Foxa2: the rise and fall of dopamine neurons.

abstract：:Modifications of mRNAs can have a profound effect on cellular function and differentiation. In this issue of Cell Stem Cell, Batista et al. (2014) describe fundamental parameters of N(6)-methyl-adenosine modification of mRNAs in embryonic stem cells and provide strong evidence that modification plays a role in exit fr...

journal_title：Cell stem cell

authors： Jalkanen AL,Wilusz J

更新日期：2014-12-04 00:00:00

abstract：:Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater understanding of the pathogenesis of BMF could improve the therapeutic options for FA patients. Using a genome-wide shRNA screen in huma...

journal_title：Cell stem cell

authors： Zhang H,Kozono DE,O'Connor KW,Vidal-Cardenas S,Rousseau A,Hamilton A,Moreau L,Gaudiano EF,Greenberger J,Bagby G,Soulier J,Grompe M,Parmar K,D'Andrea AD

更新日期：2016-05-05 00:00:00

abstract：:Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment. Here we show that continuous depletion of the neural stem cell pool, as a consequence of their division, may contribute to the age-related decrease in hippocampal neurogenesis. Our results...

journal_title：Cell stem cell

authors： Encinas JM,Michurina TV,Peunova N,Park JH,Tordo J,Peterson DA,Fishell G,Koulakov A,Enikolopov G

更新日期：2011-05-06 00:00:00

abstract：:Cell types more advanced in development than embryonic stem cells, such as EpiSCs, fail to contribute to chimeras when injected into pre-implantation-stage blastocysts, apparently because the injected cells undergo apoptosis. Here we show that transient promotion of cell survival through expression of the anti-apoptot...

journal_title：Cell stem cell

authors： Masaki H,Kato-Itoh M,Takahashi Y,Umino A,Sato H,Ito K,Yanagida A,Nishimura T,Yamaguchi T,Hirabayashi M,Era T,Loh KM,Wu SM,Weissman IL,Nakauchi H

更新日期：2016-11-03 00:00:00

abstract：:In this study, we explore endoderm cell fate regulation through the expression of lineage-determining transcription factors. We demonstrate that stable endoderm progenitors can be established from human ES cells by constitutive expression of SOX7 or SOX17, producing extraembryonic endoderm and definitive endoderm prog...

journal_title：Cell stem cell

authors： Séguin CA,Draper JS,Nagy A,Rossant J

更新日期：2008-08-07 00:00:00

abstract：:Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy. Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease. Here, we show that Tetraspanin 3 is a target of the ...

journal_title：Cell stem cell

authors： Kwon HY,Bajaj J,Ito T,Blevins A,Konuma T,Weeks J,Lytle NK,Koechlein CS,Rizzieri D,Chuah C,Oehler VG,Sasik R,Hardiman G,Reya T

更新日期：2015-08-06 00:00:00

abstract：:To prevent insertional mutagenesis arising from retroviral reactivation, cells of embryonic origin possess a unique capacity to silence retroviruses. Given the distinct modes of X chromosome inactivation between embryonic and extraembryonic lineages, we investigated paradigms of viral extinction. We show that trophect...

journal_title：Cell stem cell

authors： Golding MC,Zhang L,Mann MR

更新日期：2010-05-07 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) can either suppress or promote tumors. We found previously that incubation of human bone marrow MSCs (hMSCs) with TNF-α upregulated multiple genes including TRAIL, which has cancer apoptotic activity. Here, we show that weekly infusions into mice of hMSCs preactivated with TNF-α i...

journal_title：Cell stem cell

authors： Lee RH,Yoon N,Reneau JC,Prockop DJ

更新日期：2012-12-07 00:00:00

abstract：:Hematopoietic stem cells (HSCs) sustain hematopoiesis throughout life. HSCs exit dormancy to restore hemostasis in response to stressful events, such as acute blood loss, and must return to a quiescent state to prevent their exhaustion and resulting bone marrow failure. HSC activation is driven in part through the pho...

journal_title：Cell stem cell

authors： Baumgartner C,Toifl S,Farlik M,Halbritter F,Scheicher R,Fischer I,Sexl V,Bock C,Baccarini M

更新日期：2018-06-01 00:00:00

abstract：:Stroma is a largely understudied component of all organs that contributes to stem cell niches. Studies to define stromal components in the bone marrow have led to some unexpected findings that prompt further research. ...

journal_title：Cell stem cell

authors： Scadden DT

更新日期：2012-06-14 00:00:00

abstract：:The Wnt signaling pathway controls stem cell identity in the intestinal epithelium and in many other adult organs. The transcription factor Ascl2 (a Wnt target gene) is a master regulator of intestinal stem cell identity. It is unclear how the continuous Wnt gradient along the crypt axis is translated into discrete ex...

journal_title：Cell stem cell

authors： Schuijers J,Junker JP,Mokry M,Hatzis P,Koo BK,Sasselli V,van der Flier LG,Cuppen E,van Oudenaarden A,Clevers H

更新日期：2015-02-05 00:00:00

abstract：:Patients with type 1 diabetes (T1D) often experience gastrointestinal enteropathy (DE) of unclear etiology. Now in Cell Stem Cell, D'Addio et al. (2015) utilize organoid culture models to study the roles of stem cells in DE and show that circulating IGF/IGFBP3 controls colonic stem cell function during homeostasis and...

journal_title：Cell stem cell

authors： Cheng CW,Yilmaz ÖH

更新日期：2015-10-01 00:00:00

abstract：:Ablation of LGR5+ intestinal stem cells (ISCs) is associated with rapid restoration of the ISC compartment. Different intestinal crypt populations dedifferentiate to provide new ISCs, but the transcriptional and signaling trajectories that guide this process are unclear, and a large body of work suggests that quiescen...

journal_title：Cell stem cell

authors： Murata K,Jadhav U,Madha S,van Es J,Dean J,Cavazza A,Wucherpfennig K,Michor F,Clevers H,Shivdasani RA

更新日期：2020-03-05 00:00:00

abstract：:Developing technologies for efficient and scalable disruption of gene expression will provide powerful tools for studying gene function, developmental pathways, and disease mechanisms. Here, we develop clustered regularly interspaced short palindromic repeat interference (CRISPRi) to repress gene expression in human i...

journal_title：Cell stem cell

authors： Mandegar MA,Huebsch N,Frolov EB,Shin E,Truong A,Olvera MP,Chan AH,Miyaoka Y,Holmes K,Spencer CI,Judge LM,Gordon DE,Eskildsen TV,Villalta JE,Horlbeck MA,Gilbert LA,Krogan NJ,Sheikh SP,Weissman JS,Qi LS,So PL,Conk

更新日期：2016-04-07 00:00:00

abstract：:Although distinct human induced pluripotent stem cell (hiPSC) lines can display considerable epigenetic variation, it has been unclear whether such variability impacts their utility for disease modeling. Here, we show that although low-passage female hiPSCs retain the inactive X chromosome of the somatic cell they are...

journal_title：Cell stem cell

authors： Mekhoubad S,Bock C,de Boer AS,Kiskinis E,Meissner A,Eggan K

更新日期：2012-05-04 00:00:00

abstract：:Major developments in the neural stem cell (NSC) field in recent years provide new insights into the nature of the NSC niche. In this perspective, we integrate recent anatomical data on the organization of the two main neurogenic niches in the adult brain, the ventricular-subventricular zone (V-SVZ) and the subgranula...

journal_title：Cell stem cell

authors： Fuentealba LC,Obernier K,Alvarez-Buylla A

更新日期：2012-06-14 00:00:00

abstract：:The CRISPR-Cas9 system has been employed to generate mutant alleles in a range of different organisms. However, so far there have not been reports of use of this system for efficient correction of a genetic disease. Here we show that mice with a dominant mutation in Crygc gene that causes cataracts could be rescued by...

journal_title：Cell stem cell

authors： Wu Y,Liang D,Wang Y,Bai M,Tang W,Bao S,Yan Z,Li D,Li J

更新日期：2013-12-05 00:00:00

abstract：:Bmi1 is required for efficient self-renewal of hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs). In this study, we investigated whether leukemia-associated fusion proteins, which differ in their ability to activate Hox expression, could initiate leukemia in the absence of Bmi1. AML1-ETO and PLZF-RARα, wh...

journal_title：Cell stem cell

authors： Smith LL,Yeung J,Zeisig BB,Popov N,Huijbers I,Barnes J,Wilson AJ,Taskesen E,Delwel R,Gil J,Van Lohuizen M,So CW

更新日期：2011-06-03 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. Here, we utilized a porcine model of acute...

journal_title：Cell stem cell

authors： Ye L,Chang YH,Xiong Q,Zhang P,Zhang L,Somasundaram P,Lepley M,Swingen C,Su L,Wendel JS,Guo J,Jang A,Rosenbush D,Greder L,Dutton JR,Zhang J,Kamp TJ,Kaufman DS,Ge Y,Zhang J

更新日期：2014-12-04 00:00:00

abstract：:A diverse array of environmental factors contributes to the overall control of stem cell activity. In particular, new data continue to mount on the influence of the extracellular matrix (ECM) on stem cell fate through physical interactions with cells, such as the control of cell geometry, ECM geometry/topography at th...

journal_title：Cell stem cell

authors： Guilak F,Cohen DM,Estes BT,Gimble JM,Liedtke W,Chen CS

更新日期：2009-07-02 00:00:00

abstract：:DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in embryonic stem cells and neurons in mammals. However, its biological function in vivo is largely unknown. Here, we demonstrate that Tet1 plays an important role in regulating neural progenitor cell proliferation in adult mouse brain. Mice lacking Tet...

journal_title：Cell stem cell

authors： Zhang RR,Cui QY,Murai K,Lim YC,Smith ZD,Jin S,Ye P,Rosa L,Lee YK,Wu HP,Liu W,Xu ZM,Yang L,Ding YQ,Tang F,Meissner A,Ding C,Shi Y,Xu GL

更新日期：2013-08-01 00:00:00

abstract：:Several noncanonical type-1 Polycomb Repressive Complexes (PRC1) that act independently of PRC2 have been recently identified, but their functions in embryonic stem cells (ESCs) are unclear. Two recent reports by Morey et al. (2012a) and Wu et al. (2013) define functionally distinct roles for canonical and noncanonica...

journal_title：Cell stem cell

authors： Turner SA,Bracken AP

更新日期：2013-02-07 00:00:00

abstract：:Despite widespread interest in using human induced pluripotent stem cells (hiPSCs) in neurological disease modeling, a suitable model system to study human neuronal connectivity is lacking. Here, we report a comprehensive and efficient differentiation paradigm for hiPSCs that generate multiple CA3 pyramidal neuron sub...

journal_title：Cell stem cell

authors： Sarkar A,Mei A,Paquola ACM,Stern S,Bardy C,Klug JR,Kim S,Neshat N,Kim HJ,Ku M,Shokhirev MN,Adamowicz DH,Marchetto MC,Jappelli R,Erwin JA,Padmanabhan K,Shtrahman M,Jin X,Gage FH

更新日期：2018-05-03 00:00:00

abstract：:Cerebral organoids represent a new model in which to study human brain development outside the human body. Recently in Nature Biotechnology, Lancaster et al. (2017) tackled the lack of reproducibility, tissue homogeneity, and complexity of this system by bioengineering organoids to establish the next generation of hum...

journal_title：Cell stem cell

authors： Koch P,Ladewig J

更新日期：2017-08-03 00:00:00

abstract：:Stem cell-based therapies for Parkinson's disease are moving into a new and exciting era, with several groups pursuing clinical trials with pluripotent stem cell (PSC)-derived dopamine neurons. As many groups have ongoing or completed GMP-level cell manufacturing, we highlight key clinical translation considerations f...

journal_title：Cell stem cell

authors： Barker RA,Parmar M,Studer L,Takahashi J

更新日期：2017-11-02 00:00:00

abstract：:Alexander disease (AxD) is a leukodystrophy that primarily affects astrocytes and is caused by mutations in the astrocytic filament gene GFAP. While astrocytes are thought to have important roles in controlling myelination, AxD animal models do not recapitulate critical myelination phenotypes and it is therefore not c...

journal_title：Cell stem cell

authors： Li L,Tian E,Chen X,Chao J,Klein J,Qu Q,Sun G,Sun G,Huang Y,Warden CD,Ye P,Feng L,Li X,Cui Q,Sultan A,Douvaras P,Fossati V,Sanjana NE,Riggs AD,Shi Y

更新日期：2018-08-02 00:00:00

abstract：:Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage conversion, thereby reprogramming a somatic cell's identity. To determine the molecular mechanisms by which Gata4, Mef2c, and Tbx5 (GMT) induce conversion from a cardiac fibroblast toward an induced cardiomyocyte, we performed c...

journal_title：Cell stem cell

authors： Stone NR,Gifford CA,Thomas R,Pratt KJB,Samse-Knapp K,Mohamed TMA,Radzinsky EM,Schricker A,Ye L,Yu P,van Bemmel JG,Ivey KN,Pollard KS,Srivastava D

更新日期：2019-07-03 00:00:00

abstract：:The cellular identity of niche cells that regulate hematopoietic stem cell (HSC) self-renewal and differentiation has been debated for several years. Two recent studies in Nature (Ding and Morrison, 2013; Greenbaum et al., 2013) have shed light into the bone marrow stromal subsets making CXCL12, a chemokine critical f...

journal_title：Cell stem cell

authors： Hanoun M,Frenette PS

更新日期：2013-04-04 00:00:00

abstract：:N6-methyladenosine (m6A), the most abundant internal modification in mRNA, has been implicated in tumorigenesis. As an m6A demethylase, ALKBH5 has been shown to promote the development of breast cancer and brain tumors. However, in acute myeloid leukemia (AML), ALKBH5 was reported to be frequently deleted, implying a ...

journal_title：Cell stem cell

authors： Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J

更新日期：2020-07-02 00:00:00

abstract：:Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice (pregastrulation lethality) and humans (Seckel syndrome). Here we show that eliminating ATR in adult mice leads to de...

journal_title：Cell stem cell

authors： Ruzankina Y,Pinzon-Guzman C,Asare A,Ong T,Pontano L,Cotsarelis G,Zediak VP,Velez M,Bhandoola A,Brown EJ

更新日期：2007-06-07 00:00:00