Abstract：
:Studies in mice suggest that Olig2 gene dosage alters cerebral cortical interneuron development and contributes to trisomy-21/Down-syndrome-related intellectual disability. Xu et al. (2019) extend these studies through the remarkable use of cerebral organoid and human iPSC/mouse brain chimera experimental systems that provide an opportunity for the development of novel therapeutics.
journal_name
Cell Stem Celljournal_title
Cell stem cellauthors
Manley WF,Anderson SAdoi
10.1016/j.stem.2019.05.009subject
Has Abstractpub_date
2019-06-06 00:00:00pages
835-836issue
6eissn
1934-5909issn
1875-9777pii
S1934-5909(19)30213-9journal_volume
24pub_type
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