Control of stem cell fate by physical interactions with the extracellular matrix.

abstract：:Trophoblast stem cells (TSCs) arise from the first cell fate decision in the developing embryo and generate extra-embryonic lineages, giving rise to the fetal portion of the placenta. Mouse embryonic and extra-embryonic lineages are strictly separated by a distinct epigenetic barrier, which is not fully overcome follo...

journal_title：Cell stem cell

authors： Kubaczka C,Senner CE,Cierlitza M,Araúzo-Bravo MJ,Kuckenberg P,Peitz M,Hemberger M,Schorle H

更新日期：2015-11-05 00:00:00

abstract：:Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an auto-/paracrine physiologic circuit that controls quiescence of MB-HSCs and hematopoietic progenitors marked by histidine dec...

journal_title：Cell stem cell

authors： Chen X,Deng H,Churchill MJ,Luchsinger LL,Du X,Chu TH,Friedman RA,Middelhoff M,Ding H,Tailor YH,Wang ALE,Liu H,Niu Z,Wang H,Jiang Z,Renders S,Ho SH,Shah SV,Tishchenko P,Chang W,Swayne TC,Munteanu L,Califano A,

更新日期：2017-12-07 00:00:00

abstract：:Cellular reprogramming converts differentiated cells into induced pluripotent stem cells (iPSCs). However, this process is typically very inefficient, complicating mechanistic studies. We identified and molecularly characterized rare, early intermediates poised to reprogram with up to 95% efficiency, without perturbin...

journal_title：Cell stem cell

authors： Schwarz BA,Cetinbas M,Clement K,Walsh RM,Cheloufi S,Gu H,Langkabel J,Kamiya A,Schorle H,Meissner A,Sadreyev RI,Hochedlinger K

更新日期：2018-08-02 00:00:00

abstract：:Leukemia stem cells (LSCs) play a pivotal role in the resistance of chronic myeloid leukemia (CML) to tyrosine kinase inhibitors (TKIs) and its progression to blast crisis (BC), in part, through the alternative splicing of self-renewal and survival genes. To elucidate splice-isoform regulators of human BC LSC maintena...

journal_title：Cell stem cell

authors： Goff DJ,Court Recart A,Sadarangani A,Chun HJ,Barrett CL,Krajewska M,Leu H,Low-Marchelli J,Ma W,Shih AY,Wei J,Zhai D,Geron I,Pu M,Bao L,Chuang R,Balaian L,Gotlib J,Minden M,Martinelli G,Rusert J,Dao KH,Shazand

更新日期：2013-03-07 00:00:00

abstract：:Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer; however, their clinical application has been hindered by their low numbers in cancer patients. Here, we developed a proof-of-concept for hematopoietic stem cell-engineered iNKT (HSC-iNKT) cell therapy with the potential to provide th...

journal_title：Cell stem cell

authors： Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Ma

更新日期：2019-10-03 00:00:00

abstract：:Stem cell researchers commonly use human pluripotent stem cell lines derived by other investigators. Researchers may use lines derived elsewhere, provided that their derivation met consensus core standards. Some types of derivation raise heightened levels of ethical concern and require greater scrutiny. To maintain pu...

journal_title：Cell stem cell

authors： Lo B,Parham L,Broom C,Cedars M,Gates E,Giudice L,Halme DG,Hershon W,Kriegstein A,Kwok PY,Oberman M,Roberts C,Wagner R

更新日期：2009-02-06 00:00:00

abstract：:Centralized banking of human embryonic stem (hES) cells is an endeavor that can benefit individual research efforts and enhance international collaboration but is complicated by the fact that the science is rapidly evolving in an environment of heterogeneous laws, guidelines, and ethical standards. Written from the va...

journal_title：Cell stem cell

authors： O'Rourke PP,Abelman M,Heffernan KG

更新日期：2008-04-10 00:00:00

abstract：:Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that...

journal_title：Cell stem cell

authors： Manley WF,Anderson SA

更新日期：2019-06-06 00:00:00

abstract：:Embryonic stem cells (ESCs) are an attractive source for tissue regeneration and repair therapies because they can be differentiated into virtually any cell type in the adult body. However, for this approach to succeed, the transplanted ESCs must survive long enough to generate a therapeutic benefit. A major obstacle ...

journal_title：Cell stem cell

authors： Pearl JI,Lee AS,Leveson-Gower DB,Sun N,Ghosh Z,Lan F,Ransohoff J,Negrin RS,Davis MM,Wu JC

更新日期：2011-03-04 00:00:00

abstract：:Human induced pluripotent stem cells (HiPSCs) appear to be highly similar to human embryonic stem cells (HESCs). Using two genetic lineage-tracing systems, we demonstrate the generation of iPSC lines from human pancreatic islet beta cells. These reprogrammed cells acquired markers of pluripotent cells and differentiat...

journal_title：Cell stem cell

authors： Bar-Nur O,Russ HA,Efrat S,Benvenisty N

更新日期：2011-07-08 00:00:00

abstract：:To prevent insertional mutagenesis arising from retroviral reactivation, cells of embryonic origin possess a unique capacity to silence retroviruses. Given the distinct modes of X chromosome inactivation between embryonic and extraembryonic lineages, we investigated paradigms of viral extinction. We show that trophect...

journal_title：Cell stem cell

authors： Golding MC,Zhang L,Mann MR

更新日期：2010-05-07 00:00:00

abstract：:Cellular barcoding offers a powerful approach to characterize the growth and differentiation activity of large numbers of cotransplanted stem cells. Here, we describe a lentiviral genomic-barcoding and analysis strategy and its use to compare the clonal outputs of transplants of purified mouse and human basal mammary ...

journal_title：Cell stem cell

authors： Nguyen LV,Makarem M,Carles A,Moksa M,Kannan N,Pandoh P,Eirew P,Osako T,Kardel M,Cheung AM,Kennedy W,Tse K,Zeng T,Zhao Y,Humphries RK,Aparicio S,Eaves CJ,Hirst M

更新日期：2014-02-06 00:00:00

abstract：:Since the inception of nuclear reprogramming, the parallels between this process and tumorigenesis have become increasingly apparent. Recent studies by Abad et al. and Ohnishi et al. have now formalized this connection by demonstrating that the same transcription factors used for reprogramming to pluripotency drive tu...

journal_title：Cell stem cell

authors： Hobbs RM,Polo JM

更新日期：2014-03-06 00:00:00

abstract：:Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranula...

journal_title：Cell stem cell

authors： Fuentealba LC,Obernier K,Alvarez-Buylla A

更新日期：2012-06-14 00:00:00

abstract：:In this issue of Cell Stem Cell, Belema-Bedada et al. (2008) describe a novel mechanism by which bone marrow-derived adult mesenchymal stem cells migrate to sites of damaged heart tissue. This process is dependent on the intracellular adaptor molecule FROUNT, which interacts with the chemokine receptor CCR2. ...

journal_title：Cell stem cell

authors： Zannettino AC,Psaltis PJ,Gronthos S

更新日期：2008-06-05 00:00:00

abstract：:Nodal and Activin belong to the TGF-β superfamily and are important regulators of embryonic stem cell fate. Here we investigated whether Nodal and Activin regulate self-renewal of pancreatic cancer stem cells. Nodal and Activin were hardly detectable in more differentiated pancreatic cancer cells, while cancer stem ce...

journal_title：Cell stem cell

authors： Lonardo E,Hermann PC,Mueller MT,Huber S,Balic A,Miranda-Lorenzo I,Zagorac S,Alcala S,Rodriguez-Arabaolaza I,Ramirez JC,Torres-Ruíz R,Garcia E,Hidalgo M,Cebrián DÁ,Heuchel R,Löhr M,Berger F,Bartenstein P,Aicher A,Hee

更新日期：2011-11-04 00:00:00

abstract：:Regeneration of skin and hair follicles after wounding--a process known as wound-induced hair neogenesis (WIHN)--is a rare example of adult organogenesis in mammals. As such, WIHN provides a unique model system for deciphering mechanisms underlying mammalian regeneration. Here, we show that dsRNA, which is released fr...

journal_title：Cell stem cell

authors： Nelson AM,Reddy SK,Ratliff TS,Hossain MZ,Katseff AS,Zhu AS,Chang E,Resnik SR,Page C,Kim D,Whittam AJ,Miller LS,Garza LA

更新日期：2015-08-06 00:00:00

abstract：:The utility of induced pluripotent stem cells (iPSCs) as models to study diseases and as sources for cell therapy depends on the integrity of their genomes. Despite recent publications of DNA sequence variations in the iPSCs, the true scope of such changes for the entire genome is not clear. Here we report the whole-g...

journal_title：Cell stem cell

authors： Cheng L,Hansen NF,Zhao L,Du Y,Zou C,Donovan FX,Chou BK,Zhou G,Li S,Dowey SN,Ye Z,NISC Comparative Sequencing Program.,Chandrasekharappa SC,Yang H,Mullikin JC,Liu PP

更新日期：2012-03-02 00:00:00

abstract：:Understanding the fetal hepatic niche is essential for optimizing the generation of functional hepatocyte-like cells (hepatic cells) from human embryonic stem cells (hESCs). Here, we show that KDR (VEGFR2/FLK-1), previously assumed to be mostly restricted to mesodermal lineages, marks a hESC-derived hepatic progenitor...

journal_title：Cell stem cell

authors： Goldman O,Han S,Sourisseau M,Dziedzic N,Hamou W,Corneo B,D'Souza S,Sato T,Kotton DN,Bissig KD,Kalir T,Jacobs A,Evans T,Evans MJ,Gouon-Evans V

更新日期：2013-06-06 00:00:00

abstract：:Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from a cardiac fibroblast toward an induced cardiomyocyte, we performed c...

journal_title：Cell stem cell

authors： Stone NR,Gifford CA,Thomas R,Pratt KJB,Samse-Knapp K,Mohamed TMA,Radzinsky EM,Schricker A,Ye L,Yu P,van Bemmel JG,Ivey KN,Pollard KS,Srivastava D

更新日期：2019-07-03 00:00:00

abstract：:Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) can be achieved by viral-mediated transduction of defined transcription factors. Moving toward the eventual goal of clinical application, it is necessary to overcome limitations such as low reprogramming efficiency and genomic alterations due to ...

journal_title：Cell stem cell

authors： Feng B,Ng JH,Heng JC,Ng HH

更新日期：2009-04-03 00:00:00

abstract：:Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations f...

journal_title：Cell stem cell

authors： Barker RA,Parmar M,Studer L,Takahashi J

更新日期：2017-11-02 00:00:00

abstract：:Clonal tracking of hematopoietic stem and progenitor cells (HSPCs) has proven valuable for studying their behavior in murine recipients. Now in Cell Stem Cell, Kim et al. (2014) and Wu et al. (2014) extend these analyses to nonhuman primates, providing insights into dynamics of HSPC expansion and lineage commitment fo...

journal_title：Cell stem cell

authors： Dykstra B,Bystrykh LV

更新日期：2014-04-03 00:00:00

abstract：:Recurrent mutations in cohesin complex proteins have been identified in pre-leukemic hematopoietic stem cells and during the early development of acute myeloid leukemia and other myeloid malignancies. Although cohesins are involved in chromosome separation and DNA damage repair, cohesin complex functions during hemato...

journal_title：Cell stem cell

authors： Mazumdar C,Shen Y,Xavy S,Zhao F,Reinisch A,Li R,Corces MR,Flynn RA,Buenrostro JD,Chan SM,Thomas D,Koenig JL,Hong WJ,Chang HY,Majeti R

更新日期：2015-12-03 00:00:00

abstract：:Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process through directly activating fatty acid o...

journal_title：Cell stem cell

authors： Khoa LTP,Tsan YC,Mao F,Kremer DM,Sajjakulnukit P,Zhang L,Zhou B,Tong X,Bhanu NV,Choudhary C,Garcia BA,Yin L,Smith GD,Saunders TL,Bielas SL,Lyssiotis CA,Dou Y

更新日期：2020-09-03 00:00:00

abstract：:Understanding the mechanisms underlying neuronal fate determination will provide important insights into brain development and regenerative approaches to neurological diseases. Now in Cell Stem Cell, Masserdotti et al. (2015) use neuronal conversion of astrocytes to dissect transcriptional mechanisms of fate determina...

journal_title：Cell stem cell

authors： Wang C,Fong H,Huang Y

更新日期：2015-07-02 00:00:00

abstract：:Adult germline stem cells (AGSCs) self-renew (Thy1(+) enriched) or commit to gametogenesis (Kit(+) enriched). To better understand how chromatin regulates AGSC biology and gametogenesis, we derived stage-specific high-resolution profiles of DNA methylation, 5hmC, histone modifications/variants, and RNA-seq in AGSCs an...

journal_title：Cell stem cell

authors： Hammoud SS,Low DH,Yi C,Carrell DT,Guccione E,Cairns BR

更新日期：2014-08-07 00:00:00

abstract：:Cell types more advanced in development than embryonic stem cells, such as EpiSCs, fail to contribute to chimeras when injected into pre-implantation-stage blastocysts, apparently because the injected cells undergo apoptosis. Here we show that transient promotion of cell survival through expression of the anti-apoptot...

journal_title：Cell stem cell

authors： Masaki H,Kato-Itoh M,Takahashi Y,Umino A,Sato H,Ito K,Yanagida A,Nishimura T,Yamaguchi T,Hirabayashi M,Era T,Loh KM,Wu SM,Weissman IL,Nakauchi H

更新日期：2016-11-03 00:00:00

abstract：:Stress can activate tumor-suppressive mechanisms, causing the loss of adult stem cell function with age. In this issue of Cell Stem Cell and in Nature, Castilho et al. (2009) and Harrison et al. (2009) highlight the importance of mTOR signaling in stem cell exhaustion and mammalian aging, respectively. ...

journal_title：Cell stem cell

authors： Wood KC,Sabatini DM

更新日期：2009-09-04 00:00:00

abstract：:In this issue of Cell Stem Cell, Csaszar et al. (2012) develop a culture method that overcomes current limitations in ex vivo hematopoietic stem/progenitor cell expansion by continuously diluting inhibitory signaling factors and maintaining stem cell density. This approach enhances the generation of precursors with po...

journal_title：Cell stem cell

authors： Bernstein ID,Delaney C

更新日期：2012-02-03 00:00:00