
1934-5909issn
1875-9777pii
S1934-5909(16)00108-9journal_volume
18pub_type
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