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Multiple epigenetic modifiers induce aggressive viral extinction in extraembryonic endoderm stem cells.

Abstract：

:To prevent insertional mutagenesis arising from retroviral reactivation, cells of embryonic origin possess a unique capacity to silence retroviruses. Given the distinct modes of X chromosome inactivation between embryonic and extraembryonic lineages, we investigated paradigms of viral extinction. We show that trophectoderm stem cells do not silence retroviral transcription, whereas extraembryonic endoderm stem cells aggressively extinguish proviral transcription, even more rapidly than do embryonic stem cells. By using a short hairpin RNA library, we identified epigenetic modifiers of retroviral extinction in extraembryonic endoderm stem cells. Multiple chromatin remodeling and polycomb repressor complex proteins act to modulate integrated, as well as endogenous, retroviral element silencing, with a subset of factors displaying differential effects between stem cell types. Furthermore, our data suggest that small RNAs play a role in this process through interactions with the Argonaute family. Our results further the understanding of mechanisms regulating retroviral transcription in different stem cell lineages.

journal_name

Cell Stem Cell

journal_title

Cell stem cell

authors

Golding MC,Zhang L,Mann MR

doi

10.1016/j.stem.2010.03.014

subject

Has Abstract

pub_date

2010-05-07 00:00:00

pages

457-67

issue

5

eissn

1934-5909

issn

1875-9777

pii

S1934-5909(10)00112-8

journal_volume

6

pub_type

杂志文章

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